Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00345  |
| T6SS type | Type Unknown |
| Strain | Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 |
| Replicon (RefSeq) | chromosome (NC_012731) |
| Location | 3190436..3214872 |
| Function | anti-bacterial; anti-eukaryotic |
| Comment | Klebsiella pneumoniae type VI secretion system contributes to bacterial competition, type-1 fimbriae expression, in vivo colonization, and cell invasion. |
| References | [1] Sarris PF et al (2011) Distribution of the putative type VI secretion system core genes in Klebsiella spp. Infect Genet Evol. 11(1):157-66. [PudMed:20932940] [2] Pei-Fang Hsieh, Yi-Rou Lu, Tzu-Lung Lin, Li-Yin Lai, Jin-Town Wang et al (2019) Klebsiella Pneumoniae Type VI Secretion System Contributes to Bacterial Competition, Cell Invasion, Type-1 Fimbriae Expression, and In Vivo Colonization. J Infect Dis. 219(4):637-647. [PudMed:30202982] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagL | TssA | TssE | TssF | TssG | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| KP1_RS15665 (ychH) | 3186554..3186829 | - | 276 | WP_002910437.1 | stress-induced protein YchH | ||
| KP1_RS15670 (pth) | 3187102..3187686 | + | 585 | WP_004180389.1 | aminoacyl-tRNA hydrolase | ||
| KP1_RS15675 (ychF) | 3187804..3188895 | + | 1092 | WP_002910443.1 | redox-regulated ATPase YchF | ||
| KP1_RS15680 | 3188977..3189306 | - | 330 | WP_004145442.1 | DUF1869 domain-containing protein | ||
| KP1_RS15685 | 3189390..3190304 | - | 915 | WP_002910453.1 | sugar ABC transporter substrate-binding protein | ||
| T6CP008791 | TssA | KP1_RS15690 | 3190436..3191851 | - | 1416 | WP_004200294.1 | type VI secretion system ImpA family N-terminal domain-containing protein |
| T6CP008792 | TssE | KP1_RS15695 (tssE) | 3191871..3192314 | - | 444 | WP_004175538.1 | type VI secretion system baseplate subunit TssE |
| T6CP003506 | TssJ | KP1_RS15700 (tssJ) | 3192317..3192853 | - | 537 | WP_004175532.1 | type VI secretion system lipoprotein TssJ |
| T6CP003507 | TssG | KP1_RS15705 (tssG) | 3192834..3193850 | - | 1017 | WP_074424896.1 | type VI secretion system baseplate subunit TssG |
| T6CP003508 | TssF | KP1_RS15710 (tssF) | 3193880..3195643 | - | 1764 | WP_014907371.1 | type VI secretion system baseplate subunit TssF |
| T6CP003509 | TssM | KP1_RS15715 | 3195777..3199187 | - | 3411 | WP_041937785.1 | type VI secretion protein VasK |
| KP1_RS15720 | 3199171..3200328 | - | 1158 | WP_014907369.1 | hypothetical protein | ||
| T6CP011755 | PAAR | KP1_RS15725 | 3200332..3200598 | - | 267 | WP_004175522.1 | PAAR domain-containing protein |
| KP1_RS27900 | 3200877..3201083 | - | 207 | WP_074075361.1 | hypothetical protein | ||
| KP1_RS29815 | 3201468..3201688 | - | 221 | pseudogene | hypothetical protein | ||
| KP1_RS15740 | 3201821..3202714 | - | 894 | WP_015874921.1 | SUMF1/EgtB/PvdO family nonheme iron enzyme | ||
| KP1_RS29820 | 3202736..3202852 | - | 117 | WP_004217423.1 | hypothetical protein | ||
| KP1_RS15750 | 3202898..3203791 | - | 894 | WP_015874922.1 | SUMF1/EgtB/PvdO family nonheme iron enzyme | ||
| KP1_RS15755 | 3203967..3204860 | - | 894 | WP_014907365.1 | SUMF1/EgtB/PvdO family nonheme iron enzyme | ||
| KP1_RS29825 | 3204882..3204998 | - | 117 | WP_004217423.1 | hypothetical protein | ||
| KP1_RS15760 | 3205044..3205934 | - | 891 | WP_004180403.1 | SUMF1/EgtB/PvdO family nonheme iron enzyme | ||
| KP1_RS15770 | 3206285..3207314 | - | 1030 | pseudogene | hypothetical protein | ||
| T6CP003510 | TssI | KP1_RS15775 (vgrG) | 3208236..3210722 | - | 2487 | WP_014907360.1 | type VI secretion system tip protein VgrG |
| KP1_RS29835 | 3210873..3210997 | - | 125 | pseudogene | hypothetical protein | ||
| T6CP011756 | TagL | KP1_RS15780 | 3211181..3212878 | - | 1698 | WP_014907359.1 | OmpA family protein |
| T6CP009313 | TssL | KP1_RS15785 | 3212882..3213535 | - | 654 | WP_004891113.1 | type VI secretion system protein TssL, short form |
| T6CP003511 | TssK | KP1_RS15790 (tssK) | 3213532..3214872 | - | 1341 | WP_015874925.1 | type VI secretion system baseplate subunit TssK |
| KP1_RS15800 | 3215442..3215771 | + | 330 | WP_002910650.1 | gamma-glutamylcyclotransferase | ||
| KP1_RS15805 | 3215886..3216425 | + | 540 | WP_002910652.1 | DUF2058 domain-containing protein | ||
| KP1_RS15810 | 3216451..3217149 | - | 699 | WP_014907357.1 | RluA family pseudouridine synthase | ||
| KP1_RS15815 | 3217340..3217822 | + | 483 | WP_002910657.1 | cold shock domain-containing protein | ||
| KP1_RS15820 | 3217932..3218831 | + | 900 | WP_004152315.1 | LysR family transcriptional regulator | ||
| KP1_RS15825 | 3218806..3219615 | - | 810 | WP_004145468.1 | substrate-binding domain-containing protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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