Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00076  |
| T6SS type | Type i3 |
| Strain | Burkholderia pseudomallei K96243 |
| Replicon (RefSeq) | chromosome II (NC_006351) |
| Location | 2831227..2856994 |
| Function | - |
| Comment | - |
| References | [1] Burtnick MN et al (2011) The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei. Infect Immun. 79(4):1512-25. [PudMed:21300775] |
Bioinformatics investigation has been performed.T6SS components and genome coordinates
| Component | FHA | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BPS_RS32170 | 2826777..2827034 | + | 258 | WP_004548749.1 | transposase | ||
| BPS_RS30210 | 2827811..2828551 | + | 741 | WP_004524822.1 | hypothetical protein | ||
| BPS_RS30215 | 2828980..2829328 | + | 349 | pseudogene | recombinase family protein | ||
| BPS_RS30220 | 2829283..2829711 | - | 429 | WP_009941143.1 | DUF746 domain-containing protein | ||
| BPS_RS30225 | 2829708..2830541 | - | 834 | WP_045606131.1 | RHS repeat protein | ||
| BPS_RS30230 | 2830501..2831211 | - | 711 | WP_004539259.1 | hypothetical protein | ||
| T6CP000673 | TssI | BPS_RS30235 (tssI) | 2831227..2833431 | - | 2205 | WP_004203275.1 | type VI secretion system tip protein VgrG |
| T6CP000674 | TssH | BPS_RS30240 (tssH) | 2833428..2836094 | - | 2667 | WP_004529320.1 | type VI secretion system ATPase TssH |
| T6CP000675 | TssG | BPS_RS30245 (tssG) | 2836073..2837551 | - | 1479 | WP_004540225.1 | type VI secretion system baseplate subunit TssG |
| T6CP000676 | TssF | BPS_RS30250 (tssF) | 2837548..2839419 | - | 1872 | WP_004524812.1 | type VI secretion system baseplate subunit TssF |
| T6CP000677 | TssE | BPS_RS30255 (tssE) | 2839424..2839972 | - | 549 | WP_009935240.1 | type VI secretion system baseplate subunit TssE |
| T6CP000678 | TssD | BPS_RS30260 | 2839991..2840482 | - | 492 | WP_004190698.1 | type VI secretion system tube protein Hcp |
| T6CP000679 | TssC | BPS_RS30265 (tssC) | 2840542..2842050 | - | 1509 | WP_004190849.1 | type VI secretion system contractile sheath large subunit |
| T6CP000680 | TssB | BPS_RS30270 (tssB) | 2842043..2842621 | - | 579 | WP_004524810.1 | type VI secretion system contractile sheath small subunit |
| T6CP000681 | TssA | BPS_RS30275 (tssA) | 2842684..2843763 | - | 1080 | WP_009982092.1 | type VI secretion system protein TssA |
| BPS_RS30280 | 2843816..2846431 | - | 2616 | WP_011205731.1 | serine/threonine protein kinase | ||
| BPS_RS30285 | 2846430..2846657 | + | 228 | WP_004529325.1 | hypothetical protein | ||
| BPS_RS30290 (tagF) | 2846642..2847598 | - | 957 | WP_162478379.1 | type VI secretion system-associated protein TagF | ||
| T6CP000682 | TssM | BPS_RS30295 (tssM) | 2847580..2851209 | - | 3630 | WP_004524806.1 | type VI secretion system membrane subunit TssM |
| T6CP000683 | TssL | BPS_RS30300 | 2851212..2852528 | - | 1317 | WP_004190689.1 | DotU family type VI secretion system protein |
| T6CP000684 | TssK | BPS_RS30305 (tssK) | 2852544..2853947 | - | 1404 | WP_004530163.1 | type VI secretion system baseplate subunit TssK |
| T6CP000685 | TssJ | BPS_RS30310 (tssJ) | 2853944..2854462 | - | 519 | WP_004190712.1 | type VI secretion system lipoprotein TssJ |
| BPS_RS30315 | 2855102..2855503 | + | 402 | WP_004190377.1 | TssQ family T6SS-associated lipoprotein | ||
| T6CP011468 | FHA | BPS_RS30320 (tagH) | 2855558..2856994 | + | 1437 | WP_004555176.1 | type VI secretion system-associated FHA domain protein TagH |
| BPS_RS30325 | 2857037..2858941 | - | 1905 | WP_009941162.1 | DUF3857 and transglutaminase domain-containing protein | ||
| BPS_RS30330 | 2858960..2859145 | + | 186 | WP_004190842.1 | hypothetical protein | ||
| BPS_RS30335 | 2859411..2860655 | + | 1245 | WP_011205733.1 | flavin-dependent oxidoreductase | ||
| BPS_RS30340 | 2860783..2861028 | + | 246 | WP_076853519.1 | chorismate lyase | ||
| BPS_RS30345 | 2860965..2861282 | + | 318 | WP_009941165.1 | chorismate lyase | ||
| BPS_RS32030 | 2861331..2861507 | + | 177 | WP_004190854.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0132 |
BPSL2246 (PpiB) | protein | Unknown | Burkholderia pseudomallei K96243 | chromosome (NC_006350) | 2708622..2709113 (+) | 53719855 | T6SS-3 (BPSS2099/TssCIII and BPSS2098/HcpIII) expression (↑); T6SS-6 (hcp6) transcript (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|