References

  

  

[1] Amar Deep et al (2023) Structural insights into DarT toxin neutralization by cognate DarG antitoxin: ssDNA mimicry by DarG C-terminal domain keeps the DarT toxin inhibited. Structure (London, England : 1993). 31(7):780-789.e4. [PudMed:37167974]
[2] Rui Wang et al (2023) Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens. Nature communications. 14(1):2078. [PudMed:37045931]
[3] Yingjie Song et al (2023) Comparative analysis of five type II TA systems identified in Pseudomonas aeruginosa reveals their contributions to persistence and intracellular survival. Frontiers in cellular and infection microbiology. 13:1127786. [PudMed:36844395]
[4] Giuliana Catara et al (2023) The DarT/DarG Toxin-Antitoxin ADP-Ribosylation System as a Novel Target for a Rational Design of Innovative Antimicrobial Strategies. Pathogens (Basel, Switzerland). 12(2):240. [PudMed:36839512]
[5] Meng Li et al (2023) Type II Toxin-Antitoxin Systems in Pseudomonas aeruginosa. Toxins. 15(2):164. [PudMed:36828478]
[6] Umut Safiye Şay Coşkun et al (2023) Evaluation of toxin-antitoxin genes, antibiotic resistance, and virulence genes in Pseudomonas aeruginosa isolates. Revista da Associacao Medica Brasileira (1992). 69(1):51-55. [PudMed:36820713]
[7] Haijuan Li et al (2023) The parABSm system is involved in megaplasmid partitioning and genome integrity maintenance in Thermus thermophilus. G3 (Bethesda, Md.). 13(4):jkad038. [PudMed:36786449]
[8] Maëlle Duperray et al (2023) Tuning the expression of the bacterial relBE toxin-antitoxin system in Saccharomyces cerevisiae allows characterizing the subsequent growth inhibition. FEMS yeast research. 23:foad009. [PudMed:36722160]
[9] Shinya Ebihara et al (2023) A novel toxin-antitoxin system swpAB alters gene expression patterns and reduces virulence expression in enterohemorrhagic Escherichia coli. Microbiology and immunology. 67(4):171-184. [PudMed:36636756]
[10] K C Hernández-Ramírez et al (2023) Role of PumB antitoxin as a transcriptional regulator of the PumAB type-II toxin-antitoxin system and its endoribonuclease activity on the PumA (toxin) transcript. Molecular genetics and genomics : MGG. 298(2):455-472. [PudMed:36604348]
[11] Pamela K Garcia et al (2022) Localization of Mycobacterium tuberculosis topoisomerase I C-terminal sequence motif required for inhibition by endogenous toxin MazF4. Frontiers in microbiology. 13:1032320. [PudMed:36545199]
[12] Bo Hou et al (2022) Effects of Toxin-Antitoxin System HicAB on Biofilm Formation by Extraintestinal Pathogenic E. coli. Current microbiology. 80(1):50. [PudMed:36542185]
[13] Mikhail Zamakhaev et al (2022) VapC toxin switches M. smegmatis cells into dormancy through 23S rRNA cleavage. Archives of microbiology. 205(1):28. [PudMed:36520276]
[14] Chenchen Wang et al (2022) Structural insights into the PrpTA toxin-antitoxin system in Pseudoalteromonas rubra. Frontiers in microbiology. 13:1053255. [PudMed:36504814]
[15] Evelyne Krin et al (2023) Systematic transcriptome analysis allows the identification of new type I and type II Toxin/Antitoxin systems located in the superintegron of Vibrio cholerae. Research in microbiology. 174(1-2):103997. [PudMed:36347445]
[16] Tiffany M Halvorsen et al (2022) Comparison of Kill Switch Toxins in Plant-Beneficial Pseudomonas fluorescens Reveals Drivers of Lethality, Stability, and Escape. ACS synthetic biology. 11(11):3785-3796. [PudMed:36346907]
[17] Tannu Priya Gosain et al (2022) Disruption of MenT2 toxin impairs the growth of Mycobacterium tuberculosis in guinea pigs. Microbiology (Reading, England). 168(11):10.1099/mic.0.001246. [PudMed:36342835]
[18] Lan-Yue Zhang et al (2022) Toxin-Antitoxin Systems Alter Adaptation of Mycobacterium smegmatis to Environmental Stress. Microbiology spectrum. 10(6):e0281522. [PudMed:36318013]
[19] Yongjin Wang et al (2022) A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria. Nature communications. 13(1):6434. [PudMed:36307446]
[20] Anaïs Le Rhun et al (2023) Profiling the intragenic toxicity determinants of toxin-antitoxin systems: revisiting hok/Sok regulation. Nucleic acids research. 51(1):e4. [PudMed:36271796]
[21] Made Rai Dwitya Wiradiputra et al (2022) Toxin-Antitoxin Systems: A Key Role on Persister Formation in Salmonella enterica Serovar Typhimurium. Infection and drug resistance. 15:5813-5829. [PudMed:36213766]
[22] Yingjie Song et al (2022) The novel type II toxin-antitoxin PacTA modulates Pseudomonas aeruginosa iron homeostasis by obstructing the DNA-binding activity of Fur. Nucleic acids research. 50(18):10586-10600. [PudMed:36200834]
[23] Aleksandra Anna Bonini et al (2022) Functional characterization and transcriptional repression by Lacticaseibacillus paracasei DinJ-YafQ. Applied microbiology and biotechnology. 106(21):7113-7128. [PudMed:36194262]
[24] Victor Yu et al (2022) MqsR is a noncanonical microbial RNase toxin that is inhibited by antitoxin MqsA via steric blockage of substrate binding. The Journal of biological chemistry. 298(11):102535. [PudMed:36162504]
[25] Fuminori Kato et al (2023) A novel gyrase inhibitor from toxin-antitoxin system expressed by Staphylococcus aureus. The FEBS journal. 290(6):1502-1518. [PudMed:36148483]
[26] Shahla Shahbazi et al (2023) Zinc oxide nanoparticles impact the expression of the genes involved in toxin-antitoxin systems in multidrug-resistant Acinetobacter baumannii. Journal of basic microbiology. 63(9):1007-1015. [PudMed:36086811]
[27] Ji Sung Koo et al (2022) The Haemophilus influenzae HipBA toxin-antitoxin system adopts an unusual three-com-ponent regulatory mechanism. IUCrJ. 9(Pt 5):625-631. [PudMed:36071804]
[28] Feiyue Cheng et al (2022) The toxin-antitoxin RNA guards of CRISPR-Cas evolved high specificity through repeat degeneration. Nucleic acids research. 50(16):9442-9452. [PudMed:36018812]
[29] Shiva Hoseini et al (2022) In Vitro and In Silico Investigation of some Type II TA Genes in H. Pylori. Clinical laboratory. 68(8):10.7754/Clin.Lab.2021.211002. [PudMed:35975492]
[30] Vishma Pratap Sur et al (2022) Dynamic study of small toxic hydrophobic proteins PepA1 and PepG1 of Staphylococcus aureus. International journal of biological macromolecules. 219:1360-1371. [PudMed:35932805]
[31] Xiangkai Zhen et al (2022) Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila. Nature communications. 13(1):4333. [PudMed:35882877]
[32] Jacob Bobonis et al (2022) Bacterial retrons encode phage-defending tripartite toxin-antitoxin systems. Nature. 609(7925):144-150. [PudMed:35850148]
[33] Michele LeRoux et al (2022) The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA. Nature microbiology. 7(7):1028-1040. [PudMed:35725776]
[34] Ying-Xian Goh et al (2022) Comparative Analysis of Diverse Acetyltransferase-Type Toxin-Antitoxin Loci in Klebsiella pneumoniae. Microbiology spectrum. 10(4):e0032022. [PudMed:35703555]
[35] Itziar Chapartegui-González et al (2022) Evaluating the Contribution of the Predicted Toxin-Antitoxin System HigBA to Persistence, Biofilm Formation, and Virulence in Burkholderia pseudomallei. Infection and immunity. 90(7):e0003522. [PudMed:35695502]
[36] Francesca G Tomasi et al (2022) A tRNA-Acetylating Toxin and Detoxifying Enzyme in Mycobacterium tuberculosis. Microbiology spectrum. 10(3):e0058022. [PudMed:35638832]
[37] Hyun-Jong Eun et al (2022) The structural and functional investigation of the VapBC43 complex from Mycobacterium tuberculosis. Biochemical and biophysical research communications. 616:19-25. [PudMed:35636251]
[38] Ting Cai et al (2022) HigBA toxin-antitoxin system of Weissella cibaria is involved in response to the bile salt stress. Journal of the science of food and agriculture. 102(14):6749-6756. [PudMed:35633128]
[39] Muyang Ni et al (2022) Antitoxin CrlA of CrlTA Toxin-Antitoxin System in a Clinical Isolate Pseudomonas aeruginosa Inhibits Lytic Phage Infection. Frontiers in microbiology. 13:892021. [PudMed:35620101]
[40] Esther Shmidov et al (2022) PrrT/A, a Pseudomonas aeruginosa Bacterial Encoded Toxin-Antitoxin System Involved in Prophage Regulation and Biofilm Formation. Microbiology spectrum. 10(3):e0118222. [PudMed:35575497]
[41] Clinton C Dawson et al (2022) Discovery of a novel type IIb RelBE toxin-antitoxin system in Mycobacterium tuberculosis defined by co-regulation with an antisense RNA. Molecular microbiology. 117(6):1419-1433. [PudMed:35526138]
[42] Sonia Jain et al (2022) Unravelling the physiological roles of mazEF toxin-antitoxin system on clinical MRSA strain by CRISPR RNA-guided cytidine deaminase. Journal of biomedical science. 29(1):28. [PudMed:35524246]
[43] Mina Mahmoudi et al (2022) relBE toxin-antitoxin system as a reliable anti-biofilm target in Pseudomonas aeruginosa. Journal of applied microbiology. 133(2):683-695. [PudMed:35445489]
[44] Unnati Chauhan et al (2022) tRNAfMet Inactivating Mycobacterium tuberculosis VapBC Toxin-Antitoxin Systems as Therapeutic Targets. Antimicrobial agents and chemotherapy. 66(5):e0189621. [PudMed:35404073]
[45] Yi Zhao et al (2022) The HipAB Toxin-Antitoxin System Stabilizes a Composite Genomic Island in Shewanella putrefaciens CN-32. Frontiers in microbiology. 13:858857. [PudMed:35387082]
[46] Wei-Lin Su et al (2022) TisB Protein Protects Escherichia coli Cells Suffering Massive DNA Damage from Environmental Toxic Compounds. mBio. 13(2):e0038522. [PudMed:35377167]
[47] Daniel Edelmann et al (2022) A Shift in Perspective: A Role for the Type I Toxin TisB as Persistence-Stabilizing Factor. Frontiers in microbiology. 13:871699. [PudMed:35369430]
[48] Gopinath Chattopadhyay et al (2022) Functional and Biochemical Characterization of the MazEF6 Toxin-Antitoxin System of Mycobacterium tuberculosis. Journal of bacteriology. 204(4):e0005822. [PudMed:35357163]
[49] Ines Bleriot et al (2022) The role of PemIK (PemK/PemI) type II TA system from Klebsiella pneumoniae clinical strains in lytic phage infection. Scientific reports. 12(1):4488. [PudMed:35296704]
[50] Ciamak Ghazaei (2022) Advances in the Study of Bacterial Toxins, Their Roles and Mechanisms in Pathogenesis. The Malaysian journal of medical sciences : MJMS. 29(1):4-17. [PudMed:35283688]
[51] Joyeeta Chakraborty et al (2022) Comparative genomics analysis of statistically significant genomic islands of Helicobacter pylori strains for better understanding the disease prognosis. Bioscience reports. 42(3):BSR20212084. [PudMed:35258077]
[52] Anil Mathew Tharappel et al (2022) Inteins as Drug Targets and Therapeutic Tools. Frontiers in molecular biosciences. 9:821146. [PudMed:35211511]
[53] Yi Yang et al (2022) Comparative Genomic Analysis Reveals Preserved Features in Organohalide-Respiring Sulfurospirillum Strains. mSphere. 7(1):e0093121. [PudMed:35196120]
[54] Reinaldo Rodrigues de Souza-Neto et al (2022) MqsR toxin as a biotechnological tool for plant pathogen bacterial control. Scientific reports. 12(1):2794. [PudMed:35181693]
[55] Sabiha Shaik et al (2021) Genome Informatics and Machine Learning-Based Identification of Antimicrobial Resistance-Encoding Features and Virulence Attributes in Escherichia coli Genomes Representing Globally Prevalent Lineages, Including High-Risk Clonal Complexes. mBio. 13(1):e0379621. [PudMed:35164570]
[56] Ning Ling et al (2022) Rhizosphere bacteriome structure and functions. Nature communications. 13(1):836. [PudMed:35149704]
[57] Do-Hee Kim et al (2022) Role of PemI in the Staphylococcus aureus PemIK toxin-antitoxin complex: PemI controls PemK by acting as a PemK loop mimic. Nucleic acids research. 50(4):2319-2333. [PudMed:35141752]
[58] Shruti Kashyap et al (2022) Tobramycin Stress Induced Differential Gene Expression in Acinetobacter baumannii. Current microbiology. 79(3):88. [PudMed:35129693]
[59] Tatsuaki Kurata et al (2022) A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains. Proceedings of the National Academy of Sciences of the United States of America. 119(6):e2102212119. [PudMed:35121656]
[60] Hongmao Sun et al (2022) Discovery of Small-Molecule VapC1 Nuclease Inhibitors by Virtual Screening and Scaffold Hopping from an Atomic Structure Revealing Protein-Protein Interactions with a Native VapB1 Inhibitor. Journal of chemical information and modeling. 62(5):1249-1258. [PudMed:35103473]
[61] Eunsil Choi et al (2022) Functional characterization of HigBA toxin-antitoxin system in an Arctic bacterium, Bosea sp. PAMC 26642. Journal of microbiology (Seoul, Korea). 60(2):192-206. [PudMed:35102526]
[62] Vânia Gaio et al (2021) mazEF Homologue Has a Minor Role in Staphylococcus epidermidis 1457 Virulence Potential. Frontiers in cellular and infection microbiology. 11:803134. [PudMed:35096651]
[63] Parthasarathy Manikandan et al (2022) Identification, functional characterization, assembly and structure of ToxIN type III toxin-antitoxin complex from E. coli. Nucleic acids research. 50(3):1687-1700. [PudMed:35018473]
[64] Taylor Van Gundy et al (2022) An Antisense RNA Fine-Tunes Gene Expression of the Type II MazEF Toxin-Antitoxin System. mBio. 13(1):e0344321. [PudMed:35012340]
[65] Mary K Thompson et al (2022) Escherichia coli SymE is a DNA-binding protein that can condense the nucleoid. Molecular microbiology. 117(4):851-870. [PudMed:34964191]
[66] Juan Zhou et al (2021) Insights into the Neutralization and DNA Binding of Toxin-Antitoxin System ParESO-CopASO by Structure-Function Studies. Microorganisms. 9(12):2506. [PudMed:34946107]
[67] Arun Sharma et al (2021) HigB1 Toxin in Mycobacterium tuberculosis Is Upregulated During Stress and Required to Establish Infection in Guinea Pigs. Frontiers in microbiology. 12:748890. [PudMed:34917044]
[68] Kevin J Snead et al (2022) ParD Antitoxin Hotspot Alters a Disorder-to-Order Transition upon Binding to Its Cognate ParE Toxin, Lessening Its Interaction Affinity and Increasing Its Protease Degradation Kinetics. Biochemistry. 61(1):34-45. [PudMed:34914378]
[69] Hiroko Tamiya-Ishitsuka et al (2021) Conserved Amino Acid Moieties of Candidatus Desulforudis audaxviator MazF Determine Ribonuclease Activity and Specificity. Frontiers in microbiology. 12:748619. [PudMed:34867867]
[70] Lu Xue et al (2022) The two paralogous copies of the YoeB-YefM toxin-antitoxin module in Staphylococcus aureus differ in DNA binding and recognition patterns. The Journal of biological chemistry. 298(1):101457. [PudMed:34861238]
[71] Dukas Jurėnas et al (2021) Bistable Expression of a Toxin-Antitoxin System Located in a Cryptic Prophage of Escherichia coli O157:H7. mBio. 12(6):e0294721. [PudMed:34844426]
[72] Mohit Yadav et al (2022) Functional and transcriptional analysis of chromosomal encoded hipBAXn2 type II toxin-antitoxin (TA) module from Xenorhabdus nematophila. Microbial pathogenesis. 162:105309. [PudMed:34839000]
[73] Aya Takashima et al (2022) A toxin-antitoxin system confers stability to the IncP-7 plasmid pCAR1. Gene. 812:146068. [PudMed:34838639]
[74] Ming-Xing Zhang et al (2021) YgfY Contributes to Stress Tolerance in Shewanella oneidensis Neither as an Antitoxin Nor as a Flavinylation Factor of Succinate Dehydrogenase. Microorganisms. 9(11):2316. [PudMed:34835442]
[75] Kosuke Takada et al (2021) The hokW-sokW Locus Encodes a Type I Toxin-Antitoxin System That Facilitates the Release of Lysogenic Sp5 Phage in Enterohemorrhagic Escherichia coli O157. Toxins. 13(11):796. [PudMed:34822580]
[76] Soumyanetra Chandra et al (2021) Rapid Identification of Secondary Structure and Binding Site Residues in an Intrinsically Disordered Protein Segment. Frontiers in genetics. 12:755292. [PudMed:34795695]
[77] Virginia Hill et al (2021) Minimalistic mycoplasmas harbor different functional toxin-antitoxin systems. PLoS genetics. 17(10):e1009365. [PudMed:34673769]
[78] Charlotte Oriol et al (2021) Expanding the Staphylococcus aureus SarA Regulon to Small RNAs. mSystems. 6(5):e0071321. [PudMed:34636666]
[79] Isis Gabriela Barbosa Carvalho et al (2021) Overexpression of mqsR in Xylella fastidiosa Leads to a Priming Effect of Cells to Copper Stress Tolerance. Frontiers in microbiology. 12:712564. [PudMed:34616378]
[80] William Richardson et al (2021) Chasing the structural diversity of the transcription regulator Mycobacterium tuberculosis HigA2. IUCrJ. 8(Pt 5):823-832. [PudMed:34584743]
[81] Bikash Bogati et al (2021) Improved growth of Escherichia coli in aminoglycoside antibiotics by the zor-orz toxin-antitoxin system. Journal of bacteriology. 204(1):JB0040721. [PudMed:34570627]
[82] Grzegorz J Grabe et al (2021) Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing. Nature chemical biology. 17(12):1296-1304. [PudMed:34556858]
[83] Yingjie Song et al (2021) Type II Antitoxin HigA Is a Key Virulence Regulator in Pseudomonas aeruginosa. ACS infectious diseases. 7(10):2930-2940. [PudMed:34554722]
[84] Feiyue Cheng et al (2021) Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins. Nucleic acids research. 49(18):10677-10688. [PudMed:34551428]
[85] Uroš Zavrtanik et al (2021) Unraveling the Thermodynamics of Ultra-tight Binding of Intrinsically Disordered Proteins. Frontiers in molecular biosciences. 8:726824. [PudMed:34532345]
[86] Qibing Gu et al (2021) An Auto-Regulating Type II Toxin-Antitoxin System Modulates Drug Resistance and Virulence in Streptococcus suis. Frontiers in microbiology. 12:671706. [PudMed:34475853]
[87] Hyerin Jeon et al (2021) Identification and characterization of VapBC toxin-antitoxin system in Bosea sp. PAMC 26642 isolated from Arctic lichens. RNA (New York, N.Y.). 27(11):1374-1389. [PudMed:34429367]
[88] Marion Schuller et al (2021) Molecular basis for DarT ADP-ribosylation of a DNA base. Nature. 596(7873):597-602. [PudMed:34408320]
[89] Annabel S Lemma et al (2021) Toxin Induction or Inhibition of Transcription or Translation Posttreatment Increases Persistence to Fluoroquinolones. mBio. 12(4):e0198321. [PudMed:34399616]
[90] Valdir C Barth et al (2021) Mycobacterium tuberculosis VapC4 toxin engages small ORFs to initiate an integrated oxidative and copper stress response. Proceedings of the National Academy of Sciences of the United States of America. 118(32):e2022136118. [PudMed:34362841]
[91] Kazuo Kobayashi (2021) Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms. PLoS genetics. 17(7):e1009682. [PudMed:34280190]
[92] Tatsuaki Kurata et al (2021) RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis. Molecular cell. 81(15):3160-3170.e9. [PudMed:34174184]
[93] Alireza Japoni-Nejad et al (2021) Identification and characterization of the type II toxin-antitoxin systems in the carbapenem-resistant Acinetobacterbaumannii. Microbial pathogenesis. 158:105052. [PudMed:34147586]
[94] Gabriela Garcia-Rodriguez et al (2021) Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA. Nucleic acids research. 49(12):7164-7178. [PudMed:34139012]
[95] Qin Qi et al (2021) The higBA-Type Toxin-Antitoxin System in IncC Plasmids Is a Mobilizable Ciprofloxacin-Inducible System. mSphere. 6(3):e0042421. [PudMed:34077263]
[96] Lidia Boss et al (2021) Identification of Three Type II Toxin-Antitoxin Systems in Model Bacterial Plant Pathogen Dickeya dadantii 3937. International journal of molecular sciences. 22(11):5932. [PudMed:34073004]
[97] Kinga Chlebicka et al (2021) Impacts of the Type I Toxin-Antitoxin System, SprG1/SprF1, on Staphylococcus aureus Gene Expression. Genes. 12(5):770. [PudMed:34070083]
[98] Wonho Choi et al (2021) Functional Characterization of the mazEF Toxin-Antitoxin System in the Pathogenic Bacterium Agrobacterium tumefaciens. Microorganisms. 9(5):1107. [PudMed:34065548]
[99] Kenn Gerdes et al (2021) Phylogeny Reveals Novel HipA-Homologous Kinase Families and Toxin-Antitoxin Gene Organizations. mBio. 12(3):e0105821. [PudMed:34061596]
[100] Shahira A ElBanna et al (2021) Genomics-guided identification of a conserved CptBA-like toxin-antitoxin system in Acinetobacter baumannii. Journal of advanced research. 30:159-170. [PudMed:34026293]
[101] Hossein Kazemian et al (2021) Comparison of toxin-antitoxin expression among drug-susceptible and drug-resistant clinical isolates of Mycobacterium tuberculosis. Advances in respiratory medicine. 89(2):110-114. [PudMed:33966258]
[102] Chenglong Jin et al (2021) Structural and functional analysis of the Klebsiella pneumoniae MazEF toxin-antitoxin system. IUCrJ. 8(Pt 3):362-371. [PudMed:33953923]
[103] Ming Li et al (2021) Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems. Science (New York, N.Y.). 372(6541):eabe5601. [PudMed:33926924]
[104] Daniel Edelmann et al (2021) Elevated Expression of Toxin TisB Protects Persister Cells against Ciprofloxacin but Enhances Susceptibility to Mitomycin C. Microorganisms. 9(5):943. [PudMed:33925723]
[105] Ran Chen et al (2021) Mechanistic Insight into the Peptide Binding Modes to Two M. tb MazF Toxins. Toxins. 13(5):319. [PudMed:33925254]
[106] Inmaculada Moreno-Córdoba et al (2021) Interactions of the Streptococcus pneumoniae Toxin-Antitoxin RelBE Proteins with Their Target DNA. Microorganisms. 9(4):851. [PudMed:33921033]
[107] Jingyi Zhou et al (2021) Identification of a Toxin-Antitoxin System That Contributes to Persister Formation by Reducing NAD in Pseudomonas aeruginosa. Microorganisms. 9(4):753. [PudMed:33918483]
[108] Xiaotong Luo et al (2021) Characterization of DinJ-YafQ toxin-antitoxin module in Tetragenococcus halophilus: activity, interplay, and evolution. Applied microbiology and biotechnology. 105(9):3659-3672. [PudMed:33877415]
[109] Chantal K Guegler et al (2021) Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection. Molecular cell. 81(11):2361-2373.e9. [PudMed:33838104]
[110] Dongmei Ma et al (2021) Edwardsiella piscicida YefM-YoeB: A Type II Toxin-Antitoxin System That Is Related to Antibiotic Resistance, Biofilm Formation, Serum Survival, and Host Infection. Frontiers in microbiology. 12:646299. [PudMed:33732226]
[111] Zhili He et al (2021) AtaT Improves the Stability of Pore-Forming Protein EspB by Acetylating Lysine 206 to Enhance Strain Virulence. Frontiers in microbiology. 12:627141. [PudMed:33732222]
[112] Jingli Dai et al (2021) MazEF Toxin-Antitoxin System-Mediated DNA Damage Stress Response in Deinococcus radiodurans. Frontiers in genetics. 12:632423. [PudMed:33679894]
[113] Marina Klemenčič et al (2021) The Cysteine Protease MaOC1, a Prokaryotic Caspase Homolog, Cleaves the Antitoxin of a Type II Toxin-Antitoxin System. Frontiers in microbiology. 12:635684. [PudMed:33679669]
[114] Sirli Rosendahl et al (2021) The Disordered C-Terminus of the Chaperone DnaK Increases the Competitive Fitness of Pseudomonas putida and Facilitates the Toxicity of GraT. Microorganisms. 9(2):375. [PudMed:33668424]
[115] Prajita Paul et al (2022) The Hha-TomB toxin-antitoxin module in Salmonella enterica serovar Typhimurium limits its intracellular survival profile and regulates host immune response. Cell biology and toxicology. 38(1):111-127. [PudMed:33651227]
[116] Xiaofeng Zhou et al (2021) A Bacterial Toxin Perturbs Intracellular Amino Acid Balance To Induce Persistence. mBio. 12(1):e03020-20. [PudMed:33622732]
[117] Julia McGillick et al (2021) A YoeB toxin cleaves both RNA and DNA. Scientific reports. 11(1):3592. [PudMed:33574407]
[118] Fedor Bezrukov et al (2021) MazF toxin causes alterations in Staphylococcus aureus transcriptome, translatome and proteome that underlie bacterial dormancy. Nucleic acids research. 49(4):2085-2101. [PudMed:33544858]
[119] Immanuel Dhanasingh et al (2021) Functional and structural characterization of Deinococcus radiodurans R1 MazEF toxin-antitoxin system, Dr0416-Dr0417. Journal of microbiology (Seoul, Korea). 59(2):186-201. [PudMed:33527318]
[120] Songwei Ni et al (2021) Conjugative plasmid-encoded toxin-antitoxin system PrpT/PrpA directly controls plasmid copy number. Proceedings of the National Academy of Sciences of the United States of America. 118(4):e2011577118. [PudMed:33483419]
[121] Pauline Texier et al (2021) ClpXP-mediated Degradation of the TAC Antitoxin is Neutralized by the SecB-like Chaperone in Mycobacterium tuberculosis. Journal of molecular biology. 433(5):166815. [PudMed:33450247]
[122] Marie-Laure Pinel-Marie et al (2021) RNA antitoxin SprF1 binds ribosomes to attenuate translation and promote persister cell formation in Staphylococcus aureus. Nature microbiology. 6(2):209-220. [PudMed:33398097]
[123] Yingjie Song et al (2021) Pseudomonas aeruginosa antitoxin HigA functions as a diverse regulatory factor by recognizing specific pseudopalindromic DNA motifs. Environmental microbiology. 23(3):1541-1558. [PudMed:33346387]
[124] Sakshi Talwar et al (2020) Role of VapBC12 Toxin-Antitoxin Locus in Cholesterol-Induced Mycobacterial Persistence. mSystems. 5(6):e00855-20. [PudMed:33323416]
[125] Inga Songailiene et al (2020) HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation. Molecular cell. 80(6):955-970.e7. [PudMed:33290744]
[126] Johann Peltier et al (2020) Type I toxin-antitoxin systems contribute to the maintenance of mobile genetic elements in Clostridioides difficile. Communications biology. 3(1):718. [PudMed:33247281]
[127] Cédric Romilly et al (2020) An RNA pseudoknot is essential for standby-mediated translation of the tisB toxin mRNA in Escherichia coli. Nucleic acids research. 48(21):12336-12347. [PudMed:33231643]
[128] Lamya El Mortaji et al (2020) A peptide of a type I toxin-antitoxin system induces Helicobacter pylori morphological transformation from spiral shape to coccoids. Proceedings of the National Academy of Sciences of the United States of America. 117(49):31398-31409. [PudMed:33229580]
[129] Liis Andresen et al (2020) The Small Toxic Salmonella Protein TimP Targets the Cytoplasmic Membrane and Is Repressed by the Small RNA TimR. mBio. 11(6):e01659-20. [PudMed:33172998]
[130] Sung-Min Kang et al (2020) Structural and Functional Study of the Klebsiella pneumoniae VapBC Toxin-Antitoxin System, Including the Development of an Inhibitor That Activates VapC. Journal of medicinal chemistry. 63(22):13669-13679. [PudMed:33146528]
[131] Yuka Yashiro et al (2020) Mechanism of aminoacyl-tRNA acetylation by an aminoacyl-tRNA acetyltransferase AtaT from enterohemorrhagic E. coli. Nature communications. 11(1):5438. [PudMed:33116145]
[132] Kwadwo Boampong et al (2020) Rapid growth inhibitory activity of a YafQ-family endonuclease toxin of the Helicobacter pylori tfs4 integrative and conjugative element. Scientific reports. 10(1):18171. [PudMed:33097748]
[133] Marie B Bertelsen et al (2021) Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System. Structure (London, England : 1993). 29(2):139-150.e3. [PudMed:33096014]
[134] Zhen Li et al (2020) Characteristic and role of chromosomal type II toxin-antitoxin systems locus in Enterococcus faecalis ATCC29212. Journal of microbiology (Seoul, Korea). 58(12):1027-1036. [PudMed:33095389]
[135] Jianyun Yao et al (2020) Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system. Nucleic acids research. 48(19):11054-11067. [PudMed:33045733]
[136] Arun Sharma et al (2020) VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis. Frontiers in microbiology. 11:2037. [PudMed:33042034]
[137] Brittany N Ross et al (2020) Predicting toxins found in toxin-antitoxin systems with a role in host-induced Burkholderia pseudomallei persistence. Scientific reports. 10(1):16923. [PudMed:33037311]
[138] Pankaj Vilas Jadhav et al (2020) 2.09 Å Resolution structure of E. coli HigBA toxin-antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitoxin. The Biochemical journal. 477(20):4001-4019. [PudMed:33000860]
[139] Xiao-Lin Tian et al (2019) ClpP is required for proteolytic regulation of type II toxin-antitoxin systems and persister cell formation in Streptococcus mutans. Access microbiology. 1(8):e000054. [PudMed:32974554]
[140] Yiming Cai et al (2020) A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems. Science advances. 6(31):eabb6651. [PudMed:32923609]
[141] Lu Xue et al (2020) Distinct oligomeric structures of the YoeB-YefM complex provide insights into the conditional cooperativity of type II toxin-antitoxin system. Nucleic acids research. 48(18):10527-10541. [PudMed:32845304]
[142] Sung-Min Kang et al (2021) Structure-based design of peptides that trigger Streptococcus pneumoniae cell death. The FEBS journal. 288(5):1546-1564. [PudMed:32770723]
[143] Roberto Sierra et al (2020) Insights into the global effect on Staphylococcus aureus growth arrest by induction of the endoribonuclease MazF toxin. Nucleic acids research. 48(15):8545-8561. [PudMed:32735661]
[144] Keith Weaver (2020) The Fst/Ldr Family of Type I TA System Toxins: Potential Roles in Stress Response, Metabolism and Pathogenesis. Toxins. 12(8):474. [PudMed:32722354]
[145] Jin-Young Park et al (2020) Induced DNA bending by unique dimerization of HigA antitoxin. IUCrJ. 7(Pt 4):748-760. [PudMed:32695421]
[146] Anisha Zaveri et al (2020) Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death. Molecular microbiology. 114(4):641-652. [PudMed:32634279]
[147] Monika Janczak et al (2020) Chromosomal localization of PemIK toxin-antitoxin system results in the loss of toxicity - Characterization of pemIKSa1-Sp from Staphylococcus pseudintermedius. Microbiological research. 240:126529. [PudMed:32622987]
[148] R Álvarez et al (2020) Evaluation of functionality of type II toxin-antitoxin systems of Clostridioides difficile R20291. Microbiological research. 239:126539. [PudMed:32622285]
[149] Stepan V Ovchinnikov et al (2020) Mechanism of translation inhibition by type II GNAT toxin AtaT2. Nucleic acids research. 48(15):8617-8625. [PudMed:32597957]
[150] Jogendra Singh Nim et al (2021) Novel Toxin-antitoxin System Xn-mazEF from Xenorhabdus nematophila: Identification, Characterization and Functional Exploration. Current computer-aided drug design. 17(3):402-411. [PudMed:32586257]
[151] Karen C Hernández-Ramírez et al (2020) Virulence Conferred by PumA Toxin from the Plasmid-Encoded PumAB Toxin-Antitoxin System is Regulated by Quorum System. Current microbiology. 77(9):2535-2543. [PudMed:32556478]
[152] Sakshi Agarwal et al (2020) VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis is required for pathogenesis and modulation of host immune response. Science advances. 6(23):eaba6944. [PudMed:32537511]
[153] Jun Xu et al (2020) Functional investigation of the chromosomal ccdAB and hipAB operon in Escherichia coli Nissle 1917. Applied microbiology and biotechnology. 104(15):6731-6747. [PudMed:32535695]
[154] Jessica R Ames et al (2020) Identifying a Molecular Mechanism That Imparts Species-Specific Toxicity to YoeB Toxins. Frontiers in microbiology. 11:959. [PudMed:32528435]
[155] Izaak N Beck et al (2020) Antitoxin autoregulation of M. tuberculosis toxin-antitoxin expression through negative cooperativity arising from multiple inverted repeat sequences. The Biochemical journal. 477(12):2401-2419. [PudMed:32519742]
[156] Sirli Rosendahl et al (2020) Chromosomal toxin-antitoxin systems in Pseudomonas putida are rather selfish than beneficial. Scientific reports. 10(1):9230. [PudMed:32513960]
[157] Yoshimitsu Masuda et al (2020) Role of Toxin-Antitoxin-Regulated Persister Population and Indole in Bacterial Heat Tolerance. Applied and environmental microbiology. 86(16):e00935-20. [PudMed:32503909]
[158] Ran Chen et al (2020) Conserved Conformational Changes in the Regulation of Mycobacterium tuberculosis MazEF-mt1. ACS infectious diseases. 6(7):1783-1795. [PudMed:32485099]
[159] Itzhak Zander et al (2020) Characterization of PfiT/PfiA toxin-antitoxin system of Pseudomonas aeruginosa that affects cell elongation and prophage induction. Environmental microbiology. 22(12):5048-5057. [PudMed:32458560]
[160] Hyun-Jong Eun et al (2020) Crystal structure of the YoeBSa1-YefMSa1 complex from Staphylococcus aureus. Biochemical and biophysical research communications. 527(1):264-269. [PudMed:32446378]
[161] Kanchiyaphat Ariyachaokun et al (2020) Multi-Stress Induction of the Mycobacterium tuberculosis MbcTA Bactericidal Toxin-Antitoxin System. Toxins. 12(5):329. [PudMed:32429486]
[162] Xia Yu et al (2020) Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Communications biology. 3(1):216. [PudMed:32382148]
[163] Rie Aoi et al (2020) MazF Endoribonucleolytic Toxin Conserved in Nitrospira Specifically Cleaves the AACU, AACG, and AAUU Motifs. Toxins. 12(5):287. [PudMed:32365819]
[164] Hadiastri Kusumawardhani et al (2020) Novel Toxin-Antitoxin Module SlvT-SlvA Regulates Megaplasmid Stability and Incites Solvent Tolerance in Pseudomonas putida S12. Applied and environmental microbiology. 86(13):e00686-20. [PudMed:32358012]
[165] Steffi Jimmy et al (2020) A widespread toxin-antitoxin system exploiting growth control via alarmone signaling. Proceedings of the National Academy of Sciences of the United States of America. 117(19):10500-10510. [PudMed:32345719]
[166] Fernando Chimal-Cázares et al (2020) Molecular Characterization of SehB, a Type II Antitoxin of Salmonella enterica Serotype Typhimurium: Amino Acid Residues Involved in DNA-Binding, Homodimerization, Toxin Interaction, and Virulence. Frontiers in microbiology. 11:614. [PudMed:32328049]
[167] Lillian G Acuña et al (2020) The cis-encoded antisense RNA IsrA from Salmonella Typhimurium represses the expression of STM0294.1n (iasE), an SOS-induced gene coding for an endoribonuclease activity. Biochemical and biophysical research communications. 526(3):706-712. [PudMed:32253028]
[168] Yangmei Li et al (2020) Prophage encoding toxin/antitoxin system PfiT/PfiA inhibits Pf4 production in Pseudomonas aeruginosa. Microbial biotechnology. 13(4):1132-1144. [PudMed:32246813]
[169] Madhurima Roy et al (2020) Biochemical Characterization of VapC46 Toxin from Mycobacterium tuberculosis. Molecular biotechnology. 62(6-7):335-343. [PudMed:32236842]
[170] Charlie Y Huang et al (2020) hipBA toxin-antitoxin systems mediate persistence in Caulobacter crescentus. Scientific reports. 10(1):2865. [PudMed:32071324]
