Detailed information of accessory protein


Summary

Accessory protein ID ACP00043 experimental
Type chaperone
Related T6SS (Type) T6SS00004 (Type i1)
Strain Pseudomonas aeruginosa PAO1
Replicon chromosome
Related structure protein -
Related effector PA1863 (ModA)
Description The outer membrane protein IcmP interacts with ModA and mediated molybdate transport during bacterial competition.
Reference [1] Wang T, Du X, Ji L, et al. Pseudomonas aeruginosa T6SS-mediated molybdate transport contributes to bacterial competition during anaerobiosis. Cell Rep. 2021 Apr 13;35(2):108957. doi: 10.1016/j.celrep.2021.108957. PMID: 33852869
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed
External database links

Locus tag (Gene) PA4370 (IcmP)
Coordinates (Strand) 4898193..4899533 (+)
NCBI ID 15599566
RefSeq NC_002516
Uniprot ID Q9HW32_PSEAE
KEGG ID pae:PA4370
PDB ID -
Pfam domain hit(s)

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Domain
Pfam ID
E-value
Aligned region
Peptidase_M75PF09375.121.2e-9667..423
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Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

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Prediction                
Region    
Sequence
Outside1-446MTRMPLATASLLALAISLAGCGDDKKAEAPATPAASTQPAAPAAAPAAKVDEAAAKAVIKNYADLAEATFADALSTAKDLQKAIDAFLAKPDAETLKAAKEAWFAARTPYSQSEAFRFGNAIIDDWEGQVNAWPLDEGLIDYVAKDYQHALGNPGATANIVANTEIQVGEDKIDVKEITGEKLASLNELGGSEANVATGYHAIEFLLWGQDLNGTGPGAGNRPATDYAQGKDCTGGHCDRRAAYLKAVTDLLVSDLEYMAGQWKAGVADNYRAKLEAEPVDTGLRKMFFGMGSLSLGELAGERMKVALEANSTEDEHDCFSDDTHHTLFFNGKSIRNIYLGEYKRIDGSVVKGPSLADLVAKADAAANDTLKADLADTEAKLQAIVDSAEKDGVHFDQMIAPDNKDGQQKIRDAIAALVKQTGAIEQAAGKLGIQDLKPDNADHEF


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
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Prediction       
Probability
Cleavage site
Signal peptide sequence
LIPO(Sec/SPII)0.9982pos: 20-21. LAG-CG.MTRMPLATASLLALAISLAG


  Protein sequence: 447 a.a.    

>ACP00043 NC_002516:4898193-4899533 [Pseudomonas aeruginosa PAO1]
MTRMPLATASLLALAISLAGCGDDKKAEAPATPAASTQPAAPAAAPAAKVDEAAAKAVIKNYADLAEATFADALSTAKDL
QKAIDAFLAKPDAETLKAAKEAWFAARTPYSQSEAFRFGNAIIDDWEGQVNAWPLDEGLIDYVAKDYQHALGNPGATANI
VANTEIQVGEDKIDVKEITGEKLASLNELGGSEANVATGYHAIEFLLWGQDLNGTGPGAGNRPATDYAQGKDCTGGHCDR
RAAYLKAVTDLLVSDLEYMAGQWKAGVADNYRAKLEAEPVDTGLRKMFFGMGSLSLGELAGERMKVALEANSTEDEHDCF
SDDTHHTLFFNGKSIRNIYLGEYKRIDGSVVKGPSLADLVAKADAAANDTLKADLADTEAKLQAIVDSAEKDGVHFDQMI
APDNKDGQQKIRDAIAALVKQTGAIEQAAGKLGIQDLKPDNADHEF*

  Nucleotide sequence: 1341 bp    

>ACP00043 NC_002516:4898193-4899533 [Pseudomonas aeruginosa PAO1]
ATGACTCGTATGCCCCTGGCCACCGCCAGTCTGCTGGCCCTCGCCATCTCCCTCGCCGGCTGCGGCGACGACAAGAAAGC
CGAAGCGCCCGCAACACCGGCGGCCAGCACGCAGCCCGCCGCGCCCGCCGCCGCCCCGGCCGCCAAGGTCGACGAGGCCG
CCGCCAAGGCGGTGATCAAGAATTACGCGGACCTCGCCGAAGCCACCTTCGCCGATGCCCTGAGCACCGCCAAGGACCTG
CAGAAAGCCATCGACGCGTTCCTCGCCAAGCCTGACGCGGAGACCCTGAAAGCCGCCAAGGAAGCCTGGTTCGCCGCTCG
TACCCCTTACTCCCAGAGCGAAGCCTTCCGCTTCGGCAACGCGATCATCGACGACTGGGAAGGACAGGTTAACGCCTGGC
CGCTGGACGAAGGCCTGATCGACTATGTCGCCAAGGACTACCAGCACGCCCTGGGCAACCCCGGCGCCACCGCCAACATC
GTCGCCAACACCGAGATCCAGGTCGGCGAAGACAAGATCGACGTCAAGGAAATCACCGGCGAGAAACTGGCCAGCCTGAA
CGAGCTGGGCGGTTCCGAAGCCAACGTCGCCACCGGCTACCACGCCATCGAGTTCCTCCTCTGGGGCCAAGACCTGAACG
GCACCGGTCCCGGCGCCGGCAACCGTCCCGCCACCGACTATGCCCAGGGCAAGGACTGCACCGGCGGCCATTGCGACCGT
CGTGCCGCCTACCTGAAGGCCGTCACCGACCTGCTGGTCAGCGACCTCGAATACATGGCCGGACAGTGGAAAGCCGGCGT
CGCCGACAACTACCGCGCCAAGCTGGAGGCCGAACCGGTGGATACCGGCCTGCGCAAGATGTTCTTCGGCATGGGCAGCC
TGTCCCTCGGCGAACTGGCCGGCGAGCGCATGAAGGTCGCGCTGGAGGCCAACTCCACCGAAGACGAGCACGACTGCTTC
AGCGACGACACCCACCACACCCTGTTCTTCAACGGCAAGAGCATCCGCAACATCTACCTCGGCGAGTACAAGCGCATCGA
CGGCAGCGTGGTCAAGGGCCCGAGCCTGGCCGACCTGGTCGCCAAGGCCGACGCCGCCGCCAACGACACCCTGAAGGCCG
ACCTGGCCGACACCGAGGCCAAGCTGCAGGCCATCGTCGACAGCGCCGAGAAGGATGGCGTGCACTTCGACCAGATGATC
GCTCCGGACAACAAGGACGGCCAGCAGAAGATCCGCGACGCCATCGCCGCCCTGGTCAAGCAGACCGGCGCCATCGAGCA
GGCCGCTGGCAAGCTGGGTATCCAGGACCTGAAGCCGGACAACGCCGACCACGAGTTCTGA