Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01291  |
| T6SS type | Type i3 |
| Strain | Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 |
| Replicon (RefSeq) | chromosome (NZ_MTFW01000011) |
| Location | 10531..37913 |
| Function | - |
| Comment | - |
| References | [1] Parsons DA et al (2005) sciS, an icmF homolog in Salmonella enterica serovar Typhimurium, limits intracellular replication and decreases virulence. Infect Immun. 73(7):4338-45. [PudMed:15972528] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BWP10_RS08105 (mltD) | 5789..7156 | - | 1368 | 446567360 | murein transglycosylase D | ||
| BWP10_RS08110 (gloB) | 7228..7983 | - | 756 | 446975519 | hydroxyacylglutathione hydrolase | ||
| BWP10_RS08115 | 8018..8740 | + | 723 | 446723925 | class I SAM-dependent methyltransferase | ||
| BWP10_RS08120 (rnhA) | 8737..9204 | - | 468 | 446840616 | ribonuclease HI | ||
| BWP10_RS08125 (dnaQ) | 9268..9999 | + | 732 | 487401775 | DNA polymerase III subunit epsilon | ||
| T6CP016016 | TssA | BWP10_RS08135 | 10531..11586 | - | 1056 | 446289771 | ImpA family type VI secretion system protein |
| T6CP016017 | TssG | BWP10_RS08140 (tssG) | 11597..12592 | - | 996 | 446067389 | type VI secretion system baseplate subunit TssG |
| T6CP016018 | TssF | BWP10_RS08145 (tssF) | 12589..14472 | - | 1884 | 446293655 | type VI secretion system baseplate subunit TssF |
| T6CP016019 | TssE | BWP10_RS08150 (tssE) | 14488..14982 | - | 495 | 446030152 | type VI secretion system baseplate subunit TssE |
| BWP10_RS08155 | 14979..15803 | - | 825 | 446673189 | hypothetical protein | ||
| BWP10_RS08160 (tagK) | 15790..16692 | - | 903 | 446729368 | type VI secretion system-associated protein TagK | ||
| T6CP016020 | TssH | BWP10_RS08165 (tssH) | 17060..19699 | + | 2640 | 446371923 | type VI secretion system ATPase TssH |
| T6CP016021 | TssB | BWP10_RS08170 (tssB) | 19799..20341 | + | 543 | 446919561 | type VI secretion system contractile sheath small subunit |
| T6CP016022 | TssC | BWP10_RS08175 (tssC) | 20365..21858 | + | 1494 | 445936024 | type VI secretion system contractile sheath large subunit |
| BWP10_RS08180 | 21924..22031 | + | 108 | pseudogene | BPSL0067 family protein | ||
| BWP10_RS08185 | 22158..22490 | + | 333 | 504110516 | hypothetical protein | ||
| T6CP016023 | TssD | BWP10_RS08190 | 22744..23229 | + | 486 | 446234947 | type VI secretion system tube protein Hcp |
| BWP10_RS08200 | 23534..24019 | + | 486 | 447004294 | type VI secretion system amidase effector protein Tae4 | ||
| BWP10_RS08205 | 24004..24387 | + | 384 | 446301291 | type VI secretion system amidase immunity protein Tai4 | ||
| T6CP016024 | TssD | BWP10_RS08210 | 24530..25015 | + | 486 | 446041588 | type VI secretion system tube protein Hcp |
| T6CP016025 | TssJ | BWP10_RS08215 (tssJ) | 25082..25618 | + | 537 | 446929850 | type VI secretion system lipoprotein TssJ |
| T6CP016026 | TssK | BWP10_RS08220 (tssK) | 25622..26965 | + | 1344 | 446040877 | type VI secretion system baseplate subunit TssK |
| T6CP016027 | TssL | BWP10_RS08225 (tssL) | 26962..28266 | + | 1305 | 446054628 | type VI secretion system protein TssL, long form |
| BWP10_RS08230 | 28271..29044 | + | 774 | 446899297 | membrane protein | ||
| BWP10_RS08240 | 29247..29678 | + | 432 | 446149189 | Shiga toxin A subunit | ||
| T6CP016028 | TssM | BWP10_RS08245 (tssM) | 29712..33581 | + | 3870 | 447091705 | type VI secretion system membrane subunit TssM |
| BWP10_RS08250 | 33581..34369 | + | 789 | 447176881 | DUF2094 domain-containing protein | ||
| BWP10_RS08255 | 34366..34782 | + | 417 | 486367205 | DUF2195 family protein | ||
| BWP10_RS08260 | 34806..35327 | + | 522 | 446891128 | DUF2778 domain-containing protein | ||
| T6CP016029 | TssI | BWP10_RS08270 | 35724..37913 | + | 2190 | 445933680 | type VI secretion system tip protein VgrG |
| BWP10_RS08275 | 37937..38383 | + | 447 | 446297977 | DcrB-related protein | ||
| BWP10_RS08280 | 38402..42496 | + | 4095 | 446194801 | PAAR domain-containing protein | ||
| BWP10_RS08285 | 42490..42753 | + | 264 | 446855275 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0336 |
BWP10_01550 (ssrB) | protein | TCS-RR | Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 | chromosome (MTFW01000001) | 296600..299362 (+) | 1145677935 | sciS/TssM transcription (↑) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|