Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00612  |
| T6SS type | Type i4a |
| Strain | Pseudomonas aeruginosa M18 |
| Replicon (RefSeq) | chromosome (NC_017548) |
| Location | 2967324..2986402 |
| Function | - |
| Comment | - |
| References | [1] Wei X et al (2013) Global control of GacA on secondary metabolism, primary metabolism, secretion systems, and motility in the rhizobacterium Pseudomonas aeruginosa M18. J Bacteriol. 195(15):3387-400. [PudMed:23708134] |
Bioinformatics investigation has been performed.T6SS components and genome coordinates
| Component | Sfa3 | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| PAM18_RS13700 | 2964035..2965240 | - | 1206 | WP_023116102.1 | ABC transporter substrate-binding protein | ||
| PAM18_RS13705 | 2965441..2966082 | - | 642 | WP_003110901.1 | response regulator transcription factor | ||
| PAM18_RS13710 | 2966359..2966754 | + | 396 | WP_003089513.1 | DUF4280 domain-containing protein | ||
| PAM18_RS13715 | 2966777..2967313 | - | 537 | WP_003104933.1 | toxin-antitoxin system YwqK family antitoxin | ||
| T6CP006453 | TssI | PAM18_RS13720 (tssI) | 2967324..2969330 | - | 2007 | WP_014602899.1 | type VI secretion system tip protein VgrG |
| PAM18_RS13725 | 2969330..2969518 | - | 189 | WP_003104930.1 | hypothetical protein | ||
| PAM18_RS13730 | 2969678..2970250 | - | 573 | WP_003122693.1 | hypothetical protein | ||
| T6CP006454 | TssH | PAM18_RS13735 (tssH) | 2970272..2972821 | - | 2550 | WP_003104929.1 | type VI secretion system ATPase TssH |
| T6CP006455 | TssG | PAM18_RS13740 (tssG) | 2972823..2973839 | - | 1017 | WP_003124579.1 | type VI secretion system baseplate subunit TssG |
| T6CP006456 | TssF | PAM18_RS13745 (tssF) | 2973803..2975596 | - | 1794 | WP_014602900.1 | type VI secretion system baseplate subunit TssF |
| T6CP009049 | TssE | PAM18_RS13750 (tssE) | 2975580..2976005 | - | 426 | WP_014602901.1 | type VI secretion system baseplate subunit TssE |
| T6CP006457 | TssD | PAM18_RS13755 | 2976018..2976515 | - | 498 | WP_003089495.1 | type VI secretion system tube protein Hcp |
| T6CP006458 | TssC | PAM18_RS13760 (tssC) | 2976589..2978073 | - | 1485 | WP_003089494.1 | type VI secretion system contractile sheath large subunit |
| T6CP006459 | TssB | PAM18_RS13765 (tssB) | 2978096..2978641 | - | 546 | WP_003089493.1 | type VI secretion system contractile sheath small subunit |
| PAM18_RS13770 | 2978850..2979326 | + | 477 | WP_003124582.1 | hypothetical protein | ||
| T6CP006460 | TssK | PAM18_RS13775 (tssK) | 2979386..2980717 | + | 1332 | WP_003124583.1 | type VI secretion system baseplate subunit TssK |
| T6CP009050 | TssL | PAM18_RS13780 | 2980735..2981493 | + | 759 | WP_003104706.1 | DotU family type IV/VI secretion system protein |
| T6CP006461 | TssM | PAM18_RS13785 | 2981490..2985305 | + | 3816 | WP_014602902.1 | hypothetical protein |
| T6CP006462 | TssA | PAM18_RS13790 (tssA) | 2985302..2986402 | + | 1101 | WP_014602903.1 | type VI secretion system protein TssA |
| T6CP012534 | Sfa3 | PAM18_RS13795 | 2986512..2987597 | + | 1086 | WP_012614153.1 | sigma-54-dependent transcriptional regulator |
| PAM18_RS13800 | 2987833..2988099 | + | 267 | WP_003104712.1 | hypothetical protein | ||
| PAM18_RS13805 (msuE) | 2988259..2988819 | + | 561 | WP_003089470.1 | FMN reductase | ||
| PAM18_RS13810 (ssuD) | 2988829..2989974 | + | 1146 | WP_003104713.1 | FMNH2-dependent alkanesulfonate monooxygenase | ||
| PAM18_RS13815 | 2990004..2991188 | + | 1185 | WP_003104714.1 | FMNH2-dependent monooxygenase |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0253 |
PAM18_RS12360 (gacA) | protein | TCS-RR | Pseudomonas aeruginosa M18 | chromosome (NC_017548) | 2625815..2626459 (+) | 489180874 | hsiA1 operon transcript (↓); hsiA2 operon transcript (↓); hsiA3 operon transcript (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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