Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00948  |
| T6SS type | Type i1 |
| Strain | Aeromonas hydrophila NJ-35 |
| Replicon (GenBank) | chromosome (CP006870) |
| Location | 2935924..2976020 |
| Function | - |
| Comment | T6SS can secrete hcp and contributes to antiphagocytic activity against T.thermophila as well as the antibacterial property. |
| References | [1] Wang N et al (2015) Protective efficacy of recombinant hemolysin co-regulated protein (Hcp) of Aeromonas hydrophila in common carp (Cyprinus carpio). Fish Shellfish Immunol. 46(2):297-304. [PudMed:26093203] [2] Nannan Wang, Jin Liu, Maoda Pang, Yafeng Wu, Furqan Awan, Mark R Liles, Chengping Lu, Yongjie Liu et al (2018) Diverse Roles of Hcp Family Proteins in the Environmental Fitness and Pathogenicity of Aeromonas Hydrophila Chinese Epidemic Strain NJ-35. Appl Microbiol Biotechnol. 102(16):7083-7095. [PudMed:29862449] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| U876_13425 | 2931295..2932245 | + | 951 | 827372781 | thioredoxin reductase | ||
| U876_13430 | 2932303..2933550 | + | 1248 | 827372782 | diguanylate cyclase | ||
| U876_13435 | 2933661..2934131 | - | 471 | 827372783 | membrane protein | ||
| U876_13440 | 2934151..2934858 | + | 708 | 827372784 | leucyl/phenylalanyl-tRNA--protein transferase | ||
| U876_13445 | 2934855..2935571 | + | 717 | 827372785 | arginyl-tRNA-protein transferase | ||
| U876_13450 | 2935641..2935859 | + | 219 | 827372786 | translation initiation factor IF-1 | ||
| T6CP012961 | TssH | U876_13455 (clpA) | 2935924..2938176 | - | 2253 | 827372787 | Clp protease ClpX |
| U876_13460 (clpS) | 2938236..2938553 | - | 318 | 827372788 | Clp protease ClpS | ||
| U876_13465 | 2938782..2939000 | + | 219 | 827372789 | stationary phase/starvation inducible regulatory protein CspD | ||
| U876_13470 | 2939107..2939970 | - | 864 | 827372790 | methenyltetrahydrofolate cyclohydrolase | ||
| U876_13490 | 2940694..2940843 | + | 150 | 827372791 | transposase | ||
| U876_13495 | 2942069..2944681 | - | 2613 | 827372792 | hypothetical protein | ||
| T6CP012962 | TssI | U876_13500 | 2944800..2946848 | - | 2049 | 827372793 | type IV secretion protein Rhs |
| U876_13505 | 2946859..2947146 | - | 288 | 827372794 | hypothetical protein | ||
| T6CP012963 | TssA | U876_13510 | 2947404..2948834 | - | 1431 | 827372795 | membrane protein |
| T6CP012964 | TssM | U876_13515 | 2948881..2952366 | - | 3486 | 827372796 | type VI secretion protein IcmF |
| T6CP012965 | TssA | U876_13520 | 2952408..2953853 | - | 1446 | 827372797 | type VI secretion protein |
| U876_13525 | 2953862..2954467 | - | 606 | 827372798 | type VI secretion protein | ||
| U876_13530 | 2954467..2956005 | - | 1539 | 827372799 | ATPase AAA | ||
| T6CP012966 | TssH | U876_13535 | 2956008..2958650 | - | 2643 | 827372800 | Clp protease ClpV |
| T6CP012967 | TssL | U876_13540 | 2958671..2959450 | - | 780 | 827372801 | type IV secretion protein DotU |
| T6CP012968 | TssK | U876_13545 | 2959473..2960807 | - | 1335 | 827372802 | hypothetical protein |
| T6CP012969 | TssJ | U876_13550 | 2960810..2961325 | - | 516 | 827372803 | hypothetical protein |
| U876_13555 | 2961325..2962575 | - | 1251 | 827372804 | type VI secretion protein | ||
| T6CP012970 | TssG | U876_13560 | 2962632..2963630 | - | 999 | 827372805 | type VI secretion protein |
| T6CP012971 | TssF | U876_13565 | 2963594..2965360 | - | 1767 | 827372806 | type VI secretion protein |
| T6CP012972 | TssE | U876_13570 | 2965364..2965795 | - | 432 | 827372807 | lysozyme |
| T6CP012973 | TssC | U876_13575 | 2965802..2967280 | - | 1479 | 827372808 | type VI secretion protein |
| T6CP012974 | TssB | U876_13580 | 2967319..2967822 | - | 504 | 827372809 | type VI secretion protein |
| U876_13590 | 2970004..2970549 | - | 546 | 827372810 | hypothetical protein | ||
| U876_13595 | 2970673..2971662 | - | 990 | 827372811 | hypothetical protein | ||
| U876_13600 | 2971672..2972991 | - | 1320 | 827372812 | hypothetical protein | ||
| T6CP012975 | TssI | U876_13605 | 2972993..2975224 | - | 2232 | 827372813 | type IV secretion protein Rhs |
| T6CP012976 | TssD | U876_13610 | 2975502..2976020 | - | 519 | 827372814 | hypothetical protein |
| U876_13625 | 2977178..2977639 | - | 462 | 827372815 | histidine kinase | ||
| U876_13630 | 2977792..2979129 | + | 1338 | 827372816 | hypothetical protein | ||
| U876_13635 | 2979198..2979779 | - | 582 | 827372817 | thymidine kinase |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01871 |
U876_17730 (Tle1AH) | Tle | IMU00373 ; IMU00374 |
Aeromonas hydrophila NJ-35 | chromosome (CP006870) | 3864039..3865991 (-) | 827373601 |
| EFF01528 |
U876_17750 (hcp1) | - | - | Aeromonas hydrophila NJ-35 | chromosome (CP006870) | 3869323..3869841 (-) | 827373605 |
| EFF01529 |
U876_17565 (Hcp2) | - | - | Aeromonas hydrophila NJ-35 | chromosome (CP006870) | 3836933..3837451 (-) | 827373572 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00373 |
U876_17725 (tli1AH) | EFF01871 |
Aeromonas hydrophila NJ-35 | chromosome (CP006870) | 3863341..3864039 (-) | 827373600 |
| IMU00374 |
U876_17720 (tli2AH) | EFF01871 |
Aeromonas hydrophila NJ-35 | chromosome (CP006870) | 3862649..3863341 (-) | 827373599 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|