Detailed information of effector
Summary
| Effector ID | EFF00016  |
| Effector type | Tse |
| Cognate immunity protein | IMU00107 |
| Related T6SS (Type) | T6SS00003 (Type i3) |
| Strain | Pseudomonas aeruginosa PAO1 |
| Replicon | chromosome |
| Sequence | Protein sequence (159 a.a.); Nucleotide sequence (477 bp) |
| Description | Tse2; cytoplasmic-acting toxin |
| Reference | [1] Hood RD, Singh P, Hsu F, et al. A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria. Cell Host Microbe. 2010 Jan 21;7(1):25-37. doi: 10.1016/j.chom.2009.12.007. PMID: 20114026 [2] Russell AB, Hood RD, Bui NK, et al. Type VI secretion delivers bacteriolytic effectors to target cells. Nature. 2011 Jul 20;475(7356):343-7. doi: 10.1038/nature10244. PMID: 21776080 |
Experimental investigation has been performed.
Bioinformatics investigation has been performedExternal database links
| Locus tag (Gene) | PA2702 (Tse2) |
| Coordinates (Strand) | 3056890..3057366 (+) |
| NCBI ID | 15597898 |
| RefSeq | NC_002516 |
| Uniprot ID | TSE2_PSEAE |
| KEGG ID | pae:PA2702 |
| PDB ID | 5AKO |
Pfam domain hit(s)
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Domain | Pfam ID | E-value | Aligned region |
|---|---|---|---|
| ADPRTs_Tse2 | PF18648.3 | 1.2e-61 | 7..152 |
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Transmembrane helices
- Transmembrane helices are predicted using TMHMM 2.0 software.
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Prediction | Region | Sequence |
|---|---|---|
| Outside | 1-158 | MSYDYEKTSLTLYRAVFKANYDGDVGRYLHPDKELAEAAEVAPLLHPTFDSPNTPGVPARAPDIVAGRDGLYAPDTGGTSVFDRAGVLRRADGDFVIPDGTDIPPDLKVKQDSYNKRLQATHYTIMPAKPMYREVLMGQLDNFVRNAIRRQWEKARGL |
Signal peptides
- Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
- Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
- Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
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Prediction | Probability | Cleavage site | Signal peptide sequence |
|---|---|---|---|
| Other | 0.9889 | - | - |
Protein sequence: 159 a.a. .
>EFF00016 NC_002516:3056890-3057366 Type VI Secretion System Effector (Tse) [Pseudomonas aeruginosa PAO1]
MSYDYEKTSLTLYRAVFKANYDGDVGRYLHPDKELAEAAEVAPLLHPTFDSPNTPGVPARAPDIVAGRDGLYAPDTGGTS
VFDRAGVLRRADGDFVIPDGTDIPPDLKVKQDSYNKRLQATHYTIMPAKPMYREVLMGQLDNFVRNAIRRQWEKARGL*
MSYDYEKTSLTLYRAVFKANYDGDVGRYLHPDKELAEAAEVAPLLHPTFDSPNTPGVPARAPDIVAGRDGLYAPDTGGTS
VFDRAGVLRRADGDFVIPDGTDIPPDLKVKQDSYNKRLQATHYTIMPAKPMYREVLMGQLDNFVRNAIRRQWEKARGL*
Nucleotide sequence: 477 bp .
>EFF00016 NC_002516:3056890-3057366 Type VI Secretion System Effector (Tse) [Pseudomonas aeruginosa PAO1]
ATGTCCTACGACTACGAGAAAACCAGCCTCACCCTCTACCGGGCGGTATTCAAGGCCAACTACGACGGCGACGTCGGTCG
CTACCTGCATCCCGACAAGGAACTCGCCGAGGCTGCGGAAGTCGCCCCGCTGCTGCATCCGACCTTCGACAGCCCCAACA
CCCCTGGCGTCCCCGCCCGCGCGCCGGACATCGTCGCCGGCCGCGACGGCCTCTACGCCCCGGACACCGGCGGCACCTCG
GTGTTCGACCGCGCCGGCGTGCTGCGCCGCGCCGACGGCGACTTCGTGATACCCGACGGCACCGACATCCCGCCGGACCT
TAAGGTGAAGCAGGACAGCTACAACAAGCGCCTGCAAGCCACCCACTACACCATCATGCCGGCCAAGCCGATGTACCGGG
AGGTCCTCATGGGCCAACTGGACAACTTCGTGCGCAACGCCATCCGCCGCCAATGGGAAAAAGCCCGCGGGCTCTAG
ATGTCCTACGACTACGAGAAAACCAGCCTCACCCTCTACCGGGCGGTATTCAAGGCCAACTACGACGGCGACGTCGGTCG
CTACCTGCATCCCGACAAGGAACTCGCCGAGGCTGCGGAAGTCGCCCCGCTGCTGCATCCGACCTTCGACAGCCCCAACA
CCCCTGGCGTCCCCGCCCGCGCGCCGGACATCGTCGCCGGCCGCGACGGCCTCTACGCCCCGGACACCGGCGGCACCTCG
GTGTTCGACCGCGCCGGCGTGCTGCGCCGCGCCGACGGCGACTTCGTGATACCCGACGGCACCGACATCCCGCCGGACCT
TAAGGTGAAGCAGGACAGCTACAACAAGCGCCTGCAAGCCACCCACTACACCATCATGCCGGCCAAGCCGATGTACCGGG
AGGTCCTCATGGGCCAACTGGACAACTTCGTGCGCAACGCCATCCGCCGCCAATGGGAAAAAGCCCGCGGGCTCTAG