Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00466  |
| T6SS type | Type ii |
| Strain | Francisella tularensis subsp. holarctica LVS |
| Replicon (RefSeq) | chromosome (NC_007880) |
| Location | 102157..124300 |
| Function | anti-eukaryotic; effector translocation; virulence |
| Comment | Growth, phagosomal escape and cytopathogenicity in cultured macrophages; virulence in mouse model. IglE of F. novicida is required for T6SS in vitro. |
| References | [1] Nano FE et al (2007) The Francisella pathogenicity island. Ann N Y Acad Sci. 1105:122-37. [PudMed:17395722] [2] Broms JE et al (2012) Unique Substrates Secreted by the Type VI Secretion System of Francisella tularensis during Intramacrophage Infection. PLoS One. 7(11):e50473. [PudMed:23185631] [3] Lindgren M et al (2013) Importance of PdpC, IglC, IglI, and IglG for modulation of a host cell death pathway induced by Francisella tularensis LVS. Infect Immun. 81(6):2076-84. [PudMed:23529623] [4] Broms JE et al (2011) IglG and IglI of the Francisella pathogenicity island are important virulence determinants of Francisella tularensis LVS. Infect Immun. 79(9):3683-96. [PudMed:21690239] [5] Lindgren M et al (2013) The Francisella tularensis LVS DeltapdpC mutant exhibits a unique phenotype during intracellular infection. BMC Microbiol. 13(1):20. [PudMed:23356941] [6] de Bruin OM et al (2011) The biochemical properties of the Francisella pathogenicity island (FPI)-encoded proteins IglA, IglB, IglC, PdpB and DotU suggest roles in type VI secretion. Microbiology. 157(Pt 12):3483-91. [PudMed:21980115] [7] Broms JE et al (2012) DotU and VgrG, core components of type VI secretion systems, are essential for Francisella LVS pathogenicity. PLoS One. 7(4):e34639. [PudMed:22514651] [8] Br |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | IglC | IglD | IglE | IglF | IglG | IglH | IglI | IglJ | PdpA | PdpB | PdpC | PdpD | PdpE | TssB | TssC | TssI | TssL |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
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Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| FTL_RS00505 | 98287..98684 | - | 398 | pseudogene | DUF3568 domain-containing protein | ||
| FTL_RS00510 | 98687..99097 | - | 411 | WP_003014086.1 | DUF3568 domain-containing protein | ||
| FTL_RS00515 | 99118..99510 | - | 393 | WP_003014087.1 | DUF3568 domain-containing protein | ||
| FTL_RS00520 | 99799..100251 | + | 453 | pseudogene | nicotinamide mononucleotide transporter | ||
| FTL_RS10125 | 100311..101191 | + | 881 | WP_011457326.1 | IS630 family transposase | ||
| FTL_RS00535 | 101192..102064 | - | 873 | WP_011457343.1 | MFS transporter | ||
| FTL_RS10795 | 102049..102771 | + | 723 | pseudogene | Pathogenicity determinant protein D | ||
| T6CP004815 | TssB | FTL_RS00550 (tssB) | 102852..103406 | + | 555 | WP_003016161.1 | type VI secretion system contractile sheath small subunit |
| T6CP004816 | TssC | FTL_RS00555 (tssC) | 103420..104940 | + | 1521 | WP_010031646.1 | type VI secretion system contractile sheath large subunit |
| T6CP004817 | IglC | FTL_RS00560 | 104957..105586 | + | 630 | WP_003016165.1 | hypothetical protein |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
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Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF00563 | FTT_1347 (VgrG) | - | - | Francisella tularensis subsp. holarctica LVS | chromosome (NC_007880) | 117678..118172 (-) | 89255560 |
| EFF00562 | FTL_0118 (IglI) | - | - | Francisella tularensis subsp. holarctica LVS | chromosome (NC_007880) | 112168..113319 (-) | 89255555 |
Showing 1 to 2 of 2 rows
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| No matching records found | ||||||
Experimental investigation has been performed.
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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||