SecReT6, T6SS database

Detailed information of effector

Summary

Effector ID	EFF01122
Effector type	-
Cognate immunity protein	-
Related T6SS (Type)	T6SS00838 (Type i1)
Strain	Proteus mirabilis BB2000
Replicon	chromosome
Sequence	Protein sequence (731 a.a.); Nucleotide sequence (2193 bp)
Description	-
Reference	[1] Wenren LM, Sullivan NL, Cardarelli L, et al. Two independent pathways for self-recognition in Proteus mirabilis are linked by type VI-dependent export. mBio. 2013 Jul 23;4(4). pii: e00374-13. doi: 10.1128/mBio.00374-13. PMID: 23882014

Experimental investigation has been performed.

Bioinformatics investigation has been performed

External database links

Locus tag (Gene)	BB2000_RS03995
Coordinates (Strand)	941108..943300 (+)
NCBI ID	529236521
RefSeq	NC_022000
Uniprot ID	UPI0003843CDE
KEGG ID	-
PDB ID	-

Pfam domain hit(s)

Domain	Pfam ID	E-value	Aligned region
Phage_GPD	PF05954.13	9.3e-59	130..421
Phage_base_V	PF04717.14	2.1e-11	480..543

Transmembrane helices

Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction	Region	Sequence
Outside	1-730	MLSKDPKSTPIDPASVLKDEAINQVKNRVQSKVNETLSTPTQKVAGMASAAASLTQSASASANRVTAHPLIHGGGFTGGQTFAENQALQAAHGALLDALGMDSLESGLVFTCTIGGLPDDTFQVTEFNLTEGLSSLFSLSISAVSALPFIDFQRHLGLASSLTVKRDGVLIRKVNGILAGAVQGNTDGVKTWYHFDIRPEMWVMTLNQDSRIFQHQSVPTILKTLLDEAHVKADCQFYREDLHPERLYTTQKRESAFDFWCRLAFEEGINFWFEEEQLFYSDEHMGMTAGIHLTYNPQADTDISDSTAMTWQYGEYLCVDETIHKDNNFVRPSYPLSHENKIEQGGQHSVFESYGRFQLDDEGRPLTQVRFEQLRNGSKVGQATTNCFALMPGKIFTLSQHPHQPMNDRWQVISVSHHGVQPLADNSGGEGTQLSNSVSFIPGTQEWRPPYRYKPTADGDEVATVVGPPGEEIYVNEYGAVKVHFHWDRRGSADHSASCWVRVAMGWSGNGYGFSAVPRIGTQVLVSYLNGDIDRPMITGCTYDGRNAPPIKFPENKTQTTFRSQTHKGEGFNELRFEDAGGKQEVFLHAQKDMNTVVQNDKGTTVGANHTETIMQNQKISVHGTQTTAVQADQKNIVFGNQHSIVDGEVLIASAKGIRLISGNSALQLNPDGTITLVCNNFDFYGHGSGRIGTGELLDLNMDGAGPGNLEMKPDTSTIAQAKDQFFPKK

Signal peptides

Signal peptides and corresponding cleavage sites are predicted using SignalP 5.0 software.

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).

Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).

Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.5396	-	-

Protein sequence: 731 a.a. .

                                    >EFF01122 NC_022000:941108-943300  (Unknown) [Proteus mirabilis BB2000]
MLSKDPKSTPIDPASVLKDEAINQVKNRVQSKVNETLSTPTQKVAGMASAAASLTQSASASANRVTAHPLIHGGGFTGGQ
TFAENQALQAAHGALLDALGMDSLESGLVFTCTIGGLPDDTFQVTEFNLTEGLSSLFSLSISAVSALPFIDFQRHLGLAS
SLTVKRDGVLIRKVNGILAGAVQGNTDGVKTWYHFDIRPEMWVMTLNQDSRIFQHQSVPTILKTLLDEAHVKADCQFYRE
DLHPERLYTTQKRESAFDFWCRLAFEEGINFWFEEEQLFYSDEHMGMTAGIHLTYNPQADTDISDSTAMTWQYGEYLCVD
ETIHKDNNFVRPSYPLSHENKIEQGGQHSVFESYGRFQLDDEGRPLTQVRFEQLRNGSKVGQATTNCFALMPGKIFTLSQ
HPHQPMNDRWQVISVSHHGVQPLADNSGGEGTQLSNSVSFIPGTQEWRPPYRYKPTADGDEVATVVGPPGEEIYVNEYGA
VKVHFHWDRRGSADHSASCWVRVAMGWSGNGYGFSAVPRIGTQVLVSYLNGDIDRPMITGCTYDGRNAPPIKFPENKTQT
TFRSQTHKGEGFNELRFEDAGGKQEVFLHAQKDMNTVVQNDKGTTVGANHTETIMQNQKISVHGTQTTAVQADQKNIVFG
NQHSIVDGEVLIASAKGIRLISGNSALQLNPDGTITLVCNNFDFYGHGSGRIGTGELLDLNMDGAGPGNLEMKPDTSTIA
QAKDQFFPKK*

                                

Nucleotide sequence: 2193 bp .

