Detailed information of regulator


Summary

Regulator ID REG0054 experimental
Regulator type protein
Regulatory pathway (from literatures) Global regulator
KEGG pathway (determined by BlastKOALA) Biofilm formation - Pseudomonas aeruginosa (map02025)
Related T6SS T6SS00003 experimental (Type i3)
Strain Pseudomonas aeruginosa PAO1
Replicon chromosome
Sequence Protein sequence (796 a.a.); Nucleotide sequence (2388 bp)
Description The gene encoding Hcp1 resides in the IAHP-related virulence locus regulated by RetS and LadS.
Reference
External database links

Locus tag (Gene) PA3974 (LadS)
Coordinates (Strand) 4453289..4455676 (-)
NCBI ID 15599169
RefSeq NC_002516
Uniprot ID Q9HX42_PSEAE
KEGG ID pae:PA3974
KEGG pathway (determined by BlastKOALA) map02025
PDB ID -
  Target
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Target
Regulation (↓/↑)
Target sequence
hcp1 (PA0085) expression and secretion↓-
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Pfam domain hit(s) of regulator

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Domain
Pfam ID
E-value
Aligned region
7TMR-DISM_7TMPF07695.135.9e-56184..386
7TMR-DISMED2PF07696.135.8e-3732..171
Response_regPF00072.265.1e-27670..780
HATPase_cPF02518.286.1e-23530..644
HisKAPF00512.272.4e-14419..482
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Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

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Prediction                
Region    
Sequence
Outside1-182MRHWLILFLLALPCLAGAVSFNEQVERLPLGQSIDVFEDVRGSADINDITSRAIDSSFRRHDKDVLNAGYSRSVFWLRLDLDYRPVASSDPRTWLLELAYPPLDKLDLYLPDGQGGYRLAQRTGDTLPFASRPIRQNNYLFELGLEPNKPQRVYLRLESQGSIQAPLTLWSPKAYLEEQPER
Transmembrane helix183-205IYVLGIIYGVLLVMLIYNLFIFL
Inside206-211SVRDTS
Transmembrane helix212-234YLYYILYIASFGLYQVSVNGAGI
Outside235-248EYFWPDSPWWANAA
Transmembrane helix249-268TPFLIGSAALFGCQFARSFL
Inside269-279HTRDHSVWVDR
Transmembrane helix280-302GLLALMAVGALVMLMALTMSYAV
Outside303-306ALRL
Transmembrane helix307-329ATYLALAFTGLIFAAGILAWLRG
Inside330-335MRVARY
Transmembrane helix336-358FIIAWTAFLLGGIVNTLMVLGYL
Outside359-795PNMFLTMYASQIGSALEVGLLSLALADRINAMKEERARILQESSRKLEALNQELANSNRLKDEFLATVTHELRTPMSGVIGSLELMQTVPMDVELAEYQRTAAGSARDMMRMVNDILALIELQAGKLYPRREPFSLRGLFDSLRAQYAPRVEEKGLRFALQLDDSLPDTLEGDAGKLAQALGYLVDNAIKFTARGSVTLRVAAGRTHDGVALRVEVIDTGIGFDMAAGSDLYQRFVQADSSLTRGYGGLGIGLALCRKLVELLGGELTHESRPGQGSRFLLRLQLTQPAQGLAPPPRRAGGQAVRRPEECTVLVVEDNAINQLVTRGMLLKLGYRVRTADNGSEALELLARERPDGVLLDCQMPVMDGFATCRAIRALPGCAELPVLALTAHSHSGDRERCLAAGMSDYMAKPVKFEELQTLLHDWLLCQPIVTKSA


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
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Prediction       
Probability
Cleavage site
Signal peptide sequence
SP(Sec/SPI)0.7135pos: 18-19. AGA-VS.MRHWLILFLLALPCLAGA


  Protein sequence of regulator: 796 a.a.    .

>REG0054 NC_002516:c4455676-4453289 [Pseudomonas aeruginosa PAO1]
MRHWLILFLLALPCLAGAVSFNEQVERLPLGQSIDVFEDVRGSADINDITSRAIDSSFRRHDKDVLNAGYSRSVFWLRLD
LDYRPVASSDPRTWLLELAYPPLDKLDLYLPDGQGGYRLAQRTGDTLPFASRPIRQNNYLFELGLEPNKPQRVYLRLESQ
GSIQAPLTLWSPKAYLEEQPERIYVLGIIYGVLLVMLIYNLFIFLSVRDTSYLYYILYIASFGLYQVSVNGAGIEYFWPD
SPWWANAATPFLIGSAALFGCQFARSFLHTRDHSVWVDRGLLALMAVGALVMLMALTMSYAVALRLATYLALAFTGLIFA
AGILAWLRGMRVARYFIIAWTAFLLGGIVNTLMVLGYLPNMFLTMYASQIGSALEVGLLSLALADRINAMKEERARILQE
SSRKLEALNQELANSNRLKDEFLATVTHELRTPMSGVIGSLELMQTVPMDVELAEYQRTAAGSARDMMRMVNDILALIEL
QAGKLYPRREPFSLRGLFDSLRAQYAPRVEEKGLRFALQLDDSLPDTLEGDAGKLAQALGYLVDNAIKFTARGSVTLRVA
AGRTHDGVALRVEVIDTGIGFDMAAGSDLYQRFVQADSSLTRGYGGLGIGLALCRKLVELLGGELTHESRPGQGSRFLLR
LQLTQPAQGLAPPPRRAGGQAVRRPEECTVLVVEDNAINQLVTRGMLLKLGYRVRTADNGSEALELLARERPDGVLLDCQ
MPVMDGFATCRAIRALPGCAELPVLALTAHSHSGDRERCLAAGMSDYMAKPVKFEELQTLLHDWLLCQPIVTKSA*

  Nucleotide sequence of regulator: 2388 bp    .

