Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00535  |
| T6SS type | Type i3 |
| Strain | Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 |
| Replicon (RefSeq) | chromosome (NC_016810) |
| Location | 304656..332038 |
| Function | anti-eukaryotic; virulence |
| Comment | Contribution to pathogenesis and systemic dissemination in a mouse model of typhoid, intracellular replication in macrophages. |
| References | [1] Mulder DT et al (2012) Type VI secretion system-associated gene clusters contribute to pathogenesis of Salmonella enterica serovar Typhimurium. Infect Immun. 80(6):1996-2007. [PudMed:22493086] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagJ | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| SL1344_RS01315 (mltD) | 299914..301281 | - | 1368 | WP_000644706.1 | murein transglycosylase D | ||
| SL1344_RS01320 (gloB) | 301353..302108 | - | 756 | WP_001052775.1 | hydroxyacylglutathione hydrolase | ||
| SL1344_RS01325 | 302143..302865 | + | 723 | WP_000801238.1 | class I SAM-dependent methyltransferase | ||
| SL1344_RS01330 (rnhA) | 302862..303329 | - | 468 | WP_000917872.1 | ribonuclease HI | ||
| SL1344_RS01335 (dnaQ) | 303393..304124 | + | 732 | WP_001670675.1 | DNA polymerase III subunit epsilon | ||
| T6CP005674 | TssA | SL1344_RS01345 | 304656..305711 | - | 1056 | WP_000367626.1 | ImpA family type VI secretion system protein |
| T6CP005675 | TssG | SL1344_RS01350 (tssG) | 305722..306717 | - | 996 | WP_000145244.1 | type VI secretion system baseplate subunit TssG |
| T6CP005676 | TssF | SL1344_RS01355 (tssF) | 306714..308597 | - | 1884 | WP_000371510.1 | type VI secretion system baseplate subunit TssF |
| T6CP005677 | TssE | SL1344_RS01360 (tssE) | 308613..309107 | - | 495 | WP_000108007.1 | type VI secretion system baseplate subunit TssE |
| T6CP012821 | TagJ | SL1344_RS01365 | 309104..309928 | - | 825 | WP_000750535.1 | hypothetical protein |
| SL1344_RS01370 (tagK) | 309915..310817 | - | 903 | WP_000806681.1 | type VI secretion system-associated protein TagK | ||
| T6CP005678 | TssH | SL1344_RS01380 (tssH) | 311185..313824 | + | 2640 | WP_000449778.1 | type VI secretion system ATPase TssH |
| T6CP005679 | TssB | SL1344_RS01385 (tssB) | 313924..314466 | + | 543 | WP_000996817.1 | type VI secretion system contractile sheath small subunit |
| T6CP005680 | TssC | SL1344_RS01390 (tssC) | 314490..315983 | + | 1494 | WP_000013879.1 | type VI secretion system contractile sheath large subunit |
| SL1344_RS26505 | 316049..316156 | + | 108 | pseudogene | BPSL0067 family protein | ||
| SL1344_RS01395 | 316283..316615 | + | 333 | WP_014344502.1 | hypothetical protein | ||
| T6CP005681 | TssD | SL1344_RS01400 | 316869..317354 | + | 486 | WP_000312802.1 | type VI secretion system tube protein Hcp |
| SL1344_RS27560 | 317374..317529 | + | 156 | WP_001541860.1 | hypothetical protein | ||
| SL1344_RS01405 | 317659..318144 | + | 486 | WP_001081550.1 | type VI secretion system amidase effector protein Tae4 | ||
| SL1344_RS01410 | 318129..318512 | + | 384 | WP_000379146.1 | type VI secretion system amidase immunity protein Tai4 | ||
| T6CP005682 | TssD | SL1344_RS01415 | 318655..319140 | + | 486 | WP_000119443.1 | type VI secretion system tube protein Hcp |
| T6CP005683 | TssJ | SL1344_RS01420 (tssJ) | 319207..319743 | + | 537 | WP_001007106.1 | type VI secretion system lipoprotein TssJ |
| T6CP005684 | TssK | SL1344_RS01425 (tssK) | 319747..321090 | + | 1344 | WP_000118732.1 | type VI secretion system baseplate subunit TssK |
| T6CP005685 | TssL | SL1344_RS01430 (tssL) | 321087..322391 | + | 1305 | WP_000132483.1 | type VI secretion system protein TssL, long form |
| SL1344_RS01435 | 322396..323169 | + | 774 | WP_000976553.1 | membrane protein | ||
| SL1344_RS01440 | 323372..323803 | + | 432 | WP_000227044.1 | Shiga toxin A subunit | ||
| T6CP005686 | TssM | SL1344_RS01445 (tssM) | 323837..327706 | + | 3870 | WP_001168956.1 | type VI secretion system membrane subunit TssM |
| SL1344_RS01450 | 327706..328494 | + | 789 | WP_001254137.1 | DUF2094 domain-containing protein | ||
| SL1344_RS01455 | 328491..328907 | + | 417 | WP_001596567.1 | DUF2195 family protein | ||
| SL1344_RS01460 | 328931..329452 | + | 522 | WP_000968384.1 | DUF2778 domain-containing protein | ||
| T6CP005687 | TssI | SL1344_RS01465 | 329849..332038 | + | 2190 | WP_000011535.1 | type VI secretion system tip protein VgrG |
| SL1344_RS01470 | 332062..332508 | + | 447 | WP_000375832.1 | DcrB-related protein | ||
| SL1344_RS01475 | 332527..336123 | + | 3597 | WP_000272655.1 | PAAR domain-containing protein | ||
| SL1344_RS01480 | 336117..336380 | + | 264 | WP_000932531.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01370 |
SL1344_RS01405 | Tae | IMU00303 |
Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 | chromosome (NC_016810) | 317659..318144 (+) | 378698249 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00303 |
STM0278 (Tai4) | EFF01370 |
Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 | chromosome (NC_016810) | 318129..318512 (+) | 378698250 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|