Detailed information of regulator


Summary

Regulator ID REG0087 experimental
Regulator type protein
Regulatory pathway (from literatures) Global regulator
KEGG pathway (determined by BlastKOALA) -
Related T6SS T6SS00023 experimental (Type i3)
Strain Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Replicon chromosome
Sequence Protein sequence (138 a.a.); Nucleotide sequence (414 bp)
Description H-NS specifically binds on different regions of the S. Typhimurium SPI-6 T6SS locus.
Reference
External database links

Locus tag (Gene) STM1751 (H-NS)
Coordinates (Strand) 1847277..1847690 (+)
NCBI ID 16765095
RefSeq NC_003197
Uniprot ID HNS_SALTY
KEGG ID stm:STM1751
KEGG pathway (determined by BlastKOALA) -
PDB ID 2L93, 3NR7, 4ICG
  Target
Target Regulation (↓/↑) Target sequence
STM0272 (ClpV) promotor ↑ gatgacaccctttttattattttcgtcgtgaatgcattgttgtatgcatagatgtcttttttgaaatattatttcttttaattctgcaattgcgatttttatcttgctgttcattgattatttaatattaacggcttagttgctaattagtccctgatctgtatcattgttttgtttcgatattttttcgaggctatcaataaagaattgtttatatatttatatgcattgatgcattatttttatgaatttttatgtcacaaggcataacac
STM0279 (hcp) promotor ↑ gtaaacaatctgtggagatttaccatgaaattgatgagattgcgaaaaaatattcagggttgaaatataacggttcgatatcatcagattttaataccatgaagtgcatagattttatccatgacagggaattaaatgaattaattaaaaggcgtgtcgagaagtaaaattcaaagatattaaaagcatacgttctcttgctctgatgaatttatgggtaagaaagagctgtacaggaatagttaatctgt
STM0285 promotor ↑ gaaaaagataaggccaaaaataaagtggcaatattagataaaaaatcctatttcgatagttactatgaaaatcaggttaaatctatcgtggcaaaatatacctatattaacaaagataaagaaaaagatattttcattgcatccagcttcatgaatgctgatgagtgttctgtaagatttaatggttatattactttatccagggaattttaaaatattgattattgggtggcgagtcgaaatataatgc
STM0289 (VgrG) promotor ↑ tgctgtggttgacaatgattacaatggtggccagataagtaatgagcaccaatgataaagtatatgactggcggtgtgctggttattaatcaaatttctataaaatgcaatgcgaatctggtaagcgtaataaaaataaaatcataatattgttatgttcatttccttatttatgtaattcagtatttatgttatgtgctaatttttgtgtttttattttcatggctcttgtcagcaatataccctgttctt
STM0268 promotor ↑ gtagctcagttcgcggttgtaatactccagtagccgtggatccatgaataatgccctgtattaaaagaacgtaatgcggctcagctccatatccagcgcgctgcgtaccagaaactccgtgggatacggctgcgtcagaatttgtccgcgaatttcaaactgtagcgtgttatagctaccctgccgggttttatcgagcaagggcgtgaccctgagtgtggcggcgttcagccggggttcgaaacggata
Pfam domain hit(s) of regulator

Domain Pfam ID E-value Aligned region
Histone_HNS PF00816.23 4.1e-19 33..127
Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction                 Region     Sequence
Outside 1-137 MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSMAAAKSGTKAKRAARPAKYSYVDENGETKTWTGQGRTPAVIKKAMEEQGKQLEDFLIKE


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
Prediction        Probability Cleavage site Signal peptide sequence
Other 0.9965 - -


  Protein sequence of regulator: 138 a.a.    .

>REG0087 NC_003197:1847277-1847690 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSMA
AAKSGTKAKRAARPAKYSYVDENGETKTWTGQGRTPAVIKKAMEEQGKQLEDFLIKE*

  Nucleotide sequence of regulator: 414 bp    .

>REG0087 NC_003197:1847277-1847690 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGAGCGAAGCACTTAAAATTCTGAACAACATCCGTACTCTTCGTGCGCAGGCAAGAGAATGTACTCTGGAAACGCTTGA
AGAAATGCTGGAAAAATTAGAAGTTGTCGTTAATGAGCGTCGTGAAGAAGAAAGCGCTGCTGCTGCTGAAGTGGAAGAAC
GCACTCGTAAACTGCAACAGTATCGTGAAATGTTAATTGCCGACGGCATTGACCCGAATGAACTGCTGAATAGCATGGCT
GCCGCTAAATCCGGTACCAAAGCTAAACGCGCAGCTCGTCCGGCTAAATATAGCTATGTTGACGAAAACGGTGAAACTAA
AACCTGGACTGGCCAGGGTCGTACACCGGCTGTAATCAAAAAAGCAATGGAAGAACAAGGTAAGCAACTGGAAGATTTCC
TGATCAAGGAATAA