Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00838  |
| T6SS type | Type i1 |
| Strain | Proteus mirabilis BB2000 |
| Replicon (RefSeq) | chromosome (NC_022000) |
| Location | 916585..943300 |
| Function | anti-bacterial; effector translocation |
| Comment | Our results provide a mechanistic and physiological basis for the fundamental behaviors of self-recognition and territoriality in a bacterial model system. |
| References | [1] Gibbs KA et al (2008) Genetic determinants of self identity and social recognition in bacteria. Science. 321(5886):256-9. [PudMed:18621670] [2] Alteri CJ et al (2013) Multicellular Bacteria Deploy the Type VI Secretion System to Preemptively Strike Neighboring Cells. PLoS Pathog. 9(9):e1003608. [PudMed:24039579] [3] Wenren LM et al (2013) Two Independent Pathways for Self-Recognition in Proteus mirabilis Are Linked by Type VI-Dependent Export. MBio. 4(4). [PudMed:23882014] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 2 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BB2000_RS03885 (aphA) | 912141..912854 | + | 714 | WP_041701075.1 | acid phosphatase AphA | ||
| BB2000_RS03890 (ldtD) | 913197..914912 | + | 1716 | WP_020945424.1 | L,D-transpeptidase | ||
| BB2000_RS03895 | 915244..915792 | + | 549 | WP_004244605.1 | YcbK family protein | ||
| BB2000_RS03900 | 915842..916492 | + | 651 | WP_004247640.1 | MBL fold metallo-hydrolase | ||
| T6CP010080 | TssD | BB2000_RS03905 | 916585..917058 | - | 474 | WP_004244607.1 | Hcp family type VI secretion system effector |
| T6CP010081 | TssF | BB2000_RS03910 | 917149..918885 | - | 1737 | WP_020945425.1 | type VI secretion system baseplate subunit TssF |
| T6CP010082 | TssA | BB2000_RS03915 | 918878..920233 | - | 1356 | WP_020945426.1 | type VI secretion system ImpA family N-terminal domain-containing protein |
| T6CP010083 | TssM | BB2000_RS03920 (tssM) | 920271..923819 | - | 3549 | WP_020945427.1 | type VI secretion system membrane subunit TssM |
| T6CP010084 | TssA | BB2000_RS03925 (tssA) | 923822..925285 | - | 1464 | WP_004244611.1 | type VI secretion system protein TssA |
| BB2000_RS03930 (tagO) | 925291..925941 | - | 651 | WP_004244612.1 | type VI secretion system-associated protein TagO | ||
| BB2000_RS03935 | 925943..926731 | - | 789 | WP_020945428.1 | TssK | ||
| T6CP010085 | TssH | BB2000_RS03940 (tssH) | 926735..929446 | - | 2712 | WP_020945429.1 | type VI secretion system ATPase TssH |
| T6CP010086 | TssL | BB2000_RS03945 (icmH) | 929455..930210 | - | 756 | WP_004244617.1 | type IVB secretion system protein IcmH/DotU |
| T6CP010087 | TssK | BB2000_RS03950 (tssK) | 930203..931561 | - | 1359 | WP_004247647.1 | type VI secretion system baseplate subunit TssK |
| T6CP010088 | TssJ | BB2000_RS03955 (tssJ) | 931563..932114 | - | 552 | WP_004244619.1 | type VI secretion system lipoprotein TssJ |
| T6CP012324 | FHA | BB2000_RS03960 (tagH) | 932116..933384 | - | 1269 | WP_004247648.1 | type VI secretion system-associated FHA domain protein TagH |
| T6CP010089 | TssG | BB2000_RS03965 (tssG) | 933389..934426 | - | 1038 | WP_004244621.1 | type VI secretion system baseplate subunit TssG |
| T6CP010090 | TssF | BB2000_RS03970 (tssF) | 934390..936165 | - | 1776 | WP_017628432.1 | type VI secretion system baseplate subunit TssF |
| T6CP010091 | TssE | BB2000_RS03975 (tssE) | 936173..936604 | - | 432 | WP_004244624.1 | type VI secretion system baseplate subunit TssE |
| T6CP010092 | TssC | BB2000_RS03980 (tssC) | 936610..938088 | - | 1479 | WP_004247652.1 | type VI secretion system contractile sheath large subunit |
| T6CP010093 | TssB | BB2000_RS03985 (tssB) | 938109..938609 | - | 501 | WP_004247653.1 | type VI secretion system contractile sheath small subunit |
| T6CP010094 | TssD | BB2000_RS03990 | 940506..941024 | + | 519 | WP_004246976.1 | Hcp family type VI secretion system effector |
| T6CP010095 | TssI | BB2000_RS03995 (tssI) | 941108..943300 | + | 2193 | WP_020945430.1 | type VI secretion system tip protein VgrG |
| BB2000_RS04000 | 943326..943745 | + | 420 | WP_004251951.1 | DcrB-related protein | ||
| BB2000_RS04005 | 943810..948135 | + | 4326 | pseudogene | RHS domain-containing protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01121 |
BB2000_RS03990 | - | - | Proteus mirabilis BB2000 | chromosome (NC_022000) | 940506..941024 (+) | 529236520 |
| EFF01125 |
BB2000_RS14610 | - | - | Proteus mirabilis BB2000 | chromosome (NC_022000) | 3279668..3282772 (+) | 529238655 |
| EFF01122 |
BB2000_RS03995 | - | - | Proteus mirabilis BB2000 | chromosome (NC_022000) | 941108..943300 (+) | 529236521 |
| EFF01124 |
BB2000_RS14600 | - | - | Proteus mirabilis BB2000 | chromosome (NC_022000) | 3276277..3278448 (+) | 529238653 |
| EFF01123 |
BB2000_RS14595 | - | - | Proteus mirabilis BB2000 | chromosome (NC_022000) | 3275686..3276204 (+) | 529238652 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| ACP00027 |
BB2000_RS14605 (idsC) | chaperone | Proteus mirabilis BB2000 | chromosome (NC_022000) | 3278448..3279671 (+) | 529249287 | - | BB2000_3005 (IdsD) |