[171] Magnus Stårsta et al (2020) RHS-elements function as type II toxin-antitoxin modules that regulate intra-macrophage replication of Salmonella Typhimurium. PLoS genetics. 16(2):e1008607. [PudMed:32053596]
[172] Mohit Yadav et al (2020) The hipBAXn operon from Xenorhabdus nematophila functions as a bonafide toxin-antitoxin module. Applied microbiology and biotechnology. 104(7):3081-3095. [PudMed:32043192]
[173] Ying Liu et al (2019) Structural Insights Into the Transcriptional Regulation of HigBA Toxin-Antitoxin System by Antitoxin HigA in Pseudomonas aeruginosa. Frontiers in microbiology. 10:3158. [PudMed:32038588]
[174] Emeline Lawarée et al (2020) DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair. Cell reports. 30(5):1373-1384.e4. [PudMed:32023456]
[175] Gul Habib et al (2020) A novel type I toxin-antitoxin system modulates persister cell formation in Staphylococcus aureus. International journal of medical microbiology : IJMM. 310(2):151400. [PudMed:32001143]
[176] Hailey Findlay Black et al (2020) A competence-regulated toxin-antitoxin system in Haemophilus influenzae. PloS one. 15(1):e0217255. [PudMed:31931516]
[177] Gabriela Garcia-Rodriguez et al (2020) The Escherichia coli RnlA-RnlB toxin-antitoxin complex: production, characterization and crystallization. Acta crystallographica. Section F, Structural biology communications. 76(Pt 1):31-39. [PudMed:31929184]
[178] DongWon Park et al (2020) Crystal structure of proteolyzed VapBC and DNA-bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca2+ -dependent ribonuclease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(2):3051-3068. [PudMed:31908032]
[179] Nathan Fraikin et al (2019) Reassessing the Role of the Type II MqsRA Toxin-Antitoxin System in Stress Response and Biofilm Formation: mqsA Is Transcriptionally Uncoupled from mqsR. mBio. 10(6):e02678-19. [PudMed:31848281]
[180] Alessia Levante et al (2019) Expression of DinJ-YafQ System of Lactobacillus casei Group Strains in Response to Food Processing Stresses. Microorganisms. 7(10):438. [PudMed:31614503]
[181] Melek Cemre Manav et al (2019) The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNA Binding Domain. Structure (London, England : 1993). 27(11):1675-1685.e3. [PudMed:31495532]
[182] Dursun Nizam Korkut et al (2020) Structural insights into the AapA1 toxin of Helicobacter pylori. Biochimica et biophysica acta. General subjects. 1864(1):129423. [PudMed:31476357]
[183] Sara Masachis et al (2019) A genetic selection reveals functional metastable structures embedded in a toxin-encoding mRNA. eLife. 8:e47549. [PudMed:31411564]
[184] Brittany N Ross et al (2019) Evaluating the role of Burkholderia pseudomallei K96243 toxins BPSS0390, BPSS0395, and BPSS1584 in persistent infection. Cellular microbiology. 21(12):e13096. [PudMed:31400259]
[185] Fuminori Kato et al (2019) Genome-Wide Screening for Identification of Novel Toxin-Antitoxin Systems in Staphylococcus aureus. Applied and environmental microbiology. 85(20):e00915-19. [PudMed:31375497]
[186] Nava Hosseini et al (2019) Modulation of Toxin-Antitoxin System Rnl AB Type II in Phage-Resistant Gammaproteobacteria Surviving Photodynamic Treatment. Journal of lasers in medical sciences. 10(1):21-28. [PudMed:31360364]
[187] Laís Moreira Granato et al (2019) The ecnA Antitoxin Is Important Not Only for Human Pathogens: Evidence of Its Role in the Plant Pathogen Xanthomonas citri subsp. citri. Journal of bacteriology. 201(20):e00796-18. [PudMed:31358614]
[188] Muhammad Kamruzzaman et al (2019) A ParDE-family toxin antitoxin system in major resistance plasmids of Enterobacteriaceae confers antibiotic and heat tolerance. Scientific reports. 9(1):9872. [PudMed:31285520]
[189] Ran Chen et al (2019) Structural and Biochemical Characterization of the Cognate and Heterologous Interactions of the MazEF-mt9 TA System. ACS infectious diseases. 5(8):1306-1316. [PudMed:31267737]
[190] Hongliang Qian et al (2019) Toxin-antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA-KacT complex. Nucleic acids research. 47(14):7690-7702. [PudMed:31260525]
[191] Stine Vang Nielsen et al (2019) Serine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase. mBio. 10(3):e01138-19. [PudMed:31213559]
[192] Przemyslaw Decewicz et al (2019) Characterization of the virome of Paracoccus spp. (Alphaproteobacteria) by combined in silico and in vivo approaches. Scientific reports. 9(1):7899. [PudMed:31133656]
[193] Alberto Ferrari et al (2019) Identification and first characterization of DinJ-YafQ toxin-antitoxin systems in Lactobacillus species of biotechnological interest. Scientific reports. 9(1):7645. [PudMed:31114007]
[194] Jingyu Peng et al (2019) Chromosomally Encoded hok-sok Toxin-Antitoxin System in the Fire Blight Pathogen Erwinia amylovora: Identification and Functional Characterization. Applied and environmental microbiology. 85(15):e00724-19. [PudMed:31101613]
[195] Rongjuan Zhao et al (2019) Structure and allosteric coupling of type Ⅱ antitoxin CopASO. Biochemical and biophysical research communications. 514(4):1122-1127. [PudMed:31101334]
[196] Bing-Shuang Xu et al (2019) Conformational changes of antitoxin HigA from Escherichia coli str. K-12 upon binding of its cognate toxin HigB reveal a new regulation mechanism in toxin-antitoxin systems. Biochemical and biophysical research communications. 514(1):37-43. [PudMed:31014676]
[197] Waner Zhan et al (2019) Characterization of Two Toxin-Antitoxin Systems in Deep-Sea Streptomyces sp. SCSIO 02999. Marine drugs. 17(4):211. [PudMed:30987346]
[198] Teja Shidore et al (2019) Survey of Toxin⁻Antitoxin Systems in Erwinia amylovora Reveals Insights into Diversity and Functional Specificity. Toxins. 11(4):206. [PudMed:30959879]
[199] Ashley L Molinaro et al (2019) Crystal Structure of VapBC-1 from Nontypeable Haemophilus influenzae and the Effect of PIN Domain Mutations on Survival during Infection. Journal of bacteriology. 201(12):e00026-19. [PudMed:30936373]
[200] Akanksha Nigam et al (2019) Stress-Induced MazF-Mediated Proteins in Escherichia coli. mBio. 10(2):e00340-19. [PudMed:30914510]
[201] Mao Shaku et al (2018) Identification of MazF Homologue in Legionella pneumophila Which Cleaves RNA at the AACU Sequence. Journal of molecular microbiology and biotechnology. 28(6):269-280. [PudMed:30893701]
[202] Yunxue Guo et al (2019) Antitoxin HigA inhibits virulence gene mvfR expression in Pseudomonas aeruginosa. Environmental microbiology. 21(8):2707-2723. [PudMed:30882983]
[203] Ariel Talavera et al (2019) A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT. Nature communications. 10(1):972. [PudMed:30814507]
[204] Kai Xia et al (2019) Characterization and comparative analysis of toxin-antitoxin systems in Acetobacter pasteurianus. Journal of industrial microbiology & biotechnology. 46(6):869-882. [PudMed:30805740]
[205] Won-Su Yoon et al (2019) Structural changes of antitoxin HigA from Shigella flexneri by binding of its cognate toxin HigB. International journal of biological macromolecules. 130:99-108. [PudMed:30797012]
[206] Marc A Schureck et al (2019) Structural basis of transcriptional regulation by the HigA antitoxin. Molecular microbiology. 111(6):1449-1462. [PudMed:30793388]
[207] Diana Mendes Freire et al (2019) An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death. Molecular cell. 73(6):1282-1291.e8. [PudMed:30792174]
[208] Andres Ainelo et al (2019) Pseudomonas putida Responds to the Toxin GraT by Inducing Ribosome Biogenesis Factors and Repressing TCA Cycle Enzymes. Toxins. 11(2):103. [PudMed:30744127]
[209] Leire Bardaji et al (2019) The toxic guardians - multiple toxin-antitoxin systems provide stability, avoid deletions and maintain virulence genes of Pseudomonas syringae virulence plasmids. Mobile DNA. 10:7. [PudMed:30728866]
[210] Dukas Jurėnas et al (2019) Mechanism of regulation and neutralization of the AtaR-AtaT toxin-antitoxin system. Nature chemical biology. 15(3):285-294. [PudMed:30718814]
[211] Himani Tandon et al (2019) Mycobacterium tuberculosis Rv0366c-Rv0367c encodes a non-canonical PezAT-like toxin-antitoxin pair. Scientific reports. 9(1):1163. [PudMed:30718534]
[212] Manon Thomet et al (2019) Characterization of HicAB toxin-antitoxin module of Sinorhizobium meliloti. BMC microbiology. 19(1):10. [PudMed:30630415]
[213] Yuka Yashiro et al (2019) Crystal Structure of the Enterohemorrhagic Escherichia coli AtaT-AtaR Toxin-Antitoxin Complex. Structure (London, England : 1993). 27(3):476-484.e3. [PudMed:30612860]
[214] Frank J Piscotta et al (2019) ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism. Proceedings of the National Academy of Sciences of the United States of America. 116(3):826-834. [PudMed:30598453]
[215] Madhurima Roy et al (2019) Structural characterization of VapB46 antitoxin from Mycobacterium tuberculosis: insights into VapB46-DNA binding. The FEBS journal. 286(6):1174-1190. [PudMed:30576065]
[216] Camille Riffaud et al (2019) Functionality and cross-regulation of the four SprG/SprF type I toxin-antitoxin systems in Staphylococcus aureus. Nucleic acids research. 47(4):1740-1758. [PudMed:30551143]
[217] Noëlla Germain-Amiot et al (2019) A novel Staphylococcus aureus cis-trans type I toxin-antitoxin module with dual effects on bacteria and host cells. Nucleic acids research. 47(4):1759-1773. [PudMed:30544243]
[218] Paula Bustamante et al (2019) The roles of HicBA and a novel toxin-antitoxin-like system, TsxAB, in the stability of IncX4 resistance plasmids in Escherichia coli. The Journal of antimicrobial chemotherapy. 74(3):553-556. [PudMed:30535076]
[219] Prajita Paul et al (2018) Molecular insight to influential role of Hha-TomB toxin-antitoxin system for antibacterial activity of biogenic silver nanoparticles. Artificial cells, nanomedicine, and biotechnology. 46(sup3):S572-S584. [PudMed:30444141]
[220] Gul Habib et al (2018) Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus. Toxins. 10(11):473. [PudMed:30441856]
[221] Jiali Xu et al (2018) Identification of Three Type II Toxin-Antitoxin Systems in Streptococcus suis Serotype 2. Toxins. 10(11):467. [PudMed:30428568]
[222] Meenakumari Muthuramalingam et al (2019) The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics. Molecular microbiology. 111(2):441-454. [PudMed:30427086]
[223] Xiaodong Chi et al (2018) Biochemical characterization of mt-PemIK, a novel toxin-antitoxin system in Mycobacterium tuberculosis. FEBS letters. 592(24):4039-4050. [PudMed:30372528]
[224] Yueying Zhang et al (2018) HigB Reciprocally Controls Biofilm Formation and the Expression of Type III Secretion System Genes through Influencing the Intracellular c-di-GMP Level in Pseudomonas aeruginosa. Toxins. 10(11):424. [PudMed:30355991]
[225] Tatsuki Miyamoto et al (2018) Nitrosomonas europaea MazF Specifically Recognises the UGG Motif and Promotes Selective RNA Degradation. Frontiers in microbiology. 9:2386. [PudMed:30349517]
[226] Ashley J Winter et al (2018) The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA. The Journal of biological chemistry. 293(50):19429-19440. [PudMed:30337369]
[227] Amar Deep et al (2018) Structural, functional and biological insights into the role of Mycobacterium tuberculosis VapBC11 toxin-antitoxin system: targeting a tRNase to tackle mycobacterial adaptation. Nucleic acids research. 46(21):11639-11655. [PudMed:30329074]
[228] Andrzej Dubiel et al (2018) ClpAP protease is a universal factor that activates the parDE toxin-antitoxin system from a broad host range RK2 plasmid. Scientific reports. 8(1):15287. [PudMed:30327496]
[229] Toomas Mets et al (2019) Fragmentation of Escherichia coli mRNA by MazF and MqsR. Biochimie. 156:79-91. [PudMed:30315853]
[230] Ragnhild Bager Skjerning et al (2019) The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+. Molecular microbiology. 111(1):221-236. [PudMed:30315706]
[231] Delphine Dufour et al (2018) A tripartite toxin-antitoxin module induced by quorum sensing is associated with the persistence phenotype in Streptococcus mutans. Molecular oral microbiology. 33(6):420-429. [PudMed:30298644]
[232] Jee Soo Choi et al (2018) The small RNA, SdsR, acts as a novel type of toxin in Escherichia coli. RNA biology. 15(10):1319-1335. [PudMed:30293519]
[233] Wai Ting Chan et al (2018) The Streptococcus pneumoniaeyefM-yoeB and relBE Toxin-Antitoxin Operons Participate in Oxidative Stress and Biofilm Formation. Toxins. 10(9):378. [PudMed:30231554]
[234] Abigail Sharrock et al (2018) VapC proteins from Mycobacterium tuberculosis share ribonuclease sequence specificity but differ in regulation and toxicity. PloS one. 13(8):e0203412. [PudMed:30169502]
[235] Mohit Yadav et al (2018) TAome analysis of type-II toxin-antitoxin system from Xenorhabdus nematophila. Computational biology and chemistry. 76:293-301. [PudMed:30114602]
[236] Pan Fu et al (2018) A toxin-antitoxin system is essential for the stability of mosquitocidal plasmid pBsph of Lysinibacillus sphaericus. Microbiological research. 214:114-122. [PudMed:30031473]
[237] Dukas Jurėnas et al (2018) Crystallization and X-ray analysis of all of the players in the autoregulation of the ataRT toxin-antitoxin system. Acta crystallographica. Section F, Structural biology communications. 74(Pt 7):391-401. [PudMed:29969102]
[238] Xiaoyu Wang et al (2018) Mycobacterium tuberculosis toxin Rv2872 is an RNase involved in vancomycin stress response and biofilm development. Applied microbiology and biotechnology. 102(16):7123-7133. [PudMed:29948114]
[239] Brendan Wilcox et al (2018) Escherichia coli ItaT is a type II toxin that inhibits translation by acetylating isoleucyl-tRNAIle. Nucleic acids research. 46(15):7873-7885. [PudMed:29931259]
[240] Rashad Alkasir et al (2018) Characterization and Transcriptome Analysis of Acinetobacter baumannii Persister Cells. Microbial drug resistance (Larchmont, N.Y.). 24(10):1466-1474. [PudMed:29902105]
[241] Do-Hee Kim et al (2018) Functional insights into the Streptococcus pneumoniae HicBA toxin-antitoxin system based on a structural study. Nucleic acids research. 46(12):6371-6386. [PudMed:29878152]
[242] Julian A Rycroft et al (2018) Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection. Nature communications. 9(1):1993. [PudMed:29777131]
[243] Julija Armalytė et al (2018) The higBA Toxin-Antitoxin Module From the Opportunistic Pathogen Acinetobacter baumannii - Regulation, Activity, and Evolution. Frontiers in microbiology. 9:732. [PudMed:29706946]
[244] Andrea Rocker et al (2018) The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis. Nature communications. 9(1):1686. [PudMed:29703974]
[245] Wonho Choi et al (2018) Functional Characterization of the C-Terminus of YhaV in the Escherichia coli PrlF-YhaV Toxin-Antitoxin System. Journal of microbiology and biotechnology. 28(6):987-996. [PudMed:29642286]
[246] Ji-Li Zhao et al (2018) Viability, biofilm formation, and MazEF expression in drug-sensitive and drug-resistant Mycobacterium tuberculosis strains circulating in Xinjiang, China. Infection and drug resistance. 11:345-358. [PudMed:29563815]
[247] Qian Fei et al (2018) A Toxin-Antitoxin System VapBC15 from Synechocystis sp. PCC 6803 Shows Distinct Regulatory Features. Genes. 9(4):173. [PudMed:29561797]
[248] Xuanyan Jia et al (2018) Structure-function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN-MNT toxin-antitoxin system. The Journal of biological chemistry. 293(18):6812-6823. [PudMed:29555683]
[249] Tomoya Maeda et al (2018) Glutamine-rich toxic proteins GrtA, GrtB and GrtC together with the antisense RNA AsgR constitute a toxin-antitoxin-like system in Corynebacterium glutamicum. Molecular microbiology. 108(5):578-594. [PudMed:29537126]
[250] Anna Maikova et al (2018) Discovery of new type I toxin-antitoxin systems adjacent to CRISPR arrays in Clostridium difficile. Nucleic acids research. 46(9):4733-4751. [PudMed:29529286]
[251] Sakshi Agarwal et al (2018) System-Wide Analysis Unravels the Differential Regulation and In Vivo Essentiality of Virulence-Associated Proteins B and C Toxin-Antitoxin Systems of Mycobacterium tuberculosis. The Journal of infectious diseases. 217(11):1809-1820. [PudMed:29529224]
[252] Hannah G Hampton et al (2018) AbiEi Binds Cooperatively to the Type IV abiE Toxin-Antitoxin Operator Via a Positively-Charged Surface and Causes DNA Bending and Negative Autoregulation. Journal of molecular biology. 430(8):1141-1156. [PudMed:29518409]
[253] Sadeghi Kalani Behrooz et al (2018) Study of MazEF, sam, and phd-doc putative toxin-antitoxin systems in Staphylococcus epidermidis. Acta microbiologica et immunologica Hungarica. 65(1):81-91. [PudMed:29471693]
[254] Jun-Seob Kim et al (2018) GhoT of the GhoT/GhoS toxin/antitoxin system damages lipid membranes by forming transient pores. Biochemical and biophysical research communications. 497(2):467-472. [PudMed:29470981]
[255] Laura Fernández-García et al (2018) Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System. Antimicrobial agents and chemotherapy. 62(5):e00250-18. [PudMed:29463538]
[256] Hongliang Qian et al (2018) Identification and characterization of acetyltransferase-type toxin-antitoxin locus in Klebsiella pneumoniae. Molecular microbiology. 108(4):336-349. [PudMed:29461656]
[257] Wen Wen et al (2018) Autoregulation and Virulence Control by the Toxin-Antitoxin System SavRS in Staphylococcus aureus. Infection and immunity. 86(5):e00032-18. [PudMed:29440365]
[258] Nela Nikolic et al (2018) Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations. Nucleic acids research. 46(6):2918-2931. [PudMed:29432616]
[259] Celine Reif et al (2018) Bacillus subtilis Type I antitoxin SR6 Promotes Degradation of Toxin yonT mRNA and Is Required to Prevent Toxic yoyJ Overexpression. Toxins. 10(2):74. [PudMed:29414903]
[260] Jianyun Yao et al (2018) Type II toxin/antitoxin system ParESO /CopASO stabilizes prophage CP4So in Shewanella oneidensis. Environmental microbiology. 20(3):1224-1239. [PudMed:29411516]
[261] Francesca L Short et al (2018) The bacterial Type III toxin-antitoxin system, ToxIN, is a dynamic protein-RNA complex with stability-dependent antiviral abortive infection activity. Scientific reports. 8(1):1013. [PudMed:29343718]
[262] Zhen Li et al (2018) Identification of a functional toxin-antitoxin system located in the genomic island PYG1 of piezophilic hyperthermophilic archaeon Pyrococcus yayanosii. Extremophiles : life under extreme conditions. 22(3):347-357. [PudMed:29335804]
[263] B Schneider et al (2018) Identification and functional characterization of type II toxin/antitoxin systems in Aggregatibacter actinomycetemcomitans. Molecular oral microbiology. 33(3):224-233. [PudMed:29319934]
[264] Daniel Jaén-Luchoro et al (2017) First insights into a type II toxin-antitoxin system from the clinical isolate Mycobacterium sp. MHSD3, similar to epsilon/zeta systems. PloS one. 12(12):e0189459. [PudMed:29236773]
[265] Lauren R Walling et al (2018) Homologous VapC Toxins Inhibit Translation and Cell Growth by Sequence-Specific Cleavage of tRNAfMet. Journal of bacteriology. 200(3):e00582-17. [PudMed:29109187]
[266] Laurence Van Melderen et al (2018) Messing up translation from the start: How AtaT inhibits translation initiation in E. coli. RNA biology. 15(3):303-307. [PudMed:29099338]
[267] Hanna Sprenger et al (2017) Fic Proteins of Campylobacter fetus subsp. venerealis Form a Network of Functional Toxin-Antitoxin Systems. Frontiers in microbiology. 8:1965. [PudMed:29089929]
[268] Alexander Harms et al (2017) A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella. PLoS genetics. 13(10):e1007077. [PudMed:29073136]
[269] Amar Deep et al (2017) Crystal structure of Mycobacterium tuberculosis VapC20 toxin and its interactions with cognate antitoxin, VapB20, suggest a model for toxin-antitoxin assembly. The FEBS journal. 284(23):4066-4082. [PudMed:28986943]
[270] Do-Hwan Ahn et al (2017) Structural analyses of the MazEF4 toxin-antitoxin pair in Mycobacterium tuberculosis provide evidence for a unique extracellular death factor. The Journal of biological chemistry. 292(46):18832-18847. [PudMed:28972145]
[271] K C Hernández-Ramírez et al (2017) Plasmid pUM505 encodes a Toxin-Antitoxin system conferring plasmid stability and increased Pseudomonas aeruginosa virulence. Microbial pathogenesis. 112:259-268. [PudMed:28970172]
[272] Nela Nikolic et al (2017) MazF activation promotes translational heterogeneity of the grcA mRNA in Escherichia coli populations. PeerJ. 5:e3830. [PudMed:28948108]
[273] Giulia Pilla et al (2017) Genetic plasticity of the Shigella virulence plasmid is mediated by intra- and inter-molecular events between insertion sequences. PLoS genetics. 13(9):e1007014. [PudMed:28945748]
[274] Andrea M Hujer et al (2017) Nosocomial Outbreak of Extensively Drug-Resistant Acinetobacter baumannii Isolates Containing blaOXA-237 Carried on a Plasmid. Antimicrobial agents and chemotherapy. 61(11):e00797-17. [PudMed:28893775]
[275] Jingsi Yang et al (2017) HicAB toxin-antitoxin complex from Escherichia coli: expression and crystallization. Acta crystallographica. Section F, Structural biology communications. 73(Pt 9):505-510. [PudMed:28876228]
[276] Jing Zhang et al (2017) Expression of a Vibrio parahaemolyticus toxin in Escherichia coli results in chromosomal DNA degradation. Bioscience, biotechnology, and biochemistry. 81(10):1937-1940. [PudMed:28820009]
[277] Krzysztof Romaniuk et al (2017) Molecular characterization of the pA3J1 plasmid from the psychrotolerant Antarctic bacterium Pseudomonas sp. ANT_J3. Plasmid. 92:49-56. [PudMed:28802584]
[278] Tao Li et al (2017) Deinococcus radiodurans Toxin-Antitoxin MazEF-dr Mediates Cell Death in Response to DNA Damage Stress. Frontiers in microbiology. 8:1427. [PudMed:28798741]
[279] David Marsan et al (2017) Toxin-Antitoxin Systems in Estuarine Synechococcus Strain CB0101 and Their Transcriptomic Responses to Environmental Stressors. Frontiers in microbiology. 8:1213. [PudMed:28729858]
[280] Tatsuki Miyamoto et al (2017) Characterization of a Deinococcus radiodurans MazF: A UACA-specific RNA endoribonuclease. MicrobiologyOpen. 6(5):e00501. [PudMed:28675659]
[281] Kritika Gupta et al (2017) Contribution of the Chromosomal ccdAB Operon to Bacterial Drug Tolerance. Journal of bacteriology. 199(19):e00397-17. [PudMed:28674066]
[282] Chengkun Zheng et al (2017) Identification of four type II toxin-antitoxin systems in Actinobacillus pleuropneumoniae. FEMS microbiology letters. 364(12):10.1093/femsle/fnx126. [PudMed:28637172]
[283] Bihe Chen et al (2017) Environmental T4-Family Bacteriophages Evolve to Escape Abortive Infection via Multiple Routes in a Bacterial Host Employing "Altruistic Suicide" through Type III Toxin-Antitoxin Systems. Frontiers in microbiology. 8:1006. [PudMed:28620370]
[284] Sung-Min Kang et al (2017) Functional details of the Mycobacterium tuberculosis VapBC26 toxin-antitoxin system based on a structural study: insights into unique binding and antibiotic peptides. Nucleic acids research. 45(14):8564-8580. [PudMed:28575388]
[285] Ayalla Fedida et al (2017) Two Synechococcus genes, Two Different Effects on Cyanophage Infection. Viruses. 9(6):136. [PudMed:28574452]
[286] Chelsey M VanDrisse et al (2017) A Toxin Involved in Salmonella Persistence Regulates Its Activity by Acetylating Its Cognate Antitoxin, a Modification Reversed by CobB Sirtuin Deacetylase. mBio. 8(3):e00708-17. [PudMed:28559487]
[287] Chenglong Sun et al (2017) MqsR/MqsA Toxin/Antitoxin System Regulates Persistence and Biofilm Formation in Pseudomonas putida KT2440. Frontiers in microbiology. 8:840. [PudMed:28536573]
[288] Jing Zhang et al (2017) A RelE/ParE superfamily toxin in Vibrio parahaemolyticus has DNA nicking endonuclease activity. Biochemical and biophysical research communications. 489(1):29-34. [PudMed:28533087]
[289] Lalit Kumar Gautam et al (2017) Functional annotation of a novel toxin-antitoxin system Xn-RelT of Xenorhabdus nematophila; a combined in silico and in vitro approach. Journal of molecular modeling. 23(6):189. [PudMed:28508139]
[290] Abbas Maleki et al (2017) Novel Information about Neisseria meningitidis: Identification of the Most Important Type II Toxin Antitoxin Systems. Infectious disorders drug targets. 17(2):81-85. [PudMed:28460613]
[291] Yuki Maeda et al (2017) Characterization of YjjJ toxin of Escherichia coli. FEMS microbiology letters. 364(11):10.1093/femsle/fnx086. [PudMed:28430938]
[292] V Garcia-Fulgueiras et al (2017) Allodemic distribution of plasmids co-harbouring blaCTX-M-15/aac(6')-Ib-cr/qnrB in Klebsiella pneumoniae is the main source of extended-spectrum β-lactamases in Uruguay's paediatric hospital. Journal of global antimicrobial resistance. 9:68-73. [PudMed:28419869]
[293] Dukas Jurėnas et al (2017) AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet. Nature chemical biology. 13(6):640-646. [PudMed:28369041]
[294] San Hadži et al (2017) Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a β-strand sliding mechanism. Nucleic acids research. 45(8):4972-4983. [PudMed:28334932]
[295] Kathryn J Turnbull et al (2017) HicA toxin of Escherichia coli derepresses hicAB transcription to selectively produce HicB antitoxin. Molecular microbiology. 104(5):781-792. [PudMed:28266056]
[296] Zhongling Wen et al (2017) Interaction of Type IV Toxin/Antitoxin Systems in Cryptic Prophages of Escherichia coli K-12. Toxins. 9(3):77. [PudMed:28257056]
[297] Ajchareeya Ruangprasert et al (2017) Importance of the E. coli DinJ antitoxin carboxy terminus for toxin suppression and regulated proteolysis. Molecular microbiology. 104(1):65-77. [PudMed:28164393]
[298] Marion Duprilot et al (2017) Diversity and functionality of plasmid-borne VagCD toxin-antitoxin systems of Klebsiella pneumoniae. The Journal of antimicrobial chemotherapy. 72(5):1320-1326. [PudMed:28119479]
[299] Kenta Naka et al (2017) RnlB Antitoxin of the Escherichia coli RnlA-RnlB Toxin-Antitoxin Module Requires RNase HI for Inhibition of RnlA Toxin Activity. Toxins. 9(1):29. [PudMed:28085056]
[300] Hélène Arnion et al (2017) Mechanistic insights into type I toxin antitoxin systems in Helicobacter pylori: the importance of mRNA folding in controlling toxin expression. Nucleic acids research. 45(8):4782-4795. [PudMed:28077560]
[301] Sangeeta Jaiswal et al (2016) The Hha-TomB Toxin-Antitoxin System Shows Conditional Toxicity and Promotes Persister Cell Formation by Inhibiting Apoptosis-Like Death in S. Typhimurium. Scientific reports. 6:38204. [PudMed:27910884]
[302] Gang Li et al (2016) Genomic analyses of multidrug resistant Pseudomonas aeruginosa PA1 resequenced by single-molecule real-time sequencing. Bioscience reports. 36(6):e00418. [PudMed:27765811]
[303] Lauren R Walling et al (2016) Structural Determinants for Antitoxin Identity and Insulation of Cross Talk between Homologous Toxin-Antitoxin Systems. Journal of bacteriology. 198(24):3287-3295. [PudMed:27672196]
[304] Knut I Kristiansen et al (2016) Mutually exclusive RNA secondary structures regulate translation initiation of DinQ in Escherichia coli. RNA (New York, N.Y.). 22(11):1739-1749. [PudMed:27651528]
[305] Wai T Chan et al (2016) The Streptococcus pneumoniae pezAT Toxin-Antitoxin System Reduces β-Lactam Resistance and Genetic Competence. Frontiers in microbiology. 7:1322. [PudMed:27610103]
[306] Yueju Zhao et al (2016) Toxin YafQ Reduces Escherichia coli Growth at Low Temperatures. PloS one. 11(8):e0161577. [PudMed:27557125]
[307] Peng Li et al (2016) Identification and characterization of chromosomal relBE toxin-antitoxin locus in Streptomyces cattleya DSM46488. Scientific reports. 6:32047. [PudMed:27534445]
[308] Stefan Kopfmann et al (2016) Type II Toxin-Antitoxin Systems in the Unicellular Cyanobacterium Synechocystis sp. PCC 6803. Toxins. 8(7):228. [PudMed:27455323]
[309] Yanxia Wei et al (2016) Functional characterization of RelBE toxin-antitoxin system in probiotic Bifidobacterium longum JDM301. Acta biochimica et biophysica Sinica. 48(8):741-9. [PudMed:27451444]
[310] Lindsay R Triplett et al (2016) AvrRxo1 Is a Bifunctional Type III Secreted Effector and Toxin-Antitoxin System Component with Homologs in Diverse Environmental Contexts. PloS one. 11(7):e0158856. [PudMed:27391081]
[311] Manish Gupta et al (2016) The Chromosomal parDE2 Toxin-Antitoxin System of Mycobacterium tuberculosis H37Rv: Genetic and Functional Characterization. Frontiers in microbiology. 7:886. [PudMed:27379032]
[312] Marcus V Merfa et al (2016) The MqsRA Toxin-Antitoxin System from Xylella fastidiosa Plays a Key Role in Bacterial Fitness, Pathogenicity, and Persister Cell Formation. Frontiers in microbiology. 7:904. [PudMed:27375608]
[313] Zhangqi Shen et al (2016) Identification and functional analysis of two toxin-antitoxin systems in Campylobacter jejuni. Molecular microbiology. 101(6):909-23. [PudMed:27291507]
[314] Tatsuki Miyamoto et al (2016) AAU-Specific RNA Cleavage Mediated by MazF Toxin Endoribonuclease Conserved in Nitrosomonas europaea. Toxins. 8(6):174. [PudMed:27271670]
[315] Angela M Cheverton et al (2016) A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA. Molecular cell. 63(1):86-96. [PudMed:27264868]
[316] Hua Wan et al (2016) Structural insights into the inhibition mechanism of bacterial toxin LsoA by bacteriophage antitoxin Dmd. Molecular microbiology. 101(5):757-69. [PudMed:27169810]
[317] Gang Li et al (2016) Identification and Characterization of the HicAB Toxin-Antitoxin System in the Opportunistic Pathogen Pseudomonas aeruginosa. Toxins. 8(4):113. [PudMed:27104566]
[318] Yann G-J Sterckx et al (2016) A unique hetero-hexadecameric architecture displayed by the Escherichia coli O157 PaaA2-ParE2 antitoxin-toxin complex. Journal of molecular biology. 428(8):1589-603. [PudMed:26996937]
[319] Rebecca Page et al (2016) Toxin-antitoxin systems in bacterial growth arrest and persistence. Nature chemical biology. 12(4):208-14. [PudMed:26991085]
[320] Yong Wei et al (2016) Structural characterizations of phage antitoxin Dmd and its interactions with bacterial toxin RnlA. Biochemical and biophysical research communications. 472(4):592-7. [PudMed:26972252]
[321] Régine Brielle et al (2016) Linking bacterial type I toxins with their actions. Current opinion in microbiology. 30:114-121. [PudMed:26874964]
[322] Andres Ainelo et al (2016) The toxin GraT inhibits ribosome biogenesis. Molecular microbiology. 100(4):719-34. [PudMed:26833678]
[323] Wing Sze Ho et al (2015) The Complete Sequence and Comparative Analysis of a Multidrug-Resistance and Virulence Multireplicon IncFII Plasmid pEC302/04 from an Extraintestinal Pathogenic Escherichia coli EC302/04 Indicate Extensive Diversity of IncFII Plasmids. Frontiers in microbiology. 6:1547. [PudMed:26793180]
[324] Reut Shavit et al (2015) The vapB-vapC Operon of Acidovorax citrulli Functions as a Bona-fide Toxin-Antitoxin Module. Frontiers in microbiology. 6:1499. [PudMed:26779154]
[325] Christin Meißner et al (2016) In Vitro Characterization of the Type I Toxin-Antitoxin System bsrE/SR5 from Bacillus subtilis. The Journal of biological chemistry. 291(2):560-71. [PudMed:26565032]
[326] Yoshihiro Yamaguchi et al (2015) An endogenous protein inhibitor, YjhX (TopAI), for topoisomerase I from Escherichia coli. Nucleic acids research. 43(21):10387-96. [PudMed:26553797]
[327] Shaleen B Korch et al (2015) The Mycobacterium tuberculosis relBE toxin:antitoxin genes are stress-responsive modules that regulate growth through translation inhibition. Journal of microbiology (Seoul, Korea). 53(11):783-95. [PudMed:26502963]
[328] Françoise Wessner et al (2015) Regulatory crosstalk between type I and type II toxin-antitoxin systems in the human pathogen Enterococcus faecalis. RNA biology. 12(10):1099-108. [PudMed:26305399]
[329] Jana Melničáková et al (2015) Analysis of the Bacillus cereus SpoIIS antitoxin-toxin system reveals its three-component nature. Frontiers in microbiology. 6:808. [PudMed:26300872]
[330] Francesca L Short et al (2015) A Type III protein-RNA toxin-antitoxin system from Bacillus thuringiensis promotes plasmid retention during spore development. RNA biology. 12(9):933-7. [PudMed:26274022]
[331] Chengkun Zheng et al (2015) Identification and characterization of the chromosomal yefM-yoeB toxin-antitoxin system of Streptococcus suis. Scientific reports. 5:13125. [PudMed:26272287]
[332] Olga Averina et al (2015) Functional analysis of the type II toxin-antitoxin systems of the MazEF and RelBE families in Bifidobacterium longum subsp. infantis ATCC 15697. Anaerobe. 35(Pt B):59-67. [PudMed:26210151]
[333] In-Gyun Lee et al (2015) Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides. Nucleic acids research. 43(15):7624-37. [PudMed:26150422]
[334] Xinyue Yao et al (2015) The chromosomal SezAT toxin-antitoxin system promotes the maintenance of the SsPI-1 pathogenicity island in epidemic Streptococcus suis. Molecular microbiology. 98(2):243-57. [PudMed:26138696]
[335] Jianyun Yao et al (2015) Identification and characterization of a HEPN-MNT family type II toxin-antitoxin in Shewanella oneidensis. Microbial biotechnology. 8(6):961-73. [PudMed:26112399]
[336] Andrea Volante et al (2014) The Interplay between Different Stability Systems Contributes to Faithful Segregation: Streptococcus pyogenes pSM19035 as a Model. Microbiology spectrum. 2(4):PLAS-0007-2013. [PudMed:26104212]
[337] Silvia Heiss et al (2015) Characterization of the Lactobacillus plantarum plasmid pCD033 and generation of the plasmid free strain L. plantarum 3NSH. Plasmid. 81:9-20. [PudMed:26038184]
[338] Christopher F Schuster et al (2015) The MazEF Toxin-Antitoxin System Alters the β-Lactam Susceptibility of Staphylococcus aureus. PloS one. 10(5):e0126118. [PudMed:25965381]
[339] Miyuki Tsukuda et al (2015) Counterselection method based on conditional silencing of antitoxin genes in Escherichia coli. Journal of bioscience and bioengineering. 120(5):591-5. [PudMed:25912447]
[340] Naeem Iqbal et al (2015) Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron. Journal of bacteriology. 197(13):2150-9. [PudMed:25897030]
[341] Hans Krügel et al (2015) Expression of the toxin-antitoxin genes yefM(Lrh), yoeB(Lrh) in human Lactobacillus rhamnosus isolates. Journal of basic microbiology. 55(8):982-91. [PudMed:25832734]
[342] Uddipan Das et al (2014) Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin-antitoxin assembly. Journal of structural biology. 188(3):249-58. [PudMed:25450593]
[343] O I Demidenok et al (2013) [Bacterial toxin-antitoxin systems and perspectives for their application in medicine: a review]. Prikladnaia biokhimiia i mikrobiologiia. 49(6):539-46. [PudMed:25434177]
[344] Christopher F Schuster et al (2014) Fluorescence based primer extension technique to determine transcriptional starting points and cleavage sites of RNases in vivo. Journal of visualized experiments : JoVE. (92):e52134. [PudMed:25406941]
[345] James R Doroghazi et al (2014) Intraspecies comparison of Streptomyces pratensis genomes reveals high levels of recombination and gene conservation between strains of disparate geographic origin. BMC genomics. 15(1):970. [PudMed:25399205]
[346] Brooke Hamilton et al (2014) Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. PloS one. 9(11):e112921. [PudMed:25391136]
[347] Paula Bustamante et al (2014) Toxin-antitoxin systems in the mobile genome of Acidithiobacillus ferrooxidans. PloS one. 9(11):e112226. [PudMed:25384039]
[348] Krzysztof Fiedoruk et al (2015) Type II toxin-antitoxin systems are unevenly distributed among Escherichia coli phylogroups. Microbiology (Reading, England). 161(Pt 1):158-167. [PudMed:25378561]
[349] Marcel Prax et al (2014) Metabolic aspects of bacterial persisters. Frontiers in cellular and infection microbiology. 4:148. [PudMed:25374846]
[350] Steven De Gieter et al (2014) The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding. The Journal of biological chemistry. 289(49):34013-23. [PudMed:25326388]
[351] Keith E Weaver (2015) The Type I toxin-antitoxin par locus from Enterococcus faecalis plasmid pAD1: RNA regulation by both cis- and trans-acting elements. Plasmid. 78:65-70. [PudMed:25312777]
[352] Hyo Jung Lee et al (2015) Recovery of plasmid pEMB1, whose toxin-antitoxin system stabilizes an ampicillin resistance-conferring β-lactamase gene in Escherichia coli, from natural environments. Applied and environmental microbiology. 81(1):40-7. [PudMed:25304509]
[353] Sathish Kumar et al (2014) Quorum sensing peptides mediating interspecies bacterial cell death as a novel class of antimicrobial agents. Current opinion in microbiology. 21:22-7. [PudMed:25244032]
[354] Peng Luo et al (2014) [Bacterial SXT/R391 family from integrating conjugative elements--a review]. Wei sheng wu xue bao = Acta microbiologica Sinica. 54(5):471-9. [PudMed:25199245]
[355] Tsutomu Shimazu et al (2014) Regression of solid tumors by induction of MazF, a bacterial mRNA endoribonuclease. Journal of molecular microbiology and biotechnology. 24(4):228-33. [PudMed:25196606]
[356] Yann G J Sterckx et al (2014) Crystallization and preliminary X-ray analysis of two variants of the Escherichia coli O157 ParE2-PaaA2 toxin-antitoxin complex. Acta crystallographica. Section F, Structural biology communications. 70(Pt 9):1284-91. [PudMed:25195911]
[357] Justine Lipuma et al (2014) A vapBC-type toxin-antitoxin module of Sinorhizobium meliloti influences symbiotic efficiency and nodule senescence of Medicago sativa. Environmental microbiology. 16(12):3714-29. [PudMed:25156344]
[358] Agata L Starosta et al (2014) The bacterial translation stress response. FEMS microbiology reviews. 38(6):1172-201. [PudMed:25135187]
[359] Magdalena Szuplewska et al (2014) Mobility and generation of mosaic non-autonomous transposons by Tn3-derived inverted-repeat miniature elements (TIMEs). PloS one. 9(8):e105010. [PudMed:25121765]
[360] Richard A Proctor et al (2014) Staphylococcus aureus Small Colony Variants (SCVs): a road map for the metabolic pathways involved in persistent infections. Frontiers in cellular and infection microbiology. 4:99. [PudMed:25120957]
[361] Sabrina Bibi-Triki et al (2014) Functional and structural analysis of HicA3-HicB3, a novel toxin-antitoxin system of Yersinia pestis. Journal of bacteriology. 196(21):3712-23. [PudMed:25112480]
[362] Miguel A Matilla et al (2014) Bacteriophage ϕMAM1, a viunalikevirus, is a broad-host-range, high-efficiency generalized transducer that infects environmental and clinical isolates of the enterobacterial genera Serratia and Kluyvera. Applied and environmental microbiology. 80(20):6446-57. [PudMed:25107968]
[363] Brian P Conlon (2014) Staphylococcus aureus chronic and relapsing infections: Evidence of a role for persister cells: An investigation of persister cells, their formation and their role in S. aureus disease. BioEssays : news and reviews in molecular, cellular and developmental biology. 36(10):991-6. [PudMed:25100240]
[364] Jia Wen et al (2014) sRNA antitoxins: more than one way to repress a toxin. Toxins. 6(8):2310-35. [PudMed:25093388]
[365] Marina Mingoia et al (2014) Tn5253 family integrative and conjugative elements carrying mef(I) and catQ determinants in Streptococcus pneumoniae and Streptococcus pyogenes. Antimicrobial agents and chemotherapy. 58(10):5886-93. [PudMed:25070090]
[366] Yurong Wen et al (2014) The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic acids research. 42(15):10134-47. [PudMed:25056321]
[367] Alexandre P Y Lopes et al (2014) VapC from the leptospiral VapBC toxin-antitoxin module displays ribonuclease activity on the initiator tRNA. PloS one. 9(7):e101678. [PudMed:25047537]
[368] Ying Hu et al (2015) Toxin YafQ increases persister cell formation by reducing indole signalling. Environmental microbiology. 17(4):1275-85. [PudMed:25041421]
[369] Jana Makroczyová et al (2014) Topology of the Bacillus subtilis SpoIISA protein and its role in toxin-antitoxin function. FEMS microbiology letters. 358(2):180-7. [PudMed:25039482]
[370] L Aravind et al (2015) The natural history of ADP-ribosyltransferases and the ADP-ribosylation system. Current topics in microbiology and immunology. 384:3-32. [PudMed:25027823]
[371] Sobhan Ghafourian et al (2014) The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii. Memorias do Instituto Oswaldo Cruz. 109(4):502-5. [PudMed:25004148]
[372] Ewa Wardal et al (2014) Molecular analysis of vanA outbreak of Enterococcus faecium in two Warsaw hospitals: the importance of mobile genetic elements. BioMed research international. 2014:575367. [PudMed:25003118]
[373] Jennifer L Cottell et al (2014) Functional genomics to identify the factors contributing to successful persistence and global spread of an antibiotic resistance plasmid. BMC microbiology. 14:168. [PudMed:24961279]
[374] Dapeng Zhang et al (2014) Resilience of biochemical activity in protein domains in the face of structural divergence. Current opinion in structural biology. 26:92-103. [PudMed:24952217]
[375] Hermann Hämmerle et al (2014) Impact of Hfq on the Bacillus subtilis transcriptome. PloS one. 9(6):e98661. [PudMed:24932523]
[376] Yajing Liang et al (2014) Structural and functional characterization of Escherichia coli toxin-antitoxin complex DinJ-YafQ. The Journal of biological chemistry. 289(30):21191-202. [PudMed:24923448]
[377] Charlotte Michaux et al (2014) Involvement of Enterococcus faecalis small RNAs in stress response and virulence. Infection and immunity. 82(9):3599-611. [PudMed:24914223]
[378] Jean-Claude Ogier et al (2014) Attenuated virulence and genomic reductive evolution in the entomopathogenic bacterial symbiont species, Xenorhabdus poinarii. Genome biology and evolution. 6(6):1495-513. [PudMed:24904010]
[379] Ajchareeya Ruangprasert et al (2014) Mechanisms of toxin inhibition and transcriptional repression by Escherichia coli DinJ-YafQ. The Journal of biological chemistry. 289(30):20559-69. [PudMed:24898247]
[380] Noraida Mosqueda et al (2014) Characterization of plasmids carrying the blaOXA-24/40 carbapenemase gene and the genes encoding the AbkA/AbkB proteins of a toxin/antitoxin system. The Journal of antimicrobial chemotherapy. 69(10):2629-33. [PudMed:24879663]
[381] Oliver Wright et al (2015) GeneGuard: A modular plasmid system designed for biosafety. ACS synthetic biology. 4(3):307-16. [PudMed:24847673]
[382] Remy Loris et al (2014) Disorder- and dynamics-based regulatory mechanisms in toxin-antitoxin modules. Chemical reviews. 114(13):6933-47. [PudMed:24806488]
[383] Valerie W C Soo et al (2014) de novo synthesis of a bacterial toxin/antitoxin system. Scientific reports. 4:4807. [PudMed:24797297]
[384] Sophie Helaine et al (2014) Bacterial persisters: formation, eradication, and experimental systems. Trends in microbiology. 22(7):417-24. [PudMed:24768561]
[385] Yann G J Sterckx et al (2014) Small-angle X-ray scattering- and nuclear magnetic resonance-derived conformational ensemble of the highly flexible antitoxin PaaA2. Structure (London, England : 1993). 22(6):854-65. [PudMed:24768114]
[386] Etienne Maisonneuve et al (2014) Molecular mechanisms underlying bacterial persisters. Cell. 157(3):539-48. [PudMed:24766804]
[387] Clifford G Clark et al (2014) DNA sequence heterogeneity of Campylobacter jejuni CJIE4 prophages and expression of prophage genes. PloS one. 9(4):e95349. [PudMed:24756024]
[388] Valentina Zorzini et al (2014) Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics. Nucleic acids research. 42(10):6709-25. [PudMed:24748664]
[389] Yunxue Guo et al (2014) RalR (a DNase) and RalA (a small RNA) form a type I toxin-antitoxin system in Escherichia coli. Nucleic acids research. 42(10):6448-62. [PudMed:24748661]
[390] Min Yang et al (2014) Characterization of the interaction between a SirR family transcriptional factor of Mycobacterium tuberculosis, encoded by Rv2788, and a pair of toxin-antitoxin proteins RelJ/K, encoded by Rv3357 and Rv3358. The FEBS journal. 281(12):2726-37. [PudMed:24725376]
[391] Luary C Martínez et al (2014) Mechanisms of post-transcriptional gene regulation in bacterial biofilms. Frontiers in cellular and infection microbiology. 4:38. [PudMed:24724055]
[392] Heleen Van Acker et al (2014) Involvement of toxin-antitoxin modules in Burkholderia cenocepacia biofilm persistence. Pathogens and disease. 71(3):326-35. [PudMed:24719230]
[393] Jason M Schifano et al (2014) An RNA-seq method for defining endoribonuclease cleavage specificity identifies dual rRNA substrates for toxin MazF-mt3. Nature communications. 5:3538. [PudMed:24709835]
[394] Marie-Laure Pinel-Marie et al (2014) Dual toxic-peptide-coding Staphylococcus aureus RNA under antisense regulation targets host cells and bacterial rivals unequally. Cell reports. 7(2):424-435. [PudMed:24703849]
[395] M Hino et al (2014) Characterization of putative toxin/antitoxin systems in Vibrio parahaemolyticus. Journal of applied microbiology. 117(1):185-95. [PudMed:24698443]
[396] Hookang Im et al (2014) Crystal structure of toxin HP0892 from Helicobacter pylori with two Zn(II) at 1.8 Å resolution. Protein science : a publication of the Protein Society. 23(6):819-32. [PudMed:24677509]
[397] Ambre Sala et al (2014) Multiple toxin-antitoxin systems in Mycobacterium tuberculosis. Toxins. 6(3):1002-20. [PudMed:24662523]
[398] Vicky Merhej et al (2014) Genotyping, evolution and epidemiological findings of Rickettsia species. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 25:122-37. [PudMed:24662440]
[399] Nourkhoda Sadeghifard et al (2014) Is the mazEF toxin-antitoxin system responsible for vancomycin resistance in clinical isolates of Enterococcus faecalis? GMS hygiene and infection control. 9(1):Doc05. [PudMed:24653969]
[400] Shashikala Verma et al (2015) Structural basis of Bacillus anthracis MoxXT disruption and the modulation of MoxT ribonuclease activity by rationally designed peptides. Journal of biomolecular structure & dynamics. 33(3):606-24. [PudMed:24650157]
[401] Dabin Ren et al (2014) The ToxAvapA toxin-antitoxin locus contributes to the survival of nontypeable Haemophilus influenzae during infection. PloS one. 9(3):e91523. [PudMed:24621787]
[402] Lena Ciric et al (2014) Minocycline resistance in an oral Streptococcus infantis isolate is encoded by tet(S) on a novel small, low copy number plasmid. FEMS microbiology letters. 353(2):106-15. [PudMed:24605990]
[403] Jason M Schifano et al (2014) 23S rRNA as an a-Maz-ing new bacterial toxin target. RNA biology. 11(2):101-5. [PudMed:24525465]
[404] Ralph Bertram et al (2014) Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems. Frontiers in cellular and infection microbiology. 4:6. [PudMed:24524029]
[405] Yoshihiro Yamaguchi et al (2014) Characterization of LdrA (long direct repeat A) protein of Escherichia coli. Journal of molecular microbiology and biotechnology. 24(2):91-7. [PudMed:24513967]
[406] Aaron Butt et al (2014) The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation. The Biochemical journal. 459(2):333-44. [PudMed:24502667]
[407] Iwona Brzozowska et al (2014) The ClpXP protease is responsible for the degradation of the Epsilon antidote to the Zeta toxin of the streptococcal pSM19035 plasmid. The Journal of biological chemistry. 289(11):7514-23. [PudMed:24492616]
[408] Yurong Wen et al (2014) Toxin-Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity. Pathogens and disease. 70(3):240-9. [PudMed:24478112]
[409] Ron L Dy et al (2014) A widespread bacteriophage abortive infection system functions through a Type IV toxin-antitoxin mechanism. Nucleic acids research. 42(7):4590-605. [PudMed:24465005]
[410] Belén Pimentel et al (2014) Toxin Kid uncouples DNA replication and cell division to enforce retention of plasmid R1 in Escherichia coli cells. Proceedings of the National Academy of Sciences of the United States of America. 111(7):2734-9. [PudMed:24449860]
[411] Jonathan W Cruz et al (2014) Doc toxin is a kinase that inactivates elongation factor Tu. The Journal of biological chemistry. 289(11):7788-98. [PudMed:24448800]
[412] Finbarr Hayes et al (2014) Regulating toxin-antitoxin expression: controlled detonation of intracellular molecular timebombs. Toxins. 6(1):337-58. [PudMed:24434949]
[413] Nathalie Goeders et al (2014) Toxin-antitoxin systems as multilevel interaction systems. Toxins. 6(1):304-24. [PudMed:24434905]
[414] Yuhui Xu et al (2015) Drug resistance to Mycobacterium tuberculosis: from the traditional Chinese view to modern systems biology. Critical reviews in microbiology. 41(3):399-410. [PudMed:24433008]
[415] Oksana I Demidenok et al (2014) Toxin-antitoxin vapBC locus participates in formation of the dormant state in Mycobacterium smegmatis. FEMS microbiology letters. 352(1):69-77. [PudMed:24417293]
[416] Degang Ning et al (2013) [A hypothetical gene pair, ssl2138 and sll11092, constitutes a functional TA system on the chromosome of Synechocystis PCC 6803]. Wei sheng wu xue bao = Acta microbiologica Sinica. 53(10):1043-9. [PudMed:24409759]
[417] Sophie Helaine et al (2014) Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science (New York, N.Y.). 343(6167):204-8. [PudMed:24408438]
[418] Miguel A De la Cruz et al (2013) A toxin-antitoxin module of Salmonella promotes virulence in mice. PLoS pathogens. 9(12):e1003827. [PudMed:24385907]
[419] Arti Tripathi et al (2014) MazF-induced growth inhibition and persister generation in Escherichia coli. The Journal of biological chemistry. 289(7):4191-205. [PudMed:24375411]
[420] Hsin-Yao Cheng et al (2014) Toxin GhoT of the GhoT/GhoS toxin/antitoxin system damages the cell membrane to reduce adenosine triphosphate and to reduce growth under stress. Environmental microbiology. 16(6):1741-54. [PudMed:24373067]
[421] Jingchen Feng et al (2014) Growth feedback as a basis for persister bistability. Proceedings of the National Academy of Sciences of the United States of America. 111(1):544-9. [PudMed:24344277]
[422] Ilana Kaspy et al (2013) HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase. Nature communications. 4:3001. [PudMed:24343429]
[423] Kirsty Agnoli et al (2014) The third replicon of members of the Burkholderia cepacia Complex, plasmid pC3, plays a role in stress tolerance. Applied and environmental microbiology. 80(4):1340-8. [PudMed:24334662]
[424] Monica Markovski et al (2013) Preventing bacterial suicide: a novel toxin-antitoxin strategy. Molecular cell. 52(5):611-2. [PudMed:24332174]
[425] Jacelyn M S Loh et al (2014) Comparison of firefly luciferase and NanoLuc luciferase for biophotonic labeling of group A Streptococcus. Biotechnology letters. 36(4):829-34. [PudMed:24322775]
[426] Branislava Milunovic et al (2014) Cell growth inhibition upon deletion of four toxin-antitoxin loci from the megaplasmids of Sinorhizobium meliloti. Journal of bacteriology. 196(4):811-24. [PudMed:24317400]
[427] Zongfu Wu et al (2014) Comparative genomic analysis shows that Streptococcus suis meningitis isolate SC070731 contains a unique 105K genomic island. Gene. 535(2):156-64. [PudMed:24316490]
[428] Kenta Naka et al (2014) RNase HI stimulates the activity of RnlA toxin in Escherichia coli. Molecular microbiology. 91(3):596-605. [PudMed:24308852]
[429] Amy S Larson et al (2014) Light activation of Staphylococcus aureus toxin YoeBSa1 reveals guanosine-specific endoribonuclease activity. Biochemistry. 53(1):188-201. [PudMed:24279911]
[430] L F Mataseje et al (2014) Complete sequences of a novel blaNDM-1-harbouring plasmid from Providencia rettgeri and an FII-type plasmid from Klebsiella pneumoniae identified in Canada. The Journal of antimicrobial chemotherapy. 69(3):637-42. [PudMed:24275114]
[431] Nikita Chopra et al (2013) Linkage, mobility, and selfishness in the MazF family of bacterial toxins: a snapshot of bacterial evolution. Genome biology and evolution. 5(12):2268-84. [PudMed:24265503]
[432] Degang Ning et al (2013) Transcriptional and proteolytic regulation of the toxin-antitoxin locus vapBC10 (ssr2962/slr1767) on the chromosome of Synechocystis sp. PCC 6803. PloS one. 8(11):e80716. [PudMed:24260461]
[433] Anna Maj et al (2013) Plasmids of carotenoid-producing Paracoccus spp. (Alphaproteobacteria) - structure, diversity and evolution. PloS one. 8(11):e80258. [PudMed:24260361]
[434] Marc A Schureck et al (2014) Structure of the Proteus vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex. The Journal of biological chemistry. 289(2):1060-70. [PudMed:24257752]
[435] Simon J Unterholzner et al (2013) Toxin-antitoxin systems: Biology, identification, and application. Mobile genetic elements. 3(5):e26219. [PudMed:24251069]
[436] Katharina Schaufler et al (2013) ESBL-plasmids carrying toxin-antitoxin systems can be "cured" of wild-type Escherichia coli using a heat technique. Gut pathogens. 5(1):34. [PudMed:24245987]
[437] Christopher D Aakre et al (2013) A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp. Molecular cell. 52(5):617-28. [PudMed:24239291]
[438] O A Koksharova (2013) Bacteria and phenoptosis. Biochemistry. Biokhimiia. 78(9):963-70. [PudMed:24228917]
[439] Kristoffer S Winther et al (2013) VapC20 of Mycobacterium tuberculosis cleaves the sarcin-ricin loop of 23S rRNA. Nature communications. 4:2796. [PudMed:24225902]
[440] Carola Venturini et al (2013) Sequences of two related multiple antibiotic resistance virulence plasmids sharing a unique IS26-related molecular signature isolated from different Escherichia coli pathotypes from different hosts. PloS one. 8(11):e78862. [PudMed:24223859]
[441] Valerie W C Soo et al (2013) Antitoxin MqsA represses curli formation through the master biofilm regulator CsgD. Scientific reports. 3:3186. [PudMed:24212724]
[442] Jia Wen et al (2014) The ZorO-OrzO type I toxin-antitoxin locus: repression by the OrzO antitoxin. Nucleic acids research. 42(3):1930-46. [PudMed:24203704]
[443] T Sijbrandij et al (2014) Bacillus globigii cell size is influenced by variants of the quorum sensing peptide extracellular death factor. Antonie van Leeuwenhoek. 105(1):221-8. [PudMed:24198119]
[444] Uddipan Das et al (2013) Preliminary crystallographic analysis of recombinant VapBC-15 toxin-antitoxin complex from Mycobacterium tuberculosis. Acta crystallographica. Section F, Structural biology and crystallization communications. 69(Pt 11):1242-5. [PudMed:24192359]
[445] Melissa V Ramirez et al (2013) MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein. BMC microbiology. 13:240. [PudMed:24172039]
[446] Hedvig Tamman et al (2014) A moderate toxin, GraT, modulates growth rate and stress tolerance of Pseudomonas putida. Journal of bacteriology. 196(1):157-69. [PudMed:24163334]
[447] Daniel Castro-Roa et al (2013) The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu. Nature chemical biology. 9(12):811-7. [PudMed:24141193]
[448] Dhirendra K Simanshu et al (2013) Structural basis of mRNA recognition and cleavage by toxin MazF and its regulation by antitoxin MazE in Bacillus subtilis. Molecular cell. 52(3):447-58. [PudMed:24120662]
[449] Graham Rose et al (2013) Mapping of genotype-phenotype diversity among clinical isolates of mycobacterium tuberculosis by sequence-based transcriptional profiling. Genome biology and evolution. 5(10):1849-62. [PudMed:24115728]
[450] Yong Wei et al (2013) Structure-function studies of Escherichia coli RnlA reveal a novel toxin structure involved in bacteriophage resistance. Molecular microbiology. 90(5):956-65. [PudMed:24112600]
[451] Elsa Germain et al (2013) Molecular mechanism of bacterial persistence by HipA. Molecular cell. 52(2):248-54. [PudMed:24095282]
[452] Eva K Bjørkeng et al (2013) ICESluvan, a 94-kilobase mosaic integrative conjugative element conferring interspecies transfer of VanB-type glycopeptide resistance, a novel bacitracin resistance locus, and a toxin-antitoxin stabilization system. Journal of bacteriology. 195(23):5381-90. [PudMed:24078615]
[453] Jacelyn M S Loh et al (2013) Toxin-antitoxin-stabilized reporter plasmids for biophotonic imaging of Group A streptococcus. Applied microbiology and biotechnology. 97(22):9737-45. [PudMed:24061415]
[454] Andrej Mernik et al (2012) Differences in Unfolding Energetics of CcdB Toxins From V. fischeri and E. coli. Acta chimica Slovenica. 59(3):548-53. [PudMed:24061309]
[455] Chinar Pathak et al (2013) Crystal structure of apo and copper bound HP0894 toxin from Helicobacter pylori 26695 and insight into mRNase activity. Biochimica et biophysica acta. 1834(12):2579-90. [PudMed:24060809]
[456] Dorota Połom et al (2013) Amino acid residues crucial for specificity of toxin-antitoxin interactions in the homologous Axe-Txe and YefM-YoeB complexes. The FEBS journal. 280(22):5906-18. [PudMed:24028219]
[457] Lidia Boss et al (2013) The axe-txe complex of Enterococcus faecium presents a multilayered mode of toxin-antitoxin gene expression regulation. PloS one. 8(9):e73569. [PudMed:24019928]
[458] Lendert Gelens et al (2013) A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli. PLoS computational biology. 9(8):e1003190. [PudMed:24009490]
[459] Ilaria Cataudella et al (2013) Conditional cooperativity of toxin - antitoxin regulation can mediate bistability between growth and dormancy. PLoS computational biology. 9(8):e1003174. [PudMed:24009488]
[460] Julia J van Rensburg et al (2013) Detection of endogenous MazF enzymatic activity in Staphylococcus aureus. Analytical biochemistry. 443(1):81-7. [PudMed:23994560]
[461] Etienne Maisonneuve et al (2013) (p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity. Cell. 154(5):1140-1150. [PudMed:23993101]
[462] San Hadži et al (2013) Crystallization of the HigBA2 toxin-antitoxin complex from Vibrio cholerae. Acta crystallographica. Section F, Structural biology and crystallization communications. 69(Pt 9):1052-9. [PudMed:23989162]
[463] Andrew D Frock et al (2013) Stationary phase and nutrient levels trigger transcription of a genomic locus containing a novel peptide (TM1316) in the hyperthermophilic bacterium Thermotoga maritima. Applied and environmental microbiology. 79(21):6637-46. [PudMed:23974142]
[464] Natalie Jahn et al (2013) One antitoxin--two functions: SR4 controls toxin mRNA decay and translation. Nucleic acids research. 41(21):9870-80. [PudMed:23969414]
[465] Iwona Mruk et al (2014) To be or not to be: regulation of restriction-modification systems and other toxin-antitoxin systems. Nucleic acids research. 42(1):70-86. [PudMed:23945938]
[466] Zhoujie Xie et al (2013) Development of a tunable wide-range gene induction system useful for the study of streptococcal toxin-antitoxin systems. Applied and environmental microbiology. 79(20):6375-84. [PudMed:23934493]
[467] Dorothée L Schuessler et al (2013) Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA. Molecular microbiology. 90(1):195-207. [PudMed:23927792]
[468] Ken Vercammen et al (2013) Identification of a metagenomic gene cluster containing a new class A beta-lactamase and toxin-antitoxin systems. MicrobiologyOpen. 2(4):674-83. [PudMed:23873667]
[469] Yongqiang Gao et al (2013) Inducible cell lysis systems in microbial production of bio-based chemicals. Applied microbiology and biotechnology. 97(16):7121-9. [PudMed:23872961]
[470] Kehan Xu et al (2013) Protein expression, crystallization and preliminary X-ray crystallographic analysis of the isolated Shigella flexneri VapC toxin. Acta crystallographica. Section F, Structural biology and crystallization communications. 69(Pt 7):762-5. [PudMed:23832203]
[471] Nicoletta Nolle et al (2013) Two paralogous yefM-yoeB loci from Staphylococcus equorum encode functional toxin-antitoxin systems. Microbiology (Reading, England). 159(Pt 8):1575-1585. [PudMed:23832005]
[472] Vicky Merhej et al (2013) Postgenomic analysis of bacterial pathogens repertoire reveals genome reduction rather than virulence factors. Briefings in functional genomics. 12(4):291-304. [PudMed:23814139]
[473] Julie E Samson et al (2013) Effect of the abortive infection mechanism and type III toxin/antitoxin system AbiQ on the lytic cycle of Lactococcus lactis phages. Journal of bacteriology. 195(17):3947-56. [PudMed:23813728]
[474] Bhaskar Chandra Mohan Ramisetty et al (2015) mazEF-mediated programmed cell death in bacteria: "what is this?". Critical reviews in microbiology. 41(1):89-100. [PudMed:23799870]
[475] Rick A Fasani et al (2013) Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype. Proceedings of the National Academy of Sciences of the United States of America. 110(27):E2528-37. [PudMed:23781105]
[476] Michal Bukowski et al (2013) A regulatory role for Staphylococcus aureus toxin-antitoxin system PemIKSa. Nature communications. 4:2012. [PudMed:23774061]
[477] Vivek Anantharaman et al (2013) Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing. Biology direct. 8:15. [PudMed:23768067]
[478] O V Averina et al (2013) [Distribution of genes of toxin-antitoxin systems of mazEF and relBE families in bifidobacteria from human intestinal microbiota]. Genetika. 49(3):315-27. [PudMed:23755531]
[479] Zhe Ma et al (2013) Insight into the specific virulence related genes and toxin-antitoxin virulent pathogenicity islands in swine streptococcosis pathogen Streptococcus equi ssp. zooepidemicus strain ATCC35246. BMC genomics. 14:377. [PudMed:23742619]
[480] Sathish Kumar et al (2013) Novel quorum-sensing peptides mediating interspecies bacterial cell death. mBio. 4(3):e00314-13. [PudMed:23736285]
[481] K M Klimina et al (2013) Identification and characterization of toxin-antitoxin systems in strains of Lactobacillus rhamnosus isolated from humans. Anaerobe. 22:82-9. [PudMed:23727113]
[482] Tessa E F Quax et al (2013) Massive activation of archaeal defense genes during viral infection. Journal of virology. 87(15):8419-28. [PudMed:23698312]
[483] Milda Jurenaite et al (2013) Identification and characterization of type II toxin-antitoxin systems in the opportunistic pathogen Acinetobacter baumannii. Journal of bacteriology. 195(14):3165-72. [PudMed:23667234]
[484] Stephanie M Amato et al (2013) Metabolic control of persister formation in Escherichia coli. Molecular cell. 50(4):475-87. [PudMed:23665232]
[485] Matthew B McNeil et al (2013) YgfX (CptA) is a multimeric membrane protein that interacts with the succinate dehydrogenase assembly factor SdhE (YgfY). Microbiology (Reading, England). 159(Pt 7):1352-1365. [PudMed:23657679]
[486] Sobhan Ghafourian et al (2014) Toxin-antitoxin Systems: Classification, Biological Function and Application in Biotechnology. Current issues in molecular biology. 16:9-14. [PudMed:23652423]
[487] Jason M Schifano et al (2013) Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site. Proceedings of the National Academy of Sciences of the United States of America. 110(21):8501-6. [PudMed:23650345]
[488] Simon J Unterholzner et al (2013) Characterisation of the stbD/E toxin-antitoxin system of pEP36, a plasmid of the plant pathogen Erwinia pyrifoliae. Plasmid. 70(2):216-25. [PudMed:23632277]
[489] Laura Sevillano et al (2013) Stable expression plasmids for Streptomyces based on a toxin-antitoxin system. Microbial cell factories. 12:39. [PudMed:23617558]
[490] R Fredrik Inglis et al (2013) The role of bacteriocins as selfish genetic elements. Biology letters. 9(3):20121173. [PudMed:23616642]
[491] Carole Jaubert et al (2013) Genomics and genetics of Sulfolobus islandicus LAL14/1, a model hyperthermophilic archaeon. Open biology. 3(4):130010. [PudMed:23594878]
[492] Fang Tang et al (2013) Comparative genomic analysis of twelve Streptococcus suis (pro)phages. Genomics. 101(6):336-44. [PudMed:23587535]
[493] Ana R Freitas et al (2013) Microevolutionary events involving narrow host plasmids influences local fixation of vancomycin-resistance in Enterococcus populations. PloS one. 8(3):e60589. [PudMed:23555993]
[494] Nathalie Goeders et al (2013) Relaxed cleavage specificity within the RelE toxin family. Journal of bacteriology. 195(11):2541-9. [PudMed:23543711]
[495] Guyue Cheng et al (2013) Antibacterial action of quinolones: from target to network. European journal of medicinal chemistry. 66:555-62. [PudMed:23528390]
[496] Kingsley C Anukam et al (2013) Genome sequence of Lactobacillus pentosus KCA1: vaginal isolate from a healthy premenopausal woman. PloS one. 8(3):e59239. [PudMed:23527145]
[497] Linda Miallau et al (2013) Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes. Structure (London, England : 1993). 21(4):627-37. [PudMed:23523424]
[498] Oliver Wright et al (2013) Building-in biosafety for synthetic biology. Microbiology (Reading, England). 159(Pt 7):1221-1235. [PudMed:23519158]
[499] Sophie Helaine et al (2013) Heterogeneity of intracellular replication of bacterial pathogens. Current opinion in microbiology. 16(2):184-91. [PudMed:23485258]
[500] Hila Sberro et al (2013) Discovery of functional toxin/antitoxin systems in bacteria by shotgun cloning. Molecular cell. 50(1):136-48. [PudMed:23478446]
[501] Anne-Marie Guérout et al (2013) Characterization of the phd-doc and ccd toxin-antitoxin cassettes from Vibrio superintegrons. Journal of bacteriology. 195(10):2270-83. [PudMed:23475970]
[502] Miguel Balado et al (2013) Genetic characterization of pPHDP60, a novel conjugative plasmid from the marine fish pathogen Photobacterium damselae subsp. piscicida. Plasmid. 70(1):154-9. [PudMed:23474463]
[503] Kira S Makarova et al (2013) Comparative genomics of defense systems in archaea and bacteria. Nucleic acids research. 41(8):4360-77. [PudMed:23470997]
[504] Sung Jean Park et al (2013) Structural overview of toxin-antitoxin systems in infectious bacteria: a target for developing antimicrobial agents. Biochimica et biophysica acta. 1834(6):1155-67. [PudMed:23459128]
[505] Gregory M Cook et al (2013) Ribonucleases in bacterial toxin-antitoxin systems. Biochimica et biophysica acta. 1829(6-7):523-31. [PudMed:23454553]
[506] Degang Ning et al (2013) Characterization of a chromosomal type II toxin-antitoxin system mazEaFa in the Cyanobacterium Anabaena sp. PCC 7120. PloS one. 8(2):e56035. [PudMed:23451033]
[507] Villu Kasari et al (2013) Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli. BMC microbiology. 13:45. [PudMed:23432955]
[508] Eugeni Belda et al (2013) An updated metabolic view of the Bacillus subtilis 168 genome. Microbiology (Reading, England). 159(Pt 4):757-770. [PudMed:23429746]
[509] Steven De Gieter et al (2014) ¹H, ¹³C, and ¹⁵N backbone and side-chain chemical shift assignment of the toxin Doc in the unbound state. Biomolecular NMR assignments. 8(1):145-8. [PudMed:23420131]
[510] Elizabeth Diago-Navarro et al (2013) Cleavage of the antitoxin of the parD toxin-antitoxin system is determined by the ClpAP protease and is modulated by the relative ratio of the toxin and the antitoxin. Plasmid. 70(1):78-85. [PudMed:23419648]
[511] Angella Dorsey-Oresto et al (2013) YihE kinase is a central regulator of programmed cell death in bacteria. Cell reports. 3(2):528-37. [PudMed:23416055]
[512] Cristina Socolovschi et al (2013) Connection of toxin-antitoxin modules to inoculation eschar and arthropod vertical transmission in Rickettsiales. Comparative immunology, microbiology and infectious diseases. 36(2):199-209. [PudMed:23414774]
[513] Ragnhild Weel-Sneve et al (2013) Single transmembrane peptide DinQ modulates membrane-dependent activities. PLoS genetics. 9(2):e1003260. [PudMed:23408903]
[514] Iwona Brzozowska et al (2013) Regulation of toxin-antitoxin systems by proteolysis. Plasmid. 70(1):33-41. [PudMed:23396045]
[515] Rémy A Bonnin et al (2013) Complete sequence of broad-host-range plasmid pNOR-2000 harbouring the metallo-β-lactamase gene blaVIM-2 from Pseudomonas aeruginosa. The Journal of antimicrobial chemotherapy. 68(5):1060-5. [PudMed:23354281]
[516] Jakob Albrethsen et al (2013) Proteomic profiling of Mycobacterium tuberculosis identifies nutrient-starvation-responsive toxin-antitoxin systems. Molecular & cellular proteomics : MCP. 12(5):1180-91. [PudMed:23345537]
[517] Anke Rheinberg et al (2013) Cryptic Streptococcus mutans 5.6-kb plasmids encode a toxin-antitoxin system for plasmid stabilization. Journal of oral microbiology. 5:10.3402/jom.v5i0.19729. [PudMed:23330057]
[518] Junqiao Zhao et al (2013) Escherichia coli toxin gene hipA affects biofilm formation and DNA release. Microbiology (Reading, England). 159(Pt 3):633-640. [PudMed:23329678]
[519] Stephanie Koyanagi et al (2013) Characterization of a Streptococcus mutans intergenic region containing a small toxic peptide and its cis-encoded antisense small RNA antitoxin. PloS one. 8(1):e54291. [PudMed:23326602]
[520] Mart Krupovic et al (2013) Insights into dynamics of mobile genetic elements in hyperthermophilic environments from five new Thermococcus plasmids. PloS one. 8(1):e49044. [PudMed:23326305]
[521] Adi Steif et al (2012) The hok mRNA family. RNA biology. 9(12):1399-404. [PudMed:23324554]
[522] Sabine Brantl (2012) Bacterial type I toxin-antitoxin systems. RNA biology. 9(12):1488-90. [PudMed:23324552]
[523] Stefan Kopfmann et al (2013) Toxin-antitoxin systems on the large defense plasmid pSYSA of Synechocystis sp. PCC 6803. The Journal of biological chemistry. 288(10):7399-409. [PudMed:23322786]
[524] Steve P Bernier et al (2013) Starvation, together with the SOS response, mediates high biofilm-specific tolerance to the fluoroquinolone ofloxacin. PLoS genetics. 9(1):e1003144. [PudMed:23300476]
[525] Sylvain Durand et al (2012) The essential function of B. subtilis RNase III is to silence foreign toxin genes. PLoS genetics. 8(12):e1003181. [PudMed:23300471]
[526] O V Averina et al (2012) [Genetic instability of probiotic characteristics in the Bifidobacterium longum subsp. longum B379M strain during cultivation and maintenance]. Genetika. 48(11):1287-96. [PudMed:23297484]
[527] Kyung-Doo Han et al (2013) Identification of chromosomal HP0892-HP0893 toxin-antitoxin proteins in Helicobacter pylori and structural elucidation of their protein-protein interaction. The Journal of biological chemistry. 288(8):6004-13. [PudMed:23297406]
[528] Brian W Kwan et al (2013) Arrested protein synthesis increases persister-like cell formation. Antimicrobial agents and chemotherapy. 57(3):1468-73. [PudMed:23295927]
[529] Xiaoxue Wang et al (2013) Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS. Environmental microbiology. 15(6):1734-44. [PudMed:23289863]
[530] Christopher F Schuster et al (2013) Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate. FEMS microbiology letters. 340(2):73-85. [PudMed:23289536]
[531] Julie E Samson et al (2013) Structure and activity of AbiQ, a lactococcal endoribonuclease belonging to the type III toxin-antitoxin system. Molecular microbiology. 87(4):756-68. [PudMed:23279123]
[532] Francesca L Short et al (2013) Selectivity and self-assembly in the control of a bacterial toxin by an antitoxic noncoding RNA pseudoknot. Proceedings of the National Academy of Sciences of the United States of America. 110(3):E241-9. [PudMed:23267117]
[533] Clemente Michael Vui Ling Wong et al (2013) Characterisation of a cryptic plasmid from an Antarctic bacterium Pedobacter cryoconitis strain BG5. Plasmid. 69(2):186-93. [PudMed:23266397]
[534] Ambre Sala et al (2013) TAC from Mycobacterium tuberculosis: a paradigm for stress-responsive toxin-antitoxin systems controlled by SecB-like chaperones. Cell stress & chaperones. 18(2):129-35. [PudMed:23264229]
[535] Daniel Wibberg et al (2013) The IncF plasmid pRSB225 isolated from a municipal wastewater treatment plant's on-site preflooder combining antibiotic resistance and putative virulence functions is highly related to virulence plasmids identified in pathogenic E. coli isolates. Plasmid. 69(2):127-37. [PudMed:23212116]
[536] Andrew Slattery et al (2013) Isolation of highly persistent mutants of Salmonella enterica serovar typhimurium reveals a new toxin-antitoxin module. Journal of bacteriology. 195(4):647-57. [PudMed:23204462]
[537] Wai Ting Chan et al (2012) Toxin-antitoxin genes of the Gram-positive pathogen Streptococcus pneumoniae: so few and yet so many. Microbiology and molecular biology reviews : MMBR. 76(4):773-91. [PudMed:23204366]
[538] Andrei N Shkoporov et al (2013) Analysis of a novel 8.9kb cryptic plasmid from Bacteroides uniformis, its long-term stability and spread within human microbiota. Plasmid. 69(2):146-59. [PudMed:23201047]
[539] Xianghe Yan et al (2012) Phylogenetic identification of bacterial MazF toxin protein motifs among probiotic strains and foodborne pathogens and potential implications of engineered probiotic intervention in food. Cell & bioscience. 2(1):39. [PudMed:23186337]
[540] Elizabeth M Fozo (2012) New type I toxin-antitoxin families from "wild" and laboratory strains of E. coli: Ibs-Sib, ShoB-OhsC and Zor-Orz. RNA biology. 9(12):1504-12. [PudMed:23182878]
[541] Breann L Brown et al (2013) The Escherichia coli toxin MqsR destabilizes the transcriptional repression complex formed between the antitoxin MqsA and the mqsRA operon promoter. The Journal of biological chemistry. 288(2):1286-94. [PudMed:23172222]
[542] Quan-xin Long et al (2012) [The molecular physiological and genetic mechanisms underlying the superb efficacy of quinolones]. Yao xue xue bao = Acta pharmaceutica Sinica. 47(8):969-77. [PudMed:23162891]
[543] Dabin Ren et al (2012) Toxin-antitoxin loci vapBC-1 and vapXD contribute to survival and virulence in nontypeable Haemophilus influenzae. BMC microbiology. 12:263. [PudMed:23157645]
[544] Kira S Makarova et al (2012) Live virus-free or die: coupling of antivirus immunity and programmed suicide or dormancy in prokaryotes. Biology direct. 7:40. [PudMed:23151069]
[545] Aurore Gorlas et al (2012) Draft genome sequences of Actinomyces timonensis strain 7400942T and its prophage. Journal of bacteriology. 194(23):6613-4. [PudMed:23144376]
[546] Mitsuoki Kawano (2012) Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E. coli: hok/sok, ldr/rdl, symE/symR. RNA biology. 9(12):1520-7. [PudMed:23131729]
[547] Nour Sayed et al (2012) Functional and structural insights of a Staphylococcus aureus apoptotic-like membrane peptide from a toxin-antitoxin module. The Journal of biological chemistry. 287(52):43454-63. [PudMed:23129767]
[548] Tim R Blower et al (2012) Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism. PLoS genetics. 8(10):e1003023. [PudMed:23109916]
[549] Cassandra L Brinkman et al (2013) Characterization of the effects of an rpoC mutation that confers resistance to the Fst peptide toxin-antitoxin system toxin. Journal of bacteriology. 195(1):156-66. [PudMed:23104812]
[550] Christopher F Schuster et al (2013) Characterization of a mazEF toxin-antitoxin homologue from Staphylococcus equorum. Journal of bacteriology. 195(1):115-25. [PudMed:23104807]
[551] E Gerhart H Wagner et al (2012) The toxin-antitoxin system tisB-istR1: Expression, regulation, and biological role in persister phenotypes. RNA biology. 9(12):1513-9. [PudMed:23093802]
[552] Kim Lewis (2012) Persister cells: molecular mechanisms related to antibiotic tolerance. Handbook of experimental pharmacology. (211):121-33. [PudMed:23090599]
[553] Iris Keren et al (2012) Persister eradication: lessons from the world of natural products. Methods in enzymology. 517:387-406. [PudMed:23084949]
[554] Aaron Butt et al (2013) Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS microbiology letters. 338(1):86-94. [PudMed:23082999]
[555] Yang Liu et al (2013) Transferable multiresistance plasmids carrying cfr in Enterococcus spp. from swine and farm environment. Antimicrobial agents and chemotherapy. 57(1):42-8. [PudMed:23070165]
[556] Keith E Weaver (2012) The par toxin-antitoxin system from Enterococcus faecalis plasmid pAD1 and its chromosomal homologs. RNA biology. 9(12):1498-503. [PudMed:23059908]
[557] Sylvain Durand et al (2012) Type I toxin-antitoxin systems in Bacillus subtilis. RNA biology. 9(12):1491-7. [PudMed:23059907]
[558] J Paul Norton et al (2012) Toxin-antitoxin systems are important for niche-specific colonization and stress resistance of uropathogenic Escherichia coli. PLoS pathogens. 8(10):e1002954. [PudMed:23055930]
[559] Andrew B Smith et al (2012) A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions. PloS one. 7(9):e46499. [PudMed:23029540]
[560] Andrew B Min et al (2012) The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg²⁺ ion in the active site and a putative RNA-binding site. Protein science : a publication of the Protein Society. 21(11):1754-67. [PudMed:23011806]
[561] Kenn Gerdes et al (2012) Bacterial persistence and toxin-antitoxin loci. Annual review of microbiology. 66:103-23. [PudMed:22994490]
[562] Laurence Van Melderen (2012) GhoSTly bacterial persisters. Nature chemical biology. 8(10):812-3. [PudMed:22987009]
[563] Andreas Bøggild et al (2012) The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity. Structure (London, England : 1993). 20(10):1641-8. [PudMed:22981948]
[564] Xiaoxue Wang et al (2012) A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nature chemical biology. 8(10):855-61. [PudMed:22941047]
[565] Isabella Moll et al (2012) Selective translation during stress in Escherichia coli. Trends in biochemical sciences. 37(11):493-8. [PudMed:22939840]
[566] Véronique Roux et al (2012) Draft genome sequence of Actinomyces massiliensis strain 4401292T. Journal of bacteriology. 194(18):5121. [PudMed:22933754]
[567] Martin J McGavin et al (2012) Evolutionary blueprint for host- and niche-adaptation in Staphylococcus aureus clonal complex CC30. Frontiers in cellular and infection microbiology. 2:48. [PudMed:22919639]
[568] Dhira Satwika et al (2012) Anticodon nuclease encoding virus-like elements in yeast. Applied microbiology and biotechnology. 96(2):345-56. [PudMed:22899498]
[569] Fan Zhang et al (2012) Crystallization and preliminary crystallographic studies of the YafN-YafO complex from Escherichia coli. Acta crystallographica. Section F, Structural biology and crystallization communications. 68(Pt 8):894-7. [PudMed:22869116]
[570] Cyrielle I Kint et al (2012) The Escherichia coli GTPase ObgE modulates hydroxyl radical levels in response to DNA replication fork arrest. The FEBS journal. 279(19):3692-3704. [PudMed:22863262]
[571] Sabina Leanti La Rosa et al (2012) Construction and application of a luxABCDE reporter system for real-time monitoring of Enterococcus faecalis gene expression and growth. Applied and environmental microbiology. 78(19):7003-11. [PudMed:22843522]
[572] Arti Tripathi et al (2012) Additional role for the ccd operon of F-plasmid as a transmissible persistence factor. Proceedings of the National Academy of Sciences of the United States of America. 109(31):12497-502. [PudMed:22802647]
[573] Daniel J Rankin et al (2012) The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict. Proceedings. Biological sciences. 279(1743):3706-15. [PudMed:22787022]
[574] Michael S M Brouwer et al (2012) In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes. Mobile genetic elements. 2(1):8-12. [PudMed:22754747]
[575] Luiz Carlos Bertucci Barbosa et al (2012) Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases. European journal of medicinal chemistry. 54:591-6. [PudMed:22749642]
[576] Lígia S Muranaka et al (2012) Global expression profile of biofilm resistance to antimicrobial compounds in the plant-pathogenic bacterium Xylella fastidiosa reveals evidence of persister cells. Journal of bacteriology. 194(17):4561-9. [PudMed:22730126]
[577] Sonja Hansen et al (2012) Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis. PloS one. 7(6):e39185. [PudMed:22720069]
[578] Yann G J Sterckx et al (2012) The ParE2-PaaA2 toxin-antitoxin complex from Escherichia coli O157 forms a heterodocecamer in solution and in the crystal. Acta crystallographica. Section F, Structural biology and crystallization communications. 68(Pt 6):724-9. [PudMed:22684081]
[579] Torill C S Rosvoll et al (2012) Increased high-level gentamicin resistance in invasive Enterococcus faecium is associated with aac(6')Ie-aph(2″)Ia-encoding transferable megaplasmids hosted by major hospital-adapted lineages. FEMS immunology and medical microbiology. 66(2):166-76. [PudMed:22672387]
[580] Rachel S Koh et al (2012) Modeling suggests that gene circuit architecture controls phenotypic variability in a bacterial persistence network. BMC systems biology. 6:47. [PudMed:22607777]
[581] Natalie De Jonge et al (2012) Alternative interactions define gyrase specificity in the CcdB family. Molecular microbiology. 84(5):965-78. [PudMed:22582791]
[582] Francesca P Rothenbacher et al (2012) Clostridium difficile MazF toxin exhibits selective, not global, mRNA cleavage. Journal of bacteriology. 194(13):3464-74. [PudMed:22544268]
[583] Joanna L McKenzie et al (2012) Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry. RNA (New York, N.Y.). 18(6):1267-78. [PudMed:22539524]
[584] Fay E Dawes et al (2012) Molecular characterization of a 21.4 kilobase antibiotic resistance plasmid from an α-hemolytic Escherichia coli O108:H- human clinical isolate. PloS one. 7(4):e34718. [PudMed:22532831]
[585] Hisako Masuda et al (2012) YeeU enhances the bundling of cytoskeletal polymers of MreB and FtsZ, antagonizing the CbtA (YeeV) toxicity in Escherichia coli. Molecular microbiology. 84(5):979-89. [PudMed:22515815]
[586] Mohammad Adnan Syed et al (2012) Chromosomal bacterial type II toxin-antitoxin systems. Canadian journal of microbiology. 58(5):553-62. [PudMed:22506850]
[587] Ilaria Cataudella et al (2012) Conditional cooperativity in toxin-antitoxin regulation prevents random toxin activation and promotes fast translational recovery. Nucleic acids research. 40(14):6424-34. [PudMed:22495927]
[588] Bongsoo Lee et al (2012) Myxococcus xanthus developmental cell fate production: heterogeneous accumulation of developmental regulatory proteins and reexamination of the role of MazF in developmental lysis. Journal of bacteriology. 194(12):3058-68. [PudMed:22493014]
[589] Inma Moreno-Córdoba et al (2012) The toxin-antitoxin proteins relBE2Spn of Streptococcus pneumoniae: characterization and association to their DNA target. Proteins. 80(7):1834-46. [PudMed:22488579]
[590] Jung-Ho Park et al (2012) Intramolecular regulation of the sequence-specific mRNA interferase activity of MazF fused to a MazE fragment with a linker cleavable by specific proteases. Applied and environmental microbiology. 78(11):3794-9. [PudMed:22447587]
[591] Julia J Williams et al (2012) Artificial activation of toxin-antitoxin systems as an antibacterial strategy. Trends in microbiology. 20(6):291-8. [PudMed:22445361]
[592] Tim R Blower et al (2012) Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes. Nucleic acids research. 40(13):6158-73. [PudMed:22434880]
[593] Laura Sevillano et al (2012) Identification of the first functional toxin-antitoxin system in Streptomyces. PloS one. 7(3):e32977. [PudMed:22431991]
[594] Susan D Cline et al (2012) Regulation of the vapBC-1 toxin-antitoxin locus in nontypeable Haemophilus influenzae. PloS one. 7(3):e32199. [PudMed:22427824]
[595] Ariel Erental et al (2012) Two programmed cell death systems in Escherichia coli: an apoptotic-like death is inhibited by the mazEF-mediated death pathway. PLoS biology. 10(3):e1001281. [PudMed:22412352]
[596] Yuichi Otsuka et al (2012) Dmd of bacteriophage T4 functions as an antitoxin against Escherichia coli LsoA and RnlA toxins. Molecular microbiology. 83(4):669-81. [PudMed:22403819]
[597] Ying Zhang et al (2012) Targeting persisters for tuberculosis control. Antimicrobial agents and chemotherapy. 56(5):2223-30. [PudMed:22391538]
[598] K Georgiades (2012) Genomics of epidemic pathogens. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 18(3):213-7. [PudMed:22369153]
[599] Joanna L McKenzie et al (2012) A VapBC toxin-antitoxin module is a posttranscriptional regulator of metabolic flux in mycobacteria. Journal of bacteriology. 194(9):2189-204. [PudMed:22366418]
[600] Vincent Leung et al (2012) A stress-inducible quorum-sensing peptide mediates the formation of persister cells with noninherited multidrug tolerance. Journal of bacteriology. 194(9):2265-74. [PudMed:22366415]
[601] Assaf Shapira et al (2012) Removal of hepatitis C virus-infected cells by a zymogenized bacterial toxin. PloS one. 7(2):e32320. [PudMed:22359682]
[602] Jared D Sharp et al (2012) Growth and translation inhibition through sequence-specific RNA binding by Mycobacterium tuberculosis VapC toxin. The Journal of biological chemistry. 287(16):12835-47. [PudMed:22354968]
[603] Kevin S Lang et al (2012) Transcriptome mapping of pAR060302, a blaCMY-2-positive broad-host-range IncA/C plasmid. Applied and environmental microbiology. 78(9):3379-86. [PudMed:22344651]
[604] Brook E Heaton et al (2012) Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus. The Journal of biological chemistry. 287(15):12098-110. [PudMed:22334680]
[605] Benedikt M Beckmann et al (2012) A pRNA-induced structural rearrangement triggers 6S-1 RNA release from RNA polymerase in Bacillus subtilis. The EMBO journal. 31(7):1727-38. [PudMed:22333917]
[606] Iwona Brzozowska et al (2012) Functioning of the TA cassette of streptococcal plasmid pSM19035 in various Gram-positive bacteria. Plasmid. 68(1):51-60. [PudMed:22309878]
[607] Kristoffer S Winther et al (2012) Regulation of enteric vapBC transcription: induction by VapC toxin dimer-breaking. Nucleic acids research. 40(10):4347-57. [PudMed:22287572]
[608] Francesca L Short et al (2012) A promiscuous antitoxin of bacteriophage T4 ensures successful viral replication. Molecular microbiology. 83(4):665-8. [PudMed:22283468]
[609] Julija Armalyte et al (2012) Characterization of Escherichia coli dinJ-yafQ toxin-antitoxin system using insights from mutagenesis data. Journal of bacteriology. 194(6):1523-32. [PudMed:22247505]
[610] Ae-Ran Kwon et al (2012) Structural and biochemical characterization of HP0315 from Helicobacter pylori as a VapD protein with an endoribonuclease activity. Nucleic acids research. 40(9):4216-28. [PudMed:22241770]
[611] Hisako Masuda et al (2012) A novel membrane-bound toxin for cell division, CptA (YgfX), inhibits polymerization of cytoskeleton proteins, FtsZ and MreB, in Escherichia coli. FEMS microbiology letters. 328(2):174-81. [PudMed:22239607]
[612] Natalie Jahn et al (2012) BsrG/SR4 from Bacillus subtilis--the first temperature-dependent type I toxin-antitoxin system. Molecular microbiology. 83(3):579-98. [PudMed:22229825]
[613] Naoto Ohtani et al (2012) The third plasmid pVV8 from Thermus thermophilus HB8: isolation, characterization, and sequence determination. Extremophiles : life under extreme conditions. 16(2):237-44. [PudMed:22212656]
[614] Yosuke Tashiro et al (2012) RelE-mediated dormancy is enhanced at high cell density in Escherichia coli. Journal of bacteriology. 194(5):1169-76. [PudMed:22210768]
[615] Laura E Holberger et al (2012) A novel family of toxin/antitoxin proteins in Bacillus species. FEBS letters. 586(2):132-6. [PudMed:22200572]
[616] Rebekah Frampton et al (2012) Toxin-antitoxin systems of Mycobacterium smegmatis are essential for cell survival. The Journal of biological chemistry. 287(8):5340-56. [PudMed:22199354]
[617] Nour Sayed et al (2011) A cis-antisense RNA acts in trans in Staphylococcus aureus to control translation of a human cytolytic peptide. Nature structural & molecular biology. 19(1):105-12. [PudMed:22198463]
[618] María J Maté et al (2012) Crystal structure of the DNA-bound VapBC2 antitoxin/toxin pair from Rickettsia felis. Nucleic acids research. 40(7):3245-58. [PudMed:22140099]
[619] Lukasz Dziewit et al (2011) Functional characterization of the type II PamI restriction-modification system derived from plasmid pAMI7 of Paracoccus aminophilus JCM 7686. FEMS microbiology letters. 324(1):56-63. [PudMed:22092764]
[620] Ying Hu et al (2012) Antitoxin DinJ influences the general stress response through transcript stabilizer CspE. Environmental microbiology. 14(3):669-79. [PudMed:22026739]
[621] Jeffrey B Locke et al (2012) Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05. Antimicrobial agents and chemotherapy. 56(1):332-40. [PudMed:22024827]
[622] Degang Ning et al (2011) The proteolytic activation of the relNEs (ssr1114/slr0664) toxin-antitoxin system by both proteases Lons and ClpP2s/Xs of Synechocystis sp. PCC 6803. Current microbiology. 63(5):496-502. [PudMed:21909782]
[623] Min Woo Lee et al (2012) Xylella fastidiosa plasmid-encoded PemK toxin is an endoribonuclease. Phytopathology. 102(1):32-40. [PudMed:21864087]
[624] Yukari Maezato et al (2011) VapC6, a ribonucleolytic toxin regulates thermophilicity in the crenarchaeote Sulfolobus solfataricus. RNA (New York, N.Y.). 17(7):1381-92. [PudMed:21622901]
[625] Maria Belitsky et al (2011) The Escherichia coli extracellular death factor EDF induces the endoribonucleolytic activities of the toxins MazF and ChpBK. Molecular cell. 41(6):625-35. [PudMed:21419338]
[626] Ming-Xi Hu et al (2010) Recent advancements in toxin and antitoxin systems involved in bacterial programmed cell death. International journal of microbiology. 2010:781430. [PudMed:21253538]
[627] Tim R Blower et al (2011) A processed noncoding RNA regulates an altruistic bacterial antiviral system. Nature structural & molecular biology. 18(2):185-90. [PudMed:21240270]
[628] Mohammad Adnan Syed et al (2011) The chromosomal mazEF locus of Streptococcus mutans encodes a functional type II toxin-antitoxin addiction system. Journal of bacteriology. 193(5):1122-30. [PudMed:21183668]
[629] Kyung-Doo Han et al (2011) Functional identification of toxin-antitoxin molecules from Helicobacter pylori 26695 and structural elucidation of the molecular interactions. The Journal of biological chemistry. 286(6):4842-53. [PudMed:21123184]
[630] Jie Yuan et al (2011) The three vibrio cholerae chromosome II-encoded ParE toxins degrade chromosome I following loss of chromosome II. Journal of bacteriology. 193(3):611-9. [PudMed:21115657]
[631] Xiulin Han et al (2011) The role of Escherichia coli YrbB in the lethal action of quinolones. The Journal of antimicrobial chemotherapy. 66(2):323-31. [PudMed:21098540]
[632] Vickery L Arcus et al (2011) The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array. Protein engineering, design & selection : PEDS. 24(1-2):33-40. [PudMed:21036780]
[633] Elizabeth M Halvorsen et al (2011) Txe, an endoribonuclease of the enterococcal Axe-Txe toxin-antitoxin system, cleaves mRNA and inhibits protein synthesis. Microbiology (Reading, England). 157(Pt 2):387-397. [PudMed:21030436]
[634] Mitsunori Koga et al (2011) Escherichia coli rnlA and rnlB compose a novel toxin-antitoxin system. Genetics. 187(1):123-30. [PudMed:20980243]
[635] Luiz Carlos Bertucci Barbosa et al (2010) Function inferences from a molecular structural model of bacterial ParE toxin. Bioinformation. 4(10):438-40. [PudMed:20975905]
[636] Jie Yuan et al (2010) Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors. The Journal of biological chemistry. 285(51):40397-408. [PudMed:20952390]
[637] Min Woo Lee et al (2010) Functional characterization of replication and stability factors of an incompatibility group P-1 plasmid from Xylella fastidiosa. Applied and environmental microbiology. 76(23):7734-40. [PudMed:20935126]
[638] Stanislava Rešetárová et al (2010) Expression and localization of SpoIISA toxin during the life cycle of Bacillus subtilis. Research in microbiology. 161(9):750-6. [PudMed:20863891]
[639] Breann L Brown et al (2010) Preliminary crystallographic analysis of the Escherichia coli antitoxin MqsA (YgiT/b3021) in complex with mqsRA promoter DNA. Acta crystallographica. Section F, Structural biology and crystallization communications. 66(Pt 9):1060-3. [PudMed:20823526]
[640] Guillaume Cambray et al (2010) Integrons. Annual review of genetics. 44:141-66. [PudMed:20707672]
[641] Jeong-Sun Han et al (2010) Characterization of a chromosomal toxin-antitoxin, Rv1102c-Rv1103c system in Mycobacterium tuberculosis. Biochemical and biophysical research communications. 400(3):293-8. [PudMed:20705052]
[642] Mark A Arbing et al (2010) Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems. Structure (London, England : 1993). 18(8):996-1010. [PudMed:20696400]
[643] Sen Ye et al (2010) [The interaction between chromosome-encoded toxin Slr0664 and antitoxin Slr1114 of cyanobacteria Synechocystis sp. PCC6803]. Wei sheng wu xue bao = Acta microbiologica Sinica. 50(6):743-8. [PudMed:20687338]
[644] Eitan Rotem et al (2010) Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence. Proceedings of the National Academy of Sciences of the United States of America. 107(28):12541-6. [PudMed:20616060]
[645] Concha Nieto et al (2010) The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates. PloS one. 5(6):e11289. [PudMed:20585658]
[646] Amanda S Fivian-Hughes et al (2010) Analyzing the regulatory role of the HigA antitoxin within Mycobacterium tuberculosis. Journal of bacteriology. 192(17):4348-56. [PudMed:20585061]
[647] Elizabeth Diago-Navarro et al (2010) parD toxin-antitoxin system of plasmid R1--basic contributions, biotechnological applications and relationships with closely-related toxin-antitoxin systems. The FEBS journal. 277(15):3097-117. [PudMed:20569269]
[648] Kim Lewis (2010) Persister cells. Annual review of microbiology. 64:357-72. [PudMed:20528688]
[649] Tim F Cooper et al (2010) Within-host competition selects for plasmid-encoded toxin-antitoxin systems. Proceedings. Biological sciences. 277(1697):3149-55. [PudMed:20504809]
[650] Min Yang et al (2010) Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules. PloS one. 5(5):e10672. [PudMed:20498855]
[651] Amy S Gargis et al (2010) Complete nucleotide sequences of plasmids pACK1 and pACK3 from Staphylococcus simulans biovar staphylolyticus. Plasmid. 64(2):104-9. [PudMed:20493903]
[652] Aretha Fiebig et al (2010) Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems. Molecular microbiology. 77(1):236-51. [PudMed:20487277]
[653] Céline Goulard et al (2010) The Yersinia pestis chromosome encodes active addiction toxins. Journal of bacteriology. 192(14):3669-77. [PudMed:20472800]
[654] Hannes Mutschler et al (2010) Assembly dynamics and stability of the pneumococcal epsilon zeta antitoxin toxin (PezAT) system from Streptococcus pneumoniae. The Journal of biological chemistry. 285(28):21797-806. [PudMed:20442221]
[655] Virginia S Lioy et al (2010) Plasmid pSM19035, a model to study stable maintenance in Firmicutes. Plasmid. 64(1):1-17. [PudMed:20403380]
[656] Paul S Miclea et al (2010) Atypical transcriptional regulation and role of a new toxin-antitoxin-like module and its effect on the lipid composition of Bradyrhizobium japonicum. Molecular plant-microbe interactions : MPMI. 23(5):638-50. [PudMed:20367472]
[657] Régis Hallez et al (2010) New toxins homologous to ParE belonging to three-component toxin-antitoxin systems in Escherichia coli O157:H7. Molecular microbiology. 76(3):719-32. [PudMed:20345661]
[658] Villu Kasari et al (2010) The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. Journal of bacteriology. 192(11):2908-19. [PudMed:20233923]
[659] Li-Ling Hu et al (2010) The use of the ccdB lethal gene for constructing a zero background vector in order to clone blunt-end PCR products. Molekuliarnaia biologiia. 44(1):174-6. [PudMed:20198872]
[660] Cynthia M Sharma et al (2010) The primary transcriptome of the major human pathogen Helicobacter pylori. Nature. 464(7286):250-5. [PudMed:20164839]
[661] Elizabeth M Fozo et al (2010) Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic acids research. 38(11):3743-59. [PudMed:20156992]
[662] Kevin M Dalton et al (2010) A conserved mode of protein recognition and binding in a ParD-ParE toxin-antitoxin complex. Biochemistry. 49(10):2205-15. [PudMed:20143871]
[663] Abel Garcia-Pino et al (2010) Purification and crystallization of Phd, the antitoxin of the phd/doc operon. Acta crystallographica. Section F, Structural biology and crystallization communications. 66(Pt 2):167-71. [PudMed:20124714]
[664] Younghoon Kim et al (2010) Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environmental microbiology. 12(5):1105-21. [PudMed:20105222]
[665] Brian V Jones et al (2010) Comparative metagenomic analysis of plasmid encoded functions in the human gut microbiome. BMC genomics. 11:46. [PudMed:20085629]
[666] Mariana Gallo et al (2010) A new member of the ribbon-helix-helix transcription factor superfamily from the plant pathogen Xanthomonas axonopodis pv.citri. Journal of structural biology. 170(1):21-31. [PudMed:20060909]
[667] Breann L Brown et al (2009) Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. PLoS pathogens. 5(12):e1000706. [PudMed:20041169]
[668] Niles P Donegan et al (2010) Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcus aureus. Journal of bacteriology. 192(5):1416-22. [PudMed:20038589]
[669] Shivangi Agarwal et al (2010) PemK toxin of Bacillus anthracis is a ribonuclease: an insight into its active site, structure, and function. The Journal of biological chemistry. 285(10):7254-70. [PudMed:20022964]
[670] Torill C S Rosvoll et al (2010) PCR-based plasmid typing in Enterococcus faecium strains reveals widely distributed pRE25-, pRUM-, pIP501- and pHTbeta-related replicons associated with glycopeptide resistance and stabilizing toxin-antitoxin systems. FEMS immunology and medical microbiology. 58(2):254-68. [PudMed:20015231]
[671] Holly R Ramage et al (2009) Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS genetics. 5(12):e1000767. [PudMed:20011113]
[672] Cajetan Neubauer et al (2009) The structural basis for mRNA recognition and cleavage by the ribosome-dependent endonuclease RelE. Cell. 139(6):1084-95. [PudMed:20005802]
[673] Natalie De Jonge et al (2010) Structural and thermodynamic characterization of Vibrio fischeri CcdB. The Journal of biological chemistry. 285(8):5606-13. [PudMed:19959472]
[674] Mikkel Christensen-Dalsgaard et al (2010) Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Molecular microbiology. 75(2):333-48. [PudMed:19943910]
[675] Larissa A Singletary et al (2009) An SOS-regulated type 2 toxin-antitoxin system. Journal of bacteriology. 191(24):7456-65. [PudMed:19837801]
[676] Daniela Lepka et al (2009) Adding to Yersinia enterocolitica gene pool diversity: two cryptic plasmids from a biotype 1A isolate. Journal of biomedicine & biotechnology. 2009:398434. [PudMed:19834620]
[677] Virginia S Lioy et al (2010) A toxin-antitoxin module as a target for antimicrobial development. Plasmid. 63(1):31-9. [PudMed:19800365]
[678] Teresa Nogueira et al (2009) Horizontal gene transfer of the secretome drives the evolution of bacterial cooperation and virulence. Current biology : CB. 19(20):1683-91. [PudMed:19800234]
[679] Martin Overgaard et al (2009) RelB and RelE of Escherichia coli form a tight complex that represses transcription via the ribbon-helix-helix motif in RelB. Journal of molecular biology. 394(2):183-96. [PudMed:19747491]
[680] Djordje Francuski et al (2009) Crystal structure of the antitoxin-toxin protein complex RelB-RelE from Methanococcus jannaschii. Journal of molecular biology. 393(4):898-908. [PudMed:19712680]
[681] Ilana Kolodkin-Gal et al (2009) A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation. PloS one. 4(8):e6785. [PudMed:19707553]
[682] Natalie De Jonge et al (2009) Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain. Molecular cell. 35(2):154-63. [PudMed:19647513]
[683] Hanna Engelberg-Kulka et al (2009) Activation of a built-in bacterial programmed cell death system as a novel mechanism of action of some antibiotics. Communicative & integrative biology. 2(3):211-2. [PudMed:19641731]
[684] Michal Respondek et al (2009) Sequence-specific 1H, 15N and 13C resonance assignments of the 23.7-kDa homodimeric toxin CcdB from Vibrio fischeri. Biomolecular NMR assignments. 3(1):145-7. [PudMed:19636967]
[685] T R Blower et al (2009) Mutagenesis and functional characterization of the RNA and protein components of the toxIN abortive infection and toxin-antitoxin locus of Erwinia. Journal of bacteriology. 191(19):6029-39. [PudMed:19633081]
[686] Satoshi Yoshizumi et al (2009) Staphylococcus aureus YoeB homologues inhibit translation initiation. Journal of bacteriology. 191(18):5868-72. [PudMed:19581360]
[687] Igor Drobnak et al (2009) Energetics of MazG unfolding in correlation with its structural features. Journal of molecular biology. 392(1):63-74. [PudMed:19523960]
[688] Patricia Romero et al (2009) Comparative genomic analysis of ten Streptococcus pneumoniae temperate bacteriophages. Journal of bacteriology. 191(15):4854-62. [PudMed:19502408]
[689] Kira S Makarova et al (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biology direct. 4:19. [PudMed:19493340]
[690] W Florian Fricke et al (2009) Comparative genomics of the IncA/C multidrug resistance plasmid family. Journal of bacteriology. 191(15):4750-7. [PudMed:19482926]
[691] Gwynneth F Matcher et al (2009) The effect of the location of the proteic post-segregational stability system within the replicon of plasmid pTF-FC2 on the fine regulation of plasmid replication. Plasmid. 62(2):98-107. [PudMed:19481568]
[692] Mario Simic et al (2009) Driving forces of gyrase recognition by the addiction toxin CcdB. The Journal of biological chemistry. 284(30):20002-10. [PudMed:19465484]
[693] Jennifer Robson et al (2009) The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation. Journal of molecular biology. 390(3):353-67. [PudMed:19445953]
[694] Jennifer M Hurley et al (2009) Bacterial toxin HigB associates with ribosomes and mediates translation-dependent mRNA cleavage at A-rich sites. The Journal of biological chemistry. 284(28):18605-13. [PudMed:19423702]
[695] Kristoffer S Winther et al (2009) Ectopic production of VapCs from Enterobacteria inhibits translation and trans-activates YoeB mRNA interferase. Molecular microbiology. 72(4):918-30. [PudMed:19400780]
[696] Urszula Zielenkiewicz et al (2009) In vivo interactions between toxin-antitoxin proteins epsilon and zeta of streptococcal plasmid pSM19035 in Saccharomyces cerevisiae. Journal of bacteriology. 191(11):3677-84. [PudMed:19346303]
