Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01196  |
| T6SS type | Type i4b |
| Strain | Burkholderia cenocepacia H111 |
| Replicon (RefSeq) | chromosome (NZ_HG938370) |
| Location | 347990..367838 |
| Function | anti-bacterial |
| Comment | The Burkholderia cenocepacia T6SS1 is functional during growth under standard laboratory conditions. |
| References | [1] Spiewak HL, Shastri S, Zhang L, Schwager S, Eberl L, Vergunst AC, Thomas MS. et al (2019) Burkholderia cenocepacia utilizes a type VI secretion system for bacterial competition.. Microbiologyopen. NA. [PudMed:30628184] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| I35_RS01660 | 343210..343968 | + | 759 | WP_006477108.1 | cytochrome c1 | ||
| I35_RS01665 | 344063..344674 | + | 612 | WP_006400565.1 | glutathione S-transferase N-terminal domain-containing protein | ||
| I35_RS01670 | 344746..345267 | + | 522 | WP_006485328.1 | ClpXP protease specificity-enhancing factor | ||
| I35_RS01680 | 345746..345949 | + | 204 | WP_006485326.1 | hypothetical protein | ||
| I35_RS01685 | 346059..346859 | - | 801 | WP_006494426.1 | transporter substrate-binding domain-containing protein | ||
| I35_RS01690 | 347141..347458 | + | 318 | WP_006485338.1 | hypothetical protein | ||
| I35_RS01695 | 347540..347875 | + | 336 | WP_006494425.1 | hypothetical protein | ||
| T6CP015177 | TssL | I35_RS01700 | 347990..348772 | - | 783 | WP_006494424.1 | type IVB secretion system protein IcmH/DotU |
| T6CP015178 | TssK | I35_RS01705 (tssK) | 348769..350115 | - | 1347 | WP_006477098.1 | type VI secretion system baseplate subunit TssK |
| T6CP015179 | TssJ | I35_RS01710 (tssJ) | 350221..350820 | - | 600 | WP_006485335.1 | type VI secretion system lipoprotein TssJ |
| I35_RS01715 | 351208..351834 | + | 627 | WP_043204524.1 | tetratricopeptide repeat protein | ||
| T6CP015180 | TssB | I35_RS01720 (tssB) | 351881..352396 | + | 516 | WP_006484395.1 | type VI secretion system contractile sheath small subunit |
| T6CP015181 | TssC | I35_RS01725 (tssC) | 352412..353902 | + | 1491 | WP_006484397.1 | type VI secretion system contractile sheath large subunit |
| T6CP015182 | TssD | I35_RS01730 | 353973..354476 | + | 504 | WP_006477093.1 | type VI secretion system tube protein Hcp |
| T6CP015183 | TssE | I35_RS01735 (tssE) | 354539..355024 | + | 486 | WP_006477092.1 | type VI secretion system baseplate subunit TssE |
| T6CP015184 | TssF | I35_RS01740 (tssF) | 355101..356936 | + | 1836 | WP_006494422.1 | type VI secretion system baseplate subunit TssF |
| T6CP015185 | TssG | I35_RS01745 (tssG) | 356900..358000 | + | 1101 | WP_006494420.1 | type VI secretion system baseplate subunit TssG |
| T6CP015186 | TssH | I35_RS01750 (tssH) | 358042..360711 | + | 2670 | WP_006494419.1 | type VI secretion system ATPase TssH |
| T6CP015187 | TssA | I35_RS01755 (tssA) | 360756..361877 | + | 1122 | WP_006494418.1 | type VI secretion system protein TssA |
| I35_RS01760 | 361971..362921 | - | 951 | WP_006494417.1 | OmpA family protein | ||
| I35_RS01765 (tagF) | 362926..363915 | - | 990 | WP_006483243.1 | type VI secretion system-associated protein TagF | ||
| T6CP015188 | TssM | I35_RS01770 (tssM) | 363912..367838 | - | 3927 | WP_043204521.1 | type VI secretion system membrane subunit TssM |
| I35_RS01775 | 368140..368985 | - | 846 | WP_006488977.1 | M15 family metallopeptidase | ||
| I35_RS01780 | 369107..370099 | + | 993 | WP_006494415.1 | hypothetical protein | ||
| I35_RS01785 | 370311..371339 | + | 1029 | WP_006481924.1 | transporter | ||
| I35_RS34725 | 371367..371519 | - | 153 | WP_006481917.1 | DUF1427 family protein | ||
| I35_RS01790 | 371544..372521 | - | 978 | WP_034201070.1 | zinc-binding alcohol dehydrogenase family protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01848 |
I35_RS01730 (hcp) | - | - | Burkholderia cenocepacia H111 | chromosome (NZ_HG938370) | 353973..354476 (+) | 493523014 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|