Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00208  |
| T6SS type | Type i1 |
| Strain | Vibrio cholerae O395 |
| Replicon (RefSeq) | chromosome I (NC_009456) |
| Location | 12071..35842 |
| Function | - |
| Comment | - |
| References | [1] Bernard CS et al (2011) Regulation of type VI secretion gene clusters by sigma54 and cognate enhancer binding proteins. J Bacteriol. 193(9):2158-67. [PudMed:21378190] |
Bioinformatics investigation has been performed.T6SS components and genome coordinates
| Component | FHA | PAAR | TssA | TssC | TssE | TssF | TssG | TssH | TssI | TssJ | TssL | VasH |
| Number | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| VC0395_RS00040 (rbsB) | 7129..8007 | - | 879 | WP_000737186.1 | ribose ABC transporter substrate-binding protein RbsB | ||
| VC0395_RS00045 (rbsC) | 8068..9036 | - | 969 | WP_001997313.1 | ribose ABC transporter permease | ||
| VC0395_RS00050 (rbsA) | 9066..10568 | - | 1503 | WP_000189455.1 | ribose ABC transporter ATP-binding protein RbsA | ||
| VC0395_RS00055 (rbsD) | 10595..11014 | - | 420 | WP_001911632.1 | D-ribose pyranase | ||
| VC0395_RS00065 | 11298..11558 | + | 261 | WP_000799238.1 | DUF3012 domain-containing protein | ||
| VC0395_RS00070 | 11706..12074 | - | 369 | WP_001061295.1 | hypothetical protein | ||
| T6CP002080 | TssI | VC0395_RS00075 (tssI) | 12071..15124 | - | 3054 | WP_000113294.1 | type VI secretion system tip protein VgrG |
| T6CP009600 | TssA | VC0395_RS00085 | 15377..16639 | - | 1263 | WP_000073077.1 | ImpA family type VI secretion system protein |
| VC0395_RS00090 (tssM) | 16690..20182 | - | 3493 | pseudogene | type VI secretion system membrane subunit TssM | ||
| T6CP009601 | TssA | VC0395_RS00100 (vasJ) | 20243..21652 | - | 1410 | WP_000426093.1 | TssA family type VI secretion system protein VasJ |
| VC0395_RS00105 (tagO) | 21662..22318 | - | 657 | WP_001223389.1 | type VI secretion system-associated protein TagO | ||
| T6CP012481 | VasH | VC0395_RS00110 (vasH) | 22315..23907 | - | 1593 | WP_000084793.1 | sigma-54 dependent T6SS transcriptional regulator VasH |
| T6CP002083 | TssH | VC0395_RS00115 (tssH) | 23910..26519 | - | 2610 | WP_000619136.1 | type VI secretion system ATPase TssH |
| T6CP002084 | TssL | VC0395_RS00120 (icmH) | 26545..27318 | - | 774 | WP_000083409.1 | type IVB secretion system protein IcmH/DotU |
| VC0395_RS00125 (tssK) | 27321..28657 | - | 1337 | pseudogene | type VI secretion system baseplate subunit TssK | ||
| T6CP002087 | TssJ | VC0395_RS00130 (tssJ) | 28664..29140 | - | 477 | WP_001045311.1 | type VI secretion system lipoprotein TssJ |
| T6CP011590 | FHA | VC0395_RS00135 (tagH) | 29143..30630 | - | 1488 | WP_001089706.1 | type VI secretion system-associated FHA domain protein TagH |
| T6CP002088 | TssG | VC0395_RS00140 (tssG) | 30633..31649 | - | 1017 | WP_000510174.1 | type VI secretion system baseplate subunit TssG |
| T6CP002089 | TssF | VC0395_RS00145 (tssF) | 31613..33382 | - | 1770 | WP_000189792.1 | type VI secretion system baseplate subunit TssF |
| T6CP009599 | TssE | VC0395_RS00150 (tssE) | 33388..33813 | - | 426 | WP_000220998.1 | type VI secretion system baseplate subunit TssE |
| T6CP002090 | TssC | VC0395_RS00155 (tssC) | 33816..35291 | - | 1476 | WP_000108140.1 | type VI secretion system contractile sheath large subunit |
| VC0395_RS00160 (tssB) | 35335..35842 | - | 508 | pseudogene | type VI secretion system contractile sheath small subunit | ||
| VC0395_RS00165 | 36274..37194 | - | 921 | WP_001901866.1 | sel1 repeat family protein | ||
| T6CP011591 | PAAR | VC0395_RS00170 | 37262..37546 | - | 285 | WP_000526403.1 | type VI secretion system PAAR protein |
| VC0395_RS00175 | 38318..39997 | + | 1680 | WP_001275247.1 | RluA family pseudouridine synthase |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0180 |
VC0395_RS17530 (TsrA) | protein | Global regulator | Vibrio cholerae O395 | chromosome (NC_009457) | 2598392..2598676 (-) | 445982516 | T6SS Transciption (↑) |
| REG0181 |
VC0395_0020/VCA0117 (bEBP/vasH) | protein | Global regulator | Vibrio cholerae O395 | chromosome (NC_009456) | 22315..23907 (-) | 446006938 | T6SS gene cluster promoter (PVCA0107/VC0395_RS00160) (↓) |
| REG0182 |
VC0395_A2109 (rpoN) | protein | Global regulator | Vibrio cholerae O395 | chromosome (NC_009457) | 2265078..2266541 (+) | 446727517 | T6SS gene cluster promoter (PVCA0107/VC0395_RS00160) (↓); hcp promoter (PVCA0017/VC0395_0116) (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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