Detailed information of TA system
Experimentally validatedOverview
TA module
Type | II | Classification (family/domain) | parDE/- |
Location | 349629..350376 | Replicon | chromosome II |
Accession | NC_002506 | ||
Organism | Vibrio cholerae O1 biovar El Tor str. N16961 |
Toxin (Protein)
Gene name | parE | Uniprot ID | Q9KMJ0 |
Locus tag | VC_RS15105 | Protein ID | WP_000802136.1 |
Coordinates | 349629..349928 (-) | Length | 100 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P58093 |
Locus tag | VC_RS15110 | Protein ID | WP_001107719.1 |
Coordinates | 349925..350167 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
VC_RS15065 (VC_A0353) | 345564..345746 | + | 183 | WP_000923182.1 | DUF645 family protein | - |
VC_RS15070 (VC_A0354) | 345946..346419 | + | 474 | WP_001161076.1 | GrpB family protein | - |
VC_RS15075 | 346434..346526 | + | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
VC_RS15080 (VC_A0355) | 346568..347194 | + | 627 | WP_000365424.1 | LysE family translocator | - |
VC_RS15085 (VC_A0356) | 347317..348015 | + | 699 | WP_001890502.1 | hypothetical protein | - |
VC_RS15090 | 348025..348135 | + | 111 | WP_079857360.1 | DUF3265 domain-containing protein | - |
VC_RS15095 (VC_A0357) | 348713..348892 | + | 180 | WP_001883058.1 | DUF645 family protein | - |
VC_RS15100 (VC_A0358) | 349106..349501 | + | 396 | WP_000870857.1 | DUF3465 domain-containing protein | - |
VC_RS15105 (VC_A0359) | 349629..349928 | - | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
VC_RS15110 | 349925..350167 | - | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
VC_RS15115 (VC_A0361) | 350396..350974 | + | 579 | WP_000110120.1 | hypothetical protein | - |
VC_RS15120 | 350996..351088 | + | 93 | WP_014164112.1 | DUF3265 domain-containing protein | - |
VC_RS15125 (VC_A0363) | 351512..352195 | + | 684 | WP_000877436.1 | hypothetical protein | - |
VC_RS15130 (VC_A0364) | 352409..352675 | + | 267 | WP_000937852.1 | hypothetical protein | - |
VC_RS15135 (VC_A0365) | 352830..353428 | + | 599 | Protein_338 | hypothetical protein | - |
VC_RS15140 (VC_A0366) | 353709..354644 | + | 936 | WP_000051985.1 | restriction endonuclease | - |
VC_RS15145 | 354610..354750 | + | 141 | WP_001883049.1 | DUF3265 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Integron | catB9 | - | 309750..435387 | 125637 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T169 WP_000802136.1 NC_002506:c349928-349629 [Vibrio cholerae O1 biovar El Tor str. N16961]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T169 NC_002506:c349928-349629 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT169 WP_001107719.1 NC_002506:c350167-349925 [Vibrio cholerae O1 biovar El Tor str. N16961]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT169 NC_002506:c350167-349925 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|---|---|---|---|
T105 | Mycobacterium tuberculosis H37Rv |
46.154 |
92.857 |
0.429 |
T228 | Caulobacter crescentus CB15 |
38.776 |
100 |
0.396 |
T10079 | Pseudoalteromonas rubra strain SCSIO 6842 |
36.145 |
84.694 |
0.306 |
Multiple sequence alignment
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|---|---|---|---|
AT228 | Caulobacter crescentus CB15 |
63.014 |
91.25 |
0.575 |
AT105 | Mycobacterium tuberculosis H37Rv |
54.795 |
91.25 |
0.5 |
AT10079 | Pseudoalteromonas rubra strain SCSIO 6842 |
40.244 |
100 |
0.413 |
Multiple sequence alignment
References
(1) Naeem Iqbal et al. (2015) Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron. Journal of Bacteriology 197(13):2150-9. [PubMed:25897030]
experimental literature