Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00037  |
| T6SS type | Type i2 |
| Strain | Escherichia coli CFT073 |
| Replicon (RefSeq) | chromosome (NC_004431) |
| Location | 3217751..3253963 |
| Function | anti-eukaryotic; virulence |
| Comment | PAI-metV2 genomic island mutant (c3398-c3410 deleted) was severely attenuated in its ability to colonize the bladders of mice. |
| References | [1] Lloyd AL et al (2009) Genomic islands of uropathogenic Escherichia coli contribute to virulence. J Bacteriol. 191(11):3469-81. [PudMed:19329634] [2] Boyer F et al (2009) Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources. BMC Genomics. 0.488888889. [PudMed:19284603] [3] Leiman PG et al (2009) Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin. Proc Natl Acad Sci U S A. 106(11):4154-9. [PudMed:19251641] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagL | TssA | TssB | TssC | TssD | TssE | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| C_RS16000 (fucU) | 3213754..3214176 | + | 423 | WP_000920840.1 | L-fucose mutarotase | ||
| C_RS16005 (fucR) | 3214234..3214965 | + | 732 | WP_001305284.1 | L-fucose operon activator | ||
| C_RS16010 (rlmM) | 3215009..3216109 | - | 1101 | WP_001045530.1 | 23S rRNA (cytidine(2498)-2'-O)-methyltransferase RlmM | ||
| C_RS16015 (ygdD) | 3216102..3216497 | - | 396 | WP_000203910.1 | DUF423 domain-containing protein | ||
| C_RS16020 (gcvA) | 3216516..3217433 | - | 918 | WP_000044401.1 | glycine cleavage system transcriptional regulator GcvA | ||
| C_RS16025 (ygdI) | 3217784..3218011 | - | 228 | WP_000750398.1 | YgdI/YgdR family lipoprotein | ||
| C_RS16030 (csdA) | 3218203..3219408 | + | 1206 | WP_001327299.1 | cysteine desulfurase CsdA | ||
| C_RS16035 (csdE) | 3219408..3219851 | + | 444 | WP_000184272.1 | cysteine desulfurase sulfur acceptor subunit CsdE | ||
| C_RS16040 (tcdA) | 3219902..3220708 | - | 807 | WP_000117711.1 | tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA | ||
| C_RS16045 (mltA) | 3220785..3221882 | - | 1098 | WP_000678650.1 | murein transglycosylase A | ||
| T6CP000292 | TssB | C_RS16065 (tssB) | 3223023..3223523 | + | 501 | WP_001443093.1 | type VI secretion system contractile sheath small subunit |
| T6CP000293 | TssC | C_RS16070 (tssC) | 3223582..3225120 | + | 1539 | WP_001350147.1 | type VI secretion system contractile sheath large subunit |
| T6CP000294 | TssK | C_RS16075 (tssK) | 3225140..3226477 | + | 1338 | WP_000686689.1 | type VI secretion system baseplate subunit TssK |
| T6CP000295 | TssL | C_RS16080 (tssL) | 3226474..3227139 | + | 666 | WP_000712315.1 | type VI secretion system protein TssL, short form |
| T6CP011356 | TagL | C_RS16085 | 3227152..3228804 | + | 1653 | WP_001246526.1 | OmpA family protein |
| T6CP008393 | TssD | C_RS16090 | 3228862..3229353 | + | 492 | WP_000997068.1 | Hcp family type VI secretion system effector |
| T6CP000296 | TssH | C_RS16095 (tssH) | 3229545..3232181 | + | 2637 | WP_000147339.1 | type VI secretion system ATPase TssH |
| T6CP000297 | TssI | C_RS16100 (vgrG) | 3232193..3234655 | + | 2463 | WP_001529381.1 | type VI secretion system tip protein VgrG |
| C_RS16105 | 3234652..3235494 | + | 843 | WP_001305286.1 | hypothetical protein | ||
| C_RS16110 | 3235491..3237467 | + | 1977 | WP_000106189.1 | hypothetical protein | ||
| T6CP011357 | PAAR | C_RS16115 | 3237489..3237749 | + | 261 | WP_001443095.1 | PAAR domain-containing protein |
| C_RS16120 | 3237749..3239182 | + | 1434 | WP_000539869.1 | hypothetical protein | ||
| T6CP000298 | TssM | C_RS16125 | 3239189..3242527 | + | 3339 | WP_000832727.1 | type VI secretion protein VasK |
| T6CP009482 | TssA | C_RS16130 (tssA) | 3242520..3244130 | + | 1611 | WP_001443097.1 | type VI secretion system protein TssA |
| C_RS16135 (tssF) | 3244164..3245922 | + | 1759 | pseudogene | type VI secretion system baseplate subunit TssF | ||
| C_RS16140 (tssG) | 3245886..3246965 | + | 1080 | WP_000373314.1 | type VI secretion system baseplate subunit TssG | ||
| T6CP008394 | TssJ | C_RS16145 (tssJ) | 3246946..3247482 | + | 537 | WP_000484008.1 | type VI secretion system lipoprotein TssJ |
| T6CP000300 | TssE | C_RS16150 (tssE) | 3247486..3247914 | + | 429 | WP_000106967.1 | type VI secretion system baseplate subunit TssE |
| T6CP008395 | TssA | C_RS16155 | 3247914..3249290 | + | 1377 | WP_000157817.1 | type VI secretion system ImpA family N-terminal domain-containing protein |
| C_RS16160 | 3249590..3250537 | - | 948 | WP_001305290.1 | phosphoglycerate dehydrogenase | ||
| C_RS16165 | 3250609..3251205 | - | 597 | WP_001066223.1 | SIS domain-containing protein | ||
| C_RS16170 | 3251208..3252383 | - | 1176 | WP_000382413.1 | PatB family C-S lyase | ||
| C_RS16175 | 3252383..3253963 | - | 1581 | WP_000810557.1 | PTS transporter subunit EIIC | ||
| C_RS16180 | 3253995..3254819 | - | 825 | WP_001529383.1 | PRD domain-containing protein | ||
| C_RS16185 (amiC) | 3255077..3256330 | - | 1254 | WP_000016907.1 | N-acetylmuramoyl-L-alanine amidase AmiC | ||
| C_RS16190 (argA) | 3256562..3257893 | + | 1332 | WP_000237947.1 | amino-acid N-acetyltransferase |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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