Detailed information of T6SS
Note: only experimentally validated proteins are displayed in the graph.
Summary
| T6SS ID | T6SS00937  |
| T6SS type | Type i1 |
| Strain | Escherichia coli DE719 |
| Replicon (GenBank) | chromosome (KM251715) |
| Location | 1..24039 |
| Function | anti-eukaryotic |
| Comment | DotU contributes to intracellular survival in macrophages; DotU and T6SS-2 affect bacterial colonization and survival during infection in vivo. |
| References | [1] Wang S et al (2014) DotU expression is highly induced during in vivo infection and responsible for virulence and Hcp1 secretion in avian pathogenic Escherichia coli. Front Microbiol. 0.616666667. [PudMed:25426107] |
Experimental investigation has been performed.T6SS components and genome coordinates
| Component | FHA | TssA | TssB | TssC | TssD | TssE | TssF | TssG | TssH | TssI | TssJ | TssK | TssL | TssM |
| Number | 2 | 3 | 1 | 2 | 2 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 2 |
| Component ID | Component | Locus tag (Gene) | Coordinate | Strand | Size (bp) | NCBI ID | Product |
|---|---|---|---|---|---|---|---|
| T6CP012925 | TssD | Locus_01 (evfA) | 501..980 | - | 480 | 700289654 | EvfA |
| T6CP012926 | TssA | Locus_02 (evfB) | 998..2356 | - | 1359 | 700289655 | EvfB |
| T6CP012927 | TssM | Locus_03 (evfC) | 2367..5384 | - | 3018 | 700289656 | EvfC |
| T6CP012928 | TssM | Locus_04 (evfD) | 5416..5895 | - | 480 | 700289657 | EvfD |
| T6CP012929 | TssA | Locus_05 (evfF) | 5915..7357 | - | 1443 | 700289659 | EvfF |
| Locus_06 (evfE) | 5915..6346 | - | 432 | 700289658 | EvfE | ||
| Locus_07 (evfG) | 7362..8009 | - | 648 | 700289660 | EvfG | ||
| T6CP012931 | TssH | Locus_08 (evfH) | 8102..9160 | - | 1059 | 700289661 | EvfH |
| T6CP012932 | TssH | Locus_09 (evfI) | 9115..9744 | - | 630 | 700289662 | EvfI |
| T6CP012933 | TssH | Locus_10 (evfJ) | 9716..10864 | - | 1149 | 700289663 | EvfJ |
| T6CP012934 | TssL | Locus_11 (evfK) | 10874..11638 | - | 765 | 700289664 | EvfFK |
| T6CP012935 | TssK | Locus_12 (evfL) | 11643..12989 | - | 1347 | 700289665 | EvfL |
| T6CP012936 | TssJ | Locus_13 (evfM) | 12992..13516 | - | 525 | 700289666 | EvfM |
| T6CP012945 | FHA | Locus_14 (evfN) | 13513..14121 | - | 609 | 700289667 | EvfN |
| T6CP012946 | FHA | Locus_15 (evfO) | 14021..14794 | - | 774 | 700289668 | EvfO |
| T6CP012937 | TssG | Locus_16 (evfP) | 14811..15860 | - | 1050 | 700289669 | EvfP |
| T6CP012938 | TssF | Locus_17 (evfQ) | 15824..17665 | - | 1842 | 700289670 | EvfQ |
| T6CP012939 | TssE | Locus_18 (evfR) | 17671..18096 | - | 426 | 700289671 | EvfR |
| T6CP012940 | TssC | Locus_19 (evfS) | 18101..19156 | - | 1056 | 700289672 | EvfS |
| T6CP012941 | TssC | Locus_20 (evfT) | 19119..19586 | - | 468 | 700289673 | EvfT |
| T6CP012942 | TssB | Locus_21 (evfU) | 19609..20112 | - | 504 | 700289674 | EvfU |
| T6CP012943 | TssD | Locus_22 (evfV) | 20818..21336 | + | 519 | 700289675 | EvfV |
| T6CP012944 | TssI | Locus_23 (evfW) | 21557..23539 | + | 1983 | 700289676 | EvfW |
Genes in the 5-Kb flanking regions if available, or non-core components encoded by the T6SS gene cluster if any.
Download FASTA format files
Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negatively regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed.| Regulator ID | Locus tag (Gene) | Regulator type | Regulatory pathway | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Target (Regulation) |
|---|---|---|---|---|---|---|---|---|
| REG0273 |
W817_21870 (CpxR) | protein | TCS-RR | Escherichia coli RS218 | chromosome (NZ_CP007149) | 4360812..4361510 (-) | 446956464 | hcp2B promoter (↓) |
| REG0274 |
W817_01610 (NplE) | protein | TCS regulatory pathway | Escherichia coli RS218 | chromosome (NZ_CP007149) | 214947..215657 (+) | 446161331 | W817_RS21690 (CpxA) (↓) |
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Effector ID | Locus tag (Gene) | Classification | Cognate immunity protein | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
|---|
Experimental investigation has been performed. Bioinformatics investigation has been performed.| Immunity protein ID | Locus tag (Gene) | Cognate effector | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID |
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Experimental investigation has been performed.| Accessory protein ID | Locus tag (Gene) | Type | Organism | Replicon (Accession) | Coordinates (Strand) | NCBI ID | Related structure protein | Related effector |
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