Detailed information of TA system
Experimentally validatedOverview
TA module
Type | II | Classification (family/domain) | /RHH-GNAT |
Location | 325890..326656 | Replicon | chromosome II |
Accession | NC_002506 | ||
Organism | Vibrio cholerae O1 biovar El Tor str. N16961 |
Toxin (Protein)
Gene name | - | Uniprot ID | Q9K2P7 |
Locus tag | VC_RS14870 | Protein ID | WP_000982260.1 |
Coordinates | 325890..326387 (-) | Length | 166 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | Q9K2J6 |
Locus tag | VC_RS14875 | Protein ID | WP_000246253.1 |
Coordinates | 326384..326656 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
VC_RS14820 (VC_A0309) | 321332..322036 | + | 705 | WP_000087610.1 | HNH endonuclease | - |
VC_RS14825 (VC_A0310) | 322194..322532 | + | 339 | WP_000713853.1 | hypothetical protein | - |
VC_RS14830 (VC_A0311) | 322686..323003 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
VC_RS14835 (VC_A0312) | 323022..323264 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
VC_RS14840 (VC_A0313) | 323508..323894 | + | 387 | WP_001015867.1 | NUDIX hydrolase | - |
VC_RS14845 | 323951..324064 | + | 114 | WP_001900214.1 | hypothetical protein | - |
VC_RS14850 (VC_A0314) | 324013..324294 | + | 282 | WP_001894429.1 | DUF1289 domain-containing protein | - |
VC_RS14860 (VC_A0316) | 324552..325088 | + | 537 | WP_000469482.1 | GNAT family N-acetyltransferase | - |
VC_RS14865 (VC_A0317) | 325225..325740 | + | 516 | WP_001201509.1 | lipocalin family protein | - |
VC_RS14870 (VC_A0318) | 325890..326387 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | Toxin |
VC_RS14875 (VC_A0319) | 326384..326656 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | Antitoxin |
VC_RS14880 | 327049..327174 | + | 126 | WP_001900195.1 | DUF645 family protein | - |
VC_RS14885 | 327190..327228 | + | 39 | WP_106019118.1 | hypothetical protein | - |
VC_RS14890 (VC_A0322) | 327424..327870 | + | 447 | WP_000006157.1 | hypothetical protein | - |
VC_RS14895 (VC_A0323) | 328018..328287 | - | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | - |
VC_RS14900 (VC_A0324) | 328280..328558 | - | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
VC_RS14905 (VC_A0325) | 328844..329122 | + | 279 | WP_001921601.1 | DUF3709 domain-containing protein | - |
VC_RS14910 (VC_A0327) | 329374..329580 | + | 207 | Protein_292 | DUF3709 domain-containing protein | - |
VC_RS14915 | 329780..329881 | + | 102 | WP_001921603.1 | hypothetical protein | - |
VC_RS14920 (VC_A0328) | 329871..330257 | + | 387 | WP_000703163.1 | VOC family protein | - |
VC_RS14925 (VC_A0329) | 330452..330703 | + | 252 | WP_001890111.1 | TIGR03643 family protein | - |
VC_RS14930 | 330676..330825 | + | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
VC_RS14935 (VCA0329a) | 330917..331159 | + | 243 | WP_000107461.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Integron | catB9 | - | 309750..435387 | 125637 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18527.18 Da Isoelectric Point: 8.7753
>T165 WP_000982260.1 NC_002506:c326387-325890 [Vibrio cholerae O1 biovar El Tor str. N16961]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
>T165 NC_002506:c326387-325890 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 9683.22 Da Isoelectric Point: 6.2988
>AT165 WP_000246253.1 NC_002506:c326656-326384 [Vibrio cholerae O1 biovar El Tor str. N16961]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT165 NC_002506:c326656-326384 [Vibrio cholerae O1 biovar El Tor str. N16961]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|---|---|---|---|
T176 | Vibrio cholerae O1 biovar El Tor str. N16961 |
100 |
100 |
1 |
T10120 | Klebsiella pneumoniae subsp. pneumoniae HS11286 |
32.716 |
98.182 |
0.321 |
Multiple sequence alignment
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|---|---|---|---|
AT176 | Vibrio cholerae O1 biovar El Tor str. N16961 |
100 |
100 |
1 |
AT10120 | Klebsiella pneumoniae subsp. pneumoniae HS11286 |
32.927 |
93.182 |
0.307 |
AT200 | Escherichia coli O157:H7 str. EDL933 |
33.333 |
92.045 |
0.307 |
Multiple sequence alignment
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Q0KGB1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0F2IC79 |
References
(1) Naeem Iqbal et al. (2015) Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron. Journal of Bacteriology 197(13):2150-9. [PubMed:25897030]
experimental literature