Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00789  |
| T6SS type | Type i3 |
| Strain | Salmonella enterica GIFU10007 |
| Replicon (GenBank) | chromosome (JF766712) |
| Location | 1..38426 |
| Function | anti-eukaryotic; effector translocation; virulence |
| Comment | The T6SS was found to be associated with cytotoxicity of human epithelial cells, but not with bacterial growth or mobility in vitro; ability to invade and infect epithelial cells. |
| References | [1] Wang M et al (2011) Molecular characterization of a functional type VI secretion system in Salmonella enterica serovar Typhi. Curr Microbiol. 63(1):22-31. [PudMed:21487806] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagJ | TssA | TssB | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL |
| Number | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| Locus_01 | 758..1063 | + | 306 | AEC05379.1 | hypothetical protein | ||
| Locus_02 | 1133..1576 | - | 444 | AEC05378.1 | hypothetical protein | ||
| Locus_03 | 1578..1838 | - | 261 | AEC05377.1 | conserved hypothetical protein | ||
| Locus_04 | 1917..4448 | - | 2532 | AEC05376.1 | Rhs-family protein | ||
| Locus_05 | 4544..4837 | - | 294 | AEC05375.1 | hypothetical protein | ||
| Locus_06 | 4856..5533 | - | 678 | AEC05374.1 | hypothetical protein | ||
| T6CP011348 | PAAR | Locus_07 | 5536..9600 | - | 4065 | AEC05373.1 | Rhs-family protein |
| Locus_08 | 9619..10065 | - | 447 | AEC05372.1 | hypothetical protein | ||
| T6CP010957 | TssI | Locus_09 | 10089..12278 | - | 2190 | AEC05371.1 | Rhs-family protein |
| Locus_10 | 12641..12748 | - | 108 | AEC05370.1 | hypothetical protein | ||
| Locus_11 | 12756..13193 | - | 438 | AEC05369.1 | hypothetical protein | ||
| Locus_12 | 13220..13636 | - | 417 | AEC05368.1 | putative secreted protein | ||
| Locus_13 | 13764..14225 | - | 462 | AEC05367.1 | putative secreted protein | ||
| Locus_14 | 14210..14680 | - | 471 | AEC05366.1 | hypothetical protein | ||
| Locus_15 | 14784..15257 | - | 474 | AEC05365.1 | putative secreted protein | ||
| Locus_16 | 15242..15712 | - | 471 | AEC05364.1 | hypothetical protein | ||
| Locus_17 | 15755..16522 | - | 768 | AEC05363.1 | hypothetical protein | ||
| Locus_18 | 20620..21114 | - | 495 | AEC05362.1 | hypothetical protein | ||
| Locus_19 | 21146..21895 | - | 750 | AEC05361.1 | putative membrane protein | ||
| T6CP010958 | TssL | Locus_20 | 21900..23201 | - | 1302 | AEC05360.1 | putative membrane protein |
| T6CP010959 | TssK | Locus_21 | 23198..24541 | - | 1344 | AEC05359.1 | conserved hypothetical protein |
| T6CP010960 | TssJ | Locus_22 | 24545..25081 | - | 537 | AEC05358.1 | putative lipoprotein |
| T6CP010961 | TssD | Locus_23 | 25148..25633 | - | 486 | AEC05357.1 | Hcp-like protein |
| Locus_24 | 25870..26295 | - | 426 | AEC05356.1 | hypothetical protein | ||
| Locus_25 | 26267..26668 | - | 402 | AEC05355.1 | hypothetical protein | ||
| T6CP010962 | TssB | Locus_26 | 28253..28795 | - | 543 | AEC05354.1 | conserved hypothetical protein |
| Locus_27 | 28859..29149 | - | 291 | AEC05353.1 | hypothetical protein | ||
| Locus_28 | 29152..29250 | - | 99 | AEC05352.1 | hypothetical protein | ||
| T6CP010963 | TssH | Locus_29 | 29235..31898 | - | 2664 | AEC05351.1 | ClpB-like protein |
| Locus_30 | 32186..32257 | + | 72 | AEC05350.1 | hypothetical protein | ||
| Locus_31 | 32266..33168 | + | 903 | AEC05349.1 | hypothetical protein | ||
| T6CP012877 | TagJ | Locus_32 | 33155..33979 | + | 825 | AEC05348.1 | hypothetical protein |
| T6CP010964 | TssE | Locus_33 | 33976..34470 | + | 495 | AEC05347.1 | conserved hypothetical protein |
| T6CP010965 | TssF | Locus_34 | 34486..36369 | + | 1884 | AEC05346.1 | hypothetical protein |
| T6CP010966 | TssG | Locus_35 | 36366..37361 | + | 996 | AEC05345.1 | hypothetical protein |
| T6CP010967 | TssA | Locus_36 | 37372..37794 | + | 423 | AEC05344.1 | hypothetical protein |
| T6CP010968 | TssA | Locus_37 | 37794..38426 | + | 633 | AEC05343.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|