Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS00346 experimental
T6SS type Type i4b
Strain Edwardsiella ictaluri 93-146
Replicon (RefSeq) chromosome (NC_012779)
Location 2631752..2651730
Function effector translocation; virulence
Comment -
References
[1] Rogge ML et al (2011) Regulation of the Edwardsiella ictaluri type III secretion system by pH and phosphate concentration through EsrA, EsrB, and EsrC. Appl Environ Microbiol. 77(13):4293-302. [PudMed:21551284]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentPAARTssATssBTssCTssDTssETssFTssGTssHTssITssJTssKTssLTssM
Number11111111111111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
NT01EI_RS11875 2627131..2628156 + 1026 WP_015870885.1 IS110 family transposase
NT01EI_RS18465 2628438..2628935 - 498 pseudogene IS5 family transposase
NT01EI_RS11880 2628968..2630176 - 1209 WP_015870371.1 IS256-like element ISEic2 family transposase
NT01EI_RS11885 2630250..2630561 - 312 pseudogene IS5 family transposase
NT01EI_RS20225 2631188..2631489 + 302 pseudogene type VI secretion protein
T6CP008364 TssB NT01EI_RS11890 (tssB) 2631739..2632251 + 513 WP_015872006.1 type VI secretion system contractile sheath small subunit
T6CP008365 TssC NT01EI_RS11895 (tssC) 2632251..2633738 + 1488 WP_015872007.1 type VI secretion system contractile sheath large subunit
T6CP009343 TssD NT01EI_RS11900 2633808..2634299 + 492 WP_015872008.1 type VI secretion system tube protein Hcp
NT01EI_RS11905 2634429..2635640 + 1212 WP_015872009.1 hypothetical protein
T6CP008366 TssE NT01EI_RS11910 (tssE) 2635649..2636125 + 477 WP_015872010.1 type VI secretion system baseplate subunit TssE
T6CP008367 TssF NT01EI_RS11915 (tssF) 2636129..2637970 + 1842 WP_015872011.1 type VI secretion system baseplate subunit TssF
T6CP003512 TssG NT01EI_RS11920 (tssG) 2637967..2638992 + 1026 WP_015872012.1 type VI secretion system baseplate subunit TssG
T6CP003513 TssH NT01EI_RS11925 (tssH) 2639112..2641733 + 2622 WP_015872013.1 type VI secretion system ATPase TssH
T6CP003514 TssI NT01EI_RS11930 2641724..2643709 + 1986 WP_015872014.1 type VI secretion system tip protein VgrG
T6CP011757 PAAR NT01EI_RS11935 2643804..2644106 + 303 WP_015872015.1 PAAR domain-containing protein
T6CP003515 TssA NT01EI_RS11940 (tssA) 2644120..2645190 + 1071 WP_015872016.1 type VI secretion system protein TssA
T6CP003516 TssJ NT01EI_RS11945 (tssJ) 2645177..2645806 + 630 WP_035608788.1 type VI secretion system lipoprotein TssJ
T6CP003517 TssK NT01EI_RS11950 (tssK) 2645903..2647291 + 1389 WP_015872018.1 type VI secretion system baseplate subunit TssK
T6CP009344 TssL NT01EI_RS11955 2647288..2647938 + 651 WP_015872019.1 DotU family type IV/VI secretion system protein
T6CP003518 TssM NT01EI_RS11960 2647935..2651717 + 3783 WP_015872020.1 type VI secretion system protein ImpL
NT01EI_RS11965 (mepA) 2652338..2653204 - 867 WP_071525688.1 penicillin-insensitive murein endopeptidase
NT01EI_RS11970 (aroC) 2653176..2654261 - 1086 WP_015872023.1 chorismate synthase
NT01EI_RS11975 (prmB) 2654348..2655280 - 933 WP_015872024.1 50S ribosomal protein L3 N(5)-glutamine methyltransferase
NT01EI_RS11980 (smrB) 2655491..2656036 + 546 WP_035608785.1 endonuclease SmrB
NT01EI_RS11985 (sixA) 2656087..2656563 - 477 WP_015872026.1 phosphohistidine phosphatase SixA
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)
REG0204 experimental NT01EI_RS04325 (EsrB) protein TCS-RR Edwardsiella ictaluri 93-146 chromosome (NC_012779) 955101..955745 (-) 506350644 T6SS translocon protein EvpC secretion (↓)
REG0205 experimental NT01EI_RS04200 (EsrC) protein TCS regulatory pathway Edwardsiella ictaluri 93-146 chromosome (NC_012779) 933326..934018 (-) 737638726 T6SS translocon protein EvpC secretion (↓)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID
EFF00433 experimental NT01EI_RS11900 - - Edwardsiella ictaluri 93-146 chromosome (NC_012779) 2633808..2634299 (+) 238920627

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector