Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00944  |
| T6SS type | Type Unknown |
| Strain | Escherichia coli strain PE086 |
| Replicon (GenBank) | chromosome I (KX118289) |
| Location | 81..3542 |
| Function | anti-bacterial |
| Comment | The Hcp-ET1 is delivered by T6SS2 and t E.coli STEC004 cells deploy Hcp-ET1 to kill recipient cells. |
| References | [1] Jiale Ma, Zihao Pan, Jinhu Huang, Min Sun, Chengping Lu, Huochun Yao et al (2017) The Hcp Proteins Fused With Diverse Extended-Toxin Domains Represent a Novel Pattern of Antibacterial Effectors in Type VI Secretion Systems. Virulence. 8(7):1189-1202. [PudMed:28060574] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | Het1 | Het2 | Het3 | Het4 | Het5 | Het6 |
| Number | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| T6CP016152 | Het1 | Locus_01 (het1) | 81..1430 | + | 1350 | 1062685123 | Hcp protein |
| T6CP016153 | Het2 | Locus_02 (het2) | 1508..1858 | + | 351 | 1062685124 | colicin toxin protein |
| T6CP016154 | Het3 | Locus_03 (het3) | 1861..2145 | + | 285 | 1062685125 | colicin and pyocin immunity protein |
| T6CP016155 | Het4 | Locus_04 (het4) | 2331..2552 | + | 222 | 1062685126 | hypothetical protein |
| T6CP016156 | Het5 | Locus_05 (het5) | 2553..2843 | + | 291 | 1062685127 | colicin and pyocin immunity protein |
| T6CP016157 | Het6 | Locus_06 (het6) | 3252..3542 | + | 291 | 1062685128 | colicin and pyocin immunity protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01522 |
het1 (Hcp-ET3) | Tde | IMU00322 ; IMU00323 ; IMU00324 |
Escherichia coli strain PE086 | chromosome (KX118289) | 81..1430 (+) | 1062685123 |
| EFF01523 |
het2 (Hcp-ET4) | Tde | - | Escherichia coli strain PE086 | chromosome (KX118289) | 1508..1858 (+) | 1062685124 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00322 |
het3 | EFF01522 |
Escherichia coli strain PE086 | chromosome (KX118289) | 1861..2145 (+) | 1062685125 |
| IMU00323 |
het5 | EFF01522 |
Escherichia coli strain PE086 | chromosome (KX118289) | 2553..2843 (+) | 1062685127 |
| IMU00324 |
het6 | EFF01522 |
Escherichia coli strain PE086 | chromosome (KX118289) | 3252..3542 (+) | 1062685128 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|