Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS00463 experimental
T6SS type Type i2
Strain Escherichia coli 042
Replicon (RefSeq) chromosome (NC_017626)
Location 4852875..4885437
Function effector translocation
Comment -
References
[1] Durand E et al (2012) Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems. J Biol Chem. 287(17):14157-68. [PudMed:22371492]
[2] Felisberto-Rodrigues C et al (2011) Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar. PLoS Pathog. 7(11):e1002386. [PudMed:22102820]
[3] Dudley EG et al (2006) Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli. Mol Microbiol. 61(5):1267-82. [PudMed:16925558]
[4] Morin N et al (2013) Characterization of the AggR regulon in enteroaggregative Escherichia coli. Infect Immun. 81(1):122-32. [PudMed:23090962]
[5] Zoued A et al (2013) TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the Type VI secretion system. J Biol Chem. 288(38):27031-41. [PudMed:23921384]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentPAARTagLTssATssBTssCTssDTssETssFTssGTssHTssITssJTssKTssLTssM
Number112111111111111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
EC042_RS24130 (hha) 4848505..4848717 + 213 WP_000453331.1 hemolysin expression modulator Hha
EC042_RS24135 4849334..4849903 + 570 WP_000220727.1 inovirus Gp2 family protein
EC042_RS30730 4849941..4850099 + 159 WP_000493525.1 hypothetical protein
EC042_RS24140 4850071..4850454 + 384 WP_000271022.1 hypothetical protein
EC042_RS24145 4850444..4850863 + 420 WP_001387059.1 hypothetical protein
EC042_RS24150 4850869..4851051 + 183 WP_001216313.1 hypothetical protein
EC042_RS24155 4851172..4851795 + 624 WP_001260266.1 hypothetical protein
EC042_RS24160 4851891..4852124 + 234 WP_000124181.1 hypothetical protein
EC042_RS24165 4852177..4852368 - 192 WP_001287796.1 DUF4222 domain-containing protein
T6CP005160 TssB EC042_RS24170 (tssB) 4852875..4853372 + 498 WP_000098939.1 type VI secretion system contractile sheath small subunit
T6CP005135 TssC EC042_RS24175 (tssC) 4853394..4854938 + 1545 WP_000930191.1 type VI secretion system contractile sheath large subunit
T6CP005161 TssK EC042_RS24180 (tssK) 4854954..4856291 + 1338 WP_000708638.1 type VI secretion system baseplate subunit TssK
T6CP009328 TssL EC042_RS24185 (tssL) 4856288..4856941 + 654 WP_001040045.1 type VI secretion system protein TssL, short form
T6CP011358 TagL EC042_RS24190 4856944..4858674 + 1731 WP_000558483.1 OmpA family protein
T6CP009062 TssD EC042_RS24195 (hcp) 4858680..4859171 + 492 WP_001007313.1 type VI secretion system effector Hcp
T6CP005162 TssH EC042_RS24200 (tssH) 4859340..4861997 + 2658 WP_000431646.1 type VI secretion system ATPase TssH
EC042_RS24205 4861994..4862560 + 567 WP_000148361.1 hypothetical protein
EC042_RS28850 4862554..4863096 + 543 WP_001403984.1 hypothetical protein
T6CP005163 TssI EC042_RS24215 (vgrG) 4863083..4865608 + 2526 WP_001054503.1 type VI secretion system tip protein VgrG
EC042_RS24220 (tle1) 4865605..4867287 + 1683 WP_000170556.1 T6SS effector phospholipase Tle1-EAEC
EC042_RS24225 (tli1) 4867307..4867984 + 678 WP_000196359.1 T6SS immunity phospholipase A1-binding lipoprotein Tli1-EAEC
EC042_RS24230 (tli1) 4868128..4868805 + 678 WP_000196358.1 T6SS immunity phospholipase A1-binding lipoprotein Tli1-EAEC
T6CP011359 PAAR EC042_RS24235 4868837..4869103 + 267 WP_000033410.1 PAAR domain-containing protein
EC042_RS24240 4869107..4870255 + 1149 WP_001403985.1 hypothetical protein
T6CP005136 TssM EC042_RS24245 4870248..4873637 + 3390 WP_001037088.1 type VI secretion protein VasK
T6CP009339 TssA EC042_RS24250 (tssA) 4873637..4875235 + 1599 WP_000146515.1 type VI secretion system protein TssA
EC042_RS24255 4875237..4875929 + 693 WP_000115357.1 hypothetical protein
T6CP005137 TssF EC042_RS24260 (tssF) 4875937..4877700 + 1764 WP_000342463.1 type VI secretion system baseplate subunit TssF
T6CP005138 TssG EC042_RS24265 (tssG) 4877655..4878755 + 1101 WP_000553781.1 type VI secretion system baseplate subunit TssG
T6CP005139 TssJ EC042_RS24270 (tssJ) 4878736..4879272 + 537 WP_000974469.1 type VI secretion system lipoprotein TssJ
T6CP005140 TssE EC042_RS24275 (tssE) 4879275..4879706 + 432 WP_001137932.1 type VI secretion system baseplate subunit TssE
EC042_RS24280 4879863..4880264 + 402 WP_001403987.1 hypothetical protein
EC042_RS24285 4880420..4881664 + 1245 WP_000897032.1 GIY-YIG nuclease family protein
EC042_RS24290 4881900..4883645 + 1746 WP_024261658.1 AAA family ATPase
T6CP009064 TssA EC042_RS24300 4884070..4885437 + 1368 WP_000200211.1 type VI secretion system ImpA family N-terminal domain-containing protein
EC042_RS24305 4885652..4886212 + 561 WP_000586175.1 hypothetical protein
EC042_RS24310 4886215..4887045 + 831 WP_000370895.1 hypothetical protein
EC042_RS24315 4887086..4888318 + 1233 WP_001204642.1 phosphoadenosine phosphosulfate reductase
EC042_RS24320 4888303..4888947 + 645 WP_000502863.1 ParB N-terminal domain-containing protein
EC042_RS24325 4889026..4889295 + 270 WP_000226517.1 PerC family transcriptional regulator
EC042_RS24330 4889316..4889960 + 645 WP_001387055.1 hypothetical protein
EC042_RS24335 4890026..4890349 + 324 WP_001387054.1 hypothetical protein
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID
EFF00560 experimental EC042_RS24195 - - Escherichia coli 042 chromosome (NC_017626) 4858680..4859171 (+) 387609950

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID
IMU00313 experimental EC042_4535 (Tli1EAEC) EFF01465 experimental Escherichia coli 042 chromosome (NC_017626) 4867307..4867984 (+) 446118504

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector