Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS17509  |
| T6SS type | Type i2 |
| Strain | Burkholderia glumae BGR1 |
| Replicon (RefSeq) | chromosome II (NC_012721) |
| Location | 1382281..1422638 |
| Function | anti-eukaryotic |
| Comment | We found that both T6SS group_4 and group_5, belonging to the eukaryotic targeting system, act independently as bacterial virulence factors toward host plants. |
| References | [1] Kim N, Kim JJ, Kim I, Mannaa M, Park J, Kim J, Lee HH, Lee SB, Park DS, Sul WJ, Seo YS. et al (2020) Type VI secretion systems of plant-pathogenic Burkholderia glumae BGR1 play a functionally distinct role in interspecies interactions and virulence.. Mol Plant Pathol. 21(8):1055-1069. [PudMed:32643866] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| BGLU_RS23145 | 1377399..1378217 | + | 819 | WP_017432528.1 | FkbM family methyltransferase | ||
| BGLU_RS23150 | 1378589..1380013 | + | 1425 | WP_012733866.1 | hypothetical protein | ||
| BGLU_RS23155 | 1380562..1381587 | + | 1026 | WP_012733867.1 | aldo/keto reductase | ||
| BGLU_RS34785 | 1381599..1382159 | - | 561 | WP_127913903.1 | hypothetical protein | ||
| T6CP259617 | TssI | BGLU_RS23160 | 1382281..1385334 | + | 3054 | WP_012733868.1 | type VI secretion system tip protein VgrG |
| BGLU_RS23165 | 1385338..1385889 | + | 552 | WP_017424560.1 | hypothetical protein | ||
| BGLU_RS23170 | 1385927..1387738 | + | 1812 | WP_012733869.1 | TIGR02594 family protein | ||
| BGLU_RS23175 | 1387725..1388255 | + | 531 | WP_012733870.1 | hypothetical protein | ||
| BGLU_RS23180 | 1388418..1388756 | + | 339 | WP_012733871.1 | hypothetical protein | ||
| BGLU_RS23185 | 1388807..1389592 | - | 786 | WP_012733872.1 | aldolase | ||
| BGLU_RS23190 | 1389700..1390335 | - | 636 | WP_012733873.1 | HAD hydrolase-like protein | ||
| BGLU_RS23195 | 1390728..1391885 | - | 1158 | WP_012733874.1 | zinc-binding dehydrogenase | ||
| BGLU_RS23200 | 1392441..1393193 | + | 753 | WP_035977622.1 | hypothetical protein | ||
| T6CP259618 | TssJ | BGLU_RS23205 (tssJ) | 1393584..1394141 | - | 558 | WP_012733875.1 | type VI secretion system lipoprotein TssJ |
| T6CP259619 | TssG | BGLU_RS23210 (tssG) | 1394290..1395411 | - | 1122 | WP_012733876.1 | type VI secretion system baseplate subunit TssG |
| T6CP259620 | TssF | BGLU_RS23215 (tssF) | 1395408..1397222 | - | 1815 | WP_012733877.1 | type VI secretion system baseplate subunit TssF |
| T6CP259621 | TssA | BGLU_RS23220 (tssA) | 1397235..1398821 | - | 1587 | WP_012733878.1 | type VI secretion system protein TssA |
| T6CP259622 | TssM | BGLU_RS23225 | 1398818..1402342 | - | 3525 | WP_012733879.1 | type VI secretion protein VasK |
| BGLU_RS23230 | 1402339..1403394 | - | 1056 | WP_050811447.1 | hypothetical protein | ||
| BGLU_RS23235 | 1403442..1404646 | - | 1205 | WP_085962364.1 | IS3-like element ISBugl1 family transposase | ||
| T6CP259623 | PAAR | BGLU_RS32925 | 1404933..1405184 | - | 252 | WP_012733880.1 | PAAR domain-containing protein |
| BGLU_RS32930 | 1405236..1405982 | - | 747 | WP_012733881.1 | hypothetical protein | ||
| BGLU_RS23245 | 1405979..1408828 | - | 2850 | WP_012733882.1 | hypothetical protein | ||
| BGLU_RS32935 | 1408880..1409833 | - | 954 | WP_012733883.1 | DUF4123 domain-containing protein | ||
| T6CP259624 | TssI | BGLU_RS23255 (vgrG) | 1409841..1412201 | - | 2361 | WP_012733884.1 | type VI secretion system tip protein VgrG |
| T6CP259625 | TssC | BGLU_RS23260 (tssC) | 1412299..1413831 | - | 1533 | WP_012733885.1 | type VI secretion system contractile sheath large subunit |
| T6CP259626 | TssB | BGLU_RS23265 (tssB) | 1413874..1414386 | - | 513 | WP_012733886.1 | type VI secretion system contractile sheath small subunit |
| T6CP259627 | TssK | BGLU_RS23270 (tssK) | 1414882..1416234 | + | 1353 | WP_012733887.1 | type VI secretion system baseplate subunit TssK |
| T6CP259628 | TssL | BGLU_RS23275 | 1416231..1416962 | + | 732 | WP_012733888.1 | DotU family type IV/VI secretion system protein |
| T6CP259629 | TssL | BGLU_RS23280 | 1416959..1418767 | + | 1809 | WP_012733889.1 | OmpA family protein |
| T6CP259630 | TssD | BGLU_RS23285 | 1418865..1419350 | + | 486 | WP_012733890.1 | Hcp family type VI secretion system effector |
| T6CP259631 | TssH | BGLU_RS23290 (tssH) | 1419488..1422196 | + | 2709 | WP_012733891.1 | type VI secretion system ATPase TssH |
| T6CP259632 | TssE | BGLU_RS23295 (tssE) | 1422210..1422638 | + | 429 | WP_012733892.1 | type VI secretion system baseplate subunit TssE |
| BGLU_RS23300 | 1422882..1423388 | + | 507 | WP_012733893.1 | hypothetical protein | ||
| BGLU_RS23305 | 1423466..1424815 | - | 1350 | WP_012733894.1 | DUF2252 family protein | ||
| BGLU_RS34790 | 1424845..1425330 | + | 486 | WP_127913901.1 | hypothetical protein | ||
| BGLU_RS23310 | 1425483..1427606 | + | 2124 | WP_012733895.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF00429 |
BGLU_RS23285 | - | - | Burkholderia glumae BGR1 | chromosome (NC_012721) | 1418865..1419350 (+) | WP_012733890.1 |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|