Detailed information of regulator


Summary

Regulator ID REG0082 experimental
Regulator type protein
Regulatory pathway (from literatures) c-di-GMP regulatory pathway
KEGG pathway (determined by BlastKOALA) -
Related T6SS T6SS00016 experimental (Type i5)
Strain Agrobacterium fabrum str. C58
Replicon chromosome
Sequence Protein sequence (416 a.a.); Nucleotide sequence (1248 bp)
Description High levels of c-di-GMP are capable of down-regulating the T8SS, as seen by monitoring Hcp, ClpV and TssB production.
Reference
External database links

Locus tag (Gene) Atu1257 (DgcA)
Coordinates (Strand) 1244567..1245814 (-)
NCBI ID 159184686
RefSeq NC_003062
Uniprot ID Q7CZM8_AGRFC
KEGG ID atu:Atu1257
KEGG pathway (determined by BlastKOALA) -
PDB ID -
  Target
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Target
Regulation (↓/↑)
Target sequence
the levels of c-di-GMP↑-
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Pfam domain hit(s) of regulator

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Domain
Pfam ID
E-value
Aligned region
GGDEFPF00990.231.6e-38216..373
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Transmembrane helices

  • Transmembrane helices are predicted using TMHMM 2.0 software.

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Prediction                
Region    
Sequence
Outside1-9MLDAKTSTL
Transmembrane helix10-27LWAAETFTLAVLLGTLWL
Inside28-33HRPSRR
Transmembrane helix34-56HNLYFAAGFLATGFGTVMVALRG
Outside57-60DISS
Transmembrane helix61-83FLSIQVGNTLALSAFGFWLAGLL
Inside84-89SLEQRK
Transmembrane helix90-108LGGWIAIPALLWIAGMFVP
Outside109-117SVPEDMVAR
Transmembrane helix118-137ILLYHASAATGYFMLAGVLL
Inside138-149GSRARASRSRKV
Transmembrane helix150-169LATILILQAFAGAIVASIVI
Outside170-178PANAAVPNA
Transmembrane helix179-201IPMTSALSISGMLGFTAIIMISA
Inside202-415KIIMEDTEIRLHRLAMTDHLTGVLNRRGLLEEFEHIKKRSHGSDRYVALVLFDIDHFKKINDRYGHQSGDAVLVHFCNIAQRVIGERGLFVRMGGEEFALVAEVESPSSTVTLAEAIRSNLRLSKITARNEAIKVTTSVGISEAMIKDADLSVMMTEADRALYAAKKAGRNRTVIHVNSANVVVPAPDRDENPMDNNADRQVAALNRISAIASR


Signal peptides
  • Sec/SPI: "standard" secretory signal peptides transported by the Sec translocon and cleaved by Signal Peptidase I (Lep).
  • Sec/SPII: lipoprotein signal peptides transported by the Sec translocon and cleaved by Signal Peptidase II (Lsp).
  • Tat/SPI: Tat signal peptides transported by the Tat translocon and cleaved by Signal Peptidase I (Lep).
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Prediction       
Probability
Cleavage site
Signal peptide sequence
Other0.9953--


  Protein sequence of regulator: 416 a.a.    .

>REG0082 NC_003062:c1245814-1244567 [Agrobacterium fabrum str. C58]
MLDAKTSTLLWAAETFTLAVLLGTLWLHRPSRRHNLYFAAGFLATGFGTVMVALRGDISSFLSIQVGNTLALSAFGFWLA
GLLSLEQRKLGGWIAIPALLWIAGMFVPSVPEDMVARILLYHASAATGYFMLAGVLLGSRARASRSRKVLATILILQAFA
GAIVASIVIPANAAVPNAIPMTSALSISGMLGFTAIIMISAKIIMEDTEIRLHRLAMTDHLTGVLNRRGLLEEFEHIKKR
SHGSDRYVALVLFDIDHFKKINDRYGHQSGDAVLVHFCNIAQRVIGERGLFVRMGGEEFALVAEVESPSSTVTLAEAIRS
NLRLSKITARNEAIKVTTSVGISEAMIKDADLSVMMTEADRALYAAKKAGRNRTVIHVNSANVVVPAPDRDENPMDNNAD
RQVAALNRISAIASR*

  Nucleotide sequence of regulator: 1248 bp    .

>REG0082 NC_003062:c1245814-1244567 [Agrobacterium fabrum str. C58]
ATGCTGGATGCAAAGACGAGCACGCTACTGTGGGCGGCGGAGACGTTCACCCTTGCCGTGCTTTTGGGAACGCTGTGGCT
GCACCGCCCTTCGCGCCGGCATAATCTCTATTTCGCCGCCGGTTTCCTCGCCACAGGCTTCGGTACCGTCATGGTGGCGC
TTCGCGGGGATATTTCGAGTTTTCTGTCCATTCAGGTCGGCAATACGCTTGCACTTTCCGCCTTCGGTTTCTGGCTCGCG
GGCCTGCTATCTCTGGAGCAGCGCAAACTCGGCGGCTGGATCGCCATTCCGGCGCTATTGTGGATCGCCGGAATGTTCGT
GCCATCAGTGCCTGAAGACATGGTCGCTCGCATCCTCCTTTATCATGCCAGCGCGGCCACGGGATATTTCATGCTCGCCG
GCGTGCTTCTGGGCAGCAGGGCACGTGCTTCACGCAGCCGAAAGGTGCTGGCCACGATCCTGATCCTGCAGGCCTTTGCC
GGAGCGATCGTCGCCTCCATCGTCATCCCGGCCAATGCCGCGGTTCCCAACGCCATCCCCATGACATCGGCGCTCTCCAT
TTCCGGCATGCTCGGCTTTACGGCCATCATCATGATCAGCGCCAAGATCATCATGGAAGACACGGAGATCCGCCTCCACC
GGCTCGCCATGACCGATCACCTGACCGGTGTCCTCAACCGGCGCGGTCTGCTGGAGGAATTCGAACACATCAAGAAGCGC
TCGCACGGCTCCGACCGCTACGTGGCGCTGGTTCTCTTCGACATCGATCATTTCAAGAAGATCAATGACAGATACGGACA
TCAGTCTGGCGATGCCGTGCTTGTGCATTTCTGCAATATCGCACAACGCGTGATCGGCGAGCGCGGCCTTTTCGTCCGGA
TGGGCGGCGAGGAATTTGCGCTGGTGGCCGAAGTCGAGAGCCCGTCCAGCACCGTGACACTCGCGGAGGCCATCCGTAGC
AATCTGCGCCTCTCGAAGATCACCGCACGCAACGAAGCCATCAAGGTGACGACCAGCGTCGGCATATCCGAAGCAATGAT
CAAGGATGCCGACCTGAGCGTGATGATGACCGAGGCCGACCGCGCACTTTATGCCGCCAAGAAAGCGGGGCGCAACCGGA
CCGTCATCCATGTGAATTCGGCCAATGTCGTCGTGCCCGCCCCGGACCGGGACGAAAACCCGATGGACAACAATGCCGAC
CGGCAGGTCGCGGCACTGAACCGTATATCCGCCATCGCCAGCCGGTGA