Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS00838 experimental
T6SS type Type i1
Strain Proteus mirabilis BB2000
Replicon (RefSeq) chromosome (NC_022000)
Location 916585..943300
Function anti-bacterial; effector translocation
Comment Our results provide a mechanistic and physiological basis for the fundamental behaviors of self-recognition and territoriality in a bacterial model system.
References
[1] Wenren LM et al (2013) Two Independent Pathways for Self-Recognition in Proteus mirabilis Are Linked by Type VI-Dependent Export. MBio. 4(4). [PudMed:23882014]
[2] Gibbs KA et al (2008) Genetic determinants of self identity and social recognition in bacteria. Science. 321(5886):256-9. [PudMed:18621670]
[3] Alteri CJ et al (2013) Multicellular Bacteria Deploy the Type VI Secretion System to Preemptively Strike Neighboring Cells. PLoS Pathog. 9(9):e1003608. [PudMed:24039579]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentFHATssATssBTssCTssDTssETssFTssGTssHTssITssJTssKTssLTssM
Number12112121111111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
BB2000_RS03885 (aphA) 912141..912854 + 714 WP_041701075.1 acid phosphatase AphA
BB2000_RS03890 (ldtD) 913197..914912 + 1716 WP_020945424.1 L,D-transpeptidase
BB2000_RS03895 915244..915792 + 549 WP_004244605.1 YcbK family protein
BB2000_RS03900 915842..916492 + 651 WP_004247640.1 MBL fold metallo-hydrolase
T6CP010080 TssD BB2000_RS03905 916585..917058 - 474 WP_004244607.1 Hcp family type VI secretion system effector
T6CP010081 TssF BB2000_RS03910 917149..918885 - 1737 WP_020945425.1 type VI secretion system baseplate subunit TssF
T6CP010082 TssA BB2000_RS03915 918878..920233 - 1356 WP_020945426.1 type VI secretion system ImpA family N-terminal domain-containing protein
T6CP010083 TssM BB2000_RS03920 (tssM) 920271..923819 - 3549 WP_020945427.1 type VI secretion system membrane subunit TssM
T6CP010084 TssA BB2000_RS03925 (tssA) 923822..925285 - 1464 WP_004244611.1 type VI secretion system protein TssA
BB2000_RS03930 (tagO) 925291..925941 - 651 WP_004244612.1 type VI secretion system-associated protein TagO
BB2000_RS03935 925943..926731 - 789 WP_020945428.1 TssK
T6CP010085 TssH BB2000_RS03940 (tssH) 926735..929446 - 2712 WP_020945429.1 type VI secretion system ATPase TssH
T6CP010086 TssL BB2000_RS03945 (icmH) 929455..930210 - 756 WP_004244617.1 type IVB secretion system protein IcmH/DotU
T6CP010087 TssK BB2000_RS03950 (tssK) 930203..931561 - 1359 WP_004247647.1 type VI secretion system baseplate subunit TssK
T6CP010088 TssJ BB2000_RS03955 (tssJ) 931563..932114 - 552 WP_004244619.1 type VI secretion system lipoprotein TssJ
T6CP012324 FHA BB2000_RS03960 (tagH) 932116..933384 - 1269 WP_004247648.1 type VI secretion system-associated FHA domain protein TagH
T6CP010089 TssG BB2000_RS03965 (tssG) 933389..934426 - 1038 WP_004244621.1 type VI secretion system baseplate subunit TssG
T6CP010090 TssF BB2000_RS03970 (tssF) 934390..936165 - 1776 WP_017628432.1 type VI secretion system baseplate subunit TssF
T6CP010091 TssE BB2000_RS03975 (tssE) 936173..936604 - 432 WP_004244624.1 type VI secretion system baseplate subunit TssE
T6CP010092 TssC BB2000_RS03980 (tssC) 936610..938088 - 1479 WP_004247652.1 type VI secretion system contractile sheath large subunit
T6CP010093 TssB BB2000_RS03985 (tssB) 938109..938609 - 501 WP_004247653.1 type VI secretion system contractile sheath small subunit
T6CP010094 TssD BB2000_RS03990 940506..941024 + 519 WP_004246976.1 Hcp family type VI secretion system effector
T6CP010095 TssI BB2000_RS03995 (tssI) 941108..943300 + 2193 WP_020945430.1 type VI secretion system tip protein VgrG
BB2000_RS04000 943326..943745 + 420 WP_004251951.1 DcrB-related protein
BB2000_RS04005 943810..948135 + 4326 pseudogene RHS domain-containing protein
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID
EFF01121 experimental BB2000_RS03990 - - Proteus mirabilis BB2000 chromosome (NC_022000) 940506..941024 (+) 529236520
EFF01125 experimental BB2000_RS14610 - - Proteus mirabilis BB2000 chromosome (NC_022000) 3279668..3282772 (+) 529238655
EFF01122 experimental BB2000_RS03995 - - Proteus mirabilis BB2000 chromosome (NC_022000) 941108..943300 (+) 529236521
EFF01124 experimental BB2000_RS14600 - - Proteus mirabilis BB2000 chromosome (NC_022000) 3276277..3278448 (+) 529238653
EFF01123 experimental BB2000_RS14595 - - Proteus mirabilis BB2000 chromosome (NC_022000) 3275686..3276204 (+) 529238652

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector
ACP00027 experimental BB2000_RS14605 (idsC) chaperone Proteus mirabilis BB2000 chromosome (NC_022000) 3278448..3279671 (+) 529249287 - BB2000_3005 (IdsD)