Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00395  |
| T6SS type | Type i3 |
| Strain | Enterobacter cloacae subsp. cloacae ATCC 13047 |
| Replicon (RefSeq) | chromosome (NC_014121) |
| Location | 1551980..1588894 |
| Function | anti-bacterial; anti-eukaryotic; effector translocation |
| Comment | T6SS-1 is required for bacterial competition. Killing of E. coli by E. cloacae and Hcp1 protein secretion are dependent on a functional T6SS-1. Hcp1 protein secretion, which is T6SS-1 dependent, confers hemolytic activity to E. cloacae. |
| References | [1] Zhang H et al (2013) Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein. J Biol Chem. 288(8):5928-39. [PudMed:23288853] [2] Whitney JC et al (2014) Genetically distinct pathways guide effector export through the type VI secretion system. Mol Microbiol. 92(3):529-42. [PudMed:24589350] [3] Zhang H et al (2013) Insights into the Cross-Immunity Mechanism within Effector Families of Bacteria Type VI Secretion System from the Structure of StTae4-EcTai4 Complex. PLoS One. 8(9):e73782. [PudMed:24023903] [4] Russell AB et al (2012) A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach. Cell Host Microbe. 11(5):538-49. [PudMed:22607806] [5] Soria-Bustos J, Ares MA, G��mez-Aldapa CA, Gonz��lez-Y-Merchand JA, Gir��n JA, De la Cruz MA. et al (2020) Two Type VI Secretion Systems of Enterobacter cloacae Are Required for Bacterial Competition, Cell Adherence, and Intestinal Colonization.. Front Microbiol. 11:560488. [PudMed:33072020] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | TagJ | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
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Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| ECL_RS07500 | 1547554..1548345 | + | 792 | WP_044158197.1 | PhnD/SsuA/transferrin family substrate-binding protein | ||
| ECL_RS07505 | 1548311..1550599 | - | 2289 | WP_013096172.1 | FdhF/YdeP family oxidoreductase | ||
| ECL_RS07510 | 1551462..1551956 | + | 495 | WP_013096174.1 | hypothetical protein | ||
| T6CP004055 | TssJ | ECL_RS07515 (tssJ) | 1551980..1552483 | + | 504 | WP_013096175.1 | type VI secretion system lipoprotein TssJ |
| T6CP004056 | TssK | ECL_RS07520 (tssK) | 1552509..1553852 | + | 1344 | WP_013096176.1 | type VI secretion system baseplate subunit TssK |
| T6CP004057 | TssL | ECL_RS07525 | 1553870..1555108 | + | 1239 | WP_013096177.1 | DotU family type VI secretion system protein |
| T6CP004058 | TssM | ECL_RS07530 (tssM) | 1555111..1558731 | + | 3621 | WP_013096178.1 | type VI secretion system membrane subunit TssM |
| ECL_RS07535 (tagF) | 1558748..1559464 | + | 717 | WP_013096179.1 | type VI secretion system-associated protein TagF | ||
| T6CP004059 | TssA | ECL_RS07540 (tssA) | 1559476..1560492 | + | 1017 | WP_013096180.1 | type VI secretion system protein TssA |
| T6CP004060 | TssB | ECL_RS07545 (tssB) | 1560568..1561092 | + | 525 | WP_008502644.1 | type VI secretion system contractile sheath small subunit |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.
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Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|---|
| EFF01418 | ECL_01542 (Tae4) | Tae | IMU00269 | Enterobacter cloacae subsp. cloacae ATCC 13047 | chromosome (NC_014121) | 1563472..1563963 (+) | 502861206 |
| EFF01872 | ECL_01553 (Tle) | Tle | IMU00375 | Enterobacter cloacae subsp. cloacae ATCC 13047 | chromosome (NC_014121) | 1576408..1577826 (+) | 502861217 |
| EFF01254 | ECL_01567 (RhsA) | Tse | IMU00055 | Enterobacter cloacae subsp. cloacae ATCC 13047 | chromosome (NC_014121) | 1591543..1595931 (+) | 296101929 |
| EFF01255 | ECL_03140 (RhsB) | Tse | IMU00056 | Enterobacter cloacae subsp. cloacae ATCC 13047 | chromosome (NC_014121) | 3200343..3204599 (-) | 296103479 |
| EFF00505 | ECL_01541 (hcp) | - | - | Enterobacter cloacae subsp. cloacae ATCC 13047 | chromosome (NC_014121) | 1562931..1563413 (+) | 495778061 |
Showing 1 to 5 of 5 rows
Experimental investigation has been performed. Bioinformatics investigation has been performed.
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Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|---|---|---|---|---|---|
| IMU00055 | ECL_01568 (RhsIA) | EFF01254 | Enterobacter cloacae subsp. cloacae ATCC 13047 | chromosome (NC_014121) | 1595931..1596929 (+) | 296101930 |
| IMU00056 | ECL_03139 (RhsIB) | EFF01255 | Enterobacter cloacae subsp. cloacae ATCC 13047 | chromosome (NC_014121) | 3199746..3200309 (-) | 296103478 |
| IMU00269 | ECL_01543 (Tai4) | EFF01418 | Enterobacter cloacae subsp. cloacae ATCC 13047 | chromosome (NC_014121) | 1563960..1564313 (+) | 296101905 |
| IMU00375 | ECL_01554 (Tli) | EFF01872 | Enterobacter cloacae subsp. cloacae ATCC 13047 | chromosome (NC_014121) | 1577823..1578584 (+) | 296101916 |
Showing 1 to 4 of 4 rows
Experimental investigation has been performed.
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Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||