Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS01224  |
| T6SS type | Type i1 |
| Strain | Vibrio alginolyticus 12G01 |
| Replicon (RefSeq) | chromosome (NZ_CH902589) |
| Location | 100481..131233 |
| Function | anti-bacterial |
| Comment | V.alginolyticus can use its T6SS for interbacterial competition by showing that it is able to kill E. coli in a T6SS-dependent manner and VaT6SS1 is more active under low salt conditions (on LB plates), whereas VaT6SS2 is more active under high salt conditions (on MLB plates). Both T6SSs are active at 30ΔC, but only VaT6SS2 is also active at 37ΔC |
| References | [1] Salomon D et al (2014) Marker for type VI secretion system effectors. Proc Natl Acad Sci U S A. 111(25):9271-6. [PudMed:24927539] [2] Salomon D et al (2015) Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria. PLoS Pathog. 11(8):e1005128. [PudMed:26305100] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | PAAR | TagE | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| V12G01_RS25400 | 96412..96822 | - | 411 | 491515708 | hypothetical protein | ||
| V12G01_RS23855 | 97026..97355 | - | 330 | 686142712 | hypothetical protein | ||
| V12G01_RS25405 | 97561..98319 | - | 759 | 491515712 | hypothetical protein | ||
| V12G01_RS25410 | 98312..100468 | - | 2157 | 491515716 | hypothetical protein | ||
| T6CP015485 | PAAR | V12G01_RS25415 | 100481..101938 | - | 1458 | 491515718 | DUF4150 domain-containing protein |
| T6CP015486 | TssL | V12G01_RS25420 (icmH) | 102086..102877 | - | 792 | 491515721 | type IVB secretion system protein IcmH/DotU |
| T6CP015487 | TssK | V12G01_RS25425 (tssK) | 102874..104199 | - | 1326 | 491515724 | type VI secretion system baseplate subunit TssK |
| T6CP015488 | TssJ | V12G01_RS47885 (tssJ) | 104211..104711 | - | 501 | 491528493 | type VI secretion system lipoprotein TssJ |
| V12G01_RS23860 | 104721..106196 | - | 1476 | pseudogene | FHA domain-containing protein | ||
| V12G01_RS25430 | 106206..106805 | - | 600 | 491515728 | hypothetical protein | ||
| T6CP015490 | TssA | V12G01_RS25435 | 107309..108622 | + | 1314 | 491515730 | type VI secretion system ImpA family N-terminal domain-containing protein |
| T6CP015491 | TssM | V12G01_RS25440 (tssM) | 108650..112039 | + | 3390 | 491515732 | type VI secretion system membrane subunit TssM |
| V12G01_RS25445 | 112071..112523 | + | 453 | 491515736 | Lrp/AsnC family transcriptional regulator | ||
| T6CP015492 | TssG | V12G01_RS25450 (tssG) | 112578..113576 | - | 999 | 491515740 | type VI secretion system baseplate subunit TssG |
| T6CP015493 | TssF | V12G01_RS25455 (tssF) | 113573..115321 | - | 1749 | 491515741 | type VI secretion system baseplate subunit TssF |
| T6CP015494 | TssE | V12G01_RS25460 (tssE) | 115332..115742 | - | 411 | 491515743 | type VI secretion system baseplate subunit TssE |
| T6CP015495 | TssC | V12G01_RS25465 (tssC) | 115804..117279 | - | 1476 | 491515745 | type VI secretion system contractile sheath large subunit |
| T6CP015496 | TssB | V12G01_RS25470 (tssB) | 117288..117794 | - | 507 | 491515748 | type VI secretion system contractile sheath small subunit |
| T6CP015497 | TssA | V12G01_RS25475 (tssA) | 117821..119395 | - | 1575 | 491515750 | type VI secretion system protein TssA |
| T6CP015498 | TagE | V12G01_RS25480 | 119382..121382 | - | 2001 | 491515752 | protein kinase |
| V12G01_RS25485 | 121620..122564 | - | 945 | 491515755 | hypothetical protein | ||
| V12G01_RS25490 | 122557..123549 | - | 993 | 491515765 | DUF2169 domain-containing protein | ||
| V12G01_RS25495 | 123530..124849 | - | 1320 | 491515774 | hypothetical protein | ||
| V12G01_RS25500 | 124944..125426 | - | 483 | 491515776 | hypothetical protein | ||
| T6CP015499 | TssI | V12G01_RS25505 (tssI) | 125429..127507 | - | 2079 | 491515779 | type VI secretion system tip protein VgrG |
| T6CP015500 | TssD | V12G01_RS25510 | 127580..128098 | - | 519 | 491515782 | Hcp family type VI secretion system effector |
| T6CP015501 | TssH | V12G01_RS25515 (tssH) | 128555..131233 | + | 2679 | 686142714 | type VI secretion system ATPase TssH |
| V12G01_RS25520 | 131220..132851 | + | 1632 | 491515785 | sigma-54-dependent Fis family transcriptional regulator |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00341 |
V12G01_01430 | - | Vibrio alginolyticus 12G01 | chromosome (NZ_CH902589) | 97561..98319 (-) | 91190359 |
| IMU00359 |
V12G01_RS26200 | EFF01441 |
Vibrio alginolyticus 12G01 | chromosome (NZ_CH902589) | 308691..309341 (-) | 91190980 |
Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|