Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS17502  |
| T6SS type | Type Unknown |
| Strain | Citrobacter freundii strain CF74 |
| Replicon (GenBank) | (-) |
| Location | - |
| Function | anti-eukaryotic |
| Comment | The type VI secretion system modulates flagellar gene expression and secretion in Citrobacter freundii and contributes to adhesion and cytotoxicity to host cells and T6SS induction of IL-1β secretion and promotion of bacterial survival in mice in vivo. The C. freundii T6SS activated the inflammasomes mainly through caspase 1 and mediated pyroptosis of macrophages by releasing the cleaved gasdermin-N domain. The CF74 T6SS was required for flagellin-induced interleukin 1β release by macrophages. |
| References | [1] Liu L, Song L, Deng R, Lan R, Jin W, Tran Van Nhieu G, Cao H, Liu Q, Xiao Y, Li X, Meng G, Ren Z. et al (2021) Citrobacter freundii Activation of NLRP3 Inflammasome via the Type VI Secretion System.. J Infect Dis. 223(12):2174-2185. [PudMed:33151309] [2] Liu L et al (2015) The type VI secretion system modulates flagellar gene expression and secretion in Citrobacter freundii and contributes to the adhesion and cytotoxicity to host cells. Infect Immun. pii: IAI.03071-14. [PudMed:25870231] |
Experimental investigation has been performed.