[697] Rachel A F Wozniak et al (2009) A toxin-antitoxin system promotes the maintenance of an integrative conjugative element. PLoS genetics. 5(3):e1000439. [PudMed:19325886]
[698] Laurence Van Melderen et al (2009) Bacterial toxin-antitoxin systems: more than selfish entities? PLoS genetics. 5(3):e1000437. [PudMed:19325885]
[699] Joe J Harrison et al (2009) The chromosomal toxin gene yafQ is a determinant of multidrug tolerance for Escherichia coli growing in a biofilm. Antimicrobial agents and chemotherapy. 53(6):2253-8. [PudMed:19307375]
[700] Shahar Amitai et al (2009) Escherichia coli MazF leads to the simultaneous selective synthesis of both "death proteins" and "survival proteins". PLoS genetics. 5(3):e1000390. [PudMed:19282968]
[701] Ling Zhu et al (2009) Staphylococcus aureus MazF specifically cleaves a pentad sequence, UACAU, which is unusually abundant in the mRNA for pathogenic adhesive factor SraP. Journal of bacteriology. 191(10):3248-55. [PudMed:19251861]
[702] Ilana Kolodkin-Gal et al (2009) The stationary-phase sigma factor sigma(S) is responsible for the resistance of Escherichia coli stationary-phase cells to mazEF-mediated cell death. Journal of bacteriology. 191(9):3177-82. [PudMed:19251848]
[703] Meredith H Prysak et al (2009) Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage. Molecular microbiology. 71(5):1071-87. [PudMed:19210620]
[704] Natacha Mine et al (2009) The decay of the chromosomally encoded ccdO157 toxin-antitoxin system in the Escherichia coli species. Genetics. 181(4):1557-66. [PudMed:19189956]
[705] Niles P Donegan et al (2009) Regulation of the mazEF toxin-antitoxin module in Staphylococcus aureus and its impact on sigB expression. Journal of bacteriology. 191(8):2795-805. [PudMed:19181798]
[706] R Jayaraman (2008) Bacterial persistence: some new insights into an old phenomenon. Journal of biosciences. 33(5):795-805. [PudMed:19179767]
[707] Zhibiao Fu et al (2009) Overexpression of MazFsa in Staphylococcus aureus induces bacteriostasis by selectively targeting mRNAs for cleavage. Journal of bacteriology. 191(7):2051-9. [PudMed:19168622]
[708] Mikkel Christensen-Dalsgaard et al (2008) RNA decay by messenger RNA interferases. Methods in enzymology. 447:521-35. [PudMed:19161859]
[709] Maria A Schumacher et al (2009) Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science (New York, N.Y.). 323(5912):396-401. [PudMed:19150849]
[710] Charlotte R Cooper et al (2009) Role of vapBC toxin-antitoxin loci in the thermal stress response of Sulfolobus solfataricus. Biochemical Society transactions. 37(Pt 1):123-6. [PudMed:19143615]
[711] Hiroaki Kawano et al (2009) Long-term survival of Escherichia coli lacking the HipBA toxin-antitoxin system during prolonged cultivation. Bioscience, biotechnology, and biochemistry. 73(1):117-23. [PudMed:19129642]
[712] Peter C Fineran et al (2009) The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair. Proceedings of the National Academy of Sciences of the United States of America. 106(3):894-9. [PudMed:19124776]
[713] Yonglong Zhang et al (2009) The inhibitory mechanism of protein synthesis by YoeB, an Escherichia coli toxin. The Journal of biological chemistry. 284(11):6627-38. [PudMed:19124462]
[714] Shaleen B Korch et al (2009) Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibit mycobacterial growth and are expressed in infected human macrophages. Journal of bacteriology. 191(5):1618-30. [PudMed:19114484]
[715] Sonia Shokeen et al (2009) An intramolecular upstream helix ensures the stability of a toxin-encoding RNA in Enterococcus faecalis. Journal of bacteriology. 191(5):1528-36. [PudMed:19103923]
[716] Ilana Kolodkin-Gal et al (2008) The communication factor EDF and the toxin-antitoxin module mazEF determine the mode of action of antibiotics. PLoS biology. 6(12):e319. [PudMed:19090622]
[717] M Ahmadi et al (2007) The effect of heat stress on the antibacterial resistance and plasmid profile in Escherichia coli isolates. Pakistan journal of biological sciences : PJBS. 10(23):4261-5. [PudMed:19086582]
[718] Mikkel G Jørgensen et al (2009) HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea. Journal of bacteriology. 191(4):1191-9. [PudMed:19060138]
[719] Elizabeth M Fozo et al (2008) Small toxic proteins and the antisense RNAs that repress them. Microbiology and molecular biology reviews : MMBR. 72(4):579-89, Table of Contents. [PudMed:19052321]
[720] Elizabeth Diago-Navarro et al (2009) Novel Escherichia coli RF1 mutants with decreased translation termination activity and increased sensitivity to the cytotoxic effect of the bacterial toxins Kid and RelE. Molecular microbiology. 71(1):66-78. [PudMed:19019162]
[721] Amita Gupta (2009) Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis. FEMS microbiology letters. 290(1):45-53. [PudMed:19016878]
[722] Kanika Bajaj et al (2008) Structural correlates of the temperature sensitive phenotype derived from saturation mutagenesis studies of CcdB. Biochemistry. 47(49):12964-73. [PudMed:19006334]
[723] Abel Garcia-Pino et al (2008) Crystallization of Doc and the Phd-Doc toxin-antitoxin complex. Acta crystallographica. Section F, Structural biology and crystallization communications. 64(Pt 11):1034-8. [PudMed:18997335]
[724] Xiaojin Liu et al (2008) Genetic characterization of two putative toxin-antitoxin systems on cryptic plasmids from Bacillus thuringiensis strain YBT-1520. Journal of microbiology and biotechnology. 18(10):1630-3. [PudMed:18955810]
[725] Linda Miallau et al (2009) Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. The Journal of biological chemistry. 284(1):276-283. [PudMed:18952600]
[726] Eliane Trovatti et al (2008) Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases. Bioorganic & medicinal chemistry letters. 18(23):6161-4. [PudMed:18938079]
[727] Mikkel Christensen-Dalsgaard et al (2008) Translation affects YoeB and MazF messenger RNA interferase activities by different mechanisms. Nucleic acids research. 36(20):6472-81. [PudMed:18854355]
[728] Ana Herrero et al (2008) Characterization of pUO-StVR2, a virulence-resistance plasmid evolved from the pSLT virulence plasmid of Salmonella enterica serovar Typhimurium. Antimicrobial agents and chemotherapy. 52(12):4514-7. [PudMed:18852276]
[729] Pramod Kumar et al (2008) Crystal structure of Mycobacterium tuberculosis YefM antitoxin reveals that it is not an intrinsically unstructured protein. Journal of molecular biology. 383(3):482-93. [PudMed:18793646]
[730] Abel Garcia-Pino et al (2008) Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation. The Journal of biological chemistry. 283(45):30821-7. [PudMed:18757857]
[731] Lin Cheng et al (2008) A novel toxin-antitoxin operon talA/B from the Gram-positive bacterium Leifsonia xyli subsp. cynodontis. FEBS letters. 582(21-22):3211-6. [PudMed:18722371]
[732] Elizabeth M Fozo et al (2008) Repression of small toxic protein synthesis by the Sib and OhsC small RNAs. Molecular microbiology. 70(5):1076-93. [PudMed:18710431]
[733] Wenyi Zhang et al (2008) Complete nucleotide sequence of plasmid plca36 isolated from Lactobacillus casei Zhang. Plasmid. 60(2):131-5. [PudMed:18634821]
[734] Leo L Chan et al (2008) A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors. ACS chemical biology. 3(7):437-48. [PudMed:18582039]
[735] Julien Guglielmini et al (2008) Automated discovery and phylogenetic analysis of new toxin-antitoxin systems. BMC microbiology. 8:104. [PudMed:18578869]
[736] Ya-Li Shi et al (2008) [RelE toxin protein of Mycobacterium tuberculosis induces growth inhibition of lung cancer A-549 cell]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 39(3):368-72. [PudMed:18575317]
[737] Martin Overgaard et al (2008) Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity. Molecular microbiology. 69(4):841-57. [PudMed:18532983]
[738] H Sletvold et al (2008) Complete sequence of Enterococcus faecium pVEF3 and the detection of an omega-epsilon-zeta toxin-antitoxin module and an ABC transporter. Plasmid. 60(1):75-85. [PudMed:18511120]
[739] Guang-Yao Li et al (2008) Structural mechanism of transcriptional autorepression of the Escherichia coli RelB/RelE antitoxin/toxin module. Journal of molecular biology. 380(1):107-19. [PudMed:18501926]
[740] Bruno Périchon et al (2008) Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosides by 16S rRNA methylation and to hydrophilic fluoroquinolones by efflux. Antimicrobial agents and chemotherapy. 52(7):2581-92. [PudMed:18458128]
[741] Manuel Saavedra De Bast et al (2008) Chromosomal toxin-antitoxin systems may act as antiaddiction modules. Journal of bacteriology. 190(13):4603-9. [PudMed:18441063]
[742] Mohan Liu et al (2008) Bacterial addiction module toxin Doc inhibits translation elongation through its association with the 30S ribosomal subunit. Proceedings of the National Academy of Sciences of the United States of America. 105(15):5885-90. [PudMed:18398006]
[743] Fang Fang et al (2008) Characterization of endogenous plasmids from Lactobacillus salivarius UCC118. Applied and environmental microbiology. 74(10):3216-28. [PudMed:18390685]
[744] Sujin Lee et al (2008) Crystal structure of Escherichia coli MazG, the regulator of nutritional stress response. The Journal of biological chemistry. 283(22):15232-40. [PudMed:18353782]
[745] Ilana Kolodkin-Gal et al (2008) The extracellular death factor: physiological and genetic factors influencing its production and response in Escherichia coli. Journal of bacteriology. 190(9):3169-75. [PudMed:18310334]
[746] Xia Li et al (2008) Cleavage of mRNAs and role of tmRNA system under amino acid starvation in Escherichia coli. Molecular microbiology. 68(2):462-73. [PudMed:18284591]
[747] Longxuan Zhao et al (2008) Biochemical characterization of a chromosomal toxin-antitoxin system in Mycobacterium tuberculosis. FEBS letters. 582(5):710-4. [PudMed:18258191]
[748] Hirofumi Nariya et al (2008) MazF, an mRNA interferase, mediates programmed cell death during multicellular Myxococcus development. Cell. 132(1):55-66. [PudMed:18191220]
[749] Patrik Florek et al (2008) Expression of functional Bacillus SpoIISAB toxin-antitoxin modules in Escherichia coli. FEMS microbiology letters. 278(2):177-84. [PudMed:18096016]
[750] Kanika Bajaj et al (2007) Stereochemical criteria for prediction of the effects of proline mutations on protein stability. PLoS computational biology. 3(12):e241. [PudMed:18069886]
[751] Ilana Kolodkin-Gal et al (2007) A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli. Science (New York, N.Y.). 318(5850):652-5. [PudMed:17962566]
[752] Zhibiao Fu et al (2007) Characterization of MazFSa, an endoribonuclease from Staphylococcus aureus. Journal of bacteriology. 189(24):8871-9. [PudMed:17933891]
[753] Izhack Cherny et al (2007) Structural and thermodynamic characterization of the Escherichia coli RelBE toxin-antitoxin system: indication for a functional role of differential stability. Biochemistry. 46(43):12152-63. [PudMed:17924660]
[754] Oliver Schmidt et al (2007) prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli. Journal of molecular biology. 372(4):894-905. [PudMed:17706670]
[755] Nora R Wang et al (2007) A continuous fluorometric assay for the assessment of MazF ribonuclease activity. Analytical biochemistry. 371(2):173-83. [PudMed:17706586]
[756] Emeric W Sevin et al (2007) RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes. Genome biology. 8(8):R155. [PudMed:17678530]
[757] Monika Oberer et al (2007) The solution structure of ParD, the antidote of the ParDE toxin antitoxin module, provides the structural basis for DNA and toxin binding. Protein science : a publication of the Protein Society. 16(8):1676-88. [PudMed:17656583]
[758] Paul Carroll et al (2007) Expression of Mycobacterium tuberculosis Rv1991c using an arabinose-inducible promoter demonstrates its role as a toxin. FEMS microbiology letters. 274(1):73-82. [PudMed:17623030]
[759] Virginie Tsilibaris et al (2007) What is the benefit to Escherichia coli of having multiple toxin-antitoxin systems in its genome? Journal of bacteriology. 189(17):6101-8. [PudMed:17513477]
[760] Dayle A Daines et al (2007) VapC-1 of nontypeable Haemophilus influenzae is a ribonuclease. Journal of bacteriology. 189(14):5041-8. [PudMed:17496075]
[761] Seok Kooi Khoo et al (2007) Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae. The Journal of biological chemistry. 282(27):19606-18. [PudMed:17488720]
[762] Mitsuoki Kawano et al (2007) An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxin. Molecular microbiology. 64(3):738-54. [PudMed:17462020]
[763] Shivangi Agarwal et al (2007) Identification and characterization of a novel toxin-antitoxin module from Bacillus anthracis. FEBS letters. 581(9):1727-34. [PudMed:17416361]
[764] Natalie De Jonge et al (2007) Purification and crystallization of Vibrio fischeri CcdB and its complexes with fragments of gyrase and CcdA. Acta crystallographica. Section F, Structural biology and crystallization communications. 63(Pt 4):356-60. [PudMed:17401216]
[765] E B O'Connor et al (2007) pEOC01: a plasmid from Pediococcus acidilactici which encodes an identical streptomycin resistance (aadE) gene to that found in Campylobacter jejuni. Plasmid. 58(2):115-26. [PudMed:17395262]
[766] Kenn Gerdes et al (2007) RNA antitoxins. Current opinion in microbiology. 10(2):117-24. [PudMed:17376733]
[767] Barbara O Gvakharia et al (2007) Global transcriptional response of Nitrosomonas europaea to chloroform and chloromethane. Applied and environmental microbiology. 73(10):3440-5. [PudMed:17369330]
[768] Maria C Monti et al (2007) Interactions of Kid-Kis toxin-antitoxin complexes with the parD operator-promoter region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of Kid-Kis oligomers. Nucleic acids research. 35(5):1737-49. [PudMed:17317682]
[769] Monique B Kamphuis et al (2007) Structure and function of bacterial kid-kis and related toxin-antitoxin systems. Protein and peptide letters. 14(2):113-24. [PudMed:17305597]
[770] Rūta Motiejūnaite et al (2007) Escherichia coli dinJ-yafQ genes act as a toxin-antitoxin module. FEMS microbiology letters. 268(1):112-9. [PudMed:17263853]
[771] Myriam Wilbaux et al (2007) Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7. Journal of bacteriology. 189(7):2712-9. [PudMed:17259320]
[772] Zheng-Ling Shang et al (2007) [Molecular cloning and expression of hypothetical proteins Rv1494 and Rv1495 of M.tuberculosis H37Rv strain]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 27(1):15-9. [PudMed:17259135]
[773] Monique B Kamphuis et al (2007) Interactions between the toxin Kid of the bacterial parD system and the antitoxins Kis and MazE. Proteins. 67(1):219-31. [PudMed:17206710]
[774] Elizabeth M Moritz et al (2007) Toxin-antitoxin systems are ubiquitous and plasmid-encoded in vancomycin-resistant enterococci. Proceedings of the National Academy of Sciences of the United States of America. 104(1):311-6. [PudMed:17190821]
[775] Kalyani Mondal et al (2007) Role of stimuli-sensitive polymers in protein refolding: alpha-amylase and CcdB (controller of cell division or death B) as model proteins. Langmuir : the ACS journal of surfaces and colloids. 23(1):70-5. [PudMed:17190487]
[776] Lukasz Dziewit et al (2007) The SXT conjugative element and linear prophage N15 encode toxin-antitoxin-stabilizing systems homologous to the tad-ata module of the Paracoccus aminophilus plasmid pAMI2. Journal of bacteriology. 189(5):1983-97. [PudMed:17158670]
[777] Priya Prakash Budde et al (2007) Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae. Journal of bacteriology. 189(2):491-500. [PudMed:17085558]
[778] Hanna Engelberg-Kulka et al (2006) Bacterial programmed cell death and multicellular behavior in bacteria. PLoS genetics. 2(10):e135. [PudMed:17069462]
[779] Sarah Fico et al (2006) TasA-tasB, a new putative toxin-antitoxin (TA) system from Bacillus thuringiensis pGI1 plasmid is a widely distributed composite mazE-doc TA system. BMC genomics. 7:259. [PudMed:17038198]
[780] Mikkel Christensen-Dalsgaard et al (2006) Two higBA loci in the Vibrio cholerae superintegron encode mRNA cleaving enzymes and can stabilize plasmids. Molecular microbiology. 62(2):397-411. [PudMed:17020579]
[781] Tobias Madl et al (2006) Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA. Journal of molecular biology. 364(2):170-85. [PudMed:17007877]
[782] Andrew B Smith et al (2006) A strand-passage conformation of DNA gyrase is required to allow the bacterial toxin, CcdB, to access its binding site. Nucleic acids research. 34(17):4667-76. [PudMed:16963775]
[783] Kira S Makarova et al (2006) The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria. Bioinformatics (Oxford, England). 22(21):2581-4. [PudMed:16895922]
[784] Virginia S Lioy et al (2006) pSM19035-encoded zeta toxin induces stasis followed by death in a subpopulation of cells. Microbiology (Reading, England). 152(Pt 8):2365-2379. [PudMed:16849801]
[785] Monica Bodogai et al (2006) The ntrPR operon of Sinorhizobium meliloti is organized and functions as a toxin-antitoxin module. Molecular plant-microbe interactions : MPMI. 19(7):811-22. [PudMed:16838793]
[786] Sabrina Tachdjian et al (2006) Dynamic metabolic adjustments and genome plasticity are implicated in the heat shock response of the extremely thermoacidophilic archaeon Sulfolobus solfataricus. Journal of bacteriology. 188(12):4553-9. [PudMed:16740961]
[787] Shaleen B Korch et al (2006) Ectopic overexpression of wild-type and mutant hipA genes in Escherichia coli: effects on macromolecular synthesis and persister formation. Journal of bacteriology. 188(11):3826-36. [PudMed:16707675]
[788] C Cruzeiro-Silva et al (2006) In-Cell NMR spectroscopy: inhibition of autologous protein expression reduces Escherichia coli lysis. Cell biochemistry and biophysics. 44(3):497-502. [PudMed:16679537]
[789] Olga N Umanskaya et al (2006) Inhibition of DNA topoisomerase II may trigger illegitimate recombination in living cells: experiments with a model system. Journal of cellular biochemistry. 99(2):598-608. [PudMed:16676353]
[790] Nora Vázquez-Laslop et al (2006) Increased persistence in Escherichia coli caused by controlled expression of toxins or other unrelated proteins. Journal of bacteriology. 188(10):3494-7. [PudMed:16672603]
[791] Ilana Kolodkin-Gal et al (2006) Induction of Escherichia coli chromosomal mazEF by stressful conditions causes an irreversible loss of viability. Journal of bacteriology. 188(9):3420-3. [PudMed:16621839]
[792] Marisela Aguirre-Ramírez et al (2006) Expression of the F plasmid ccd toxin-antitoxin system in Escherichia coli cells under nutritional stress. Canadian journal of microbiology. 52(1):24-30. [PudMed:16541156]
[793] Lieven Buts et al (2005) Crystallization of the C-terminal domain of the addiction antidote CcdA in complex with its toxin CcdB. Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 10):949-52. [PudMed:16511204]
[794] Veronica G Godoy et al (2006) Y-family DNA polymerases respond to DNA damage-independent inhibition of replication fork progression. The EMBO journal. 25(4):868-79. [PudMed:16482223]
[795] H Ogata et al (2005) Rickettsia felis, from culture to genome sequencing. Annals of the New York Academy of Sciences. 1063:26-34. [PudMed:16481487]
[796] Concha Nieto et al (2006) The chromosomal relBE2 toxin-antitoxin locus of Streptococcus pneumoniae: characterization and use of a bioluminescence resonance energy transfer assay to detect toxin-antitoxin interaction. Molecular microbiology. 59(4):1280-96. [PudMed:16430700]
[797] Monique B Kamphuis et al (2006) Model for RNA binding and the catalytic site of the RNase Kid of the bacterial parD toxin-antitoxin system. Journal of molecular biology. 357(1):115-26. [PudMed:16413033]
[798] Miryam Gross et al (2006) MazG -- a regulator of programmed cell death in Escherichia coli. Molecular microbiology. 59(2):590-601. [PudMed:16390452]
[799] Kanika Bajaj et al (2005) Mutagenesis-based definitions and probes of residue burial in proteins. Proceedings of the National Academy of Sciences of the United States of America. 102(45):16221-6. [PudMed:16251276]
[800] José A C Lemos et al (2005) Characteristics of Streptococcus mutans strains lacking the MazEF and RelBE toxin-antitoxin modules. FEMS microbiology letters. 253(2):251-7. [PudMed:16243456]
[801] Hanna Engelberg-Kulka et al (2005) mazEF: a chromosomal toxin-antitoxin module that triggers programmed cell death in bacteria. Journal of cell science. 118(Pt 19):4327-32. [PudMed:16179604]
[802] Jessica M Silvaggi et al (2005) Small untranslated RNA antitoxin in Bacillus subtilis. Journal of bacteriology. 187(19):6641-50. [PudMed:16166525]
[803] Yan Jiang et al (2005) The complete sequence and analysis of the large virulence plasmid pSS of Shigella sonnei. Plasmid. 54(2):149-59. [PudMed:16122562]
[804] Urszula Zielenkiewicz et al (2005) The toxin-antitoxin system of the streptococcal plasmid pSM19035. Journal of bacteriology. 187(17):6094-105. [PudMed:16109951]
[805] Katsuhiko Kamada et al (2005) Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin. Molecular cell. 19(4):497-509. [PudMed:16109374]
[806] Izhack Cherny et al (2005) The YoeB toxin is a folded protein that forms a physical complex with the unfolded YefM antitoxin. Implications for a structural-based differential stability of toxin-antitoxin systems. The Journal of biological chemistry. 280(34):30063-72. [PudMed:15980067]
[807] Cédric Y Szpirer et al (2005) Separate-component-stabilization system for protein and DNA production without the use of antibiotics. BioTechniques. 38(5):775-81. [PudMed:15945374]
[808] Olivier Pellegrini et al (2005) The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor. Molecular microbiology. 56(5):1139-48. [PudMed:15882409]
[809] Kenn Gerdes et al (2005) Prokaryotic toxin-antitoxin stress response loci. Nature reviews. Microbiology. 3(5):371-82. [PudMed:15864262]
[810] Minh-Hoa Dao-Thi et al (2005) Molecular basis of gyrase poisoning by the addiction toxin CcdB. Journal of molecular biology. 348(5):1091-102. [PudMed:15854646]
[811] Ana J Muñoz-Gómez et al (2005) RNase/anti-RNase activities of the bacterial parD toxin-antitoxin system. Journal of bacteriology. 187(9):3151-7. [PudMed:15838042]
[812] Daniel N Wilson et al (2005) RelBE or not to be. Nature structural & molecular biology. 12(4):282-4. [PudMed:15809644]
[813] Hisanori Takagi et al (2005) Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects. Nature structural & molecular biology. 12(4):327-31. [PudMed:15768033]
[814] Xueyan Zhao et al (2005) Percolation of the phd repressor-operator interface. Journal of bacteriology. 187(6):1901-12. [PudMed:15743936]
[815] Jurij Lah et al (2005) Energetics of structural transitions of the addiction antitoxin MazE: is a programmed bacterial cell death dependent on the intrinsically flexible nature of the antitoxins? The Journal of biological chemistry. 280(17):17397-407. [PudMed:15735309]
[816] Deo Prakash Pandey et al (2005) Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes. Nucleic acids research. 33(3):966-76. [PudMed:15718296]
[817] Elisabeth Sørvig et al (2005) Plasmid p256 from Lactobacillus plantarum represents a new type of replicon in lactic acid bacteria, and contains a toxin-antitoxin-like plasmid maintenance system. Microbiology (Reading, England). 151(Pt 2):421-431. [PudMed:15699191]
[818] James Estle McKinley et al (2005) Characterization of the Phd repressor-antitoxin boundary. Journal of bacteriology. 187(2):765-70. [PudMed:15629948]
[819] Jörg Vogel et al (2004) The small RNA IstR inhibits synthesis of an SOS-induced toxic peptide. Current biology : CB. 14(24):2271-6. [PudMed:15620655]
[820] Shahar Amitai et al (2004) MazF-mediated cell death in Escherichia coli: a point of no return. Journal of bacteriology. 186(24):8295-300. [PudMed:15576778]
[821] Iris Keren et al (2004) Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. Journal of bacteriology. 186(24):8172-80. [PudMed:15576765]
[822] Gilad Bachrach et al (2004) Characterization of the novel Fusobacterium nucleatum plasmid pKH9 and evidence of an addiction system. Applied and environmental microbiology. 70(12):6957-62. [PudMed:15574887]
[823] Akshay Bhinge et al (2004) Accurate detection of protein:ligand binding sites using molecular dynamics simulations. Structure (London, England : 1993). 12(11):1989-99. [PudMed:15530363]
[824] R Hazan et al (2004) Escherichia coli mazEF-mediated cell death as a defense mechanism that inhibits the spread of phage P1. Molecular genetics and genomics : MGG. 272(2):227-34. [PudMed:15316771]
[825] Susanne K Christensen et al (2004) Delayed-relaxed response explained by hyperactivation of RelE. Molecular microbiology. 53(2):587-97. [PudMed:15228536]
[826] Yi Xuan Zhang et al (2004) Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome. Cell research. 14(3):208-16. [PudMed:15225414]
[827] Ana J Muñoz-Gómez et al (2004) Insights into the specificity of RNA cleavage by the Escherichia coli MazF toxin. FEBS letters. 567(2-3):316-20. [PudMed:15178344]
[828] Minh Hoa Dao-Thi et al (2004) Crystallization of CcdB in complex with a GyrA fragment. Acta crystallographica. Section D, Biological crystallography. 60(Pt 6):1132-4. [PudMed:15159578]
[829] Ronen Hazan et al (2004) Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions. Journal of bacteriology. 186(11):3663-9. [PudMed:15150257]
[830] Ghadiyaram Chakshusmathi et al (2004) Design of temperature-sensitive mutants solely from amino acid sequence. Proceedings of the National Academy of Sciences of the United States of America. 101(21):7925-30. [PudMed:15148363]
[831] Jeremy Allen Smith et al (2004) Modular organization of the Phd repressor/antitoxin protein. Journal of bacteriology. 186(9):2692-8. [PudMed:15090510]
[832] Hanna Engelberg-Kulka et al (2004) Bacterial programmed cell death systems as targets for antibiotics. Trends in microbiology. 12(2):66-71. [PudMed:15036322]
[833] Shelly M Deane et al (2004) Plasmid evolution and interaction between the plasmid addiction stability systems of two related broad-host-range IncQ-like plasmids. Journal of bacteriology. 186(7):2123-33. [PudMed:15028698]
[834] Junjie Zhang et al (2004) Interference of mRNA function by sequence-specific endoribonuclease PemK. The Journal of biological chemistry. 279(20):20678-84. [PudMed:15024022]
[835] Susanne K Christensen et al (2004) Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system. Molecular microbiology. 51(6):1705-17. [PudMed:15009896]
[836] Kanika Bajaj et al (2004) Thermodynamic characterization of monomeric and dimeric forms of CcdB (controller of cell division or death B protein). The Biochemical journal. 380(Pt 2):409-17. [PudMed:14763902]
[837] Izhack Cherny et al (2004) The YefM antitoxin defines a family of natively unfolded proteins: implications as a novel antibacterial target. The Journal of biological chemistry. 279(9):8252-61. [PudMed:14672926]
[838] Vivek Anantharaman et al (2003) New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system. Genome biology. 4(12):R81. [PudMed:14659018]
[839] Shaleen B Korch et al (2003) Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis. Molecular microbiology. 50(4):1199-213. [PudMed:14622409]
[840] Jason M Brown et al (2003) A novel family of Escherichia coli toxin-antitoxin gene pairs. Journal of bacteriology. 185(22):6600-8. [PudMed:14594833]
[841] Yonglong Zhang et al (2003) MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli. Molecular cell. 12(4):913-23. [PudMed:14580342]
[842] Susanne K Christensen et al (2003) Toxin-antitoxin loci as stress-response-elements: ChpAK/MazF and ChpBK cleave translated RNAs and are counteracted by tmRNA. Journal of molecular biology. 332(4):809-19. [PudMed:12972253]
[843] Junjie Zhang et al (2003) Characterization of the interactions within the mazEF addiction module of Escherichia coli. The Journal of biological chemistry. 278(34):32300-6. [PudMed:12810711]
[844] Rebecca D Parr et al (2003) New donor vector for generation of histidine-tagged fusion proteins using the Gateway Cloning System. Plasmid. 49(2):179-83. [PudMed:12726771]
[845] Katsuhiko Kamada et al (2003) Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition. Molecular cell. 11(4):875-84. [PudMed:12718874]
[846] Guillermo de la Cueva-Méndez (2003) Distressing bacteria: structure of a prokaryotic detox program. Molecular cell. 11(4):848-50. [PudMed:12718870]
[847] Thomas Nyström (2003) Conditional senescence in bacteria: death of the immortals. Molecular microbiology. 48(1):17-23. [PudMed:12657042]
[848] Boaz Sat et al (2003) The Escherichia coli mazEF suicide module mediates thymineless death. Journal of bacteriology. 185(6):1803-7. [PudMed:12618443]
[849] Ruth Grady et al (2003) Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium. Molecular microbiology. 47(5):1419-32. [PudMed:12603745]
[850] Anton Meinhart et al (2003) Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation. Proceedings of the National Academy of Sciences of the United States of America. 100(4):1661-6. [PudMed:12571357]
[851] John F Barrett (2001) Targeting DNA gyrase. Expert opinion on therapeutic targets. 5(4):531-533. [PudMed:12540265]
[852] Jurij Lah et al (2003) Recognition of the intrinsically flexible addiction antidote MazE by a dromedary single domain antibody fragment. Structure, thermodynamics of binding, stability, and influence on interactions with DNA. The Journal of biological chemistry. 278(16):14101-11. [PudMed:12533537]
[853] Ana G Camacho et al (2002) In vitro and in vivo stability of the epsilon2zeta2 protein complex of the broad host-range Streptococcus pyogenes pSM19035 addiction system. Biological chemistry. 383(11):1701-13. [PudMed:12530535]
[854] Kim Pedersen et al (2003) The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site. Cell. 112(1):131-40. [PudMed:12526800]
[855] David Hargreaves et al (2002) Structural and functional analysis of the kid toxin protein from E. coli plasmid R1. Structure (London, England : 1993). 10(10):1425-33. [PudMed:12377128]
[856] Kim Pedersen et al (2002) Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins. Molecular microbiology. 45(2):501-10. [PudMed:12123459]
[857] Mitsuoki Kawano et al (2002) Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli. Molecular microbiology. 45(2):333-49. [PudMed:12123448]
[858] Noureddine Allali et al (2002) The highly conserved TldD and TldE proteins of Escherichia coli are involved in microcin B17 processing and in CcdA degradation. Journal of bacteriology. 184(12):3224-31. [PudMed:12029038]
[859] Yong Jiang et al (2002) ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyrase. Molecular microbiology. 44(4):971-9. [PudMed:12010492]
[860] Laurence Van Melderen (2002) Molecular interactions of the CcdB poison with its bacterial target, the DNA gyrase. International journal of medical microbiology : IJMM. 291(6-7):537-44. [PudMed:11890555]
[861] Belinda M Lew et al (2002) An in vivo screening system against protein splicing useful for the isolation of non-splicing mutants or inhibitors of the RecA intein of Mycobacterium tuberculosis. Gene. 282(1-2):169-77. [PudMed:11814689]
[862] Monika Oberer et al (2002) The anti-toxin ParD of plasmid RK2 consists of two structurally distinct moieties and belongs to the ribbon-helix-helix family of DNA-binding proteins. The Biochemical journal. 361(Pt 1):41-7. [PudMed:11743881]
[863] Minh-Hoa Dao-Thi et al (2002) Intricate interactions within the ccd plasmid addiction system. The Journal of biological chemistry. 277(5):3733-42. [PudMed:11741897]
[864] A P Pomerantsev et al (2001) Genetic organization of the Francisella plasmid pFNL10. Plasmid. 46(3):210-22. [PudMed:11735370]
[865] S K Christensen et al (2001) RelE, a global inhibitor of translation, is activated during nutritional stress. Proceedings of the National Academy of Sciences of the United States of America. 98(25):14328-33. [PudMed:11717402]
[866] T J Greenfield et al (2001) Antisense RNA regulation of the par post-segregational killing system: structural analysis and mechanism of binding of the antisense RNA, RNAII and its target, RNAI. Molecular microbiology. 42(2):527-37. [PudMed:11703673]
[867] M Picardeau et al (2001) Killing effect and antitoxic activity of the Leptospira interrogans toxin-antitoxin system in Escherichia coli. Journal of bacteriology. 183(21):6494-7. [PudMed:11591696]
[868] M Chatterji et al (2001) Effect of different classes of inhibitors on DNA gyrase from Mycobacterium smegmatis. The Journal of antimicrobial chemotherapy. 48(4):479-85. [PudMed:11581225]
[869] H Afif et al (2001) The ratio between CcdA and CcdB modulates the transcriptional repression of the ccd poison-antidote system. Molecular microbiology. 41(1):73-82. [PudMed:11454201]
[870] E Adler et al (2001) Bacillus subtilis locus encoding a killer protein and its antidote. Journal of bacteriology. 183(12):3574-81. [PudMed:11371520]
[871] J S Brown et al (2001) A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence. Molecular microbiology. 40(3):572-85. [PudMed:11359564]
[872] Q B Tian et al (2001) Specific protein-DNA and protein-protein interaction in the hig gene system, a plasmid-borne proteic killer gene system of plasmid Rts1. Plasmid. 45(2):63-74. [PudMed:11322821]
[873] A Meinhart et al (2001) Crystallization and preliminary X-ray diffraction studies of the epsilonzeta addiction system encoded by Streptococcus pyogenes plasmid pSM19035. Acta crystallographica. Section D, Biological crystallography. 57(Pt 5):745-7. [PudMed:11320325]
[874] C Galvani et al (2001) Purification of the RelB and RelE proteins of Escherichia coli: RelE binds to RelB and to ribosomes. Journal of bacteriology. 183(8):2700-3. [PudMed:11274135]
