199013

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 399461..400020 Replicon chromosome
Accession NZ_CP072850
Organism Vibrio cholerae MO10

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag KAF59_RS15945 Protein ID WP_000578476.1
Coordinates 399461..399739 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag KAF59_RS15950 Protein ID WP_000381183.1
Coordinates 399736..400020 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAF59_RS15900 (KAF59_15900) 394761..395198 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
KAF59_RS15905 (KAF59_15905) 395259..395480 + 222 Protein_431 GNAT family N-acetyltransferase -
KAF59_RS15910 (KAF59_15910) 395655..396527 + 873 WP_000254716.1 DUF3800 domain-containing protein -
KAF59_RS15915 (KAF59_15915) 396677..397276 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
KAF59_RS15920 (KAF59_15920) 397333..397401 + 69 Protein_434 acetyltransferase -
KAF59_RS15925 (KAF59_15925) 397468..397737 + 270 WP_001114075.1 DUF4160 domain-containing protein -
KAF59_RS15930 (KAF59_15930) 397731..398252 + 522 WP_000921691.1 DUF2442 domain-containing protein -
KAF59_RS15935 (KAF59_15935) 398551..398676 + 126 WP_001905700.1 DUF645 family protein -
KAF59_RS15940 (KAF59_15940) 398927..399322 + 396 WP_001000867.1 hypothetical protein -
KAF59_RS15945 (KAF59_15945) 399461..399739 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
KAF59_RS15950 (KAF59_15950) 399736..400020 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KAF59_RS15955 (KAF59_15955) 400214..400729 + 516 WP_000343779.1 GNAT family protein -
KAF59_RS15960 (KAF59_15960) 400913..401326 + 414 WP_000049420.1 VOC family protein -
KAF59_RS15965 (KAF59_15965) 401881..403058 + 1178 WP_086010879.1 IS3-like element ISVch4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306928..402189 95261
inside Integron catB9 - 312008..401813 89805
flank IS/Tn - - 394761..395198 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T199013 WP_000578476.1 NZ_CP072850:c399739-399461 [Vibrio cholerae MO10]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T199013 NZ_CP097103:c4051754-4051179 [Pseudomonas sp. NY11382]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAATCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACAGGGCCATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTACCCGATCCGAACGATCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGTGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTAGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGATGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT199013 WP_000381183.1 NZ_CP072850:c400020-399736 [Vibrio cholerae MO10]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT199013 NZ_CP097103:c4052221-4051751 [Pseudomonas sp. NY11382]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTTAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTAGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References