Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00069  |
| T6SS type | Type i3 |
| Strain | Burkholderia mallei ATCC 23344 |
| Replicon (RefSeq) | chromosome II (NC_006349) |
| Location | 429068..465354 |
| Function | - |
| Comment | - |
| References | [1] Schell MA et al (2007) Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol Microbiol. 64(6):1466-85. [PudMed:17555434] |
Bioinformatics investigation has been performed.T6SS components and genome coordinates
| Component | TssB | TssC | TssD | TssE | TssF | TssG | TssI | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BMA_RS18145 | 425119..426153 | + | 1035 | WP_004190433.1 | lipase secretion chaperone | ||
| BMA_RS18150 | 426255..427784 | - | 1530 | WP_004200631.1 | PLP-dependent aminotransferase family protein | ||
| BMA_RS18155 | 427893..428993 | + | 1101 | WP_004190757.1 | ABC transporter ATP-binding protein | ||
| BMA_RS18160 | 429068..430114 | + | 1047 | WP_004190781.1 | ABC transporter substrate-binding protein | ||
| BMA_RS18165 | 430215..431474 | + | 1260 | WP_004196172.1 | ABC transporter permease | ||
| BMA_RS18170 | 431505..432331 | + | 827 | pseudogene | ABC transporter permease | ||
| BMA_RS18175 | 432426..432857 | - | 432 | pseudogene | peptidase S53 | ||
| BMA_RS18180 | 432906..434026 | - | 1121 | WP_038802950.1 | IS3 family transposase | ||
| T6CP005062 | TssB | BMA_RS18185 (tssB) | 434096..434563 | + | 468 | pseudogene | type VI secretion system contractile sheath small subunit |
| T6CP005063 | TssC | BMA_RS18190 (tssC) | 434566..436071 | + | 1506 | WP_004190846.1 | type VI secretion system contractile sheath large subunit |
| T6CP005064 | TssD | BMA_RS18195 | 436215..436742 | + | 528 | WP_004196178.1 | type VI secretion system tube protein Hcp |
| T6CP009349 | TssE | BMA_RS18200 | 436822..437253 | + | 432 | WP_004190879.1 | GPW/gp25 family protein |
| T6CP005065 | TssF | BMA_RS18205 (tssF) | 437267..439129 | + | 1863 | WP_004196180.1 | type VI secretion system baseplate subunit TssF |
| T6CP005066 | TssG | BMA_RS18210 (tssG) | 439126..440115 | + | 990 | WP_004190851.1 | type VI secretion system baseplate subunit TssG |
| BMA_RS18215 (tssH) | 440118..442988 | + | 2871 | pseudogene | type VI secretion system ATPase TssH | ||
| T6CP005067 | TssI | BMA_RS18220 (vgrG) | 442979..445225 | + | 2247 | WP_004196185.1 | type VI secretion system tip protein VgrG |
| T6CP005068 | TssI | BMA_RS18225 (vgrG) | 445391..447679 | + | 2289 | WP_004190563.1 | type VI secretion system tip protein VgrG |
| BMA_RS18230 | 447683..449899 | + | 2217 | WP_004200633.1 | pentapeptide repeat-containing protein | ||
| BMA_RS18235 | 449899..450969 | + | 1071 | WP_004202229.1 | pentapeptide repeat-containing protein | ||
| BMA_RS18240 | 450972..451688 | + | 717 | WP_004266663.1 | DUF3540 domain-containing protein | ||
| BMA_RS18245 | 451731..452120 | + | 390 | WP_004190606.1 | DUF4150 domain-containing protein | ||
| BMA_RS18250 (tssK) | 452305..453450 | + | 1146 | WP_004196199.1 | type VI secretion system baseplate subunit TssK | ||
| BMA_RS18255 | 453469..454077 | + | 609 | WP_004206248.1 | type VI secretion system baseplate subunit TssK | ||
| T6CP005070 | TssL | BMA_RS18260 | 454160..455818 | + | 1659 | WP_004190463.1 | type IVB secretion system protein IcmH/DotU |
| T6CP005071 | TssM | BMA_RS18265 (tssM) | 455815..459318 | + | 3504 | WP_004190265.1 | type VI secretion system membrane subunit TssM |
| BMA_RS18270 | 459377..459736 | + | 360 | WP_004190863.1 | hypothetical protein | ||
| BMA_RS18275 | 459759..460184 | + | 426 | WP_004190471.1 | hypothetical protein | ||
| BMA_RS18280 | 460505..460780 | + | 276 | WP_004190745.1 | hypothetical protein | ||
| BMA_RS18285 | 461331..462230 | + | 900 | WP_004186983.1 | alpha/beta hydrolase | ||
| BMA_RS18290 | 462272..462562 | - | 291 | WP_004201077.1 | hypothetical protein | ||
| BMA_RS18295 | 462452..463771 | + | 1320 | WP_004186962.1 | glycosyltransferase | ||
| BMA_RS18300 | 463768..465354 | + | 1587 | WP_004184379.1 | DHA2 family efflux MFS transporter permease subunit | ||
| BMA_RS18305 | 465619..466614 | + | 996 | WP_004186828.1 | glycosyltransferase family 2 protein | ||
| BMA_RS18315 | 466919..468514 | + | 1596 | WP_004196352.1 | efflux transporter outer membrane subunit | ||
| BMA_RS18320 | 468995..470248 | + | 1254 | WP_004186853.1 | efflux RND transporter periplasmic adaptor subunit |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|