Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS00225 experimental
T6SS type Type i3
Strain Yersinia pseudotuberculosis IP 31758
Replicon (RefSeq) chromosome (NC_009708)
Location 3850633..3874248
Function -
Comment T6SS-4 promotes Y. pseudotuberculosis survival in high osmolarity conditions and lead to resistance to deoxycholate.
References
[1] Gueguen E et al (2013) Expression of a Yersinia pseudotuberculosis Type VI Secretion System Is Responsive to Envelope Stresses through the OmpR Transcriptional Activator. PLoS One. 8(6):e66615. [PudMed:23840509]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentPAARTssATssBTssCTssDTssETssFTssGTssHTssITssJTssKTssL
Number1111111111111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
YPSIP31758_RS18425 (rapA) 3847096..3850002 + 2907 WP_011191719.1 RNA polymerase-associated protein RapA
YPSIP31758_RS18430 3850258..3850611 - 354 WP_002210468.1 hypothetical protein
YPSIP31758_RS18435 (tssM) 3850633..3854074 - 3442 pseudogene type VI secretion system membrane subunit TssM
T6CP002243 TssL YPSIP31758_RS18440 (icmH) 3854136..3855746 - 1611 WP_011191718.1 type IVB secretion system protein IcmH/DotU
T6CP002244 TssK YPSIP31758_RS18445 (tssK) 3855743..3857098 - 1356 WP_002210470.1 type VI secretion system baseplate subunit TssK
T6CP002245 TssJ YPSIP31758_RS18450 (tssJ) 3857218..3857709 - 492 WP_011191717.1 type VI secretion system lipoprotein TssJ
T6CP011612 PAAR YPSIP31758_RS18455 3857702..3858067 - 366 WP_002214737.1 DUF4150 domain-containing protein
YPSIP31758_RS18460 3858073..3858690 - 618 WP_002210473.1 DUF3540 domain-containing protein
YPSIP31758_RS18465 3858683..3859786 - 1104 WP_002214739.1 pentapeptide repeat-containing protein
YPSIP31758_RS18470 3859812..3862031 - 2220 WP_002224087.1 pentapeptide repeat-containing protein
T6CP002246 TssI YPSIP31758_RS18475 (vgrG) 3862044..3864392 - 2349 WP_012105682.1 type VI secretion system tip protein VgrG
T6CP002247 TssH YPSIP31758_RS18480 (tssH) 3864496..3867084 - 2589 WP_002210475.1 type VI secretion system ATPase TssH
T6CP002248 TssG YPSIP31758_RS18485 (tssG) 3867102..3868085 - 984 WP_012105683.1 type VI secretion system baseplate subunit TssG
T6CP002249 TssF YPSIP31758_RS18490 (tssF) 3868078..3869922 - 1845 WP_011191714.1 type VI secretion system baseplate subunit TssF
T6CP002250 TssE YPSIP31758_RS18495 3869955..3870398 - 444 WP_002210478.1 type VI secretion system baseplate subunit TssE
T6CP002251 TssD YPSIP31758_RS18500 3870472..3870990 - 519 WP_002210479.1 type VI secretion system tube protein Hcp
T6CP002252 TssC YPSIP31758_RS18505 (tssC) 3871153..3872655 - 1503 WP_002210480.1 type VI secretion system contractile sheath large subunit
T6CP002253 TssB YPSIP31758_RS18510 (tssB) 3872664..3873224 - 561 WP_002210481.1 type VI secretion system contractile sheath small subunit
T6CP002254 TssA YPSIP31758_RS18515 3873235..3874248 - 1014 WP_002210482.1 ImpA family type VI secretion system protein
YPSIP31758_RS18520 (rovC) 3874578..3875321 + 744 WP_002214747.1 hexameric transcriptional regulator RovC
YPSIP31758_RS18525 (rluA) 3876544..3877164 + 621 WP_002210485.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA
YPSIP31758_RS18530 (djlA) 3877481..3878314 - 834 WP_011191713.1 co-chaperone DjlA
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0185 experimental YpsIP31758_3980 (ompR) protein TCS-RR Yersinia pseudotuberculosis IP 31758 chromosome (NC_009708) 4465260..4465979 (-) 490527984 T6SS-4 promoter (↓)
REG0186 experimental YpsIP31758_3441 (lptD) protein Unknown Yersinia pseudotuberculosis IP 31758 chromosome (NC_009708) 3878499..3880841 (+) 499505072 YpsIP31758_3980 (ompR) (↓)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector