Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) relBE/RHH-RelE
Location 328018..328558 Replicon chromosome II
Accession NC_002506
Organism Vibrio cholerae O1 biovar El Tor str. N16961

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag VC_RS14895 Protein ID WP_000277238.1
Coordinates 328018..328287 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag VC_RS14900 Protein ID WP_001258569.1
Coordinates 328280..328558 (-) Length 93 a.a.

Genomic Context

VC_RS14840VC_RS14845VC_RS14850VC_RS14860VC_RS14865VC_RS14880VC_RS14885VC_RS14890VC_RS14905VC_RS14910VC_RS14915VC_RS14920VC_RS14925VC_RS14930VC_RS14935VC_RS14940VC_RS18625VC_RS18630VC_RS14950VC_RS14835VC_RS14870VC_RS14875VC_RS14895VC_RS14900
Location: 323508..323894 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 323951..324064 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 324013..324294 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 324552..325088 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 325225..325740 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 327049..327174 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 327190..327228 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 327424..327870 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 328844..329122 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 329374..329580 (207 bp)
Type: Others
Protein ID: Protein_292
Location: 329780..329881 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 329871..330257 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 330452..330703 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 330676..330825 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 330917..331159 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 331411..331689 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 332064..332207 (144 bp)
Type: Others
Protein ID: Protein_299
Location: 332261..332299 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 332511..332978 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 323022..323264 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 325890..326387 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 326384..326656 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 328018..328287 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 328280..328558 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VC_RS14835 (VC_A0312)323022..323264-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VC_RS14840 (VC_A0313)323508..323894+387WP_001015867.1NUDIX hydrolase-
VC_RS14845323951..324064+114WP_001900214.1hypothetical protein-
VC_RS14850 (VC_A0314)324013..324294+282WP_001894429.1DUF1289 domain-containing protein-
VC_RS14860 (VC_A0316)324552..325088+537WP_000469482.1GNAT family N-acetyltransferase-
VC_RS14865 (VC_A0317)325225..325740+516WP_001201509.1lipocalin family protein-
VC_RS14870 (VC_A0318)325890..326387-498WP_000982260.1GNAT family N-acetyltransferase-
VC_RS14875 (VC_A0319)326384..326656-273WP_000246253.1DUF1778 domain-containing protein-
VC_RS14880327049..327174+126WP_001900195.1DUF645 family protein-
VC_RS14885327190..327228+39WP_106019118.1hypothetical protein-
VC_RS14890 (VC_A0322)327424..327870+447WP_000006157.1hypothetical protein-
VC_RS14895 (VC_A0323)328018..328287-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
VC_RS14900 (VC_A0324)328280..328558-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
VC_RS14905 (VC_A0325)328844..329122+279WP_001921601.1DUF3709 domain-containing protein-
VC_RS14910 (VC_A0327)329374..329580+207Protein_292DUF3709 domain-containing protein-
VC_RS14915329780..329881+102WP_001921603.1hypothetical protein-
VC_RS14920 (VC_A0328)329871..330257+387WP_000703163.1VOC family protein-
VC_RS14925 (VC_A0329)330452..330703+252WP_001890111.1TIGR03643 family protein-
VC_RS14930330676..330825+150WP_071908333.1DUF3265 domain-containing protein-
VC_RS14935 (VCA0329a)330917..331159+243WP_000107461.1hypothetical protein-
VC_RS14940 (VCA0329b)331411..331689+279WP_000280324.1DUF3709 domain-containing protein-
VC_RS18625332064..332207+144Protein_299DUF645 family protein-
VC_RS18630332261..332299+39WP_082798268.1hypothetical protein-
VC_RS14950 (VC_A0330)332511..332978+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegroncatB9-309750..435387125637


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T166 WP_000277238.1 NC_002506:c328287-328018 [Vibrio cholerae O1 biovar El Tor str. N16961]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T166 NC_002506:c328287-328018 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT166 WP_001258569.1 NC_002506:c328558-328280 [Vibrio cholerae O1 biovar El Tor str. N16961]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT166 NC_002506:c328558-328280 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T10095Clostridium difficile R20291

47.778

100

0.483

T6286Campylobacter jejuni subsp. jejuni IA3902

47.778

100

0.483

T28Helicobacter pylori 26695

44.944

100

0.455

T6127Helicobacter pylori 26695

41.758

100

0.427

T10181Aggregatibacter actinomycetemcomitans D11S 1

44.578

94.318

0.42

T6256Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222

41.111

100

0.416

T10088Helicobacter pylori P12

39.13

100

0.404

T10070Tetragenococcus halophilus NBRC 12172

38.636

98.876

0.382

T665Streptococcus mutans UA159

35.165

100

0.36

T10111Lacticaseibacillus paracasei strain 4366 DinJ and YafQ genes

31.633

100

0.348
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Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT10136Pseudomonas savastanoi

35

86.957

0.304
Showing 1 to 1 of 1 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References

(1) Naeem Iqbal et al. (2015) Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron. Journal of Bacteriology 197(13):2150-9. [PubMed:25897030] experimental


experimental experimental literature