SecReT6, T6SS database

Detailed information of component protein

Summary

Component ID	T6CP010975
Component protein type	TssH
T6SS ID (Type)	T6SS00787 (Type i1)
Strain	Escherichia coli RS218
Replicon	chromosome
Sequence	Protein sequence (353 a.a.); Nucleotide sequence (1059 bp)
Reference	[1] Zhou Y, Tao J, Yu H, et al. Hcp family proteins secreted via the type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Infect Immun. 2012 Mar;80(3):1243-51. doi: 10.1128/IAI.05994-11. Epub 2011 Dec 19. PMID: 22184413

Experimental investigation has been performed on this T6SS

External database links

Locus tag (Gene)	-
Coordinate (Strand)	8072..9130 (-)
NCBI ID	356875275
GenBank	JN837480
Uniprot ID	G8IRL6_ECOLX
KEGG ID	-
PDB ID	-

Pfam domain hit(s)

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Domain	Pfam ID	E-value	Aligned region
AAA_2	PF07724.16	1.4e-38	72..233
ClpB_D2-small	PF10431.11	7.5e-09	239..316

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Transmembrane helices

Transmembrane helices are predicted using TMHMM 2.0 software.

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Prediction	Region	Sequence
Outside	1-352	MLVSPHVDKKQIAAVIAEWTGVPLNRLSQNEMSVITDLPVWLGGTIKGQDLAIASLHKHLLTARADLRRPGRPLGAFLLAGPSGVGKTETVLQLAELLYGGRQYLTTINMSEFQEKHTVSRLIGSPPGYVGYGEGGVLTEAIRQKPYSVVLLDEVEKAHPDVLNLFYQAFDKGEMADGEGRLIDCKNIVFFLTSNLGYQVIVEHADDPETMQEALYPVLADFFKPALLARMEVVPYLPLSKETLATIIAGKLARLDNVLRSRFGADVIIGPEVTDEIMSRVTRAENGARMLESVIDGDMLPPLSLLLLQKMAANTAIARIRLSAADGAFTADVEDALPDDAVTPQTEDETVL

Signal peptides

Signal peptides and corresponding cleavage sites are predicted using SignalP 5.0 software.

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).

Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).

Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).

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Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9944	-	-

Protein sequence: 353 a.a.

						>T6CP010975 JN837480:c9130-8072 [Escherichia coli RS218] [TssH]
MLVSPHVDKKQIAAVIAEWTGVPLNRLSQNEMSVITDLPVWLGGTIKGQDLAIASLHKHLLTARADLRRPGRPLGAFLLA
GPSGVGKTETVLQLAELLYGGRQYLTTINMSEFQEKHTVSRLIGSPPGYVGYGEGGVLTEAIRQKPYSVVLLDEVEKAHP
DVLNLFYQAFDKGEMADGEGRLIDCKNIVFFLTSNLGYQVIVEHADDPETMQEALYPVLADFFKPALLARMEVVPYLPLS
KETLATIIAGKLARLDNVLRSRFGADVIIGPEVTDEIMSRVTRAENGARMLESVIDGDMLPPLSLLLLQKMAANTAIARI
RLSAADGAFTADVEDALPDDAVTPQTEDETVL*					

Nucleotide sequence: 1059 bp

						>T6CP010975 JN837480:c9130-8072 [Escherichia coli RS218] [TssH]
TTGCTGGTTTCCCCGCATGTCGATAAAAAACAGATTGCAGCGGTGATTGCTGAATGGACCGGCGTGCCGCTTAACCGCCT
GTCACAGAATGAGATGTCGGTCATCACCGACCTGCCGGTATGGCTCGGCGGCACCATCAAGGGCCAGGACCTGGCGATTG
CCAGCCTGCATAAACACCTGCTGACCGCACGCGCCGACCTGCGCCGTCCGGGACGCCCGCTTGGTGCGTTCCTGCTGGCT
GGCCCCAGCGGCGTGGGTAAAACCGAAACCGTCCTGCAACTGGCGGAACTGCTCTATGGCGGACGTCAATACCTGACCAC
CATCAATATGTCTGAGTTCCAGGAGAAACACACCGTTTCGCGGCTGATTGGCTCTCCTCCGGGTTATGTCGGCTACGGTG
AAGGCGGCGTACTGACCGAAGCGATTCGCCAGAAACCGTACTCGGTGGTGCTGCTCGATGAAGTAGAAAAAGCGCACCCG
GATGTACTCAACCTGTTCTACCAGGCGTTTGACAAGGGCGAGATGGCAGACGGTGAAGGCCGCCTGATTGACTGTAAAAA
TATCGTTTTCTTCCTGACCTCCAACCTTGGCTACCAGGTGATTGTCGAACACGCCGATGACCCGGAAACCATGCAGGAAG
CCCTCTATCCGGTGCTGGCGGACTTCTTTAAACCTGCTCTGCTGGCGCGCATGGAAGTGGTGCCTTACCTACCGCTGTCG
AAAGAGACGCTCGCTACCATTATTGCCGGGAAACTGGCCCGCCTGGATAACGTGCTGCGCAGCCGCTTTGGCGCGGACGT
GATTATTGGGCCGGAAGTGACGGACGAAATCATGAGCCGCGTCACCCGCGCGGAAAACGGCGCGAGGATGCTGGAATCGG
TTATCGACGGCGACATGCTGCCGCCGCTCTCGCTGCTGCTGTTGCAGAAAATGGCGGCCAACACGGCGATTGCCCGGATT
CGCCTGTCGGCGGCAGACGGTGCGTTCACGGCAGATGTGGAAGATGCGCTGCCTGATGATGCCGTGACACCGCAAACAGA
GGACGAAACGGTTTTATGA					