Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00613  |
| T6SS type | Type i1 |
| Strain | Pseudomonas aeruginosa M18 |
| Replicon (RefSeq) | chromosome (NC_017548) |
| Location | 3757284..3776259 |
| Function | - |
| Comment | - |
| References | [1] Wei X et al (2013) Global control of GacA on secondary metabolism, primary metabolism, secretion systems, and motility in the rhizobacterium Pseudomonas aeruginosa M18. J Bacteriol. 195(15):3387-400. [PudMed:23708134] |
Bioinformatics investigation has been performed.T6SS components and genome coordinates
| Component | FHA | Sfa2 | Stk1 | Stp1 | TssA | TssB | TssC | TssE | TssF | TssG | TssH | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| PAM18_RS17280 | 3752833..3753153 | + | 321 | WP_003087644.1 | hypothetical protein | ||
| PAM18_RS17285 | 3753210..3753767 | + | 558 | WP_003087642.1 | Smr/MutS family protein | ||
| PAM18_RS17290 (folE) | 3753845..3754390 | + | 546 | WP_003087639.1 | GTP cyclohydrolase I FolE | ||
| PAM18_RS17295 | 3754455..3754916 | - | 462 | WP_003087637.1 | bacteriohemerythrin | ||
| PAM18_RS17300 | 3755162..3755542 | + | 381 | WP_003114616.1 | VOC family protein | ||
| T6CP012535 | Stk1 | PAM18_RS17305 | 3755570..3756559 | - | 990 | WP_003097784.1 | serine/threonine protein kinase |
| T6CP012536 | Stp1 | PAM18_RS17310 | 3756556..3757284 | - | 729 | WP_003087627.1 | serine/threonine-protein phosphatase |
| T6CP006463 | TssM | PAM18_RS17315 (tssM) | 3757284..3760811 | - | 3528 | WP_014603068.1 | type VI secretion system membrane subunit TssM |
| T6CP006464 | TssL | PAM18_RS17320 (icmH) | 3760827..3761696 | - | 870 | WP_003087622.1 | type IVB secretion system protein IcmH/DotU |
| T6CP006465 | TssK | PAM18_RS17325 (tssK) | 3761699..3763030 | - | 1332 | WP_003097790.1 | type VI secretion system baseplate subunit TssK |
| T6CP006466 | TssJ | PAM18_RS17330 (tssJ) | 3763027..3763533 | - | 507 | WP_041025242.1 | type VI secretion system lipoprotein TssJ |
| T6CP012073 | FHA | PAM18_RS17335 (tagH) | 3763539..3764732 | - | 1194 | WP_003114611.1 | type VI secretion system-associated FHA domain protein TagH |
| PAM18_RS17340 | 3764750..3764890 | - | 141 | WP_003087614.1 | hypothetical protein | ||
| T6CP012537 | Sfa2 | PAM18_RS17345 | 3764979..3766490 | - | 1512 | WP_003097799.1 | sigma-54-dependent Fis family transcriptional regulator |
| T6CP006467 | TssH | PAM18_RS17350 (tssH) | 3766501..3769134 | - | 2634 | WP_019371917.1 | type VI secretion system ATPase TssH |
| T6CP006468 | TssG | PAM18_RS17355 (tssG) | 3769141..3770148 | - | 1008 | WP_003097804.1 | type VI secretion system baseplate subunit TssG |
| T6CP006469 | TssF | PAM18_RS17360 (tssF) | 3770112..3771899 | - | 1788 | WP_014603071.1 | type VI secretion system baseplate subunit TssF |
| PAM18_RS30240 | 3772059..3772226 | - | 168 | pseudogene | PAAR domain-containing protein | ||
| T6CP009051 | TssE | PAM18_RS17365 (tssE) | 3772237..3772644 | - | 408 | WP_003097809.1 | type VI secretion system baseplate subunit TssE |
| T6CP006470 | TssC | PAM18_RS17370 (tssC) | 3772657..3774132 | - | 1476 | WP_003087596.1 | type VI secretion system contractile sheath large subunit |
| T6CP006471 | TssB | PAM18_RS17375 (tssB) | 3774161..3774667 | - | 507 | WP_003114607.1 | type VI secretion system contractile sheath small subunit |
| T6CP009572 | TssA | PAM18_RS17380 (tssA) | 3774703..3776259 | - | 1557 | WP_003097814.1 | type VI secretion system protein TssA |
| PAM18_RS17385 | 3777431..3778033 | - | 603 | WP_003097816.1 | glutathione S-transferase family protein | ||
| PAM18_RS17390 | 3778089..3779255 | - | 1167 | WP_003097818.1 | PLP-dependent aminotransferase family protein | ||
| PAM18_RS17395 | 3779337..3779813 | + | 477 | WP_003097819.1 | MarR family transcriptional regulator | ||
| PAM18_RS17400 | 3779863..3780498 | - | 636 | WP_003097821.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0253 |
PAM18_RS12360 (gacA) | protein | TCS-RR | Pseudomonas aeruginosa M18 | chromosome (NC_017548) | 2625815..2626459 (+) | 489180874 | hsiA1 operon transcript (↓); hsiA2 operon transcript (↓); hsiA3 operon transcript (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|