Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01215  |
| T6SS type | Type i2 |
| Strain | Klebsiella pneumoniae strain Kp52.145 |
| Replicon (RefSeq) | chromosome (NZ_FO834906) |
| Location | 2564540..2589406 |
| Function | anti-bacterial; anti-eukaryotic |
| Comment | Kp52145 T6SS-dependent intra and inter species bacterial competition is dependent on VgrG4 and GST-VgrG4 caused a strong inhibition of yeast growth show VgrG4 is a bona fide T6SS toxin and that the C-terminal extension containing the DUF2345 domain is sufficient for the anti-bacterial and anti-eukaryotic effect |
| References | [1] Storey D, McNally A, |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssF | TssG | TssH | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BN49_RS13995 | 2559601..2560515 | - | 915 | WP_016529242.1 | LysR family transcriptional regulator | ||
| BN49_RS14000 | 2560624..2561385 | + | 762 | WP_016529243.1 | SDR family oxidoreductase | ||
| BN49_RS14005 | 2561602..2563134 | + | 1533 | WP_016529244.1 | HD domain-containing protein | ||
| BN49_RS14010 | 2563333..2563899 | - | 567 | WP_004190556.1 | DJ-1/PfpI family protein | ||
| T6CP015368 | TssB | BN49_RS14020 (tssB) | 2564540..2565031 | + | 492 | WP_016530462.1 | type VI secretion system contractile sheath small subunit |
| T6CP015369 | TssC | BN49_RS14025 (tssC) | 2565074..2566612 | + | 1539 | WP_016530463.1 | type VI secretion system contractile sheath large subunit |
| T6CP015370 | TssK | BN49_RS14030 (tssK) | 2566622..2567965 | + | 1344 | WP_171819472.1 | type VI secretion system baseplate subunit TssK |
| T6CP015371 | TssL | BN49_RS14035 | 2567962..2568651 | + | 690 | WP_004176431.1 | type VI secretion system protein TssL, short form |
| BN49_RS14040 | 2568648..2570354 | + | 1707 | WP_046043125.1 | OmpA family protein | ||
| BN49_RS14045 (hcp) | 2570359..2570850 | + | 492 | pseudogene | type VI secretion system effector Hcp | ||
| T6CP015372 | TssH | BN49_RS14050 (tssH) | 2571115..2573769 | + | 2655 | WP_046043127.1 | type VI secretion system ATPase TssH |
| BN49_RS14055 (vgrG) | 2573771..2576257 | + | 2487 | pseudogene | type VI secretion system tip protein VgrG | ||
| BN49_RS14060 | 2576259..2577307 | + | 1049 | pseudogene | hypothetical protein | ||
| BN49_RS14065 | 2577297..2579231 | + | 1935 | WP_042940556.1 | DUF3274 domain-containing protein | ||
| BN49_RS14070 | 2579321..2579584 | + | 264 | WP_016529150.1 | PAAR domain-containing protein | ||
| BN49_RS29060 | 2579584..2581023 | + | 1440 | WP_071609112.1 | hypothetical protein | ||
| T6CP015373 | TssM | BN49_RS14075 | 2581020..2584415 | + | 3396 | WP_032102817.1 | type VI secretion protein VasK |
| T6CP015374 | TssA | BN49_RS14080 (tssA) | 2584412..2586004 | + | 1593 | WP_004183804.1 | type VI secretion system protein TssA |
| T6CP015375 | TssF | BN49_RS14085 (tssF) | 2586083..2587837 | + | 1755 | WP_004892596.1 | type VI secretion system baseplate subunit TssF |
| T6CP015376 | TssG | BN49_RS14090 (tssG) | 2587801..2588886 | + | 1086 | WP_004190503.1 | type VI secretion system baseplate subunit TssG |
| T6CP015377 | TssJ | BN49_RS14095 (tssJ) | 2588864..2589406 | + | 543 | WP_004176417.1 | type VI secretion system lipoprotein TssJ |
| BN49_RS14100 | 2589533..2590027 | + | 495 | WP_004176416.1 | hypothetical protein | ||
| BN49_RS14105 (bdcA) | 2590094..2590768 | - | 675 | WP_046043130.1 | SDR family oxidoreductase | ||
| BN49_RS14110 | 2590842..2591435 | + | 594 | WP_004179574.1 | TetR/AcrR family transcriptional regulator | ||
| BN49_RS14115 | 2591440..2592195 | - | 756 | WP_016530650.1 | SDR family oxidoreductase | ||
| BN49_RS14120 | 2592354..2593232 | + | 879 | WP_004151595.1 | AraC family transcriptional regulator | ||
| BN49_RS14125 | 2593283..2593489 | - | 207 | WP_016528839.1 | DUF1471 domain-containing protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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