Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00346  |
| T6SS type | Type i4b |
| Strain | Edwardsiella ictaluri 93-146 |
| Replicon (RefSeq) | chromosome (NC_012779) |
| Location | 2631752..2651730 |
| Function | effector translocation; virulence |
| Comment | - |
| References | [1] Rogge ML et al (2011) Regulation of the Edwardsiella ictaluri type III secretion system by pH and phosphate concentration through EsrA, EsrB, and EsrC. Appl Environ Microbiol. 77(13):4293-302. [PudMed:21551284] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| NT01EI_RS11875 | 2627131..2628156 | + | 1026 | WP_015870885.1 | IS110 family transposase | ||
| NT01EI_RS18465 | 2628438..2628935 | - | 498 | pseudogene | IS5 family transposase | ||
| NT01EI_RS11880 | 2628968..2630176 | - | 1209 | WP_015870371.1 | IS256-like element ISEic2 family transposase | ||
| NT01EI_RS11885 | 2630250..2630561 | - | 312 | pseudogene | IS5 family transposase | ||
| NT01EI_RS20225 | 2631188..2631489 | + | 302 | pseudogene | type VI secretion protein | ||
| T6CP008364 | TssB | NT01EI_RS11890 (tssB) | 2631739..2632251 | + | 513 | WP_015872006.1 | type VI secretion system contractile sheath small subunit |
| T6CP008365 | TssC | NT01EI_RS11895 (tssC) | 2632251..2633738 | + | 1488 | WP_015872007.1 | type VI secretion system contractile sheath large subunit |
| T6CP009343 | TssD | NT01EI_RS11900 | 2633808..2634299 | + | 492 | WP_015872008.1 | type VI secretion system tube protein Hcp |
| NT01EI_RS11905 | 2634429..2635640 | + | 1212 | WP_015872009.1 | hypothetical protein | ||
| T6CP008366 | TssE | NT01EI_RS11910 (tssE) | 2635649..2636125 | + | 477 | WP_015872010.1 | type VI secretion system baseplate subunit TssE |
| T6CP008367 | TssF | NT01EI_RS11915 (tssF) | 2636129..2637970 | + | 1842 | WP_015872011.1 | type VI secretion system baseplate subunit TssF |
| T6CP003512 | TssG | NT01EI_RS11920 (tssG) | 2637967..2638992 | + | 1026 | WP_015872012.1 | type VI secretion system baseplate subunit TssG |
| T6CP003513 | TssH | NT01EI_RS11925 (tssH) | 2639112..2641733 | + | 2622 | WP_015872013.1 | type VI secretion system ATPase TssH |
| T6CP003514 | TssI | NT01EI_RS11930 | 2641724..2643709 | + | 1986 | WP_015872014.1 | type VI secretion system tip protein VgrG |
| T6CP011757 | PAAR | NT01EI_RS11935 | 2643804..2644106 | + | 303 | WP_015872015.1 | PAAR domain-containing protein |
| T6CP003515 | TssA | NT01EI_RS11940 (tssA) | 2644120..2645190 | + | 1071 | WP_015872016.1 | type VI secretion system protein TssA |
| T6CP003516 | TssJ | NT01EI_RS11945 (tssJ) | 2645177..2645806 | + | 630 | WP_035608788.1 | type VI secretion system lipoprotein TssJ |
| T6CP003517 | TssK | NT01EI_RS11950 (tssK) | 2645903..2647291 | + | 1389 | WP_015872018.1 | type VI secretion system baseplate subunit TssK |
| T6CP009344 | TssL | NT01EI_RS11955 | 2647288..2647938 | + | 651 | WP_015872019.1 | DotU family type IV/VI secretion system protein |
| T6CP003518 | TssM | NT01EI_RS11960 | 2647935..2651717 | + | 3783 | WP_015872020.1 | type VI secretion system protein ImpL |
| NT01EI_RS11965 (mepA) | 2652338..2653204 | - | 867 | WP_071525688.1 | penicillin-insensitive murein endopeptidase | ||
| NT01EI_RS11970 (aroC) | 2653176..2654261 | - | 1086 | WP_015872023.1 | chorismate synthase | ||
| NT01EI_RS11975 (prmB) | 2654348..2655280 | - | 933 | WP_015872024.1 | 50S ribosomal protein L3 N(5)-glutamine methyltransferase | ||
| NT01EI_RS11980 (smrB) | 2655491..2656036 | + | 546 | WP_035608785.1 | endonuclease SmrB | ||
| NT01EI_RS11985 (sixA) | 2656087..2656563 | - | 477 | WP_015872026.1 | phosphohistidine phosphatase SixA |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0204 |
NT01EI_RS04325 (EsrB) | protein | TCS-RR | Edwardsiella ictaluri 93-146 | chromosome (NC_012779) | 955101..955745 (-) | 506350644 | T6SS translocon protein EvpC secretion (↓) |
| REG0205 |
NT01EI_RS04200 (EsrC) | protein | TCS regulatory pathway | Edwardsiella ictaluri 93-146 | chromosome (NC_012779) | 933326..934018 (-) | 737638726 | T6SS translocon protein EvpC secretion (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF00433 |
NT01EI_RS11900 | - | - | Edwardsiella ictaluri 93-146 | chromosome (NC_012779) | 2633808..2634299 (+) | 238920627 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|