[875] R Hazan et al (2001) Postsegregational killing mediated by the P1 phage "addiction module" phd-doc requires the Escherichia coli programmed cell death system mazEF. Journal of bacteriology. 183(6):2046-50. [PudMed:11222604]
[876] B Sat et al (2001) Programmed cell death in Escherichia coli: some antibiotics can trigger mazEF lethality. Journal of bacteriology. 183(6):2041-5. [PudMed:11222603]
[877] P M Clissold et al (2000) PIN domains in nonsense-mediated mRNA decay and RNAi. Current biology : CB. 10(24):R888-90. [PudMed:11137022]
[878] I Marianovsky et al (2001) The regulation of the Escherichia coli mazEF promoter involves an unusual alternating palindrome. The Journal of biological chemistry. 276(8):5975-84. [PudMed:11071896]
[879] T F Cooper et al (2000) Postsegregational killing does not increase plasmid stability but acts to mediate the exclusion of competing plasmids. Proceedings of the National Academy of Sciences of the United States of America. 97(23):12643-8. [PudMed:11058151]
[880] K Lewis (2000) Programmed death in bacteria. Microbiology and molecular biology reviews : MMBR. 64(3):503-14. [PudMed:10974124]
[881] G Mittenhuber (1999) Occurrence of mazEF-like antitoxin/toxin systems in bacteria. Journal of molecular microbiology and biotechnology. 1(2):295-302. [PudMed:10943559]
[882] M Oberer et al (1999) Thermodynamic properties and DNA binding of the ParD protein from the broad host-range plasmid RK2/RP4 killing system. Biological chemistry. 380(12):1413-20. [PudMed:10661868]
[883] K Gerdes (2000) Toxin-antitoxin modules may regulate synthesis of macromolecules during nutritional stress. Journal of bacteriology. 182(3):561-72. [PudMed:10633087]
[884] M R Barer et al (1999) Bacterial viability and culturability. Advances in microbial physiology. 41:93-137. [PudMed:10500845]
[885] D E Rawlings (1999) Proteic toxin-antitoxin, bacterial plasmid addiction systems and their evolution with special reference to the pas system of pTF-FC2. FEMS microbiology letters. 176(2):269-77. [PudMed:10427709]
[886] K Pedersen et al (1999) Multiple hok genes on the chromosome of Escherichia coli. Molecular microbiology. 32(5):1090-102. [PudMed:10361310]
[887] E Gazit et al (1999) The Doc toxin and Phd antidote proteins of the bacteriophage P1 plasmid addiction system form a heterotrimeric complex. The Journal of biological chemistry. 274(24):16813-8. [PudMed:10358024]
[888] T J Falla et al (1999) Stabilization of Rhizobium symbiosis plasmids. Microbiology (Reading, England). 145 ( Pt 3):515-516. [PudMed:10217483]
[889] R Loris et al (1999) Crystal structure of CcdB, a topoisomerase poison from E. coli. Journal of molecular biology. 285(4):1667-77. [PudMed:9917404]
[890] H Grønlund et al (1999) Toxin-antitoxin systems homologous with relBE of Escherichia coli plasmid P307 are ubiquitous in prokaryotes. Journal of molecular biology. 285(4):1401-15. [PudMed:9917385]
[891] E Gazit et al (1999) Stability and DNA binding of the phd protein of the phage P1 plasmid addiction system. The Journal of biological chemistry. 274(5):2652-7. [PudMed:9915794]
[892] H Engelberg-Kulka et al (1998) rexB of bacteriophage lambda is an anti-cell death gene. Proceedings of the National Academy of Sciences of the United States of America. 95(26):15481-6. [PudMed:9860994]
[893] F Hayes (1998) A family of stability determinants in pathogenic bacteria. Journal of bacteriology. 180(23):6415-8. [PudMed:9829958]
[894] R Magnuson et al (1998) Corepression of the P1 addiction operon by Phd and Doc. Journal of bacteriology. 180(23):6342-51. [PudMed:9829946]
[895] M Gotfredsen et al (1998) The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family. Molecular microbiology. 29(4):1065-76. [PudMed:9767574]
[896] A S Smith et al (1998) Autoregulation of the pTF-FC2 proteic poison-antidote plasmid addiction system (pas) is essential for plasmid stabilization. Journal of bacteriology. 180(20):5463-5. [PudMed:9765582]
[897] A S Smith et al (1997) The poison-antidote stability system of the broad-host-range Thiobacillus ferrooxidans plasmid pTF-FC2. Molecular microbiology. 26(5):961-70. [PudMed:9426133]
[898] C L Easter et al (1997) Contribution of different segments of the par region to stable maintenance of the broad-host-range plasmid RK2. Journal of bacteriology. 179(20):6472-9. [PudMed:9335298]
[899] Garry A Bloomfield et al (1997) Analysis of sequences flanking the vap regions of Dichelobacter nodosus: evidence for multiple integration events, a killer system, and a new genetic element. Microbiology (Reading, England). 143 ( Pt 2):553-562. [PudMed:9043132]
[900] R Magnuson et al (1996) Autoregulation of the plasmid addiction operon of bacteriophage P1. The Journal of biological chemistry. 271(31):18705-10. [PudMed:8702525]
[901] E Aizenman et al (1996) An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death. Proceedings of the National Academy of Sciences of the United States of America. 93(12):6059-63. [PudMed:8650219]
[902] Q B Tian et al (1996) A new plasmid-encoded proteic killer gene system: cloning, sequencing, and analyzing hig locus of plasmid Rts1. Biochemical and biophysical research communications. 220(2):280-4. [PudMed:8645296]
[903] E P Johnson et al (1996) Plasmid RK2 toxin protein ParE: purification and interaction with the ParD antitoxin protein. Journal of bacteriology. 178(5):1420-9. [PudMed:8631720]
[904] H Lehnherr et al (1993) Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained. Journal of molecular biology. 233(3):414-28. [PudMed:8411153]
[905] Y Masuda et al (1993) chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100. Journal of bacteriology. 175(21):6850-6. [PudMed:8226627]
[906] D S Black et al (1994) Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. Journal of bacteriology. 176(13):4081-91. [PudMed:8021189]
[907] P Bernard et al (1994) Positive-selection vectors using the F plasmid ccdB killer gene. Gene. 148(1):71-4. [PudMed:7926841]
[908] H Lehnherr et al (1995) Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 92(8):3274-7. [PudMed:7724551]
[909] B F Cheetham et al (1995) Identification of a gene encoding a bacteriophage-related integrase in a vap region of the Dichelobacter nodosus genome. Gene. 162(1):53-8. [PudMed:7557417]
[910] P Bernard (1995) New ccdB positive-selection cloning vectors with kanamycin or chloramphenicol selectable markers. Gene. 162(1):159-60. [PudMed:7557407]
[911] R B Jensen et al (1995) Comparison of ccd of F, parDE of RP4, and parD of R1 using a novel conditional replication control system of plasmid R1. Molecular microbiology. 17(2):211-20. [PudMed:7494470]
[912] R B Jensen et al (1995) Programmed cell death in bacteria: proteic plasmid stabilization systems. Molecular microbiology. 17(2):205-10. [PudMed:7494469]
[913] H S Moyed et al (1983) hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis. Journal of bacteriology. 155(2):768-75. [PudMed:6348026]
[914] A Jaffé et al (1985) Effects of the ccd function of the F plasmid on bacterial growth. Journal of bacteriology. 163(3):841-9. [PudMed:3897195]
[915] A Bravo et al (1987) Identification of components of a new stability system of plasmid R1, ParD, that is close to the origin of replication of this plasmid. Molecular & general genetics : MGG. 210(1):101-10. [PudMed:3323833]
[916] M J Ruiz-Echevarría et al (1991) Structural and functional comparison between the stability systems ParD of plasmid R1 and Ccd of plasmid F. Molecular & general genetics : MGG. 225(3):355-62. [PudMed:2017133]
[917] A K Nielsen et al (1991) The rifampicin-inducible genes srnB from F and pnd from R483 are regulated by antisense RNAs and mediate plasmid maintenance by killing of plasmid-free segregants. Molecular microbiology. 5(8):1961-73. [PudMed:1722558]
[918] D S Black et al (1991) Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. Journal of bacteriology. 173(18):5732-9. [PudMed:1715862]
[919] K Gerdes et al (1990) Mechanism of post-segregational killing by the hok/sok system of plasmid R1: sok antisense RNA regulates formation of a hok mRNA species correlated with killing of plasmid-free cells. Molecular microbiology. 4(11):1807-18. [PudMed:1707122]
[920] G D Pullinger et al (1992) A Salmonella dublin virulence plasmid locus that affects bacterial growth under nutrient-limited conditions. Molecular microbiology. 6(12):1631-43. [PudMed:1495391]
[921] M E Katz et al (1992) Molecular characterization of a genomic region associated with virulence in Dichelobacter nodosus. Infection and immunity. 60(11):4586-92. [PudMed:1398971]
[1] Meng Li et al (2023) Type II Toxin-Antitoxin Systems in Pseudomonas aeruginosa. Toxins. 15(2):164. [PudMed:36828478]
[2] Made Rai Dwitya Wiradiputra et al (2022) Toxin-Antitoxin Systems: A Key Role on Persister Formation in Salmonella enterica Serovar Typhimurium. Infection and drug resistance. 15:5813-5829. [PudMed:36213766]
[3] Ciamak Ghazaei (2022) Advances in the Study of Bacterial Toxins, Their Roles and Mechanisms in Pathogenesis. The Malaysian journal of medical sciences : MJMS. 29(1):4-17. [PudMed:35283688]
[4] Anil Mathew Tharappel et al (2022) Inteins as Drug Targets and Therapeutic Tools. Frontiers in molecular biosciences. 9:821146. [PudMed:35211511]
[5] Nava Hosseini et al (2019) Modulation of Toxin-Antitoxin System Rnl AB Type II in Phage-Resistant Gammaproteobacteria Surviving Photodynamic Treatment. Journal of lasers in medical sciences. 10(1):21-28. [PudMed:31360364]
[6] Rebecca Page et al (2016) Toxin-antitoxin systems in bacterial growth arrest and persistence. Nature chemical biology. 12(4):208-14. [PudMed:26991085]
[7] Régine Brielle et al (2016) Linking bacterial type I toxins with their actions. Current opinion in microbiology. 30:114-121. [PudMed:26874964]
[8] O I Demidenok et al (2013) [Bacterial toxin-antitoxin systems and perspectives for their application in medicine: a review]. Prikladnaia biokhimiia i mikrobiologiia. 49(6):539-46. [PudMed:25434177]
[9] Marcel Prax et al (2014) Metabolic aspects of bacterial persisters. Frontiers in cellular and infection microbiology. 4:148. [PudMed:25374846]
[10] Peng Luo et al (2014) [Bacterial SXT/R391 family from integrating conjugative elements--a review]. Wei sheng wu xue bao = Acta microbiologica Sinica. 54(5):471-9. [PudMed:25199245]
[11] Agata L Starosta et al (2014) The bacterial translation stress response. FEMS microbiology reviews. 38(6):1172-201. [PudMed:25135187]
[12] Richard A Proctor et al (2014) Staphylococcus aureus Small Colony Variants (SCVs): a road map for the metabolic pathways involved in persistent infections. Frontiers in cellular and infection microbiology. 4:99. [PudMed:25120957]
[13] Brian P Conlon (2014) Staphylococcus aureus chronic and relapsing infections: Evidence of a role for persister cells: An investigation of persister cells, their formation and their role in S. aureus disease. BioEssays : news and reviews in molecular, cellular and developmental biology. 36(10):991-6. [PudMed:25100240]
[14] Jia Wen et al (2014) sRNA antitoxins: more than one way to repress a toxin. Toxins. 6(8):2310-35. [PudMed:25093388]
[15] Dapeng Zhang et al (2014) Resilience of biochemical activity in protein domains in the face of structural divergence. Current opinion in structural biology. 26:92-103. [PudMed:24952217]
[16] Remy Loris et al (2014) Disorder- and dynamics-based regulatory mechanisms in toxin-antitoxin modules. Chemical reviews. 114(13):6933-47. [PudMed:24806488]
[17] Sophie Helaine et al (2014) Bacterial persisters: formation, eradication, and experimental systems. Trends in microbiology. 22(7):417-24. [PudMed:24768561]
[18] Etienne Maisonneuve et al (2014) Molecular mechanisms underlying bacterial persisters. Cell. 157(3):539-48. [PudMed:24766804]
[19] Luary C Martínez et al (2014) Mechanisms of post-transcriptional gene regulation in bacterial biofilms. Frontiers in cellular and infection microbiology. 4:38. [PudMed:24724055]
[20] Ambre Sala et al (2014) Multiple toxin-antitoxin systems in Mycobacterium tuberculosis. Toxins. 6(3):1002-20. [PudMed:24662523]
[21] Vicky Merhej et al (2014) Genotyping, evolution and epidemiological findings of Rickettsia species. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 25:122-37. [PudMed:24662440]
[22] Ralph Bertram et al (2014) Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems. Frontiers in cellular and infection microbiology. 4:6. [PudMed:24524029]
[23] Yurong Wen et al (2014) Toxin-Antitoxin systems: their role in persistence, biofilm formation, and pathogenicity. Pathogens and disease. 70(3):240-9. [PudMed:24478112]
[24] Finbarr Hayes et al (2014) Regulating toxin-antitoxin expression: controlled detonation of intracellular molecular timebombs. Toxins. 6(1):337-58. [PudMed:24434949]
[25] Nathalie Goeders et al (2014) Toxin-antitoxin systems as multilevel interaction systems. Toxins. 6(1):304-24. [PudMed:24434905]
[26] Yuhui Xu et al (2015) Drug resistance to Mycobacterium tuberculosis: from the traditional Chinese view to modern systems biology. Critical reviews in microbiology. 41(3):399-410. [PudMed:24433008]
[27] Anna Maj et al (2013) Plasmids of carotenoid-producing Paracoccus spp. (Alphaproteobacteria) - structure, diversity and evolution. PloS one. 8(11):e80258. [PudMed:24260361]
[28] Simon J Unterholzner et al (2013) Toxin-antitoxin systems: Biology, identification, and application. Mobile genetic elements. 3(5):e26219. [PudMed:24251069]
[29] O A Koksharova (2013) Bacteria and phenoptosis. Biochemistry. Biokhimiia. 78(9):963-70. [PudMed:24228917]
[30] Iwona Mruk et al (2014) To be or not to be: regulation of restriction-modification systems and other toxin-antitoxin systems. Nucleic acids research. 42(1):70-86. [PudMed:23945938]
[31] Yongqiang Gao et al (2013) Inducible cell lysis systems in microbial production of bio-based chemicals. Applied microbiology and biotechnology. 97(16):7121-9. [PudMed:23872961]
[32] Bhaskar Chandra Mohan Ramisetty et al (2015) mazEF-mediated programmed cell death in bacteria: "what is this?". Critical reviews in microbiology. 41(1):89-100. [PudMed:23799870]
[33] Sobhan Ghafourian et al (2014) Toxin-antitoxin Systems: Classification, Biological Function and Application in Biotechnology. Current issues in molecular biology. 16:9-14. [PudMed:23652423]
[34] Guyue Cheng et al (2013) Antibacterial action of quinolones: from target to network. European journal of medicinal chemistry. 66:555-62. [PudMed:23528390]
[35] Sophie Helaine et al (2013) Heterogeneity of intracellular replication of bacterial pathogens. Current opinion in microbiology. 16(2):184-91. [PudMed:23485258]
[36] Kira S Makarova et al (2013) Comparative genomics of defense systems in archaea and bacteria. Nucleic acids research. 41(8):4360-77. [PudMed:23470997]
[37] Sung Jean Park et al (2013) Structural overview of toxin-antitoxin systems in infectious bacteria: a target for developing antimicrobial agents. Biochimica et biophysica acta. 1834(6):1155-67. [PudMed:23459128]
[38] Gregory M Cook et al (2013) Ribonucleases in bacterial toxin-antitoxin systems. Biochimica et biophysica acta. 1829(6-7):523-31. [PudMed:23454553]
[39] Iwona Brzozowska et al (2013) Regulation of toxin-antitoxin systems by proteolysis. Plasmid. 70(1):33-41. [PudMed:23396045]
[40] Sabine Brantl (2012) Bacterial type I toxin-antitoxin systems. RNA biology. 9(12):1488-90. [PudMed:23324552]
[41] Christopher F Schuster et al (2013) Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate. FEMS microbiology letters. 340(2):73-85. [PudMed:23289536]
[42] Wai Ting Chan et al (2012) Toxin-antitoxin genes of the Gram-positive pathogen Streptococcus pneumoniae: so few and yet so many. Microbiology and molecular biology reviews : MMBR. 76(4):773-91. [PudMed:23204366]
[43] Quan-xin Long et al (2012) [The molecular physiological and genetic mechanisms underlying the superb efficacy of quinolones]. Yao xue xue bao = Acta pharmaceutica Sinica. 47(8):969-77. [PudMed:23162891]
[44] Kira S Makarova et al (2012) Live virus-free or die: coupling of antivirus immunity and programmed suicide or dormancy in prokaryotes. Biology direct. 7:40. [PudMed:23151069]
[45] Mitsuoki Kawano (2012) Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E. coli: hok/sok, ldr/rdl, symE/symR. RNA biology. 9(12):1520-7. [PudMed:23131729]
[46] E Gerhart H Wagner et al (2012) The toxin-antitoxin system tisB-istR1: Expression, regulation, and biological role in persister phenotypes. RNA biology. 9(12):1513-9. [PudMed:23093802]
[47] Kim Lewis (2012) Persister cells: molecular mechanisms related to antibiotic tolerance. Handbook of experimental pharmacology. (211):121-33. [PudMed:23090599]
[48] Iris Keren et al (2012) Persister eradication: lessons from the world of natural products. Methods in enzymology. 517:387-406. [PudMed:23084949]
[49] Sylvain Durand et al (2012) Type I toxin-antitoxin systems in Bacillus subtilis. RNA biology. 9(12):1491-7. [PudMed:23059907]
[50] Mohammad Adnan Syed et al (2012) Chromosomal bacterial type II toxin-antitoxin systems. Canadian journal of microbiology. 58(5):553-62. [PudMed:22506850]
[51] Julia J Williams et al (2012) Artificial activation of toxin-antitoxin systems as an antibacterial strategy. Trends in microbiology. 20(6):291-8. [PudMed:22445361]
[52] Ying Zhang et al (2012) Targeting persisters for tuberculosis control. Antimicrobial agents and chemotherapy. 56(5):2223-30. [PudMed:22391538]
[53] K Georgiades (2012) Genomics of epidemic pathogens. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 18(3):213-7. [PudMed:22369153]
[54] Ming-Xi Hu et al (2010) Recent advancements in toxin and antitoxin systems involved in bacterial programmed cell death. International journal of microbiology. 2010:781430. [PudMed:21253538]
[55] Vickery L Arcus et al (2011) The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array. Protein engineering, design & selection : PEDS. 24(1-2):33-40. [PudMed:21036780]
[56] Guillaume Cambray et al (2010) Integrons. Annual review of genetics. 44:141-66. [PudMed:20707672]
[57] Elizabeth Diago-Navarro et al (2010) parD toxin-antitoxin system of plasmid R1--basic contributions, biotechnological applications and relationships with closely-related toxin-antitoxin systems. The FEBS journal. 277(15):3097-117. [PudMed:20569269]
[58] Kim Lewis (2010) Persister cells. Annual review of microbiology. 64:357-72. [PudMed:20528688]
[59] Virginia S Lioy et al (2010) Plasmid pSM19035, a model to study stable maintenance in Firmicutes. Plasmid. 64(1):1-17. [PudMed:20403380]
[60] Laurence Van Melderen et al (2009) Bacterial toxin-antitoxin systems: more than selfish entities? PLoS genetics. 5(3):e1000437. [PudMed:19325885]
[61] R Jayaraman (2008) Bacterial persistence: some new insights into an old phenomenon. Journal of biosciences. 33(5):795-805. [PudMed:19179767]
[62] Elizabeth M Fozo et al (2008) Small toxic proteins and the antisense RNAs that repress them. Microbiology and molecular biology reviews : MMBR. 72(4):579-89, Table of Contents. [PudMed:19052321]
[63] Kenn Gerdes et al (2007) RNA antitoxins. Current opinion in microbiology. 10(2):117-24. [PudMed:17376733]
[64] Hanna Engelberg-Kulka et al (2006) Bacterial programmed cell death and multicellular behavior in bacteria. PLoS genetics. 2(10):e135. [PudMed:17069462]
[65] Hanna Engelberg-Kulka et al (2005) mazEF: a chromosomal toxin-antitoxin module that triggers programmed cell death in bacteria. Journal of cell science. 118(Pt 19):4327-32. [PudMed:16179604]
[66] Kenn Gerdes et al (2005) Prokaryotic toxin-antitoxin stress response loci. Nature reviews. Microbiology. 3(5):371-82. [PudMed:15864262]
[67] Hanna Engelberg-Kulka et al (2004) Bacterial programmed cell death systems as targets for antibiotics. Trends in microbiology. 12(2):66-71. [PudMed:15036322]
[68] Guillermo de la Cueva-Méndez (2003) Distressing bacteria: structure of a prokaryotic detox program. Molecular cell. 11(4):848-50. [PudMed:12718870]
[69] Thomas Nyström (2003) Conditional senescence in bacteria: death of the immortals. Molecular microbiology. 48(1):17-23. [PudMed:12657042]
[70] John F Barrett (2001) Targeting DNA gyrase. Expert opinion on therapeutic targets. 5(4):531-533. [PudMed:12540265]
[71] Laurence Van Melderen (2002) Molecular interactions of the CcdB poison with its bacterial target, the DNA gyrase. International journal of medical microbiology : IJMM. 291(6-7):537-44. [PudMed:11890555]
[72] P M Clissold et al (2000) PIN domains in nonsense-mediated mRNA decay and RNAi. Current biology : CB. 10(24):R888-90. [PudMed:11137022]
[73] K Lewis (2000) Programmed death in bacteria. Microbiology and molecular biology reviews : MMBR. 64(3):503-14. [PudMed:10974124]
[74] K Gerdes (2000) Toxin-antitoxin modules may regulate synthesis of macromolecules during nutritional stress. Journal of bacteriology. 182(3):561-72. [PudMed:10633087]
[75] M R Barer et al (1999) Bacterial viability and culturability. Advances in microbial physiology. 41:93-137. [PudMed:10500845]
[76] D E Rawlings (1999) Proteic toxin-antitoxin, bacterial plasmid addiction systems and their evolution with special reference to the pas system of pTF-FC2. FEMS microbiology letters. 176(2):269-77. [PudMed:10427709]
[77] T J Falla et al (1999) Stabilization of Rhizobium symbiosis plasmids. Microbiology (Reading, England). 145 ( Pt 3):515-516. [PudMed:10217483]
[78] R B Jensen et al (1995) Programmed cell death in bacteria: proteic plasmid stabilization systems. Molecular microbiology. 17(2):205-10. [PudMed:7494469]
[1] Rui Wang et al (2023) Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens. Nature communications. 14(1):2078. [PudMed:37045931]
[2] Yingjie Song et al (2023) Comparative analysis of five type II TA systems identified in Pseudomonas aeruginosa reveals their contributions to persistence and intracellular survival. Frontiers in cellular and infection microbiology. 13:1127786. [PudMed:36844395]
[3] Haijuan Li et al (2023) The parABSm system is involved in megaplasmid partitioning and genome integrity maintenance in Thermus thermophilus. G3 (Bethesda, Md.). 13(4):jkad038. [PudMed:36786449]
[4] Maëlle Duperray et al (2023) Tuning the expression of the bacterial relBE toxin-antitoxin system in Saccharomyces cerevisiae allows characterizing the subsequent growth inhibition. FEMS yeast research. 23:foad009. [PudMed:36722160]
[5] Shinya Ebihara et al (2023) A novel toxin-antitoxin system swpAB alters gene expression patterns and reduces virulence expression in enterohemorrhagic Escherichia coli. Microbiology and immunology. 67(4):171-184. [PudMed:36636756]
[6] K C Hernández-Ramírez et al (2023) Role of PumB antitoxin as a transcriptional regulator of the PumAB type-II toxin-antitoxin system and its endoribonuclease activity on the PumA (toxin) transcript. Molecular genetics and genomics : MGG. 298(2):455-472. [PudMed:36604348]
[7] Pamela K Garcia et al (2022) Localization of Mycobacterium tuberculosis topoisomerase I C-terminal sequence motif required for inhibition by endogenous toxin MazF4. Frontiers in microbiology. 13:1032320. [PudMed:36545199]
[8] Bo Hou et al (2022) Effects of Toxin-Antitoxin System HicAB on Biofilm Formation by Extraintestinal Pathogenic E. coli. Current microbiology. 80(1):50. [PudMed:36542185]
[9] Mikhail Zamakhaev et al (2022) VapC toxin switches M. smegmatis cells into dormancy through 23S rRNA cleavage. Archives of microbiology. 205(1):28. [PudMed:36520276]
[10] Evelyne Krin et al (2023) Systematic transcriptome analysis allows the identification of new type I and type II Toxin/Antitoxin systems located in the superintegron of Vibrio cholerae. Research in microbiology. 174(1-2):103997. [PudMed:36347445]
[11] Tannu Priya Gosain et al (2022) Disruption of MenT2 toxin impairs the growth of Mycobacterium tuberculosis in guinea pigs. Microbiology (Reading, England). 168(11):10.1099/mic.0.001246. [PudMed:36342835]
[12] Lan-Yue Zhang et al (2022) Toxin-Antitoxin Systems Alter Adaptation of Mycobacterium smegmatis to Environmental Stress. Microbiology spectrum. 10(6):e0281522. [PudMed:36318013]
[13] Yongjin Wang et al (2022) A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria. Nature communications. 13(1):6434. [PudMed:36307446]
[14] Anaïs Le Rhun et al (2023) Profiling the intragenic toxicity determinants of toxin-antitoxin systems: revisiting hok/Sok regulation. Nucleic acids research. 51(1):e4. [PudMed:36271796]
[15] Yingjie Song et al (2022) The novel type II toxin-antitoxin PacTA modulates Pseudomonas aeruginosa iron homeostasis by obstructing the DNA-binding activity of Fur. Nucleic acids research. 50(18):10586-10600. [PudMed:36200834]
[16] Aleksandra Anna Bonini et al (2022) Functional characterization and transcriptional repression by Lacticaseibacillus paracasei DinJ-YafQ. Applied microbiology and biotechnology. 106(21):7113-7128. [PudMed:36194262]
[17] Fuminori Kato et al (2023) A novel gyrase inhibitor from toxin-antitoxin system expressed by Staphylococcus aureus. The FEBS journal. 290(6):1502-1518. [PudMed:36148483]
[18] Ji Sung Koo et al (2022) The Haemophilus influenzae HipBA toxin-antitoxin system adopts an unusual three-com-ponent regulatory mechanism. IUCrJ. 9(Pt 5):625-631. [PudMed:36071804]
[19] Feiyue Cheng et al (2022) The toxin-antitoxin RNA guards of CRISPR-Cas evolved high specificity through repeat degeneration. Nucleic acids research. 50(16):9442-9452. [PudMed:36018812]
[20] Shiva Hoseini et al (2022) In Vitro and In Silico Investigation of some Type II TA Genes in H. Pylori. Clinical laboratory. 68(8):10.7754/Clin.Lab.2021.211002. [PudMed:35975492]
[21] Vishma Pratap Sur et al (2022) Dynamic study of small toxic hydrophobic proteins PepA1 and PepG1 of Staphylococcus aureus. International journal of biological macromolecules. 219:1360-1371. [PudMed:35932805]
[22] Xiangkai Zhen et al (2022) Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila. Nature communications. 13(1):4333. [PudMed:35882877]
[23] Jacob Bobonis et al (2022) Bacterial retrons encode phage-defending tripartite toxin-antitoxin systems. Nature. 609(7925):144-150. [PudMed:35850148]
[24] Michele LeRoux et al (2022) The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA. Nature microbiology. 7(7):1028-1040. [PudMed:35725776]
[25] Itziar Chapartegui-González et al (2022) Evaluating the Contribution of the Predicted Toxin-Antitoxin System HigBA to Persistence, Biofilm Formation, and Virulence in Burkholderia pseudomallei. Infection and immunity. 90(7):e0003522. [PudMed:35695502]
[26] Francesca G Tomasi et al (2022) A tRNA-Acetylating Toxin and Detoxifying Enzyme in Mycobacterium tuberculosis. Microbiology spectrum. 10(3):e0058022. [PudMed:35638832]
[27] Hyun-Jong Eun et al (2022) The structural and functional investigation of the VapBC43 complex from Mycobacterium tuberculosis. Biochemical and biophysical research communications. 616:19-25. [PudMed:35636251]
[28] Ting Cai et al (2022) HigBA toxin-antitoxin system of Weissella cibaria is involved in response to the bile salt stress. Journal of the science of food and agriculture. 102(14):6749-6756. [PudMed:35633128]
[29] Muyang Ni et al (2022) Antitoxin CrlA of CrlTA Toxin-Antitoxin System in a Clinical Isolate Pseudomonas aeruginosa Inhibits Lytic Phage Infection. Frontiers in microbiology. 13:892021. [PudMed:35620101]
[30] Esther Shmidov et al (2022) PrrT/A, a Pseudomonas aeruginosa Bacterial Encoded Toxin-Antitoxin System Involved in Prophage Regulation and Biofilm Formation. Microbiology spectrum. 10(3):e0118222. [PudMed:35575497]
[31] Clinton C Dawson et al (2022) Discovery of a novel type IIb RelBE toxin-antitoxin system in Mycobacterium tuberculosis defined by co-regulation with an antisense RNA. Molecular microbiology. 117(6):1419-1433. [PudMed:35526138]
[32] Sonia Jain et al (2022) Unravelling the physiological roles of mazEF toxin-antitoxin system on clinical MRSA strain by CRISPR RNA-guided cytidine deaminase. Journal of biomedical science. 29(1):28. [PudMed:35524246]
[33] Mina Mahmoudi et al (2022) relBE toxin-antitoxin system as a reliable anti-biofilm target in Pseudomonas aeruginosa. Journal of applied microbiology. 133(2):683-695. [PudMed:35445489]
[34] Unnati Chauhan et al (2022) tRNAfMet Inactivating Mycobacterium tuberculosis VapBC Toxin-Antitoxin Systems as Therapeutic Targets. Antimicrobial agents and chemotherapy. 66(5):e0189621. [PudMed:35404073]
[35] Yi Zhao et al (2022) The HipAB Toxin-Antitoxin System Stabilizes a Composite Genomic Island in Shewanella putrefaciens CN-32. Frontiers in microbiology. 13:858857. [PudMed:35387082]
[36] Wei-Lin Su et al (2022) TisB Protein Protects Escherichia coli Cells Suffering Massive DNA Damage from Environmental Toxic Compounds. mBio. 13(2):e0038522. [PudMed:35377167]
[37] Daniel Edelmann et al (2022) A Shift in Perspective: A Role for the Type I Toxin TisB as Persistence-Stabilizing Factor. Frontiers in microbiology. 13:871699. [PudMed:35369430]
[38] Gopinath Chattopadhyay et al (2022) Functional and Biochemical Characterization of the MazEF6 Toxin-Antitoxin System of Mycobacterium tuberculosis. Journal of bacteriology. 204(4):e0005822. [PudMed:35357163]
[39] Ines Bleriot et al (2022) The role of PemIK (PemK/PemI) type II TA system from Klebsiella pneumoniae clinical strains in lytic phage infection. Scientific reports. 12(1):4488. [PudMed:35296704]
[40] Shruti Kashyap et al (2022) Tobramycin Stress Induced Differential Gene Expression in Acinetobacter baumannii. Current microbiology. 79(3):88. [PudMed:35129693]
[41] Tatsuaki Kurata et al (2022) A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains. Proceedings of the National Academy of Sciences of the United States of America. 119(6):e2102212119. [PudMed:35121656]
[42] Hongmao Sun et al (2022) Discovery of Small-Molecule VapC1 Nuclease Inhibitors by Virtual Screening and Scaffold Hopping from an Atomic Structure Revealing Protein-Protein Interactions with a Native VapB1 Inhibitor. Journal of chemical information and modeling. 62(5):1249-1258. [PudMed:35103473]
[43] Eunsil Choi et al (2022) Functional characterization of HigBA toxin-antitoxin system in an Arctic bacterium, Bosea sp. PAMC 26642. Journal of microbiology (Seoul, Korea). 60(2):192-206. [PudMed:35102526]
[44] Vânia Gaio et al (2021) mazEF Homologue Has a Minor Role in Staphylococcus epidermidis 1457 Virulence Potential. Frontiers in cellular and infection microbiology. 11:803134. [PudMed:35096651]
[45] Parthasarathy Manikandan et al (2022) Identification, functional characterization, assembly and structure of ToxIN type III toxin-antitoxin complex from E. coli. Nucleic acids research. 50(3):1687-1700. [PudMed:35018473]
[46] Taylor Van Gundy et al (2022) An Antisense RNA Fine-Tunes Gene Expression of the Type II MazEF Toxin-Antitoxin System. mBio. 13(1):e0344321. [PudMed:35012340]
[47] Arun Sharma et al (2021) HigB1 Toxin in Mycobacterium tuberculosis Is Upregulated During Stress and Required to Establish Infection in Guinea Pigs. Frontiers in microbiology. 12:748890. [PudMed:34917044]
[48] Kevin J Snead et al (2022) ParD Antitoxin Hotspot Alters a Disorder-to-Order Transition upon Binding to Its Cognate ParE Toxin, Lessening Its Interaction Affinity and Increasing Its Protease Degradation Kinetics. Biochemistry. 61(1):34-45. [PudMed:34914378]
[49] Hiroko Tamiya-Ishitsuka et al (2021) Conserved Amino Acid Moieties of Candidatus Desulforudis audaxviator MazF Determine Ribonuclease Activity and Specificity. Frontiers in microbiology. 12:748619. [PudMed:34867867]
[50] Dukas Jurėnas et al (2021) Bistable Expression of a Toxin-Antitoxin System Located in a Cryptic Prophage of Escherichia coli O157:H7. mBio. 12(6):e0294721. [PudMed:34844426]
[51] Mohit Yadav et al (2022) Functional and transcriptional analysis of chromosomal encoded hipBAXn2 type II toxin-antitoxin (TA) module from Xenorhabdus nematophila. Microbial pathogenesis. 162:105309. [PudMed:34839000]
[52] Aya Takashima et al (2022) A toxin-antitoxin system confers stability to the IncP-7 plasmid pCAR1. Gene. 812:146068. [PudMed:34838639]
[53] Ming-Xing Zhang et al (2021) YgfY Contributes to Stress Tolerance in Shewanella oneidensis Neither as an Antitoxin Nor as a Flavinylation Factor of Succinate Dehydrogenase. Microorganisms. 9(11):2316. [PudMed:34835442]
[54] Kosuke Takada et al (2021) The hokW-sokW Locus Encodes a Type I Toxin-Antitoxin System That Facilitates the Release of Lysogenic Sp5 Phage in Enterohemorrhagic Escherichia coli O157. Toxins. 13(11):796. [PudMed:34822580]
[55] Soumyanetra Chandra et al (2021) Rapid Identification of Secondary Structure and Binding Site Residues in an Intrinsically Disordered Protein Segment. Frontiers in genetics. 12:755292. [PudMed:34795695]
[56] Virginia Hill et al (2021) Minimalistic mycoplasmas harbor different functional toxin-antitoxin systems. PLoS genetics. 17(10):e1009365. [PudMed:34673769]
[57] Charlotte Oriol et al (2021) Expanding the Staphylococcus aureus SarA Regulon to Small RNAs. mSystems. 6(5):e0071321. [PudMed:34636666]
[58] Isis Gabriela Barbosa Carvalho et al (2021) Overexpression of mqsR in Xylella fastidiosa Leads to a Priming Effect of Cells to Copper Stress Tolerance. Frontiers in microbiology. 12:712564. [PudMed:34616378]
[59] Bikash Bogati et al (2021) Improved growth of Escherichia coli in aminoglycoside antibiotics by the zor-orz toxin-antitoxin system. Journal of bacteriology. 204(1):JB0040721. [PudMed:34570627]
[60] Yingjie Song et al (2021) Type II Antitoxin HigA Is a Key Virulence Regulator in Pseudomonas aeruginosa. ACS infectious diseases. 7(10):2930-2940. [PudMed:34554722]
[61] Feiyue Cheng et al (2021) Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins. Nucleic acids research. 49(18):10677-10688. [PudMed:34551428]
[62] Uroš Zavrtanik et al (2021) Unraveling the Thermodynamics of Ultra-tight Binding of Intrinsically Disordered Proteins. Frontiers in molecular biosciences. 8:726824. [PudMed:34532345]
