Detailed information of regulator


Summary

Regulator ID REG0121 experimental
Regulator type protein
Regulatory pathway (from literatures) QS regulatory pathway
KEGG pathway (determined by BlastKOALA) Metabolic pathways (map01100); Cysteine and methionine metabolism (map00270); Quorum sensing (map02024)
Related T6SS T6SS00049 insolico (Type i4b)
Strain Chromobacterium violaceum ATCC 12472
Replicon chromosome
Sequence Protein sequence (218 a.a.); Nucleotide sequence (654 bp)
Description CviR binding to the cviI promoter is required for high-level production of autoinducer at high cell density, suggesting that, as in other canonical LuxIR-type quorum-sensing systems, a positive-feedback loop operates.
Reference
External database links

Locus tag (Gene) CV_RS23145 (CviI)
Coordinates (Strand) 4426967..4427620 (-)
NCBI ID 499450174
RefSeq NC_005085
Uniprot ID UPI00001BE021
KEGG ID -
KEGG pathway (determined by BlastKOALA) map01100; map00270; map02024
PDB ID -
  Target
Target Regulation (↓/↑) Target sequence
CV_RS20220 (CviR) ↓ 1169634970
Pfam domain hit(s) of regulator

Domain Pfam ID E-value Aligned region
Autoind_synth PF00765.19 6.4e-22 19..188
Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

Prediction                 Region     Sequence
Outside 1-217 MKDFFPLQQGGLVLEWVNTETKLRQLWAFRHRIFREQLQWVPLCEDGFDRDAYDDFSDNLVLCRDGEVVGAIRLTTGEHPFMLEEEFSRLLAPGERIGKGAEYSEITRLAVDREALGARESIMAARLLYLGAWLWSQVQGVRWMYFVVEPVFYRRLVMMGFPIVPVGIPRPLDGGVMSMTGLLDWRQAKTELIRSLTRGVSSPSACQALWHEYDYSH


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
Prediction        Probability Cleavage site Signal peptide sequence
Other 0.9952 - -


  Protein sequence of regulator: 218 a.a.    .

>REG0121 NC_005085:c4427620-4426967 [Chromobacterium violaceum ATCC 12472]
MKDFFPLQQGGLVLEWVNTETKLRQLWAFRHRIFREQLQWVPLCEDGFDRDAYDDFSDNLVLCRDGEVVGAIRLTTGEHP
FMLEEEFSRLLAPGERIGKGAEYSEITRLAVDREALGARESIMAARLLYLGAWLWSQVQGVRWMYFVVEPVFYRRLVMMG
FPIVPVGIPRPLDGGVMSMTGLLDWRQAKTELIRSLTRGVSSPSACQALWHEYDYSH*

  Nucleotide sequence of regulator: 654 bp    .

>REG0121 NC_005085:c4427620-4426967 [Chromobacterium violaceum ATCC 12472]
ATGAAAGATTTTTTTCCGCTGCAACAAGGTGGACTGGTACTGGAGTGGGTCAATACTGAAACTAAGCTGCGACAGTTGTG
GGCGTTCCGTCACAGAATCTTCCGGGAACAGCTGCAGTGGGTGCCCTTATGCGAGGACGGTTTCGATCGGGACGCATACG
ATGATTTTTCCGACAACTTGGTATTGTGCCGGGATGGCGAGGTCGTCGGCGCGATACGGTTGACTACCGGAGAGCATCCT
TTCATGTTGGAGGAAGAGTTCTCGCGCTTGCTGGCGCCGGGCGAGCGGATAGGCAAGGGGGCGGAATATTCGGAAATCAC
CCGACTGGCCGTGGACAGGGAAGCGCTGGGCGCGCGCGAGTCCATCATGGCGGCCAGATTGCTCTATCTGGGCGCGTGGC
TGTGGTCCCAGGTTCAGGGCGTGCGCTGGATGTATTTCGTCGTGGAGCCGGTGTTTTACCGGCGCCTGGTGATGATGGGC
TTCCCCATCGTGCCGGTAGGCATACCCCGCCCACTGGATGGCGGGGTGATGTCGATGACGGGCTTGCTGGACTGGAGGCA
GGCGAAAACCGAGCTTATCCGTTCACTAACTCGCGGGGTGTCATCGCCAAGTGCATGCCAAGCACTATGGCATGAGTACG
ATTATTCGCATTGA