>REG0054 NC_002516:c4455676-4453289 [Pseudomonas aeruginosa PAO1]
ATGCGGCACTGGCTGATTCTCTTTCTTCTTGCGTTGCCGTGCCTGGCGGGTGCGGTGAGCTTCAACGAGCAGGTCGAGCG
CCTGCCGCTGGGGCAGTCCATCGACGTGTTCGAGGACGTGCGCGGTAGCGCCGATATCAACGACATCACCTCGCGGGCCA
TCGACAGCAGCTTCCGCCGCCATGACAAGGACGTGCTCAATGCCGGCTATTCGCGCTCGGTGTTCTGGTTGCGCCTGGAC
CTGGACTACCGGCCGGTCGCCTCCAGCGATCCGCGCACCTGGCTGCTGGAGCTGGCCTATCCGCCGCTGGACAAGCTCGA
CCTCTACCTGCCCGATGGCCAGGGCGGCTACCGCCTCGCCCAGCGCACCGGCGACACATTGCCGTTCGCCAGTCGGCCGA
TCCGGCAGAACAACTACCTGTTCGAACTCGGCCTCGAGCCGAACAAGCCGCAGCGTGTCTACCTGCGGCTGGAAAGCCAG
GGGTCGATCCAGGCGCCGCTGACCCTGTGGTCGCCCAAGGCCTACCTGGAGGAGCAGCCCGAACGCATCTATGTGCTCGG
CATCATCTATGGCGTGCTGCTGGTGATGCTGATCTACAACCTGTTCATCTTCCTCAGCGTCCGCGATACCAGCTATCTCT
ACTACATCCTCTATATCGCTTCGTTCGGGCTCTACCAGGTCTCGGTGAACGGCGCCGGCATCGAGTACTTCTGGCCCGAC
AGCCCCTGGTGGGCGAACGCCGCCACGCCATTCCTGATCGGTTCGGCGGCGCTGTTCGGCTGCCAGTTCGCGCGCAGCTT
CCTGCATACCCGCGACCACAGCGTGTGGGTCGACCGCGGCCTGCTGGCGCTGATGGCGGTCGGCGCGCTGGTCATGCTGA
TGGCGCTGACCATGAGCTACGCCGTGGCCCTGCGCCTGGCCACCTACCTGGCGCTGGCCTTCACCGGCCTGATCTTCGCC
GCCGGCATCCTCGCCTGGCTGCGCGGCATGCGCGTGGCGCGCTATTTCATCATCGCCTGGACCGCCTTCCTTCTCGGCGG
CATCGTCAACACCCTGATGGTCCTCGGCTACCTGCCGAACATGTTCCTCACCATGTATGCCAGCCAGATCGGTTCGGCGC
TGGAGGTGGGCTTGCTGTCGCTGGCACTGGCCGACCGGATCAACGCAATGAAGGAGGAGCGCGCGCGAATCCTCCAGGAG
TCCAGCCGCAAGCTGGAAGCGCTGAACCAGGAACTGGCCAACAGCAACCGCCTGAAGGACGAGTTCCTCGCCACCGTCAC
CCACGAACTGCGCACCCCGATGAGCGGGGTGATCGGTTCGCTGGAGCTGATGCAGACGGTGCCGATGGACGTCGAACTCG
CCGAGTACCAGCGCACCGCCGCCGGTTCGGCGCGGGACATGATGCGGATGGTCAACGACATCCTCGCCCTCATCGAACTG
CAGGCCGGCAAGCTCTACCCGCGCCGCGAGCCGTTCAGCCTGCGCGGCCTGTTCGACAGCCTGCGCGCGCAGTACGCGCC
GCGCGTCGAGGAGAAGGGCCTGCGCTTCGCCCTGCAACTGGACGACAGCCTGCCGGACACCCTCGAAGGTGATGCCGGCA
AGCTGGCCCAGGCGCTGGGCTACCTGGTCGACAACGCGATCAAGTTCACCGCCAGGGGCAGCGTGACCCTGCGCGTCGCC
GCCGGGCGTACCCATGACGGGGTGGCGCTGCGGGTGGAAGTGATCGACACCGGCATCGGTTTCGACATGGCCGCCGGCAG
CGACCTCTACCAGCGTTTCGTCCAGGCCGACAGCTCGTTGACCCGTGGCTACGGAGGCCTCGGCATCGGCCTGGCGCTGT
GCCGCAAGCTGGTGGAACTGCTTGGCGGCGAGCTGACCCACGAGTCCCGGCCGGGGCAGGGCAGCCGCTTCCTCCTGCGC
CTGCAACTGACCCAGCCGGCCCAGGGCCTGGCGCCGCCGCCGCGGCGCGCCGGCGGGCAGGCGGTGCGGCGTCCCGAGGA
GTGCACGGTGCTGGTGGTGGAGGACAACGCCATCAACCAGTTGGTGACTCGCGGCATGCTGCTCAAGCTCGGCTACCGGG
TGCGCACCGCCGACAACGGCAGCGAGGCCCTGGAGTTGCTGGCGCGCGAGCGGCCGGACGGCGTACTGCTCGACTGCCAG
ATGCCGGTGATGGACGGCTTCGCCACCTGTCGGGCGATCCGCGCGCTGCCCGGCTGCGCGGAACTGCCGGTGCTGGCGTT
GACCGCCCACAGCCACAGCGGCGATCGCGAGCGCTGCCTGGCGGCGGGCATGAGCGACTACATGGCCAAGCCGGTCAAGT
TCGAAGAGTTGCAGACCCTGCTGCACGATTGGCTGCTGTGCCAGCCGATCGTCACCAAGTCCGCCTGA