Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 320866..321444 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag CSW01_RS15585 Protein ID WP_001180243.1
Coordinates 320866..321183 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag CSW01_RS15590 Protein ID WP_000557292.1
Coordinates 321202..321444 (-) Length 81 a.a.

Genomic Context

CSW01_RS15535CSW01_RS15545CSW01_RS15560CSW01_RS15565CSW01_RS15570CSW01_RS15575CSW01_RS15595CSW01_RS15600CSW01_RS15605CSW01_RS15620CSW01_RS15625CSW01_RS15650CSW01_RS19800CSW01_RS15660CSW01_RS15585CSW01_RS15590CSW01_RS15635CSW01_RS15640
Location: 316390..316572 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 316926..317108 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 317303..317980 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 318142..319350 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 319512..320216 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 320374..320712 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 321688..322074 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 322131..322244 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 322193..322474 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 322732..323268 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 323405..323920 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 325229..325354 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 325370..325408 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 325604..326050 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 320866..321183 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 321202..321444 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 324070..324567 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 324564..324836 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSW01_RS15535316390..316572+183WP_000923340.1DUF645 family protein-
CSW01_RS15545316926..317108+183WP_000923153.1DUF645 family protein-
CSW01_RS15560317303..317980+678WP_000254617.1HNH endonuclease-
CSW01_RS15565318142..319350+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
CSW01_RS15570319512..320216+705WP_000087610.1HNH endonuclease-
CSW01_RS15575320374..320712+339WP_000713853.1hypothetical protein-
CSW01_RS15585320866..321183-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CSW01_RS15590321202..321444-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
CSW01_RS15595321688..322074+387WP_001015867.1NUDIX hydrolase-
CSW01_RS15600322131..322244+114WP_001900214.1hypothetical protein-
CSW01_RS15605322193..322474+282WP_001894429.1DUF1289 domain-containing protein-
CSW01_RS15620322732..323268+537WP_000469482.1GNAT family N-acetyltransferase-
CSW01_RS15625323405..323920+516WP_001201509.1lipocalin family protein-
CSW01_RS15635324070..324567-498WP_000982260.1GNAT family N-acetyltransferase-
CSW01_RS15640324564..324836-273WP_000246253.1DUF1778 domain-containing protein-
CSW01_RS15650325229..325354+126WP_001900195.1DUF645 family protein-
CSW01_RS19800325370..325408+39WP_106019118.1hypothetical protein-
CSW01_RS15660325604..326050+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304226..433944129718
insideIntegron--309306..433568124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T87016 WP_001180243.1 NZ_CP024163:c321183-320866 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T87016 NZ_CP024163:c321183-320866 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT87016 WP_000557292.1 NZ_CP024163:c321444-321202 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT87016 NZ_CP024163:c321444-321202 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References