Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00225  |
| T6SS type | Type i3 |
| Strain | Yersinia pseudotuberculosis IP 31758 |
| Replicon (RefSeq) | chromosome (NC_009708) |
| Location | 3850633..3874248 |
| Function | - |
| Comment | T6SS-4 promotes Y. pseudotuberculosis survival in high osmolarity conditions and lead to resistance to deoxycholate. |
| References | [1] Gueguen E et al (2013) Expression of a Yersinia pseudotuberculosis Type VI Secretion System Is Responsive to Envelope Stresses through the OmpR Transcriptional Activator. PLoS One. 8(6):e66615. [PudMed:23840509] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| YPSIP31758_RS18425 (rapA) | 3847096..3850002 | + | 2907 | WP_011191719.1 | RNA polymerase-associated protein RapA | ||
| YPSIP31758_RS18430 | 3850258..3850611 | - | 354 | WP_002210468.1 | hypothetical protein | ||
| YPSIP31758_RS18435 (tssM) | 3850633..3854074 | - | 3442 | pseudogene | type VI secretion system membrane subunit TssM | ||
| T6CP002243 | TssL | YPSIP31758_RS18440 (icmH) | 3854136..3855746 | - | 1611 | WP_011191718.1 | type IVB secretion system protein IcmH/DotU |
| T6CP002244 | TssK | YPSIP31758_RS18445 (tssK) | 3855743..3857098 | - | 1356 | WP_002210470.1 | type VI secretion system baseplate subunit TssK |
| T6CP002245 | TssJ | YPSIP31758_RS18450 (tssJ) | 3857218..3857709 | - | 492 | WP_011191717.1 | type VI secretion system lipoprotein TssJ |
| T6CP011612 | PAAR | YPSIP31758_RS18455 | 3857702..3858067 | - | 366 | WP_002214737.1 | DUF4150 domain-containing protein |
| YPSIP31758_RS18460 | 3858073..3858690 | - | 618 | WP_002210473.1 | DUF3540 domain-containing protein | ||
| YPSIP31758_RS18465 | 3858683..3859786 | - | 1104 | WP_002214739.1 | pentapeptide repeat-containing protein | ||
| YPSIP31758_RS18470 | 3859812..3862031 | - | 2220 | WP_002224087.1 | pentapeptide repeat-containing protein | ||
| T6CP002246 | TssI | YPSIP31758_RS18475 (vgrG) | 3862044..3864392 | - | 2349 | WP_012105682.1 | type VI secretion system tip protein VgrG |
| T6CP002247 | TssH | YPSIP31758_RS18480 (tssH) | 3864496..3867084 | - | 2589 | WP_002210475.1 | type VI secretion system ATPase TssH |
| T6CP002248 | TssG | YPSIP31758_RS18485 (tssG) | 3867102..3868085 | - | 984 | WP_012105683.1 | type VI secretion system baseplate subunit TssG |
| T6CP002249 | TssF | YPSIP31758_RS18490 (tssF) | 3868078..3869922 | - | 1845 | WP_011191714.1 | type VI secretion system baseplate subunit TssF |
| T6CP002250 | TssE | YPSIP31758_RS18495 | 3869955..3870398 | - | 444 | WP_002210478.1 | type VI secretion system baseplate subunit TssE |
| T6CP002251 | TssD | YPSIP31758_RS18500 | 3870472..3870990 | - | 519 | WP_002210479.1 | type VI secretion system tube protein Hcp |
| T6CP002252 | TssC | YPSIP31758_RS18505 (tssC) | 3871153..3872655 | - | 1503 | WP_002210480.1 | type VI secretion system contractile sheath large subunit |
| T6CP002253 | TssB | YPSIP31758_RS18510 (tssB) | 3872664..3873224 | - | 561 | WP_002210481.1 | type VI secretion system contractile sheath small subunit |
| T6CP002254 | TssA | YPSIP31758_RS18515 | 3873235..3874248 | - | 1014 | WP_002210482.1 | ImpA family type VI secretion system protein |
| YPSIP31758_RS18520 (rovC) | 3874578..3875321 | + | 744 | WP_002214747.1 | hexameric transcriptional regulator RovC | ||
| YPSIP31758_RS18525 (rluA) | 3876544..3877164 | + | 621 | WP_002210485.1 | bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA | ||
| YPSIP31758_RS18530 (djlA) | 3877481..3878314 | - | 834 | WP_011191713.1 | co-chaperone DjlA |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0185 |
YpsIP31758_3980 (ompR) | protein | TCS-RR | Yersinia pseudotuberculosis IP 31758 | chromosome (NC_009708) | 4465260..4465979 (-) | 490527984 | T6SS-4 promoter (↓) |
| REG0186 |
YpsIP31758_3441 (lptD) | protein | Unknown | Yersinia pseudotuberculosis IP 31758 | chromosome (NC_009708) | 3878499..3880841 (+) | 499505072 | YpsIP31758_3980 (ompR) (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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