Detailed information of T6SS

Note: only experimentally validated proteins are displayed in the graph.


Summary

T6SS ID T6SS00948 experimental
T6SS type Type i1
Strain Aeromonas hydrophila NJ-35
Replicon (GenBank) chromosome (CP006870)
Location 2935924..2976020
Function -
Comment T6SS can secrete hcp and contributes to antiphagocytic activity against T.thermophila as well as the antibacterial property.
References
[1] Wang N et al (2015) Protective efficacy of recombinant hemolysin co-regulated protein (Hcp) of Aeromonas hydrophila in common carp (Cyprinus carpio). Fish Shellfish Immunol. 46(2):297-304. [PudMed:26093203]
[2] Nannan Wang, Jin Liu, Maoda Pang, Yafeng Wu, Furqan Awan, Mark R Liles, Chengping Lu, Yongjie Liu et al (2018) Diverse Roles of Hcp Family Proteins in the Environmental Fitness and Pathogenicity of Aeromonas Hydrophila Chinese Epidemic Strain NJ-35. Appl Microbiol Biotechnol. 102(16):7083-7095. [PudMed:29862449]
experimental Experimental investigation has been performed.

T6SS components and genome coordinates

ComponentTssATssBTssCTssDTssETssFTssGTssHTssITssJTssKTssLTssM
Number2111111221111


Component ID Component Locus tag (Gene) Coordinate Strand Size (bp) NCBI ID Product
U876_13425 2931295..2932245 + 951 827372781 thioredoxin reductase
U876_13430 2932303..2933550 + 1248 827372782 diguanylate cyclase
U876_13435 2933661..2934131 - 471 827372783 membrane protein
U876_13440 2934151..2934858 + 708 827372784 leucyl/phenylalanyl-tRNA--protein transferase
U876_13445 2934855..2935571 + 717 827372785 arginyl-tRNA-protein transferase
U876_13450 2935641..2935859 + 219 827372786 translation initiation factor IF-1
T6CP012961 TssH U876_13455 (clpA) 2935924..2938176 - 2253 827372787 Clp protease ClpX
U876_13460 (clpS) 2938236..2938553 - 318 827372788 Clp protease ClpS
U876_13465 2938782..2939000 + 219 827372789 stationary phase/starvation inducible regulatory protein CspD
U876_13470 2939107..2939970 - 864 827372790 methenyltetrahydrofolate cyclohydrolase
U876_13490 2940694..2940843 + 150 827372791 transposase
U876_13495 2942069..2944681 - 2613 827372792 hypothetical protein
T6CP012962 TssI U876_13500 2944800..2946848 - 2049 827372793 type IV secretion protein Rhs
U876_13505 2946859..2947146 - 288 827372794 hypothetical protein
T6CP012963 TssA U876_13510 2947404..2948834 - 1431 827372795 membrane protein
T6CP012964 TssM U876_13515 2948881..2952366 - 3486 827372796 type VI secretion protein IcmF
T6CP012965 TssA U876_13520 2952408..2953853 - 1446 827372797 type VI secretion protein
U876_13525 2953862..2954467 - 606 827372798 type VI secretion protein
U876_13530 2954467..2956005 - 1539 827372799 ATPase AAA
T6CP012966 TssH U876_13535 2956008..2958650 - 2643 827372800 Clp protease ClpV
T6CP012967 TssL U876_13540 2958671..2959450 - 780 827372801 type IV secretion protein DotU
T6CP012968 TssK U876_13545 2959473..2960807 - 1335 827372802 hypothetical protein
T6CP012969 TssJ U876_13550 2960810..2961325 - 516 827372803 hypothetical protein
U876_13555 2961325..2962575 - 1251 827372804 type VI secretion protein
T6CP012970 TssG U876_13560 2962632..2963630 - 999 827372805 type VI secretion protein
T6CP012971 TssF U876_13565 2963594..2965360 - 1767 827372806 type VI secretion protein
T6CP012972 TssE U876_13570 2965364..2965795 - 432 827372807 lysozyme
T6CP012973 TssC U876_13575 2965802..2967280 - 1479 827372808 type VI secretion protein
T6CP012974 TssB U876_13580 2967319..2967822 - 504 827372809 type VI secretion protein
U876_13590 2970004..2970549 - 546 827372810 hypothetical protein
U876_13595 2970673..2971662 - 990 827372811 hypothetical protein
U876_13600 2971672..2972991 - 1320 827372812 hypothetical protein
T6CP012975 TssI U876_13605 2972993..2975224 - 2232 827372813 type IV secretion protein Rhs
T6CP012976 TssD U876_13610 2975502..2976020 - 519 827372814 hypothetical protein
U876_13625 2977178..2977639 - 462 827372815 histidine kinase
U876_13630 2977792..2979129 + 1338 827372816 hypothetical protein
U876_13635 2979198..2979779 - 582 827372817 thymidine kinase
flank Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files

    

Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Regulator ID Locus tag (Gene) Regulator type Regulatory pathway Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Target (Regulation)

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Effector ID Locus tag (Gene) Classification Cognate immunity protein Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID
EFF01871 experimental U876_17730 (Tle1AH) Tle IMU00373 experimental; IMU00374 experimental Aeromonas hydrophila NJ-35 chromosome (CP006870) 3864039..3865991 (-) 827373601
EFF01528 experimental U876_17750 (hcp1) - - Aeromonas hydrophila NJ-35 chromosome (CP006870) 3869323..3869841 (-) 827373605
EFF01529 experimental U876_17565 (Hcp2) - - Aeromonas hydrophila NJ-35 chromosome (CP006870) 3836933..3837451 (-) 827373572

experimental Experimental investigation has been performed.
insolico Bioinformatics investigation has been performed.
Immunity protein ID Locus tag (Gene) Cognate effector Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID
IMU00373 experimental U876_17725 (tli1AH) EFF01871 experimental Aeromonas hydrophila NJ-35 chromosome (CP006870) 3863341..3864039 (-) 827373600
IMU00374 experimental U876_17720 (tli2AH) EFF01871 experimental Aeromonas hydrophila NJ-35 chromosome (CP006870) 3862649..3863341 (-) 827373599

experimental Experimental investigation has been performed.
Accessory protein ID Locus tag (Gene) Type             Organism                 Replicon (Accession) Coordinates (Strand) NCBI ID Related structure protein Related effector