Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00787  |
| T6SS type | Type i1 |
| Strain | Escherichia coli RS218 |
| Replicon (GenBank) | chromosome (JN837480) |
| Location | 1..23615 |
| Function | anti-eukaryotic; effector translocation; adherence |
| Comment | T6SS-associated Hcp family proteins are likely to contribute to the pathogenesis of E. coli meningitis; Adhesion to and invasion of human brain microvascular endothelial cells. |
| References | [1] Zhou Y et al (2012) Hcp family proteins secreted via the type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Infect Immun. 80(3):1243-51. [PudMed:22184413] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 2 | 3 | 1 | 2 | 2 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 2 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| T6CP010969 | TssD | Locus_01 (evfA) | 471..950 | - | 480 | 356875268 | EvfA |
| T6CP010970 | TssA | Locus_02 (evfB) | 968..2326 | - | 1359 | 356875269 | EvfB |
| T6CP010971 | TssM | Locus_03 (evfC) | 2337..5354 | - | 3018 | 356875270 | EvfC |
| T6CP010972 | TssM | Locus_04 (evfD) | 5386..5865 | - | 480 | 356875272 | EvfD |
| T6CP010973 | TssA | Locus_05 (evfF) | 5885..7327 | - | 1443 | 356875273 | EvfF |
| Locus_06 (evfE) | 5885..6316 | - | 432 | 356875271 | EvfE | ||
| Locus_07 (evfG) | 7332..7979 | - | 648 | 356875274 | EvfG | ||
| T6CP010975 | TssH | Locus_08 (evfH) | 8072..9130 | - | 1059 | 356875275 | EvfH |
| T6CP010976 | TssH | Locus_09 (evfI) | 9085..9714 | - | 630 | 356875276 | EvfI |
| T6CP010977 | TssH | Locus_10 (evfJ) | 9686..10834 | - | 1149 | 356875277 | EvfJ |
| T6CP010978 | TssL | Locus_11 (evfK) | 10844..11608 | - | 765 | 356875278 | EvfK |
| T6CP010979 | TssK | Locus_12 (evfL) | 11613..12959 | - | 1347 | 356875279 | EvfL |
| T6CP010980 | TssJ | Locus_13 (evfM) | 12962..13486 | - | 525 | 356875280 | EvfM |
| T6CP012274 | FHA | Locus_14 (evfN) | 13483..14091 | - | 609 | 356875281 | EvfN |
| T6CP012275 | FHA | Locus_15 (evfO) | 13991..14764 | - | 774 | 356875282 | EvfO |
| T6CP010981 | TssG | Locus_16 (evfP) | 14781..15830 | - | 1050 | 356875283 | EvfP |
| T6CP010982 | TssF | Locus_17 (evfQ) | 15794..17635 | - | 1842 | 356875284 | EvfQ |
| T6CP010983 | TssE | Locus_18 (evfR) | 17641..18066 | - | 426 | 356875285 | EvfR |
| T6CP010984 | TssC | Locus_19 (evfS) | 18071..19126 | - | 1056 | 356875286 | EvfS |
| T6CP010985 | TssC | Locus_20 (evfT) | 19089..19556 | - | 468 | 356875287 | EvfT |
| T6CP010986 | TssB | Locus_21 (evfU) | 19579..20082 | - | 504 | 356875288 | EvfU |
| T6CP010987 | TssD | Locus_22 (evfV) | 20788..21306 | + | 519 | 356875290 | EvfV |
| T6CP010988 | TssI | Locus_23 (evfW) | 21527..23509 | + | 1983 | 356875289 | EvfW |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
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Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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