Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


T6SS ID T6SS00548 experimental
T6SS type Type i2
Strain Klebsiella pneumoniae subsp. pneumoniae HS11286
Replicon (RefSeq) chromosome (NC_016845)
Location 2326237..2353260
Function anti-bacterial
Comment Hcp was present only in the supernatant of the wild type strain but not in ΔvipA mutant.WT-V caused a statistically significant impairment/killing of the Δtle1KPΔtli1KP-V mutant, but the Δtle1KP-V mutant did not. Additionally, when the prey (Δtle1KPΔtli1KP-V) was complemented with tli1KP, the inhibition by the attacker WT-V was same to the attacker Δtle1KP-V.
[1] Liu L, Ye M, Li X, Li J, Deng Z, Yao YF, Ou HY. et al (2017) Identification and Characterization of an Antibacterial Type VI Secretion System in the Carbapenem-Resistant Strain Klebsiella pneumoniae HS11286.. Front Cell Infect Microbiol. 0.598611111. [PudMed:29085808]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
KPHS_22930 2322412..2322621 + 210 YP_005226593.1 hypothetical protein
KPHS_22940 2323071..2324558 + 1488 YP_005226594.1 putative reverse transcriptase/maturase
KPHS_22950 2325143..2325391 - 249 YP_005226595.1 DinI family protein
KPHS_22960 2325956..2326078 + 123 YP_005226596.1 hypothetical protein
T6CP005798 TssB KPHS_22970 2326237..2326728 + 492 YP_005226597.1 type VI secretion system contractile sheath small subunit
T6CP005799 TssC KPHS_22980 2326771..2328315 + 1545 YP_005226598.1 EvpB/family type VI secretion protein
T6CP005800 TssK KPHS_22990 2328325..2329668 + 1344 YP_005226599.1 type VI secretion system baseplate subunit TssK
T6CP008981 TssL KPHS_23000 2329665..2330354 + 690 YP_005226600.1 DotU family type IV/VI secretion system protein
T6CP011987 TagL KPHS_23010 2330351..2332057 + 1707 YP_005226601.1 OmpA/MotB domain-containing protein
T6CP008982 TssD KPHS_23020 2332062..2332553 + 492 YP_005226602.1 Hcp family type VI secretion system effector
T6CP005801 TssH KPHS_23030 2332818..2335472 + 2655 YP_005226603.1 putative protease
T6CP005802 TssI KPHS_23040 2335474..2337843 + 2370 YP_005226604.1 Rhs element Vgr protein
KPHS_23050 2337844..2338623 + 780 YP_005226605.1 DUF4123 domain-containing protein
KPHS_23060 2338687..2339217 + 531 YP_005226606.1 putative lipoprotein
KPHS_23070 2339286..2339816 + 531 YP_005226607.1 putative lipoprotein
KPHS_23080 2339884..2340414 + 531 YP_005226608.1 putative lipoprotein
KPHS_23090 2340482..2341012 + 531 YP_005226609.1 putative lipoprotein
KPHS_23100 2341000..2342034 + 1035 YP_005226610.1 DUF2235 domain-containing protein
KPHS_23110 2342120..2343418 + 1299 YP_005226611.1 hypothetical protein
T6CP011986 PAAR KPHS_23120 2343463..2343720 + 258 YP_005226612.1 PaaR repeat-containing protein
KPHS_23130 2343717..2344856 + 1140 YP_005226613.1 hypothetical protein
T6CP005803 TssM KPHS_23140 2344840..2348265 + 3426 YP_005226614.1 ImcF domain-containing protein
T6CP009367 TssA KPHS_23150 2348265..2348672 + 408 YP_005226615.1 type VI secretion-associated protein
KPHS_23160 2348724..2349857 + 1134 YP_005226616.1 type VI secretion-associated protein
T6CP005804 TssF KPHS_23170 2349937..2351691 + 1755 YP_005226617.1 type VI secretion system baseplate subunit TssF
T6CP005805 TssG KPHS_23180 2351655..2352740 + 1086 YP_005226618.1 type VI secretion system baseplate subunit TssG
T6CP005806 TssJ KPHS_23190 2352718..2353260 + 543 YP_005226619.1 type VI secretion system lipoprotein TssJ
KPHS_23200 2353231..2353359 - 129 YP_005226620.1 hypothetical protein
KPHS_23210 2353389..2353883 + 495 YP_005226621.1 hypothetical protein
KPHS_23220 2353950..2354663 - 714 YP_005226622.1 oxidoreductase
KPHS_23230 2354737..2355330 + 594 YP_005226623.1 putative regulatory protein TetR
KPHS_23240 2355335..2356090 - 756 YP_005226624.1 putative dehydrogenase/reductase oxidoreductase protein
KPHS_23250 2356249..2357127 + 879 YP_005226625.1 putative ARAC-type regulatory protein
KPHS_23260 2357178..2357384 - 207 YP_005226626.1 DUF1471 domain-containing protein
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files


Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID
EFF18621 experimental KPHS_23105 (Tle1KP) Tle IMU17297 experimental Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome (NC_016845) 2341000..2343418 (+) -

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector