SecReT6, T6SS database

Detailed information of regulator

Summary

Regulator ID	REG0022
Regulator type	protein
Regulatory pathway (from literatures)	QS regulatory pathway
KEGG pathway (determined by BlastKOALA)	-
Related T6SS	T6SS01168 (Type i1)
Strain	Vibrio cholerae C6706
Replicon	chromosome
Sequence	Protein sequence (203 a.a.); Nucleotide sequence (609 bp)
Description	T6SS-mediated killing are positively regulated by CytR, TfoX, HapR, and QstR.
Reference	[1] Watve SS, Thomas J, Hammer BK. CytR Is a Global Positive Regulator of Competence, Type VI Secretion, and Chitinases in Vibrio cholerae. PLoS One. 2015 Sep 24;10(9):e0138834. doi: 10.1371/journal.pone.0138834. eCollection 2015. PMID: 26401962

External database links

Locus tag (Gene)	GPY04_RS03590 (TfoX)
Coordinates (Strand)	777344..777952 (+)
NCBI ID	487807468
RefSeq	NZ_CP046844
Uniprot ID	Q9KSV3_VIBCH, A0A0X1KVV8_VIBCO, A0A0H3AJZ6_VIBC3, D7H802_VIBCL, A0A0H3PX92_VIBCL, C3LLK0_VIBCM, A0A2K2UTX7_VIBCL
KEGG ID	vcm:VCM66_1109, vch:VC1153, vco:VC0395_A0723
KEGG pathway (determined by BlastKOALA)	-
PDB ID	-

Target

Loading, please wait

Target	Regulation (↓/↑)	Target sequence
Unknown	↓	-

Showing 1 to 1 of 1 rows

Pfam domain hit(s) of regulator

Loading, please wait

Domain	Pfam ID	E-value	Aligned region
TfoX_C	PF04994.15	2.3e-28	119..197
TfoX_N	PF04993.15	4.3e-22	16..106

Showing 1 to 2 of 2 rows

Transmembrane helices

Transmembrane helices are predicted using TMHMM 2.0 software.

Loading, please wait

Prediction	Region	Sequence
Outside	1-202	VIKGSMDMNEQQFFDYVTKFGAYQKRSMFGGIGLFQHDAMYVLVSEDRIFVRGGEELDPELLALGCEKYRHVKKQTTATVNYYDITELYEQHHPELDSIIERSIQFSVNQREFQRSAASRRLRDLPNMQLTLERMVKKAGIDDVETFMSLGAPEVFNKVRQAYGSDVDVKLLWKFAGAIEGIHWKLLQEPRKRQLLESCQQR

Signal peptides

Signal peptides and corresponding cleavage sites are predicted using SignalP 5.0 software.

Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).

Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).

Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).

Loading, please wait

Prediction	Probability	Cleavage site	Signal peptide sequence
Other	0.9949	-	-

Protein sequence of regulator: 203 a.a. .

                                    >REG0022 NZ_CP046844:777344-777952 [Vibrio cholerae C6706]
VIKGSMDMNEQQFFDYVTKFGAYQKRSMFGGIGLFQHDAMYVLVSEDRIFVRGGEELDPELLALGCEKYRHVKKQTTATV
NYYDITELYEQHHPELDSIIERSIQFSVNQREFQRSAASRRLRDLPNMQLTLERMVKKAGIDDVETFMSLGAPEVFNKVR
QAYGSDVDVKLLWKFAGAIEGIHWKLLQEPRKRQLLESCQQR*

                                 

Nucleotide sequence of regulator: 609 bp .

                                    >REG0022 NZ_CP046844:777344-777952 [Vibrio cholerae C6706]
GTGATTAAAGGATCAATGGATATGAATGAGCAACAGTTTTTCGACTACGTAACTAAGTTTGGCGCCTACCAAAAACGCTC
GATGTTTGGTGGTATTGGCTTGTTTCAACACGACGCTATGTATGTGTTGGTCAGTGAAGACCGCATTTTTGTGCGTGGTG
GAGAAGAGCTCGACCCTGAGCTCTTGGCCTTAGGGTGCGAGAAATATCGCCATGTTAAAAAACAGACAACGGCAACCGTA
AACTATTACGACATCACTGAACTGTATGAGCAACATCACCCTGAGCTAGACTCGATTATTGAACGCTCGATTCAGTTTTC
TGTGAATCAGCGGGAATTTCAACGCTCAGCAGCCAGTCGTCGTCTACGGGATTTACCCAATATGCAACTGACTTTGGAGC
GTATGGTAAAAAAAGCGGGCATTGACGATGTGGAAACTTTTATGAGCCTCGGTGCGCCAGAAGTGTTTAATAAGGTGCGT
CAAGCTTATGGAAGTGATGTCGATGTAAAACTACTGTGGAAGTTTGCGGGTGCGATTGAAGGCATTCACTGGAAACTGCT
GCAAGAGCCGCGTAAGCGCCAACTGTTAGAAAGTTGTCAGCAGCGTTAA

                                