                                    >EFF01122 NC_022000:941108-943300  (Unknown) [Proteus mirabilis BB2000]
ATGCTTAGCAAAGATCCGAAATCAACGCCCATTGACCCGGCATCCGTTTTAAAAGATGAAGCCATCAATCAAGTGAAAAA
TAGGGTGCAATCCAAAGTGAACGAAACGCTATCGACACCCACGCAAAAGGTGGCCGGGATGGCCTCAGCAGCGGCCTCGC
TCACTCAATCAGCCAGCGCATCGGCCAATCGCGTGACGGCTCATCCCCTGATCCACGGTGGCGGTTTTACCGGTGGACAA
ACATTCGCTGAAAACCAAGCACTCCAAGCGGCCCATGGGGCGTTACTTGATGCATTAGGCATGGACAGCCTCGAAAGTGG
TTTGGTGTTCACTTGCACCATTGGTGGATTGCCTGACGACACCTTTCAAGTCACCGAATTTAATCTTACCGAAGGATTAT
CCTCGCTATTTTCGCTGTCCATCAGTGCGGTCAGTGCCTTACCCTTTATCGATTTTCAGCGCCATCTTGGCTTAGCCTCA
TCATTAACGGTCAAACGCGATGGGGTGTTGATCCGCAAAGTCAACGGTATCTTAGCCGGGGCAGTACAAGGCAATACCGA
CGGAGTGAAAACGTGGTATCACTTCGATATTCGCCCTGAAATGTGGGTGATGACCCTCAATCAAGACAGCCGTATTTTTC
AACATCAATCGGTGCCGACCATCTTAAAAACCTTATTGGATGAGGCCCATGTTAAAGCGGATTGCCAATTCTACCGTGAA
GATCTACACCCTGAACGTCTCTACACCACCCAAAAACGCGAATCGGCATTTGATTTTTGGTGTCGACTGGCGTTTGAAGA
GGGCATTAACTTCTGGTTTGAAGAAGAACAACTGTTTTACAGCGATGAACATATGGGGATGACGGCGGGTATTCACCTCA
CCTATAACCCGCAGGCCGACACCGATATCAGCGATAGCACTGCCATGACTTGGCAATATGGCGAATATTTGTGTGTGGAT
GAAACTATCCATAAAGACAACAACTTTGTTCGTCCTTCTTATCCGTTGTCTCATGAAAACAAAATTGAGCAGGGGGGACA
GCACAGTGTGTTTGAAAGTTATGGTCGTTTTCAATTAGACGATGAAGGTCGACCTCTGACACAGGTGCGCTTTGAGCAAT
TACGTAACGGCAGCAAAGTGGGGCAAGCGACAACAAACTGTTTTGCGCTGATGCCCGGCAAAATCTTCACCTTATCTCAG
CATCCCCATCAGCCGATGAATGATCGCTGGCAAGTGATCAGCGTCAGCCATCATGGTGTACAGCCACTGGCGGACAATAG
CGGGGGCGAAGGCACACAACTGTCGAATAGCGTCTCCTTTATTCCGGGCACGCAAGAGTGGCGTCCCCCTTATCGTTATA
AACCGACTGCCGACGGCGATGAAGTGGCGACGGTGGTAGGACCGCCGGGGGAAGAAATCTACGTCAATGAATATGGCGCC
GTGAAAGTGCATTTTCATTGGGATCGTCGGGGAAGTGCCGATCACAGTGCTTCATGCTGGGTGCGGGTTGCCATGGGTTG
GAGTGGAAATGGCTATGGTTTTTCTGCGGTACCGCGCATCGGCACACAAGTGCTGGTCAGTTACCTGAATGGGGATATCG
ACAGACCGATGATTACCGGTTGTACCTATGATGGTCGTAACGCACCACCGATTAAGTTCCCAGAGAATAAGACACAAACC
ACTTTCCGTAGCCAAACCCACAAAGGGGAAGGTTTTAATGAACTGCGTTTTGAAGATGCCGGCGGTAAGCAAGAGGTGTT
TCTTCATGCGCAGAAGGATATGAATACCGTAGTCCAAAACGATAAAGGAACGACGGTAGGCGCCAATCATACTGAAACCA
TTATGCAAAACCAAAAGATCTCAGTACATGGTACGCAAACTACGGCGGTTCAAGCGGATCAAAAAAATATCGTGTTTGGT
AATCAACATTCAATCGTGGATGGTGAAGTGTTGATCGCATCAGCCAAAGGTATTCGTTTAATTAGTGGCAACTCGGCACT
TCAATTAAACCCTGACGGGACTATCACCTTAGTGTGTAACAACTTTGATTTTTACGGTCACGGTAGCGGTCGGATTGGTA
CTGGTGAGTTATTAGATTTGAATATGGACGGGGCAGGTCCCGGAAACCTTGAGATGAAACCCGATACTAGCACTATCGCT
CAAGCGAAAGATCAGTTTTTCCCTAAAAAATAA

                                