145400

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 374691..375219 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag GQX72_RS15695 Protein ID WP_000221352.1
Coordinates 374691..374981 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag GQX72_RS15700 Protein ID WP_000213183.1
Coordinates 374971..375219 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX72_RS19040 369961..370071 + 111 WP_134814058.1 DUF3265 domain-containing protein -
GQX72_RS15655 370248..370373 + 126 WP_001944767.1 DUF645 family protein -
GQX72_RS15660 370389..370427 + 39 WP_106019119.1 hypothetical protein -
GQX72_RS15665 370640..371644 + 1005 WP_000964925.1 LD-carboxypeptidase -
GQX72_RS15670 371797..372243 + 447 WP_000128977.1 hypothetical protein -
GQX72_RS15675 372363..373292 + 930 WP_000335802.1 hypothetical protein -
GQX72_RS15680 373289..373399 + 111 WP_071917832.1 DUF3265 domain-containing protein -
GQX72_RS15685 373427..373903 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
GQX72_RS15690 374040..374555 + 516 WP_001201520.1 lipocalin family protein -
GQX72_RS15695 374691..374981 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQX72_RS15700 374971..375219 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GQX72_RS15715 375790..376443 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
GQX72_RS15720 376715..377140 + 426 WP_000415748.1 hypothetical protein -
GQX72_RS15725 377348..377743 + 396 WP_000649527.1 DUF3465 domain-containing protein -
GQX72_RS15730 377894..378424 + 531 WP_000415563.1 hypothetical protein -
GQX72_RS15735 378562..379062 + 501 WP_000789723.1 hypothetical protein -
GQX72_RS15740 379218..379616 + 399 WP_001882293.1 hypothetical protein -
GQX72_RS15745 379716..380180 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305960..411159 105199
inside Integron - - 311040..410783 99743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T145400 WP_000221352.1 NZ_CP047060:c374981-374691 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T145400 NZ_CP062376:c179225-179130 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT145400 WP_000213183.1 NZ_CP047060:c375219-374971 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT145400 NZ_CP062376:179043-179102 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References