Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00017  |
| T6SS type | Type i3 |
| Strain | Yersinia pestis CO92 |
| Replicon (RefSeq) | chromosome (NC_003143) |
| Location | 526127..562682 |
| Function | anti-eukaryotic; virulence |
| Comment | Phagocytosis-promoting activity in macrophage-like J774.A1 cells. |
| References | [1] Cathelyn JS et al (2006) RovA, a global regulator of Yersinia pestis, specifically required for bubonic plague. Proc Natl Acad Sci U S A. 103(36):13514-9. [PudMed:16938880] [2] Robinson JB et al (2009) Evaluation of a Yersinia pestis mutant impaired in a thermoregulated type VI-like secretion system in flea, macrophage and murine models. Microb Pathog. 47(5):243-51. [PudMed:19716410] [3] Boyer F et al (2009) Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 0.488888889. [PudMed:19284603] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| YPO_RS03450 | 521134..521598 | + | 465 | WP_002210493.1 | DUF3757 domain-containing protein | ||
| YPO_RS03455 (apaH) | 521688..522557 | - | 870 | WP_002210492.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | ||
| YPO_RS03460 (apaG) | 522574..522951 | - | 378 | WP_002210491.1 | Co2+/Mg2+ efflux protein ApaG | ||
| YPO_RS03465 (rsmA) | 522965..523783 | - | 819 | WP_002210490.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | ||
| YPO_RS03470 (pdxA) | 523776..524771 | - | 996 | WP_002210489.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | ||
| YPO_RS03475 (surA) | 524755..526059 | - | 1305 | WP_002210488.1 | peptidylprolyl isomerase SurA | ||
| YPO_RS03480 (lptD) | 526127..528469 | - | 2343 | WP_002228111.1 | LPS assembly protein LptD | ||
| YPO_RS03485 (djlA) | 528654..529487 | + | 834 | WP_002210486.1 | co-chaperone DjlA | ||
| YPO_RS03490 (rluA) | 529785..530405 | - | 621 | WP_002210485.1 | bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA | ||
| YPO_RS03495 | 531628..532371 | - | 744 | WP_002214747.1 | hexameric transcriptional regulator RovC | ||
| T6CP000125 | TssA | YPO_RS03500 | 532701..533714 | + | 1014 | WP_002210482.1 | ImpA family type VI secretion system protein |
| T6CP000126 | TssB | YPO_RS03505 (tssB) | 533725..534285 | + | 561 | WP_002210481.1 | type VI secretion system contractile sheath small subunit |
| T6CP000127 | TssC | YPO_RS03510 (tssC) | 534294..535796 | + | 1503 | WP_002210480.1 | type VI secretion system contractile sheath large subunit |
| T6CP000128 | TssD | YPO_RS03515 | 535959..536477 | + | 519 | WP_002210479.1 | type VI secretion system tube protein Hcp |
| T6CP000129 | TssE | YPO_RS03520 | 536551..536994 | + | 444 | WP_002210478.1 | type VI secretion system baseplate subunit TssE |
| T6CP000130 | TssF | YPO_RS03525 (tssF) | 537027..538871 | + | 1845 | WP_002210477.1 | type VI secretion system baseplate subunit TssF |
| T6CP000131 | TssG | YPO_RS03530 (tssG) | 538864..539847 | + | 984 | WP_002210476.1 | type VI secretion system baseplate subunit TssG |
| T6CP000132 | TssH | YPO_RS03535 (tssH) | 539865..542453 | + | 2589 | WP_002210475.1 | type VI secretion system ATPase TssH |
| T6CP000133 | TssI | YPO_RS03540 (vgrG) | 542557..544905 | + | 2349 | WP_002210474.1 | type VI secretion system tip protein VgrG |
| YPO_RS03545 | 544918..545490 | + | 573 | WP_002228110.1 | DUF2169 domain-containing protein | ||
| YPO_RS03550 | 545515..547137 | + | 1623 | WP_002228109.1 | pentapeptide repeat-containing protein | ||
| YPO_RS03555 | 547163..548266 | + | 1104 | WP_002214739.1 | pentapeptide repeat-containing protein | ||
| YPO_RS03560 | 548259..548876 | + | 618 | WP_002210473.1 | DUF3540 domain-containing protein | ||
| T6CP011405 | PAAR | YPO_RS03565 | 548882..549247 | + | 366 | WP_002214737.1 | DUF4150 domain-containing protein |
| T6CP000134 | TssJ | YPO_RS03570 (tssJ) | 549240..549731 | + | 492 | WP_002210471.1 | type VI secretion system lipoprotein TssJ |
| T6CP000135 | TssK | YPO_RS03575 (tssK) | 549851..551206 | + | 1356 | WP_002210470.1 | type VI secretion system baseplate subunit TssK |
| T6CP000136 | TssL | YPO_RS03580 | 551203..552813 | + | 1611 | WP_002210469.1 | type IVB secretion system protein IcmH/DotU |
| T6CP008410 | TssM | YPO_RS03585 (tssM) | 552875..556315 | + | 3441 | WP_002214734.1 | type VI secretion system membrane subunit TssM |
| YPO_RS03590 | 556337..556690 | + | 354 | WP_002210468.1 | hypothetical protein | ||
| YPO_RS03595 (rapA) | 556946..559852 | - | 2907 | WP_002220588.1 | RNA polymerase-associated protein RapA | ||
| YPO_RS03600 | 560313..562682 | - | 2370 | WP_002210466.1 | DNA polymerase II | ||
| YPO_RS03605 | 562878..563645 | + | 768 | WP_002210465.1 | DedA family protein | ||
| YPO_RS03610 (thiQ) | 563714..564424 | - | 711 | WP_002210464.1 | thiamine ABC transporter ATP-binding protein ThiQ | ||
| YPO_RS03615 (thiP) | 564411..566018 | - | 1608 | WP_002214276.1 | thiamine/thiamine pyrophosphate ABC transporter permease ThiP | ||
| YPO_RS03620 | 565994..566986 | - | 993 | WP_002214274.1 | thiamine ABC transporter substrate binding subunit |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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