87016

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 320866..321444 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag CSW01_RS15585 Protein ID WP_001180243.1
Coordinates 320866..321183 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag CSW01_RS15590 Protein ID WP_000557292.1
Coordinates 321202..321444 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSW01_RS15535 316390..316572 + 183 WP_000923340.1 DUF645 family protein -
CSW01_RS15545 316926..317108 + 183 WP_000923153.1 DUF645 family protein -
CSW01_RS15560 317303..317980 + 678 WP_000254617.1 HNH endonuclease -
CSW01_RS15565 318142..319350 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
CSW01_RS15570 319512..320216 + 705 WP_000087610.1 HNH endonuclease -
CSW01_RS15575 320374..320712 + 339 WP_000713853.1 hypothetical protein -
CSW01_RS15585 320866..321183 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSW01_RS15590 321202..321444 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSW01_RS15595 321688..322074 + 387 WP_001015867.1 NUDIX hydrolase -
CSW01_RS15600 322131..322244 + 114 WP_001900214.1 hypothetical protein -
CSW01_RS15605 322193..322474 + 282 WP_001894429.1 DUF1289 domain-containing protein -
CSW01_RS15620 322732..323268 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
CSW01_RS15625 323405..323920 + 516 WP_001201509.1 lipocalin family protein -
CSW01_RS15635 324070..324567 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
CSW01_RS15640 324564..324836 - 273 WP_000246253.1 DUF1778 domain-containing protein -
CSW01_RS15650 325229..325354 + 126 WP_001900195.1 DUF645 family protein -
CSW01_RS19800 325370..325408 + 39 WP_106019118.1 hypothetical protein -
CSW01_RS15660 325604..326050 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304226..433944 129718
inside Integron - - 309306..433568 124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T87016 WP_001180243.1 NZ_CP024163:c321183-320866 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T87016 NZ_CP024163:c321183-320866 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT87016 WP_000557292.1 NZ_CP024163:c321444-321202 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT87016 NZ_CP024163:c321444-321202 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References