Detailed information of TA system
Experimentally validatedOverview
TA module
Type | II | Classification (family/domain) | relBE/PHD-RelE |
Location | 387652..388301 | Replicon | chromosome II |
Accession | NC_002506 | ||
Organism | Vibrio cholerae O1 biovar El Tor str. N16961 |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | VC_RS15415 | Protein ID | Protein_396 |
Coordinates | 387942..388193 (+) | Length | 84 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | D0IIK3 |
Locus tag | VC_RS15410 | Protein ID | WP_000086649.1 |
Coordinates | 387664..387945 (+) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
VC_RS15375 (VC_A0415) | 382786..383145 | + | 360 | WP_001071514.1 | VOC family protein | - |
VC_RS15380 (VC_A0416) | 383328..383651 | + | 324 | WP_001889156.1 | DUF3709 domain-containing protein | - |
VC_RS15385 (VC_A0417) | 383932..384468 | + | 537 | WP_000469482.1 | GNAT family N-acetyltransferase | - |
VC_RS15390 (VC_A0418) | 385229..385411 | + | 183 | WP_000947517.1 | DUF645 family protein | - |
VC_RS15395 (VC_A0419) | 385530..386315 | + | 786 | WP_001176447.1 | hypothetical protein | - |
VC_RS15400 (VC_A0420) | 386417..386779 | + | 363 | WP_170831679.1 | DUF4144 domain-containing protein | - |
VC_RS15405 (VC_A0421) | 387025..387450 | + | 426 | WP_000735184.1 | hypothetical protein | - |
VC_RS15410 (VC_A0422) | 387664..387945 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
VC_RS15415 (VC_A0423) | 387942..388193 | + | 252 | Protein_396 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
VC_RS15420 (VC_A0424) | 388406..388729 | + | 324 | WP_001999495.1 | DUF3709 domain-containing protein | - |
VC_RS15425 (VC_A0425) | 389015..389410 | + | 396 | WP_000870868.1 | DUF3465 domain-containing protein | - |
VC_RS15435 (VC_A0426) | 389600..389821 | + | 222 | WP_043987927.1 | DUF1289 domain-containing protein | - |
VC_RS15445 (VC_A0428) | 390185..390610 | + | 426 | WP_000415748.1 | hypothetical protein | - |
VC_RS15450 | 390936..391169 | + | 234 | WP_001999499.1 | DUF3709 domain-containing protein | - |
VC_RS15455 (VC_A0431) | 391358..391753 | + | 396 | WP_001889207.1 | DUF4144 domain-containing protein | - |
VC_RS15460 (VC_A0432) | 391972..392361 | + | 390 | WP_000491261.1 | VOC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Integron | catB9 | - | 309750..435387 | 125637 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9702.31 Da Isoelectric Point: 6.2167
>T172 Protein_396 NC_002506:387942-388193 [Vibrio cholerae O1 biovar El Tor str. N16961]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTLR
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTLR
Download Length: 252 bp
>T172 NC_002506:387942-388193 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACATTACGT
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACATTACGT
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT172 WP_000086649.1 NC_002506:387664-387945 [Vibrio cholerae O1 biovar El Tor str. N16961]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT172 NC_002506:387664-387945 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|---|---|---|---|
T178 | Vibrio cholerae O1 biovar El Tor str. N16961 |
42.683 |
97.619 |
0.417 |
Multiple sequence alignment
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|---|---|---|---|
AT10077 | Agrobacterium tumefaciens str. C58 |
41.538 |
77.381 |
0.321 |
AT6285 | Streptomyces cattleya NRRL 8057 = DSM 46488 |
31.395 |
96.629 |
0.303 |
Multiple sequence alignment
References
(1) Naeem Iqbal et al. (2015) Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron. Journal of Bacteriology 197(13):2150-9. [PubMed:25897030]
experimental literature