[63] Qibing Gu et al (2021) An Auto-Regulating Type II Toxin-Antitoxin System Modulates Drug Resistance and Virulence in Streptococcus suis. Frontiers in microbiology. 12:671706. [PudMed:34475853]
[64] Hyerin Jeon et al (2021) Identification and characterization of VapBC toxin-antitoxin system in Bosea sp. PAMC 26642 isolated from Arctic lichens. RNA (New York, N.Y.). 27(11):1374-1389. [PudMed:34429367]
[65] Annabel S Lemma et al (2021) Toxin Induction or Inhibition of Transcription or Translation Posttreatment Increases Persistence to Fluoroquinolones. mBio. 12(4):e0198321. [PudMed:34399616]
[66] Valdir C Barth et al (2021) Mycobacterium tuberculosis VapC4 toxin engages small ORFs to initiate an integrated oxidative and copper stress response. Proceedings of the National Academy of Sciences of the United States of America. 118(32):e2022136118. [PudMed:34362841]
[67] Kazuo Kobayashi (2021) Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms. PLoS genetics. 17(7):e1009682. [PudMed:34280190]
[68] Tatsuaki Kurata et al (2021) RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis. Molecular cell. 81(15):3160-3170.e9. [PudMed:34174184]
[69] Alireza Japoni-Nejad et al (2021) Identification and characterization of the type II toxin-antitoxin systems in the carbapenem-resistant Acinetobacterbaumannii. Microbial pathogenesis. 158:105052. [PudMed:34147586]
[70] Qin Qi et al (2021) The higBA-Type Toxin-Antitoxin System in IncC Plasmids Is a Mobilizable Ciprofloxacin-Inducible System. mSphere. 6(3):e0042421. [PudMed:34077263]
[71] Lidia Boss et al (2021) Identification of Three Type II Toxin-Antitoxin Systems in Model Bacterial Plant Pathogen Dickeya dadantii 3937. International journal of molecular sciences. 22(11):5932. [PudMed:34073004]
[72] Kinga Chlebicka et al (2021) Impacts of the Type I Toxin-Antitoxin System, SprG1/SprF1, on Staphylococcus aureus Gene Expression. Genes. 12(5):770. [PudMed:34070083]
[73] Wonho Choi et al (2021) Functional Characterization of the mazEF Toxin-Antitoxin System in the Pathogenic Bacterium Agrobacterium tumefaciens. Microorganisms. 9(5):1107. [PudMed:34065548]
[74] Shahira A ElBanna et al (2021) Genomics-guided identification of a conserved CptBA-like toxin-antitoxin system in Acinetobacter baumannii. Journal of advanced research. 30:159-170. [PudMed:34026293]
[75] Hossein Kazemian et al (2021) Comparison of toxin-antitoxin expression among drug-susceptible and drug-resistant clinical isolates of Mycobacterium tuberculosis. Advances in respiratory medicine. 89(2):110-114. [PudMed:33966258]
[76] Ming Li et al (2021) Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems. Science (New York, N.Y.). 372(6541):eabe5601. [PudMed:33926924]
[77] Daniel Edelmann et al (2021) Elevated Expression of Toxin TisB Protects Persister Cells against Ciprofloxacin but Enhances Susceptibility to Mitomycin C. Microorganisms. 9(5):943. [PudMed:33925723]
[78] Inmaculada Moreno-Córdoba et al (2021) Interactions of the Streptococcus pneumoniae Toxin-Antitoxin RelBE Proteins with Their Target DNA. Microorganisms. 9(4):851. [PudMed:33921033]
[79] Jingyi Zhou et al (2021) Identification of a Toxin-Antitoxin System That Contributes to Persister Formation by Reducing NAD in Pseudomonas aeruginosa. Microorganisms. 9(4):753. [PudMed:33918483]
[80] Xiaotong Luo et al (2021) Characterization of DinJ-YafQ toxin-antitoxin module in Tetragenococcus halophilus: activity, interplay, and evolution. Applied microbiology and biotechnology. 105(9):3659-3672. [PudMed:33877415]
[81] Chantal K Guegler et al (2021) Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection. Molecular cell. 81(11):2361-2373.e9. [PudMed:33838104]
[82] Dongmei Ma et al (2021) Edwardsiella piscicida YefM-YoeB: A Type II Toxin-Antitoxin System That Is Related to Antibiotic Resistance, Biofilm Formation, Serum Survival, and Host Infection. Frontiers in microbiology. 12:646299. [PudMed:33732226]
[83] Zhili He et al (2021) AtaT Improves the Stability of Pore-Forming Protein EspB by Acetylating Lysine 206 to Enhance Strain Virulence. Frontiers in microbiology. 12:627141. [PudMed:33732222]
[84] Jingli Dai et al (2021) MazEF Toxin-Antitoxin System-Mediated DNA Damage Stress Response in Deinococcus radiodurans. Frontiers in genetics. 12:632423. [PudMed:33679894]
[85] Marina Klemenčič et al (2021) The Cysteine Protease MaOC1, a Prokaryotic Caspase Homolog, Cleaves the Antitoxin of a Type II Toxin-Antitoxin System. Frontiers in microbiology. 12:635684. [PudMed:33679669]
[86] Sirli Rosendahl et al (2021) The Disordered C-Terminus of the Chaperone DnaK Increases the Competitive Fitness of Pseudomonas putida and Facilitates the Toxicity of GraT. Microorganisms. 9(2):375. [PudMed:33668424]
[87] Prajita Paul et al (2022) The Hha-TomB toxin-antitoxin module in Salmonella enterica serovar Typhimurium limits its intracellular survival profile and regulates host immune response. Cell biology and toxicology. 38(1):111-127. [PudMed:33651227]
[88] Xiaofeng Zhou et al (2021) A Bacterial Toxin Perturbs Intracellular Amino Acid Balance To Induce Persistence. mBio. 12(1):e03020-20. [PudMed:33622732]
[89] Julia McGillick et al (2021) A YoeB toxin cleaves both RNA and DNA. Scientific reports. 11(1):3592. [PudMed:33574407]
[90] Fedor Bezrukov et al (2021) MazF toxin causes alterations in Staphylococcus aureus transcriptome, translatome and proteome that underlie bacterial dormancy. Nucleic acids research. 49(4):2085-2101. [PudMed:33544858]
[91] Immanuel Dhanasingh et al (2021) Functional and structural characterization of Deinococcus radiodurans R1 MazEF toxin-antitoxin system, Dr0416-Dr0417. Journal of microbiology (Seoul, Korea). 59(2):186-201. [PudMed:33527318]
[92] Songwei Ni et al (2021) Conjugative plasmid-encoded toxin-antitoxin system PrpT/PrpA directly controls plasmid copy number. Proceedings of the National Academy of Sciences of the United States of America. 118(4):e2011577118. [PudMed:33483419]
[93] Marie-Laure Pinel-Marie et al (2021) RNA antitoxin SprF1 binds ribosomes to attenuate translation and promote persister cell formation in Staphylococcus aureus. Nature microbiology. 6(2):209-220. [PudMed:33398097]
[94] Yingjie Song et al (2021) Pseudomonas aeruginosa antitoxin HigA functions as a diverse regulatory factor by recognizing specific pseudopalindromic DNA motifs. Environmental microbiology. 23(3):1541-1558. [PudMed:33346387]
[95] Sakshi Talwar et al (2020) Role of VapBC12 Toxin-Antitoxin Locus in Cholesterol-Induced Mycobacterial Persistence. mSystems. 5(6):e00855-20. [PudMed:33323416]
[96] Inga Songailiene et al (2020) HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation. Molecular cell. 80(6):955-970.e7. [PudMed:33290744]
[97] Johann Peltier et al (2020) Type I toxin-antitoxin systems contribute to the maintenance of mobile genetic elements in Clostridioides difficile. Communications biology. 3(1):718. [PudMed:33247281]
[98] Cédric Romilly et al (2020) An RNA pseudoknot is essential for standby-mediated translation of the tisB toxin mRNA in Escherichia coli. Nucleic acids research. 48(21):12336-12347. [PudMed:33231643]
[99] Lamya El Mortaji et al (2020) A peptide of a type I toxin-antitoxin system induces Helicobacter pylori morphological transformation from spiral shape to coccoids. Proceedings of the National Academy of Sciences of the United States of America. 117(49):31398-31409. [PudMed:33229580]
[100] Liis Andresen et al (2020) The Small Toxic Salmonella Protein TimP Targets the Cytoplasmic Membrane and Is Repressed by the Small RNA TimR. mBio. 11(6):e01659-20. [PudMed:33172998]
[101] Yuka Yashiro et al (2020) Mechanism of aminoacyl-tRNA acetylation by an aminoacyl-tRNA acetyltransferase AtaT from enterohemorrhagic E. coli. Nature communications. 11(1):5438. [PudMed:33116145]
[102] Kwadwo Boampong et al (2020) Rapid growth inhibitory activity of a YafQ-family endonuclease toxin of the Helicobacter pylori tfs4 integrative and conjugative element. Scientific reports. 10(1):18171. [PudMed:33097748]
[103] Zhen Li et al (2020) Characteristic and role of chromosomal type II toxin-antitoxin systems locus in Enterococcus faecalis ATCC29212. Journal of microbiology (Seoul, Korea). 58(12):1027-1036. [PudMed:33095389]
[104] Arun Sharma et al (2020) VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis. Frontiers in microbiology. 11:2037. [PudMed:33042034]
[105] Brittany N Ross et al (2020) Predicting toxins found in toxin-antitoxin systems with a role in host-induced Burkholderia pseudomallei persistence. Scientific reports. 10(1):16923. [PudMed:33037311]
[106] Xiao-Lin Tian et al (2019) ClpP is required for proteolytic regulation of type II toxin-antitoxin systems and persister cell formation in Streptococcus mutans. Access microbiology. 1(8):e000054. [PudMed:32974554]
[107] Yiming Cai et al (2020) A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems. Science advances. 6(31):eabb6651. [PudMed:32923609]
[108] Roberto Sierra et al (2020) Insights into the global effect on Staphylococcus aureus growth arrest by induction of the endoribonuclease MazF toxin. Nucleic acids research. 48(15):8545-8561. [PudMed:32735661]
[109] Keith Weaver (2020) The Fst/Ldr Family of Type I TA System Toxins: Potential Roles in Stress Response, Metabolism and Pathogenesis. Toxins. 12(8):474. [PudMed:32722354]
[110] Anisha Zaveri et al (2020) Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death. Molecular microbiology. 114(4):641-652. [PudMed:32634279]
[111] Monika Janczak et al (2020) Chromosomal localization of PemIK toxin-antitoxin system results in the loss of toxicity - Characterization of pemIKSa1-Sp from Staphylococcus pseudintermedius. Microbiological research. 240:126529. [PudMed:32622987]
[112] R Álvarez et al (2020) Evaluation of functionality of type II toxin-antitoxin systems of Clostridioides difficile R20291. Microbiological research. 239:126539. [PudMed:32622285]
[113] Stepan V Ovchinnikov et al (2020) Mechanism of translation inhibition by type II GNAT toxin AtaT2. Nucleic acids research. 48(15):8617-8625. [PudMed:32597957]
[114] Jogendra Singh Nim et al (2021) Novel Toxin-antitoxin System Xn-mazEF from Xenorhabdus nematophila: Identification, Characterization and Functional Exploration. Current computer-aided drug design. 17(3):402-411. [PudMed:32586257]
[115] Karen C Hernández-Ramírez et al (2020) Virulence Conferred by PumA Toxin from the Plasmid-Encoded PumAB Toxin-Antitoxin System is Regulated by Quorum System. Current microbiology. 77(9):2535-2543. [PudMed:32556478]
[116] Sakshi Agarwal et al (2020) VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis is required for pathogenesis and modulation of host immune response. Science advances. 6(23):eaba6944. [PudMed:32537511]
[117] Jun Xu et al (2020) Functional investigation of the chromosomal ccdAB and hipAB operon in Escherichia coli Nissle 1917. Applied microbiology and biotechnology. 104(15):6731-6747. [PudMed:32535695]
[118] Jessica R Ames et al (2020) Identifying a Molecular Mechanism That Imparts Species-Specific Toxicity to YoeB Toxins. Frontiers in microbiology. 11:959. [PudMed:32528435]
[119] Izaak N Beck et al (2020) Antitoxin autoregulation of M. tuberculosis toxin-antitoxin expression through negative cooperativity arising from multiple inverted repeat sequences. The Biochemical journal. 477(12):2401-2419. [PudMed:32519742]
[120] Sirli Rosendahl et al (2020) Chromosomal toxin-antitoxin systems in Pseudomonas putida are rather selfish than beneficial. Scientific reports. 10(1):9230. [PudMed:32513960]
[121] Yoshimitsu Masuda et al (2020) Role of Toxin-Antitoxin-Regulated Persister Population and Indole in Bacterial Heat Tolerance. Applied and environmental microbiology. 86(16):e00935-20. [PudMed:32503909]
[122] Itzhak Zander et al (2020) Characterization of PfiT/PfiA toxin-antitoxin system of Pseudomonas aeruginosa that affects cell elongation and prophage induction. Environmental microbiology. 22(12):5048-5057. [PudMed:32458560]
[123] Kanchiyaphat Ariyachaokun et al (2020) Multi-Stress Induction of the Mycobacterium tuberculosis MbcTA Bactericidal Toxin-Antitoxin System. Toxins. 12(5):329. [PudMed:32429486]
[124] Xia Yu et al (2020) Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism. Communications biology. 3(1):216. [PudMed:32382148]
[125] Rie Aoi et al (2020) MazF Endoribonucleolytic Toxin Conserved in Nitrospira Specifically Cleaves the AACU, AACG, and AAUU Motifs. Toxins. 12(5):287. [PudMed:32365819]
[126] Hadiastri Kusumawardhani et al (2020) Novel Toxin-Antitoxin Module SlvT-SlvA Regulates Megaplasmid Stability and Incites Solvent Tolerance in Pseudomonas putida S12. Applied and environmental microbiology. 86(13):e00686-20. [PudMed:32358012]
[127] Steffi Jimmy et al (2020) A widespread toxin-antitoxin system exploiting growth control via alarmone signaling. Proceedings of the National Academy of Sciences of the United States of America. 117(19):10500-10510. [PudMed:32345719]
[128] Fernando Chimal-Cázares et al (2020) Molecular Characterization of SehB, a Type II Antitoxin of Salmonella enterica Serotype Typhimurium: Amino Acid Residues Involved in DNA-Binding, Homodimerization, Toxin Interaction, and Virulence. Frontiers in microbiology. 11:614. [PudMed:32328049]
[129] Lillian G Acuña et al (2020) The cis-encoded antisense RNA IsrA from Salmonella Typhimurium represses the expression of STM0294.1n (iasE), an SOS-induced gene coding for an endoribonuclease activity. Biochemical and biophysical research communications. 526(3):706-712. [PudMed:32253028]
[130] Yangmei Li et al (2020) Prophage encoding toxin/antitoxin system PfiT/PfiA inhibits Pf4 production in Pseudomonas aeruginosa. Microbial biotechnology. 13(4):1132-1144. [PudMed:32246813]
[131] Madhurima Roy et al (2020) Biochemical Characterization of VapC46 Toxin from Mycobacterium tuberculosis. Molecular biotechnology. 62(6-7):335-343. [PudMed:32236842]
[132] Charlie Y Huang et al (2020) hipBA toxin-antitoxin systems mediate persistence in Caulobacter crescentus. Scientific reports. 10(1):2865. [PudMed:32071324]
[133] Magnus Stårsta et al (2020) RHS-elements function as type II toxin-antitoxin modules that regulate intra-macrophage replication of Salmonella Typhimurium. PLoS genetics. 16(2):e1008607. [PudMed:32053596]
[134] Mohit Yadav et al (2020) The hipBAXn operon from Xenorhabdus nematophila functions as a bonafide toxin-antitoxin module. Applied microbiology and biotechnology. 104(7):3081-3095. [PudMed:32043192]
[135] Emeline Lawarée et al (2020) DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair. Cell reports. 30(5):1373-1384.e4. [PudMed:32023456]
[136] Gul Habib et al (2020) A novel type I toxin-antitoxin system modulates persister cell formation in Staphylococcus aureus. International journal of medical microbiology : IJMM. 310(2):151400. [PudMed:32001143]
[137] Hailey Findlay Black et al (2020) A competence-regulated toxin-antitoxin system in Haemophilus influenzae. PloS one. 15(1):e0217255. [PudMed:31931516]
[138] Nathan Fraikin et al (2019) Reassessing the Role of the Type II MqsRA Toxin-Antitoxin System in Stress Response and Biofilm Formation: mqsA Is Transcriptionally Uncoupled from mqsR. mBio. 10(6):e02678-19. [PudMed:31848281]
[139] Alessia Levante et al (2019) Expression of DinJ-YafQ System of Lactobacillus casei Group Strains in Response to Food Processing Stresses. Microorganisms. 7(10):438. [PudMed:31614503]
[140] Sara Masachis et al (2019) A genetic selection reveals functional metastable structures embedded in a toxin-encoding mRNA. eLife. 8:e47549. [PudMed:31411564]
[141] Brittany N Ross et al (2019) Evaluating the role of Burkholderia pseudomallei K96243 toxins BPSS0390, BPSS0395, and BPSS1584 in persistent infection. Cellular microbiology. 21(12):e13096. [PudMed:31400259]
[142] Fuminori Kato et al (2019) Genome-Wide Screening for Identification of Novel Toxin-Antitoxin Systems in Staphylococcus aureus. Applied and environmental microbiology. 85(20):e00915-19. [PudMed:31375497]
[143] Laís Moreira Granato et al (2019) The ecnA Antitoxin Is Important Not Only for Human Pathogens: Evidence of Its Role in the Plant Pathogen Xanthomonas citri subsp. citri. Journal of bacteriology. 201(20):e00796-18. [PudMed:31358614]
[144] Muhammad Kamruzzaman et al (2019) A ParDE-family toxin antitoxin system in major resistance plasmids of Enterobacteriaceae confers antibiotic and heat tolerance. Scientific reports. 9(1):9872. [PudMed:31285520]
[145] Ran Chen et al (2019) Structural and Biochemical Characterization of the Cognate and Heterologous Interactions of the MazEF-mt9 TA System. ACS infectious diseases. 5(8):1306-1316. [PudMed:31267737]
[146] Stine Vang Nielsen et al (2019) Serine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase. mBio. 10(3):e01138-19. [PudMed:31213559]
[147] Przemyslaw Decewicz et al (2019) Characterization of the virome of Paracoccus spp. (Alphaproteobacteria) by combined in silico and in vivo approaches. Scientific reports. 9(1):7899. [PudMed:31133656]
[148] Alberto Ferrari et al (2019) Identification and first characterization of DinJ-YafQ toxin-antitoxin systems in Lactobacillus species of biotechnological interest. Scientific reports. 9(1):7645. [PudMed:31114007]
[149] Jingyu Peng et al (2019) Chromosomally Encoded hok-sok Toxin-Antitoxin System in the Fire Blight Pathogen Erwinia amylovora: Identification and Functional Characterization. Applied and environmental microbiology. 85(15):e00724-19. [PudMed:31101613]
[150] Waner Zhan et al (2019) Characterization of Two Toxin-Antitoxin Systems in Deep-Sea Streptomyces sp. SCSIO 02999. Marine drugs. 17(4):211. [PudMed:30987346]
[151] Teja Shidore et al (2019) Survey of Toxin⁻Antitoxin Systems in Erwinia amylovora Reveals Insights into Diversity and Functional Specificity. Toxins. 11(4):206. [PudMed:30959879]
[152] Akanksha Nigam et al (2019) Stress-Induced MazF-Mediated Proteins in Escherichia coli. mBio. 10(2):e00340-19. [PudMed:30914510]
[153] Mao Shaku et al (2018) Identification of MazF Homologue in Legionella pneumophila Which Cleaves RNA at the AACU Sequence. Journal of molecular microbiology and biotechnology. 28(6):269-280. [PudMed:30893701]
[154] Yunxue Guo et al (2019) Antitoxin HigA inhibits virulence gene mvfR expression in Pseudomonas aeruginosa. Environmental microbiology. 21(8):2707-2723. [PudMed:30882983]
[155] Ariel Talavera et al (2019) A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT. Nature communications. 10(1):972. [PudMed:30814507]
[156] Kai Xia et al (2019) Characterization and comparative analysis of toxin-antitoxin systems in Acetobacter pasteurianus. Journal of industrial microbiology & biotechnology. 46(6):869-882. [PudMed:30805740]
[157] Won-Su Yoon et al (2019) Structural changes of antitoxin HigA from Shigella flexneri by binding of its cognate toxin HigB. International journal of biological macromolecules. 130:99-108. [PudMed:30797012]
[158] Marc A Schureck et al (2019) Structural basis of transcriptional regulation by the HigA antitoxin. Molecular microbiology. 111(6):1449-1462. [PudMed:30793388]
[159] Diana Mendes Freire et al (2019) An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death. Molecular cell. 73(6):1282-1291.e8. [PudMed:30792174]
[160] Andres Ainelo et al (2019) Pseudomonas putida Responds to the Toxin GraT by Inducing Ribosome Biogenesis Factors and Repressing TCA Cycle Enzymes. Toxins. 11(2):103. [PudMed:30744127]
[161] Leire Bardaji et al (2019) The toxic guardians - multiple toxin-antitoxin systems provide stability, avoid deletions and maintain virulence genes of Pseudomonas syringae virulence plasmids. Mobile DNA. 10:7. [PudMed:30728866]
[162] Himani Tandon et al (2019) Mycobacterium tuberculosis Rv0366c-Rv0367c encodes a non-canonical PezAT-like toxin-antitoxin pair. Scientific reports. 9(1):1163. [PudMed:30718534]
[163] Manon Thomet et al (2019) Characterization of HicAB toxin-antitoxin module of Sinorhizobium meliloti. BMC microbiology. 19(1):10. [PudMed:30630415]
[164] Frank J Piscotta et al (2019) ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism. Proceedings of the National Academy of Sciences of the United States of America. 116(3):826-834. [PudMed:30598453]
[165] Madhurima Roy et al (2019) Structural characterization of VapB46 antitoxin from Mycobacterium tuberculosis: insights into VapB46-DNA binding. The FEBS journal. 286(6):1174-1190. [PudMed:30576065]
[166] Camille Riffaud et al (2019) Functionality and cross-regulation of the four SprG/SprF type I toxin-antitoxin systems in Staphylococcus aureus. Nucleic acids research. 47(4):1740-1758. [PudMed:30551143]
[167] Noëlla Germain-Amiot et al (2019) A novel Staphylococcus aureus cis-trans type I toxin-antitoxin module with dual effects on bacteria and host cells. Nucleic acids research. 47(4):1759-1773. [PudMed:30544243]
[168] Paula Bustamante et al (2019) The roles of HicBA and a novel toxin-antitoxin-like system, TsxAB, in the stability of IncX4 resistance plasmids in Escherichia coli. The Journal of antimicrobial chemotherapy. 74(3):553-556. [PudMed:30535076]
[169] Prajita Paul et al (2018) Molecular insight to influential role of Hha-TomB toxin-antitoxin system for antibacterial activity of biogenic silver nanoparticles. Artificial cells, nanomedicine, and biotechnology. 46(sup3):S572-S584. [PudMed:30444141]
[170] Gul Habib et al (2018) Bioinformatics and Functional Assessment of Toxin-Antitoxin Systems in Staphylococcus aureus. Toxins. 10(11):473. [PudMed:30441856]
[171] Jiali Xu et al (2018) Identification of Three Type II Toxin-Antitoxin Systems in Streptococcus suis Serotype 2. Toxins. 10(11):467. [PudMed:30428568]
[172] Meenakumari Muthuramalingam et al (2019) The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics. Molecular microbiology. 111(2):441-454. [PudMed:30427086]
[173] Xiaodong Chi et al (2018) Biochemical characterization of mt-PemIK, a novel toxin-antitoxin system in Mycobacterium tuberculosis. FEBS letters. 592(24):4039-4050. [PudMed:30372528]
[174] Yueying Zhang et al (2018) HigB Reciprocally Controls Biofilm Formation and the Expression of Type III Secretion System Genes through Influencing the Intracellular c-di-GMP Level in Pseudomonas aeruginosa. Toxins. 10(11):424. [PudMed:30355991]
[175] Tatsuki Miyamoto et al (2018) Nitrosomonas europaea MazF Specifically Recognises the UGG Motif and Promotes Selective RNA Degradation. Frontiers in microbiology. 9:2386. [PudMed:30349517]
[176] Ashley J Winter et al (2018) The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA. The Journal of biological chemistry. 293(50):19429-19440. [PudMed:30337369]
[177] Amar Deep et al (2018) Structural, functional and biological insights into the role of Mycobacterium tuberculosis VapBC11 toxin-antitoxin system: targeting a tRNase to tackle mycobacterial adaptation. Nucleic acids research. 46(21):11639-11655. [PudMed:30329074]
[178] Andrzej Dubiel et al (2018) ClpAP protease is a universal factor that activates the parDE toxin-antitoxin system from a broad host range RK2 plasmid. Scientific reports. 8(1):15287. [PudMed:30327496]
[179] Toomas Mets et al (2019) Fragmentation of Escherichia coli mRNA by MazF and MqsR. Biochimie. 156:79-91. [PudMed:30315853]
[180] Ragnhild Bager Skjerning et al (2019) The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+. Molecular microbiology. 111(1):221-236. [PudMed:30315706]
[181] Delphine Dufour et al (2018) A tripartite toxin-antitoxin module induced by quorum sensing is associated with the persistence phenotype in Streptococcus mutans. Molecular oral microbiology. 33(6):420-429. [PudMed:30298644]
[182] Jee Soo Choi et al (2018) The small RNA, SdsR, acts as a novel type of toxin in Escherichia coli. RNA biology. 15(10):1319-1335. [PudMed:30293519]
[183] Wai Ting Chan et al (2018) The Streptococcus pneumoniaeyefM-yoeB and relBE Toxin-Antitoxin Operons Participate in Oxidative Stress and Biofilm Formation. Toxins. 10(9):378. [PudMed:30231554]
[184] Abigail Sharrock et al (2018) VapC proteins from Mycobacterium tuberculosis share ribonuclease sequence specificity but differ in regulation and toxicity. PloS one. 13(8):e0203412. [PudMed:30169502]
[185] Mohit Yadav et al (2018) TAome analysis of type-II toxin-antitoxin system from Xenorhabdus nematophila. Computational biology and chemistry. 76:293-301. [PudMed:30114602]
[186] Pan Fu et al (2018) A toxin-antitoxin system is essential for the stability of mosquitocidal plasmid pBsph of Lysinibacillus sphaericus. Microbiological research. 214:114-122. [PudMed:30031473]
[187] Xiaoyu Wang et al (2018) Mycobacterium tuberculosis toxin Rv2872 is an RNase involved in vancomycin stress response and biofilm development. Applied microbiology and biotechnology. 102(16):7123-7133. [PudMed:29948114]
[188] Brendan Wilcox et al (2018) Escherichia coli ItaT is a type II toxin that inhibits translation by acetylating isoleucyl-tRNAIle. Nucleic acids research. 46(15):7873-7885. [PudMed:29931259]
[189] Rashad Alkasir et al (2018) Characterization and Transcriptome Analysis of Acinetobacter baumannii Persister Cells. Microbial drug resistance (Larchmont, N.Y.). 24(10):1466-1474. [PudMed:29902105]
[190] Julian A Rycroft et al (2018) Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection. Nature communications. 9(1):1993. [PudMed:29777131]
[191] Julija Armalytė et al (2018) The higBA Toxin-Antitoxin Module From the Opportunistic Pathogen Acinetobacter baumannii - Regulation, Activity, and Evolution. Frontiers in microbiology. 9:732. [PudMed:29706946]
[192] Andrea Rocker et al (2018) The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis. Nature communications. 9(1):1686. [PudMed:29703974]
[193] Wonho Choi et al (2018) Functional Characterization of the C-Terminus of YhaV in the Escherichia coli PrlF-YhaV Toxin-Antitoxin System. Journal of microbiology and biotechnology. 28(6):987-996. [PudMed:29642286]
[194] Ji-Li Zhao et al (2018) Viability, biofilm formation, and MazEF expression in drug-sensitive and drug-resistant Mycobacterium tuberculosis strains circulating in Xinjiang, China. Infection and drug resistance. 11:345-358. [PudMed:29563815]
[195] Qian Fei et al (2018) A Toxin-Antitoxin System VapBC15 from Synechocystis sp. PCC 6803 Shows Distinct Regulatory Features. Genes. 9(4):173. [PudMed:29561797]
[196] Tomoya Maeda et al (2018) Glutamine-rich toxic proteins GrtA, GrtB and GrtC together with the antisense RNA AsgR constitute a toxin-antitoxin-like system in Corynebacterium glutamicum. Molecular microbiology. 108(5):578-594. [PudMed:29537126]
[197] Anna Maikova et al (2018) Discovery of new type I toxin-antitoxin systems adjacent to CRISPR arrays in Clostridium difficile. Nucleic acids research. 46(9):4733-4751. [PudMed:29529286]
[198] Sakshi Agarwal et al (2018) System-Wide Analysis Unravels the Differential Regulation and In Vivo Essentiality of Virulence-Associated Proteins B and C Toxin-Antitoxin Systems of Mycobacterium tuberculosis. The Journal of infectious diseases. 217(11):1809-1820. [PudMed:29529224]
[199] Hannah G Hampton et al (2018) AbiEi Binds Cooperatively to the Type IV abiE Toxin-Antitoxin Operator Via a Positively-Charged Surface and Causes DNA Bending and Negative Autoregulation. Journal of molecular biology. 430(8):1141-1156. [PudMed:29518409]
[200] Jun-Seob Kim et al (2018) GhoT of the GhoT/GhoS toxin/antitoxin system damages lipid membranes by forming transient pores. Biochemical and biophysical research communications. 497(2):467-472. [PudMed:29470981]
[201] Hongliang Qian et al (2018) Identification and characterization of acetyltransferase-type toxin-antitoxin locus in Klebsiella pneumoniae. Molecular microbiology. 108(4):336-349. [PudMed:29461656]
[202] Wen Wen et al (2018) Autoregulation and Virulence Control by the Toxin-Antitoxin System SavRS in Staphylococcus aureus. Infection and immunity. 86(5):e00032-18. [PudMed:29440365]
[203] Nela Nikolic et al (2018) Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations. Nucleic acids research. 46(6):2918-2931. [PudMed:29432616]
[204] Celine Reif et al (2018) Bacillus subtilis Type I antitoxin SR6 Promotes Degradation of Toxin yonT mRNA and Is Required to Prevent Toxic yoyJ Overexpression. Toxins. 10(2):74. [PudMed:29414903]
[205] Jianyun Yao et al (2018) Type II toxin/antitoxin system ParESO /CopASO stabilizes prophage CP4So in Shewanella oneidensis. Environmental microbiology. 20(3):1224-1239. [PudMed:29411516]
[206] Francesca L Short et al (2018) The bacterial Type III toxin-antitoxin system, ToxIN, is a dynamic protein-RNA complex with stability-dependent antiviral abortive infection activity. Scientific reports. 8(1):1013. [PudMed:29343718]
[207] Zhen Li et al (2018) Identification of a functional toxin-antitoxin system located in the genomic island PYG1 of piezophilic hyperthermophilic archaeon Pyrococcus yayanosii. Extremophiles : life under extreme conditions. 22(3):347-357. [PudMed:29335804]
[208] B Schneider et al (2018) Identification and functional characterization of type II toxin/antitoxin systems in Aggregatibacter actinomycetemcomitans. Molecular oral microbiology. 33(3):224-233. [PudMed:29319934]
[209] Daniel Jaén-Luchoro et al (2017) First insights into a type II toxin-antitoxin system from the clinical isolate Mycobacterium sp. MHSD3, similar to epsilon/zeta systems. PloS one. 12(12):e0189459. [PudMed:29236773]
[210] Lauren R Walling et al (2018) Homologous VapC Toxins Inhibit Translation and Cell Growth by Sequence-Specific Cleavage of tRNAfMet. Journal of bacteriology. 200(3):e00582-17. [PudMed:29109187]
[211] Hanna Sprenger et al (2017) Fic Proteins of Campylobacter fetus subsp. venerealis Form a Network of Functional Toxin-Antitoxin Systems. Frontiers in microbiology. 8:1965. [PudMed:29089929]
[212] Alexander Harms et al (2017) A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella. PLoS genetics. 13(10):e1007077. [PudMed:29073136]
[213] K C Hernández-Ramírez et al (2017) Plasmid pUM505 encodes a Toxin-Antitoxin system conferring plasmid stability and increased Pseudomonas aeruginosa virulence. Microbial pathogenesis. 112:259-268. [PudMed:28970172]
[214] Nela Nikolic et al (2017) MazF activation promotes translational heterogeneity of the grcA mRNA in Escherichia coli populations. PeerJ. 5:e3830. [PudMed:28948108]
[215] Giulia Pilla et al (2017) Genetic plasticity of the Shigella virulence plasmid is mediated by intra- and inter-molecular events between insertion sequences. PLoS genetics. 13(9):e1007014. [PudMed:28945748]
[216] Jing Zhang et al (2017) Expression of a Vibrio parahaemolyticus toxin in Escherichia coli results in chromosomal DNA degradation. Bioscience, biotechnology, and biochemistry. 81(10):1937-1940. [PudMed:28820009]
[217] Krzysztof Romaniuk et al (2017) Molecular characterization of the pA3J1 plasmid from the psychrotolerant Antarctic bacterium Pseudomonas sp. ANT_J3. Plasmid. 92:49-56. [PudMed:28802584]
[218] Tao Li et al (2017) Deinococcus radiodurans Toxin-Antitoxin MazEF-dr Mediates Cell Death in Response to DNA Damage Stress. Frontiers in microbiology. 8:1427. [PudMed:28798741]
[219] David Marsan et al (2017) Toxin-Antitoxin Systems in Estuarine Synechococcus Strain CB0101 and Their Transcriptomic Responses to Environmental Stressors. Frontiers in microbiology. 8:1213. [PudMed:28729858]
[220] Tatsuki Miyamoto et al (2017) Characterization of a Deinococcus radiodurans MazF: A UACA-specific RNA endoribonuclease. MicrobiologyOpen. 6(5):e00501. [PudMed:28675659]
[221] Kritika Gupta et al (2017) Contribution of the Chromosomal ccdAB Operon to Bacterial Drug Tolerance. Journal of bacteriology. 199(19):e00397-17. [PudMed:28674066]
[222] Chengkun Zheng et al (2017) Identification of four type II toxin-antitoxin systems in Actinobacillus pleuropneumoniae. FEMS microbiology letters. 364(12):10.1093/femsle/fnx126. [PudMed:28637172]
[223] Bihe Chen et al (2017) Environmental T4-Family Bacteriophages Evolve to Escape Abortive Infection via Multiple Routes in a Bacterial Host Employing "Altruistic Suicide" through Type III Toxin-Antitoxin Systems. Frontiers in microbiology. 8:1006. [PudMed:28620370]
[224] Ayalla Fedida et al (2017) Two Synechococcus genes, Two Different Effects on Cyanophage Infection. Viruses. 9(6):136. [PudMed:28574452]
[225] Chelsey M VanDrisse et al (2017) A Toxin Involved in Salmonella Persistence Regulates Its Activity by Acetylating Its Cognate Antitoxin, a Modification Reversed by CobB Sirtuin Deacetylase. mBio. 8(3):e00708-17. [PudMed:28559487]
[226] Chenglong Sun et al (2017) MqsR/MqsA Toxin/Antitoxin System Regulates Persistence and Biofilm Formation in Pseudomonas putida KT2440. Frontiers in microbiology. 8:840. [PudMed:28536573]
[227] Jing Zhang et al (2017) A RelE/ParE superfamily toxin in Vibrio parahaemolyticus has DNA nicking endonuclease activity. Biochemical and biophysical research communications. 489(1):29-34. [PudMed:28533087]
[228] Lalit Kumar Gautam et al (2017) Functional annotation of a novel toxin-antitoxin system Xn-RelT of Xenorhabdus nematophila; a combined in silico and in vitro approach. Journal of molecular modeling. 23(6):189. [PudMed:28508139]
[229] Abbas Maleki et al (2017) Novel Information about Neisseria meningitidis: Identification of the Most Important Type II Toxin Antitoxin Systems. Infectious disorders drug targets. 17(2):81-85. [PudMed:28460613]
[230] Yuki Maeda et al (2017) Characterization of YjjJ toxin of Escherichia coli. FEMS microbiology letters. 364(11):10.1093/femsle/fnx086. [PudMed:28430938]
[231] V Garcia-Fulgueiras et al (2017) Allodemic distribution of plasmids co-harbouring blaCTX-M-15/aac(6')-Ib-cr/qnrB in Klebsiella pneumoniae is the main source of extended-spectrum β-lactamases in Uruguay's paediatric hospital. Journal of global antimicrobial resistance. 9:68-73. [PudMed:28419869]
[232] Dukas Jurėnas et al (2017) AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet. Nature chemical biology. 13(6):640-646. [PudMed:28369041]
