58399

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 404838..405397 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ85_RS16295 Protein ID WP_000578476.1
Coordinates 404838..405116 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ85_RS16300 Protein ID WP_000381183.1
Coordinates 405113..405397 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ85_RS16250 399916..400422 + 507 WP_000393074.1 hypothetical protein -
ASZ85_RS16255 400579..400965 + 387 WP_000703163.1 VOC family protein -
ASZ85_RS16260 401222..401425 + 204 WP_001911580.1 hypothetical protein -
ASZ85_RS16265 401620..401871 + 252 WP_001890111.1 TIGR03643 family protein -
ASZ85_RS16270 401844..401993 + 150 WP_071908333.1 DUF3265 domain-containing protein -
ASZ85_RS16275 402140..402565 + 426 WP_000415750.1 hypothetical protein -
ASZ85_RS16280 402771..403394 + 624 WP_000247070.1 DUF1349 domain-containing protein -
ASZ85_RS16285 403607..404086 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
ASZ85_RS16290 404274..404687 + 414 WP_000049420.1 VOC family protein -
ASZ85_RS16295 404838..405116 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ASZ85_RS16300 405113..405397 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ85_RS16310 405592..406107 + 516 WP_001201520.1 lipocalin family protein -
ASZ85_RS16315 406172..406768 + 597 WP_000255434.1 hypothetical protein -
ASZ85_RS16330 407160..407342 + 183 WP_000923182.1 DUF645 family protein -
ASZ85_RS16335 407542..408015 + 474 WP_001161076.1 GrpB family protein -
ASZ85_RS16340 408030..408122 + 93 WP_014378730.1 DUF3265 domain-containing protein -
ASZ85_RS16345 408164..408790 + 627 WP_000365424.1 LysE family translocator -
ASZ85_RS16350 408913..409611 + 699 WP_001890502.1 hypothetical protein -
ASZ85_RS16355 409621..409731 + 111 WP_079857360.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 338285..496833 158548
inside Integron - - 343365..496457 153092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58399 WP_000578476.1 NZ_CP013318:c405116-404838 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58399 NZ_CP013318:c405116-404838 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58399 WP_000381183.1 NZ_CP013318:c405397-405113 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58399 NZ_CP013318:c405397-405113 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References