Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00535  |
| T6SS type | Type i3 |
| Strain | Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 |
| Replicon (RefSeq) | chromosome (NC_016810) |
| Location | 304656..332038 |
| Function | anti-eukaryotic; virulence |
| Comment | Contribution to pathogenesis and systemic dissemination in a mouse model of typhoid, intracellular replication in macrophages. |
| References | [1] Mulder DT et al (2012) Type VI secretion system-associated gene clusters contribute to pathogenesis of Salmonella enterica serovar Typhimurium. Infect Immun. 80(6):1996-2007. [PudMed:22493086] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagJ | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
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Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| SL1344_RS01315 (mltD) | 299914..301281 | - | 1368 | WP_000644706.1 | murein transglycosylase D | ||
| SL1344_RS01320 (gloB) | 301353..302108 | - | 756 | WP_001052775.1 | hydroxyacylglutathione hydrolase | ||
| SL1344_RS01325 | 302143..302865 | + | 723 | WP_000801238.1 | class I SAM-dependent methyltransferase | ||
| SL1344_RS01330 (rnhA) | 302862..303329 | - | 468 | WP_000917872.1 | ribonuclease HI | ||
| SL1344_RS01335 (dnaQ) | 303393..304124 | + | 732 | WP_001670675.1 | DNA polymerase III subunit epsilon | ||
| T6CP005674 | TssA | SL1344_RS01345 | 304656..305711 | - | 1056 | WP_000367626.1 | ImpA family type VI secretion system protein |
| T6CP005675 | TssG | SL1344_RS01350 (tssG) | 305722..306717 | - | 996 | WP_000145244.1 | type VI secretion system baseplate subunit TssG |
| T6CP005676 | TssF | SL1344_RS01355 (tssF) | 306714..308597 | - | 1884 | WP_000371510.1 | type VI secretion system baseplate subunit TssF |
| T6CP005677 | TssE | SL1344_RS01360 (tssE) | 308613..309107 | - | 495 | WP_000108007.1 | type VI secretion system baseplate subunit TssE |
| T6CP012821 | TagJ | SL1344_RS01365 | 309104..309928 | - | 825 | WP_000750535.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
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Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01370 | SL1344_RS01405 | Tae | IMU00303 | Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 | chromosome (NC_016810) | 317659..318144 (+) | 378698249 |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00303 | STM0278 (Tai4) | EFF01370 | Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 | chromosome (NC_016810) | 318129..318512 (+) | 378698250 |
Showing 1 to 1 of 1 rows
Experimental investigation has been performed.
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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||