Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00463  |
| T6SS type | Type i2 |
| Strain | Escherichia coli 042 |
| Replicon (RefSeq) | chromosome (NC_017626) |
| Location | 4852875..4885437 |
| Function | effector translocation |
| Comment | - |
| References | [1] Morin N et al (2013) Characterization of the AggR regulon in enteroaggregative Escherichia coli. Infect Immun. 81(1):122-32. [PudMed:23090962] [2] Zoued A et al (2013) TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the Type VI secretion system. J Biol Chem. 288(38):27031-41. [PudMed:23921384] [3] Durand E et al (2012) Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems. J Biol Chem. 287(17):14157-68. [PudMed:22371492] [4] Dudley EG et al (2006) Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli. Mol Microbiol. 61(5):1267-82. [PudMed:16925558] [5] Felisberto-Rodrigues C et al (2011) Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar. PLoS Pathog. 7(11):e1002386. [PudMed:22102820] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagL | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| EC042_RS24130 (hha) | 4848505..4848717 | + | 213 | WP_000453331.1 | hemolysin expression modulator Hha | ||
| EC042_RS24135 | 4849334..4849903 | + | 570 | WP_000220727.1 | inovirus Gp2 family protein | ||
| EC042_RS30730 | 4849941..4850099 | + | 159 | WP_000493525.1 | hypothetical protein | ||
| EC042_RS24140 | 4850071..4850454 | + | 384 | WP_000271022.1 | hypothetical protein | ||
| EC042_RS24145 | 4850444..4850863 | + | 420 | WP_001387059.1 | hypothetical protein | ||
| EC042_RS24150 | 4850869..4851051 | + | 183 | WP_001216313.1 | hypothetical protein | ||
| EC042_RS24155 | 4851172..4851795 | + | 624 | WP_001260266.1 | hypothetical protein | ||
| EC042_RS24160 | 4851891..4852124 | + | 234 | WP_000124181.1 | hypothetical protein | ||
| EC042_RS24165 | 4852177..4852368 | - | 192 | WP_001287796.1 | DUF4222 domain-containing protein | ||
| T6CP005160 | TssB | EC042_RS24170 (tssB) | 4852875..4853372 | + | 498 | WP_000098939.1 | type VI secretion system contractile sheath small subunit |
| T6CP005135 | TssC | EC042_RS24175 (tssC) | 4853394..4854938 | + | 1545 | WP_000930191.1 | type VI secretion system contractile sheath large subunit |
| T6CP005161 | TssK | EC042_RS24180 (tssK) | 4854954..4856291 | + | 1338 | WP_000708638.1 | type VI secretion system baseplate subunit TssK |
| T6CP009328 | TssL | EC042_RS24185 (tssL) | 4856288..4856941 | + | 654 | WP_001040045.1 | type VI secretion system protein TssL, short form |
| T6CP011358 | TagL | EC042_RS24190 | 4856944..4858674 | + | 1731 | WP_000558483.1 | OmpA family protein |
| T6CP009062 | TssD | EC042_RS24195 (hcp) | 4858680..4859171 | + | 492 | WP_001007313.1 | type VI secretion system effector Hcp |
| T6CP005162 | TssH | EC042_RS24200 (tssH) | 4859340..4861997 | + | 2658 | WP_000431646.1 | type VI secretion system ATPase TssH |
| EC042_RS24205 | 4861994..4862560 | + | 567 | WP_000148361.1 | hypothetical protein | ||
| EC042_RS28850 | 4862554..4863096 | + | 543 | WP_001403984.1 | hypothetical protein | ||
| T6CP005163 | TssI | EC042_RS24215 (vgrG) | 4863083..4865608 | + | 2526 | WP_001054503.1 | type VI secretion system tip protein VgrG |
| EC042_RS24220 (tle1) | 4865605..4867287 | + | 1683 | WP_000170556.1 | T6SS effector phospholipase Tle1-EAEC | ||
| EC042_RS24225 (tli1) | 4867307..4867984 | + | 678 | WP_000196359.1 | T6SS immunity phospholipase A1-binding lipoprotein Tli1-EAEC | ||
| EC042_RS24230 (tli1) | 4868128..4868805 | + | 678 | WP_000196358.1 | T6SS immunity phospholipase A1-binding lipoprotein Tli1-EAEC | ||
| T6CP011359 | PAAR | EC042_RS24235 | 4868837..4869103 | + | 267 | WP_000033410.1 | PAAR domain-containing protein |
| EC042_RS24240 | 4869107..4870255 | + | 1149 | WP_001403985.1 | hypothetical protein | ||
| T6CP005136 | TssM | EC042_RS24245 | 4870248..4873637 | + | 3390 | WP_001037088.1 | type VI secretion protein VasK |
| T6CP009339 | TssA | EC042_RS24250 (tssA) | 4873637..4875235 | + | 1599 | WP_000146515.1 | type VI secretion system protein TssA |
| EC042_RS24255 | 4875237..4875929 | + | 693 | WP_000115357.1 | hypothetical protein | ||
| T6CP005137 | TssF | EC042_RS24260 (tssF) | 4875937..4877700 | + | 1764 | WP_000342463.1 | type VI secretion system baseplate subunit TssF |
| T6CP005138 | TssG | EC042_RS24265 (tssG) | 4877655..4878755 | + | 1101 | WP_000553781.1 | type VI secretion system baseplate subunit TssG |
| T6CP005139 | TssJ | EC042_RS24270 (tssJ) | 4878736..4879272 | + | 537 | WP_000974469.1 | type VI secretion system lipoprotein TssJ |
| T6CP005140 | TssE | EC042_RS24275 (tssE) | 4879275..4879706 | + | 432 | WP_001137932.1 | type VI secretion system baseplate subunit TssE |
| EC042_RS24280 | 4879863..4880264 | + | 402 | WP_001403987.1 | hypothetical protein | ||
| EC042_RS24285 | 4880420..4881664 | + | 1245 | WP_000897032.1 | GIY-YIG nuclease family protein | ||
| EC042_RS24290 | 4881900..4883645 | + | 1746 | WP_024261658.1 | AAA family ATPase | ||
| T6CP009064 | TssA | EC042_RS24300 | 4884070..4885437 | + | 1368 | WP_000200211.1 | type VI secretion system ImpA family N-terminal domain-containing protein |
| EC042_RS24305 | 4885652..4886212 | + | 561 | WP_000586175.1 | hypothetical protein | ||
| EC042_RS24310 | 4886215..4887045 | + | 831 | WP_000370895.1 | hypothetical protein | ||
| EC042_RS24315 | 4887086..4888318 | + | 1233 | WP_001204642.1 | phosphoadenosine phosphosulfate reductase | ||
| EC042_RS24320 | 4888303..4888947 | + | 645 | WP_000502863.1 | ParB N-terminal domain-containing protein | ||
| EC042_RS24325 | 4889026..4889295 | + | 270 | WP_000226517.1 | PerC family transcriptional regulator | ||
| EC042_RS24330 | 4889316..4889960 | + | 645 | WP_001387055.1 | hypothetical protein | ||
| EC042_RS24335 | 4890026..4890349 | + | 324 | WP_001387054.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF00560 |
EC042_RS24195 | - | - | Escherichia coli 042 | chromosome (NC_017626) | 4858680..4859171 (+) | 387609950 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00313 |
EC042_4535 (Tli1EAEC) | EFF01465 |
Escherichia coli 042 | chromosome (NC_017626) | 4867307..4867984 (+) | 446118504 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|