[233] Kathryn J Turnbull et al (2017) HicA toxin of Escherichia coli derepresses hicAB transcription to selectively produce HicB antitoxin. Molecular microbiology. 104(5):781-792. [PudMed:28266056]
[234] Zhongling Wen et al (2017) Interaction of Type IV Toxin/Antitoxin Systems in Cryptic Prophages of Escherichia coli K-12. Toxins. 9(3):77. [PudMed:28257056]
[235] Ajchareeya Ruangprasert et al (2017) Importance of the E. coli DinJ antitoxin carboxy terminus for toxin suppression and regulated proteolysis. Molecular microbiology. 104(1):65-77. [PudMed:28164393]
[236] Marion Duprilot et al (2017) Diversity and functionality of plasmid-borne VagCD toxin-antitoxin systems of Klebsiella pneumoniae. The Journal of antimicrobial chemotherapy. 72(5):1320-1326. [PudMed:28119479]
[237] Hélène Arnion et al (2017) Mechanistic insights into type I toxin antitoxin systems in Helicobacter pylori: the importance of mRNA folding in controlling toxin expression. Nucleic acids research. 45(8):4782-4795. [PudMed:28077560]
[238] Sangeeta Jaiswal et al (2016) The Hha-TomB Toxin-Antitoxin System Shows Conditional Toxicity and Promotes Persister Cell Formation by Inhibiting Apoptosis-Like Death in S. Typhimurium. Scientific reports. 6:38204. [PudMed:27910884]
[239] Lauren R Walling et al (2016) Structural Determinants for Antitoxin Identity and Insulation of Cross Talk between Homologous Toxin-Antitoxin Systems. Journal of bacteriology. 198(24):3287-3295. [PudMed:27672196]
[240] Knut I Kristiansen et al (2016) Mutually exclusive RNA secondary structures regulate translation initiation of DinQ in Escherichia coli. RNA (New York, N.Y.). 22(11):1739-1749. [PudMed:27651528]
[241] Wai T Chan et al (2016) The Streptococcus pneumoniae pezAT Toxin-Antitoxin System Reduces β-Lactam Resistance and Genetic Competence. Frontiers in microbiology. 7:1322. [PudMed:27610103]
[242] Yueju Zhao et al (2016) Toxin YafQ Reduces Escherichia coli Growth at Low Temperatures. PloS one. 11(8):e0161577. [PudMed:27557125]
[243] Peng Li et al (2016) Identification and characterization of chromosomal relBE toxin-antitoxin locus in Streptomyces cattleya DSM46488. Scientific reports. 6:32047. [PudMed:27534445]
[244] Stefan Kopfmann et al (2016) Type II Toxin-Antitoxin Systems in the Unicellular Cyanobacterium Synechocystis sp. PCC 6803. Toxins. 8(7):228. [PudMed:27455323]
[245] Yanxia Wei et al (2016) Functional characterization of RelBE toxin-antitoxin system in probiotic Bifidobacterium longum JDM301. Acta biochimica et biophysica Sinica. 48(8):741-9. [PudMed:27451444]
[246] Lindsay R Triplett et al (2016) AvrRxo1 Is a Bifunctional Type III Secreted Effector and Toxin-Antitoxin System Component with Homologs in Diverse Environmental Contexts. PloS one. 11(7):e0158856. [PudMed:27391081]
[247] Manish Gupta et al (2016) The Chromosomal parDE2 Toxin-Antitoxin System of Mycobacterium tuberculosis H37Rv: Genetic and Functional Characterization. Frontiers in microbiology. 7:886. [PudMed:27379032]
[248] Marcus V Merfa et al (2016) The MqsRA Toxin-Antitoxin System from Xylella fastidiosa Plays a Key Role in Bacterial Fitness, Pathogenicity, and Persister Cell Formation. Frontiers in microbiology. 7:904. [PudMed:27375608]
[249] Zhangqi Shen et al (2016) Identification and functional analysis of two toxin-antitoxin systems in Campylobacter jejuni. Molecular microbiology. 101(6):909-23. [PudMed:27291507]
[250] Tatsuki Miyamoto et al (2016) AAU-Specific RNA Cleavage Mediated by MazF Toxin Endoribonuclease Conserved in Nitrosomonas europaea. Toxins. 8(6):174. [PudMed:27271670]
[251] Angela M Cheverton et al (2016) A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA. Molecular cell. 63(1):86-96. [PudMed:27264868]
[252] Gang Li et al (2016) Identification and Characterization of the HicAB Toxin-Antitoxin System in the Opportunistic Pathogen Pseudomonas aeruginosa. Toxins. 8(4):113. [PudMed:27104566]
[253] Andres Ainelo et al (2016) The toxin GraT inhibits ribosome biogenesis. Molecular microbiology. 100(4):719-34. [PudMed:26833678]
[254] Reut Shavit et al (2015) The vapB-vapC Operon of Acidovorax citrulli Functions as a Bona-fide Toxin-Antitoxin Module. Frontiers in microbiology. 6:1499. [PudMed:26779154]
[255] Christin Meißner et al (2016) In Vitro Characterization of the Type I Toxin-Antitoxin System bsrE/SR5 from Bacillus subtilis. The Journal of biological chemistry. 291(2):560-71. [PudMed:26565032]
[256] Yoshihiro Yamaguchi et al (2015) An endogenous protein inhibitor, YjhX (TopAI), for topoisomerase I from Escherichia coli. Nucleic acids research. 43(21):10387-96. [PudMed:26553797]
[257] Shaleen B Korch et al (2015) The Mycobacterium tuberculosis relBE toxin:antitoxin genes are stress-responsive modules that regulate growth through translation inhibition. Journal of microbiology (Seoul, Korea). 53(11):783-95. [PudMed:26502963]
[258] Françoise Wessner et al (2015) Regulatory crosstalk between type I and type II toxin-antitoxin systems in the human pathogen Enterococcus faecalis. RNA biology. 12(10):1099-108. [PudMed:26305399]
[259] Jana Melničáková et al (2015) Analysis of the Bacillus cereus SpoIIS antitoxin-toxin system reveals its three-component nature. Frontiers in microbiology. 6:808. [PudMed:26300872]
[260] Francesca L Short et al (2015) A Type III protein-RNA toxin-antitoxin system from Bacillus thuringiensis promotes plasmid retention during spore development. RNA biology. 12(9):933-7. [PudMed:26274022]
[261] Chengkun Zheng et al (2015) Identification and characterization of the chromosomal yefM-yoeB toxin-antitoxin system of Streptococcus suis. Scientific reports. 5:13125. [PudMed:26272287]
[262] Olga Averina et al (2015) Functional analysis of the type II toxin-antitoxin systems of the MazEF and RelBE families in Bifidobacterium longum subsp. infantis ATCC 15697. Anaerobe. 35(Pt B):59-67. [PudMed:26210151]
[263] In-Gyun Lee et al (2015) Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides. Nucleic acids research. 43(15):7624-37. [PudMed:26150422]
[264] Xinyue Yao et al (2015) The chromosomal SezAT toxin-antitoxin system promotes the maintenance of the SsPI-1 pathogenicity island in epidemic Streptococcus suis. Molecular microbiology. 98(2):243-57. [PudMed:26138696]
[265] Jianyun Yao et al (2015) Identification and characterization of a HEPN-MNT family type II toxin-antitoxin in Shewanella oneidensis. Microbial biotechnology. 8(6):961-73. [PudMed:26112399]
[266] Andrea Volante et al (2014) The Interplay between Different Stability Systems Contributes to Faithful Segregation: Streptococcus pyogenes pSM19035 as a Model. Microbiology spectrum. 2(4):PLAS-0007-2013. [PudMed:26104212]
[267] Christopher F Schuster et al (2015) The MazEF Toxin-Antitoxin System Alters the β-Lactam Susceptibility of Staphylococcus aureus. PloS one. 10(5):e0126118. [PudMed:25965381]
[268] Miyuki Tsukuda et al (2015) Counterselection method based on conditional silencing of antitoxin genes in Escherichia coli. Journal of bioscience and bioengineering. 120(5):591-5. [PudMed:25912447]
[269] Naeem Iqbal et al (2015) Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron. Journal of bacteriology. 197(13):2150-9. [PudMed:25897030]
[270] Hans Krügel et al (2015) Expression of the toxin-antitoxin genes yefM(Lrh), yoeB(Lrh) in human Lactobacillus rhamnosus isolates. Journal of basic microbiology. 55(8):982-91. [PudMed:25832734]
[271] Uddipan Das et al (2014) Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin-antitoxin assembly. Journal of structural biology. 188(3):249-58. [PudMed:25450593]
[272] Christopher F Schuster et al (2014) Fluorescence based primer extension technique to determine transcriptional starting points and cleavage sites of RNases in vivo. Journal of visualized experiments : JoVE. (92):e52134. [PudMed:25406941]
[273] James R Doroghazi et al (2014) Intraspecies comparison of Streptomyces pratensis genomes reveals high levels of recombination and gene conservation between strains of disparate geographic origin. BMC genomics. 15(1):970. [PudMed:25399205]
[274] Brooke Hamilton et al (2014) Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. PloS one. 9(11):e112921. [PudMed:25391136]
[275] Paula Bustamante et al (2014) Toxin-antitoxin systems in the mobile genome of Acidithiobacillus ferrooxidans. PloS one. 9(11):e112226. [PudMed:25384039]
[276] Steven De Gieter et al (2014) The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding. The Journal of biological chemistry. 289(49):34013-23. [PudMed:25326388]
[277] Keith E Weaver (2015) The Type I toxin-antitoxin par locus from Enterococcus faecalis plasmid pAD1: RNA regulation by both cis- and trans-acting elements. Plasmid. 78:65-70. [PudMed:25312777]
[278] Hyo Jung Lee et al (2015) Recovery of plasmid pEMB1, whose toxin-antitoxin system stabilizes an ampicillin resistance-conferring β-lactamase gene in Escherichia coli, from natural environments. Applied and environmental microbiology. 81(1):40-7. [PudMed:25304509]
[279] Sathish Kumar et al (2014) Quorum sensing peptides mediating interspecies bacterial cell death as a novel class of antimicrobial agents. Current opinion in microbiology. 21:22-7. [PudMed:25244032]
[280] Justine Lipuma et al (2014) A vapBC-type toxin-antitoxin module of Sinorhizobium meliloti influences symbiotic efficiency and nodule senescence of Medicago sativa. Environmental microbiology. 16(12):3714-29. [PudMed:25156344]
[281] Marina Mingoia et al (2014) Tn5253 family integrative and conjugative elements carrying mef(I) and catQ determinants in Streptococcus pneumoniae and Streptococcus pyogenes. Antimicrobial agents and chemotherapy. 58(10):5886-93. [PudMed:25070090]
[282] Alexandre P Y Lopes et al (2014) VapC from the leptospiral VapBC toxin-antitoxin module displays ribonuclease activity on the initiator tRNA. PloS one. 9(7):e101678. [PudMed:25047537]
[283] Ying Hu et al (2015) Toxin YafQ increases persister cell formation by reducing indole signalling. Environmental microbiology. 17(4):1275-85. [PudMed:25041421]
[284] Jana Makroczyová et al (2014) Topology of the Bacillus subtilis SpoIISA protein and its role in toxin-antitoxin function. FEMS microbiology letters. 358(2):180-7. [PudMed:25039482]
[285] L Aravind et al (2015) The natural history of ADP-ribosyltransferases and the ADP-ribosylation system. Current topics in microbiology and immunology. 384:3-32. [PudMed:25027823]
[286] Sobhan Ghafourian et al (2014) The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii. Memorias do Instituto Oswaldo Cruz. 109(4):502-5. [PudMed:25004148]
[287] Ewa Wardal et al (2014) Molecular analysis of vanA outbreak of Enterococcus faecium in two Warsaw hospitals: the importance of mobile genetic elements. BioMed research international. 2014:575367. [PudMed:25003118]
[288] Hermann Hämmerle et al (2014) Impact of Hfq on the Bacillus subtilis transcriptome. PloS one. 9(6):e98661. [PudMed:24932523]
[289] Charlotte Michaux et al (2014) Involvement of Enterococcus faecalis small RNAs in stress response and virulence. Infection and immunity. 82(9):3599-611. [PudMed:24914223]
[290] Jean-Claude Ogier et al (2014) Attenuated virulence and genomic reductive evolution in the entomopathogenic bacterial symbiont species, Xenorhabdus poinarii. Genome biology and evolution. 6(6):1495-513. [PudMed:24904010]
[291] Ajchareeya Ruangprasert et al (2014) Mechanisms of toxin inhibition and transcriptional repression by Escherichia coli DinJ-YafQ. The Journal of biological chemistry. 289(30):20559-69. [PudMed:24898247]
[292] Valerie W C Soo et al (2014) de novo synthesis of a bacterial toxin/antitoxin system. Scientific reports. 4:4807. [PudMed:24797297]
[293] Clifford G Clark et al (2014) DNA sequence heterogeneity of Campylobacter jejuni CJIE4 prophages and expression of prophage genes. PloS one. 9(4):e95349. [PudMed:24756024]
[294] Yunxue Guo et al (2014) RalR (a DNase) and RalA (a small RNA) form a type I toxin-antitoxin system in Escherichia coli. Nucleic acids research. 42(10):6448-62. [PudMed:24748661]
[295] Min Yang et al (2014) Characterization of the interaction between a SirR family transcriptional factor of Mycobacterium tuberculosis, encoded by Rv2788, and a pair of toxin-antitoxin proteins RelJ/K, encoded by Rv3357 and Rv3358. The FEBS journal. 281(12):2726-37. [PudMed:24725376]
[296] Heleen Van Acker et al (2014) Involvement of toxin-antitoxin modules in Burkholderia cenocepacia biofilm persistence. Pathogens and disease. 71(3):326-35. [PudMed:24719230]
[297] Jason M Schifano et al (2014) An RNA-seq method for defining endoribonuclease cleavage specificity identifies dual rRNA substrates for toxin MazF-mt3. Nature communications. 5:3538. [PudMed:24709835]
[298] Marie-Laure Pinel-Marie et al (2014) Dual toxic-peptide-coding Staphylococcus aureus RNA under antisense regulation targets host cells and bacterial rivals unequally. Cell reports. 7(2):424-435. [PudMed:24703849]
[299] M Hino et al (2014) Characterization of putative toxin/antitoxin systems in Vibrio parahaemolyticus. Journal of applied microbiology. 117(1):185-95. [PudMed:24698443]
[300] Nourkhoda Sadeghifard et al (2014) Is the mazEF toxin-antitoxin system responsible for vancomycin resistance in clinical isolates of Enterococcus faecalis? GMS hygiene and infection control. 9(1):Doc05. [PudMed:24653969]
[301] Dabin Ren et al (2014) The ToxAvapA toxin-antitoxin locus contributes to the survival of nontypeable Haemophilus influenzae during infection. PloS one. 9(3):e91523. [PudMed:24621787]
[302] Jason M Schifano et al (2014) 23S rRNA as an a-Maz-ing new bacterial toxin target. RNA biology. 11(2):101-5. [PudMed:24525465]
[303] Yoshihiro Yamaguchi et al (2014) Characterization of LdrA (long direct repeat A) protein of Escherichia coli. Journal of molecular microbiology and biotechnology. 24(2):91-7. [PudMed:24513967]
[304] Aaron Butt et al (2014) The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation. The Biochemical journal. 459(2):333-44. [PudMed:24502667]
[305] Iwona Brzozowska et al (2014) The ClpXP protease is responsible for the degradation of the Epsilon antidote to the Zeta toxin of the streptococcal pSM19035 plasmid. The Journal of biological chemistry. 289(11):7514-23. [PudMed:24492616]
[306] Ron L Dy et al (2014) A widespread bacteriophage abortive infection system functions through a Type IV toxin-antitoxin mechanism. Nucleic acids research. 42(7):4590-605. [PudMed:24465005]
[307] Belén Pimentel et al (2014) Toxin Kid uncouples DNA replication and cell division to enforce retention of plasmid R1 in Escherichia coli cells. Proceedings of the National Academy of Sciences of the United States of America. 111(7):2734-9. [PudMed:24449860]
[308] Jonathan W Cruz et al (2014) Doc toxin is a kinase that inactivates elongation factor Tu. The Journal of biological chemistry. 289(11):7788-98. [PudMed:24448800]
[309] Oksana I Demidenok et al (2014) Toxin-antitoxin vapBC locus participates in formation of the dormant state in Mycobacterium smegmatis. FEMS microbiology letters. 352(1):69-77. [PudMed:24417293]
[310] Degang Ning et al (2013) [A hypothetical gene pair, ssl2138 and sll11092, constitutes a functional TA system on the chromosome of Synechocystis PCC 6803]. Wei sheng wu xue bao = Acta microbiologica Sinica. 53(10):1043-9. [PudMed:24409759]
[311] Sophie Helaine et al (2014) Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science (New York, N.Y.). 343(6167):204-8. [PudMed:24408438]
[312] Miguel A De la Cruz et al (2013) A toxin-antitoxin module of Salmonella promotes virulence in mice. PLoS pathogens. 9(12):e1003827. [PudMed:24385907]
[313] Arti Tripathi et al (2014) MazF-induced growth inhibition and persister generation in Escherichia coli. The Journal of biological chemistry. 289(7):4191-205. [PudMed:24375411]
[314] Hsin-Yao Cheng et al (2014) Toxin GhoT of the GhoT/GhoS toxin/antitoxin system damages the cell membrane to reduce adenosine triphosphate and to reduce growth under stress. Environmental microbiology. 16(6):1741-54. [PudMed:24373067]
[315] Jingchen Feng et al (2014) Growth feedback as a basis for persister bistability. Proceedings of the National Academy of Sciences of the United States of America. 111(1):544-9. [PudMed:24344277]
[316] Ilana Kaspy et al (2013) HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase. Nature communications. 4:3001. [PudMed:24343429]
[317] Branislava Milunovic et al (2014) Cell growth inhibition upon deletion of four toxin-antitoxin loci from the megaplasmids of Sinorhizobium meliloti. Journal of bacteriology. 196(4):811-24. [PudMed:24317400]
[318] Kenta Naka et al (2014) RNase HI stimulates the activity of RnlA toxin in Escherichia coli. Molecular microbiology. 91(3):596-605. [PudMed:24308852]
[319] Amy S Larson et al (2014) Light activation of Staphylococcus aureus toxin YoeBSa1 reveals guanosine-specific endoribonuclease activity. Biochemistry. 53(1):188-201. [PudMed:24279911]
[320] Degang Ning et al (2013) Transcriptional and proteolytic regulation of the toxin-antitoxin locus vapBC10 (ssr2962/slr1767) on the chromosome of Synechocystis sp. PCC 6803. PloS one. 8(11):e80716. [PudMed:24260461]
[321] Katharina Schaufler et al (2013) ESBL-plasmids carrying toxin-antitoxin systems can be "cured" of wild-type Escherichia coli using a heat technique. Gut pathogens. 5(1):34. [PudMed:24245987]
[322] Christopher D Aakre et al (2013) A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp. Molecular cell. 52(5):617-28. [PudMed:24239291]
[323] Kristoffer S Winther et al (2013) VapC20 of Mycobacterium tuberculosis cleaves the sarcin-ricin loop of 23S rRNA. Nature communications. 4:2796. [PudMed:24225902]
[324] Valerie W C Soo et al (2013) Antitoxin MqsA represses curli formation through the master biofilm regulator CsgD. Scientific reports. 3:3186. [PudMed:24212724]
[325] Jia Wen et al (2014) The ZorO-OrzO type I toxin-antitoxin locus: repression by the OrzO antitoxin. Nucleic acids research. 42(3):1930-46. [PudMed:24203704]
[326] T Sijbrandij et al (2014) Bacillus globigii cell size is influenced by variants of the quorum sensing peptide extracellular death factor. Antonie van Leeuwenhoek. 105(1):221-8. [PudMed:24198119]
[327] Melissa V Ramirez et al (2013) MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein. BMC microbiology. 13:240. [PudMed:24172039]
[328] Hedvig Tamman et al (2014) A moderate toxin, GraT, modulates growth rate and stress tolerance of Pseudomonas putida. Journal of bacteriology. 196(1):157-69. [PudMed:24163334]
[329] Daniel Castro-Roa et al (2013) The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu. Nature chemical biology. 9(12):811-7. [PudMed:24141193]
[330] Dhirendra K Simanshu et al (2013) Structural basis of mRNA recognition and cleavage by toxin MazF and its regulation by antitoxin MazE in Bacillus subtilis. Molecular cell. 52(3):447-58. [PudMed:24120662]
[331] Elsa Germain et al (2013) Molecular mechanism of bacterial persistence by HipA. Molecular cell. 52(2):248-54. [PudMed:24095282]
[332] Eva K Bjørkeng et al (2013) ICESluvan, a 94-kilobase mosaic integrative conjugative element conferring interspecies transfer of VanB-type glycopeptide resistance, a novel bacitracin resistance locus, and a toxin-antitoxin stabilization system. Journal of bacteriology. 195(23):5381-90. [PudMed:24078615]
[333] Lidia Boss et al (2013) The axe-txe complex of Enterococcus faecium presents a multilayered mode of toxin-antitoxin gene expression regulation. PloS one. 8(9):e73569. [PudMed:24019928]
[334] Lendert Gelens et al (2013) A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli. PLoS computational biology. 9(8):e1003190. [PudMed:24009490]
[335] Ilaria Cataudella et al (2013) Conditional cooperativity of toxin - antitoxin regulation can mediate bistability between growth and dormancy. PLoS computational biology. 9(8):e1003174. [PudMed:24009488]
[336] Julia J van Rensburg et al (2013) Detection of endogenous MazF enzymatic activity in Staphylococcus aureus. Analytical biochemistry. 443(1):81-7. [PudMed:23994560]
[337] Etienne Maisonneuve et al (2013) (p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity. Cell. 154(5):1140-1150. [PudMed:23993101]
[338] Andrew D Frock et al (2013) Stationary phase and nutrient levels trigger transcription of a genomic locus containing a novel peptide (TM1316) in the hyperthermophilic bacterium Thermotoga maritima. Applied and environmental microbiology. 79(21):6637-46. [PudMed:23974142]
[339] Natalie Jahn et al (2013) One antitoxin--two functions: SR4 controls toxin mRNA decay and translation. Nucleic acids research. 41(21):9870-80. [PudMed:23969414]
[340] Zhoujie Xie et al (2013) Development of a tunable wide-range gene induction system useful for the study of streptococcal toxin-antitoxin systems. Applied and environmental microbiology. 79(20):6375-84. [PudMed:23934493]
[341] Dorothée L Schuessler et al (2013) Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA. Molecular microbiology. 90(1):195-207. [PudMed:23927792]
[342] Ken Vercammen et al (2013) Identification of a metagenomic gene cluster containing a new class A beta-lactamase and toxin-antitoxin systems. MicrobiologyOpen. 2(4):674-83. [PudMed:23873667]
[343] Nicoletta Nolle et al (2013) Two paralogous yefM-yoeB loci from Staphylococcus equorum encode functional toxin-antitoxin systems. Microbiology (Reading, England). 159(Pt 8):1575-1585. [PudMed:23832005]
[344] Vicky Merhej et al (2013) Postgenomic analysis of bacterial pathogens repertoire reveals genome reduction rather than virulence factors. Briefings in functional genomics. 12(4):291-304. [PudMed:23814139]
[345] Julie E Samson et al (2013) Effect of the abortive infection mechanism and type III toxin/antitoxin system AbiQ on the lytic cycle of Lactococcus lactis phages. Journal of bacteriology. 195(17):3947-56. [PudMed:23813728]
[346] Rick A Fasani et al (2013) Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype. Proceedings of the National Academy of Sciences of the United States of America. 110(27):E2528-37. [PudMed:23781105]
[347] Michal Bukowski et al (2013) A regulatory role for Staphylococcus aureus toxin-antitoxin system PemIKSa. Nature communications. 4:2012. [PudMed:23774061]
[348] Zhe Ma et al (2013) Insight into the specific virulence related genes and toxin-antitoxin virulent pathogenicity islands in swine streptococcosis pathogen Streptococcus equi ssp. zooepidemicus strain ATCC35246. BMC genomics. 14:377. [PudMed:23742619]
[349] Sathish Kumar et al (2013) Novel quorum-sensing peptides mediating interspecies bacterial cell death. mBio. 4(3):e00314-13. [PudMed:23736285]
[350] K M Klimina et al (2013) Identification and characterization of toxin-antitoxin systems in strains of Lactobacillus rhamnosus isolated from humans. Anaerobe. 22:82-9. [PudMed:23727113]
[351] Tessa E F Quax et al (2013) Massive activation of archaeal defense genes during viral infection. Journal of virology. 87(15):8419-28. [PudMed:23698312]
[352] Milda Jurenaite et al (2013) Identification and characterization of type II toxin-antitoxin systems in the opportunistic pathogen Acinetobacter baumannii. Journal of bacteriology. 195(14):3165-72. [PudMed:23667234]
[353] Stephanie M Amato et al (2013) Metabolic control of persister formation in Escherichia coli. Molecular cell. 50(4):475-87. [PudMed:23665232]
[354] Matthew B McNeil et al (2013) YgfX (CptA) is a multimeric membrane protein that interacts with the succinate dehydrogenase assembly factor SdhE (YgfY). Microbiology (Reading, England). 159(Pt 7):1352-1365. [PudMed:23657679]
[355] Jason M Schifano et al (2013) Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site. Proceedings of the National Academy of Sciences of the United States of America. 110(21):8501-6. [PudMed:23650345]
[356] Simon J Unterholzner et al (2013) Characterisation of the stbD/E toxin-antitoxin system of pEP36, a plasmid of the plant pathogen Erwinia pyrifoliae. Plasmid. 70(2):216-25. [PudMed:23632277]
[357] R Fredrik Inglis et al (2013) The role of bacteriocins as selfish genetic elements. Biology letters. 9(3):20121173. [PudMed:23616642]
[358] Fang Tang et al (2013) Comparative genomic analysis of twelve Streptococcus suis (pro)phages. Genomics. 101(6):336-44. [PudMed:23587535]
[359] Ana R Freitas et al (2013) Microevolutionary events involving narrow host plasmids influences local fixation of vancomycin-resistance in Enterococcus populations. PloS one. 8(3):e60589. [PudMed:23555993]
[360] Nathalie Goeders et al (2013) Relaxed cleavage specificity within the RelE toxin family. Journal of bacteriology. 195(11):2541-9. [PudMed:23543711]
[361] Linda Miallau et al (2013) Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes. Structure (London, England : 1993). 21(4):627-37. [PudMed:23523424]
[362] Hila Sberro et al (2013) Discovery of functional toxin/antitoxin systems in bacteria by shotgun cloning. Molecular cell. 50(1):136-48. [PudMed:23478446]
[363] Anne-Marie Guérout et al (2013) Characterization of the phd-doc and ccd toxin-antitoxin cassettes from Vibrio superintegrons. Journal of bacteriology. 195(10):2270-83. [PudMed:23475970]
[364] Degang Ning et al (2013) Characterization of a chromosomal type II toxin-antitoxin system mazEaFa in the Cyanobacterium Anabaena sp. PCC 7120. PloS one. 8(2):e56035. [PudMed:23451033]
[365] Villu Kasari et al (2013) Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli. BMC microbiology. 13:45. [PudMed:23432955]
[366] Elizabeth Diago-Navarro et al (2013) Cleavage of the antitoxin of the parD toxin-antitoxin system is determined by the ClpAP protease and is modulated by the relative ratio of the toxin and the antitoxin. Plasmid. 70(1):78-85. [PudMed:23419648]
[367] Angella Dorsey-Oresto et al (2013) YihE kinase is a central regulator of programmed cell death in bacteria. Cell reports. 3(2):528-37. [PudMed:23416055]
[368] Ragnhild Weel-Sneve et al (2013) Single transmembrane peptide DinQ modulates membrane-dependent activities. PLoS genetics. 9(2):e1003260. [PudMed:23408903]
[369] Jakob Albrethsen et al (2013) Proteomic profiling of Mycobacterium tuberculosis identifies nutrient-starvation-responsive toxin-antitoxin systems. Molecular & cellular proteomics : MCP. 12(5):1180-91. [PudMed:23345537]
[370] Anke Rheinberg et al (2013) Cryptic Streptococcus mutans 5.6-kb plasmids encode a toxin-antitoxin system for plasmid stabilization. Journal of oral microbiology. 5:10.3402/jom.v5i0.19729. [PudMed:23330057]
[371] Junqiao Zhao et al (2013) Escherichia coli toxin gene hipA affects biofilm formation and DNA release. Microbiology (Reading, England). 159(Pt 3):633-640. [PudMed:23329678]
[372] Stephanie Koyanagi et al (2013) Characterization of a Streptococcus mutans intergenic region containing a small toxic peptide and its cis-encoded antisense small RNA antitoxin. PloS one. 8(1):e54291. [PudMed:23326602]
[373] Mart Krupovic et al (2013) Insights into dynamics of mobile genetic elements in hyperthermophilic environments from five new Thermococcus plasmids. PloS one. 8(1):e49044. [PudMed:23326305]
[374] Adi Steif et al (2012) The hok mRNA family. RNA biology. 9(12):1399-404. [PudMed:23324554]
[375] Stefan Kopfmann et al (2013) Toxin-antitoxin systems on the large defense plasmid pSYSA of Synechocystis sp. PCC 6803. The Journal of biological chemistry. 288(10):7399-409. [PudMed:23322786]
[376] Steve P Bernier et al (2013) Starvation, together with the SOS response, mediates high biofilm-specific tolerance to the fluoroquinolone ofloxacin. PLoS genetics. 9(1):e1003144. [PudMed:23300476]
[377] Sylvain Durand et al (2012) The essential function of B. subtilis RNase III is to silence foreign toxin genes. PLoS genetics. 8(12):e1003181. [PudMed:23300471]
[378] O V Averina et al (2012) [Genetic instability of probiotic characteristics in the Bifidobacterium longum subsp. longum B379M strain during cultivation and maintenance]. Genetika. 48(11):1287-96. [PudMed:23297484]
[379] Kyung-Doo Han et al (2013) Identification of chromosomal HP0892-HP0893 toxin-antitoxin proteins in Helicobacter pylori and structural elucidation of their protein-protein interaction. The Journal of biological chemistry. 288(8):6004-13. [PudMed:23297406]
[380] Brian W Kwan et al (2013) Arrested protein synthesis increases persister-like cell formation. Antimicrobial agents and chemotherapy. 57(3):1468-73. [PudMed:23295927]
[381] Xiaoxue Wang et al (2013) Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS. Environmental microbiology. 15(6):1734-44. [PudMed:23289863]
[382] Francesca L Short et al (2013) Selectivity and self-assembly in the control of a bacterial toxin by an antitoxic noncoding RNA pseudoknot. Proceedings of the National Academy of Sciences of the United States of America. 110(3):E241-9. [PudMed:23267117]
[383] Ambre Sala et al (2013) TAC from Mycobacterium tuberculosis: a paradigm for stress-responsive toxin-antitoxin systems controlled by SecB-like chaperones. Cell stress & chaperones. 18(2):129-35. [PudMed:23264229]
[384] Andrew Slattery et al (2013) Isolation of highly persistent mutants of Salmonella enterica serovar typhimurium reveals a new toxin-antitoxin module. Journal of bacteriology. 195(4):647-57. [PudMed:23204462]
[385] Xianghe Yan et al (2012) Phylogenetic identification of bacterial MazF toxin protein motifs among probiotic strains and foodborne pathogens and potential implications of engineered probiotic intervention in food. Cell & bioscience. 2(1):39. [PudMed:23186337]
[386] Elizabeth M Fozo (2012) New type I toxin-antitoxin families from "wild" and laboratory strains of E. coli: Ibs-Sib, ShoB-OhsC and Zor-Orz. RNA biology. 9(12):1504-12. [PudMed:23182878]
[387] Breann L Brown et al (2013) The Escherichia coli toxin MqsR destabilizes the transcriptional repression complex formed between the antitoxin MqsA and the mqsRA operon promoter. The Journal of biological chemistry. 288(2):1286-94. [PudMed:23172222]
[388] Dabin Ren et al (2012) Toxin-antitoxin loci vapBC-1 and vapXD contribute to survival and virulence in nontypeable Haemophilus influenzae. BMC microbiology. 12:263. [PudMed:23157645]
[389] Nour Sayed et al (2012) Functional and structural insights of a Staphylococcus aureus apoptotic-like membrane peptide from a toxin-antitoxin module. The Journal of biological chemistry. 287(52):43454-63. [PudMed:23129767]
[390] Tim R Blower et al (2012) Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism. PLoS genetics. 8(10):e1003023. [PudMed:23109916]
[391] Cassandra L Brinkman et al (2013) Characterization of the effects of an rpoC mutation that confers resistance to the Fst peptide toxin-antitoxin system toxin. Journal of bacteriology. 195(1):156-66. [PudMed:23104812]
[392] Christopher F Schuster et al (2013) Characterization of a mazEF toxin-antitoxin homologue from Staphylococcus equorum. Journal of bacteriology. 195(1):115-25. [PudMed:23104807]
[393] Aaron Butt et al (2013) Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS microbiology letters. 338(1):86-94. [PudMed:23082999]
[394] Yang Liu et al (2013) Transferable multiresistance plasmids carrying cfr in Enterococcus spp. from swine and farm environment. Antimicrobial agents and chemotherapy. 57(1):42-8. [PudMed:23070165]
[395] Keith E Weaver (2012) The par toxin-antitoxin system from Enterococcus faecalis plasmid pAD1 and its chromosomal homologs. RNA biology. 9(12):1498-503. [PudMed:23059908]
[396] Sylvain Durand et al (2012) Type I toxin-antitoxin systems in Bacillus subtilis. RNA biology. 9(12):1491-7. [PudMed:23059907]
[397] J Paul Norton et al (2012) Toxin-antitoxin systems are important for niche-specific colonization and stress resistance of uropathogenic Escherichia coli. PLoS pathogens. 8(10):e1002954. [PudMed:23055930]
[398] Andrew B Smith et al (2012) A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions. PloS one. 7(9):e46499. [PudMed:23029540]
[399] Kenn Gerdes et al (2012) Bacterial persistence and toxin-antitoxin loci. Annual review of microbiology. 66:103-23. [PudMed:22994490]
[400] Xiaoxue Wang et al (2012) A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nature chemical biology. 8(10):855-61. [PudMed:22941047]
[401] Isabella Moll et al (2012) Selective translation during stress in Escherichia coli. Trends in biochemical sciences. 37(11):493-8. [PudMed:22939840]
[402] Martin J McGavin et al (2012) Evolutionary blueprint for host- and niche-adaptation in Staphylococcus aureus clonal complex CC30. Frontiers in cellular and infection microbiology. 2:48. [PudMed:22919639]
[403] Dhira Satwika et al (2012) Anticodon nuclease encoding virus-like elements in yeast. Applied microbiology and biotechnology. 96(2):345-56. [PudMed:22899498]
[404] Cyrielle I Kint et al (2012) The Escherichia coli GTPase ObgE modulates hydroxyl radical levels in response to DNA replication fork arrest. The FEBS journal. 279(19):3692-3704. [PudMed:22863262]
[405] Sabina Leanti La Rosa et al (2012) Construction and application of a luxABCDE reporter system for real-time monitoring of Enterococcus faecalis gene expression and growth. Applied and environmental microbiology. 78(19):7003-11. [PudMed:22843522]
[406] Arti Tripathi et al (2012) Additional role for the ccd operon of F-plasmid as a transmissible persistence factor. Proceedings of the National Academy of Sciences of the United States of America. 109(31):12497-502. [PudMed:22802647]
[407] Lígia S Muranaka et al (2012) Global expression profile of biofilm resistance to antimicrobial compounds in the plant-pathogenic bacterium Xylella fastidiosa reveals evidence of persister cells. Journal of bacteriology. 194(17):4561-9. [PudMed:22730126]
[408] Sonja Hansen et al (2012) Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis. PloS one. 7(6):e39185. [PudMed:22720069]
[409] Torill C S Rosvoll et al (2012) Increased high-level gentamicin resistance in invasive Enterococcus faecium is associated with aac(6')Ie-aph(2″)Ia-encoding transferable megaplasmids hosted by major hospital-adapted lineages. FEMS immunology and medical microbiology. 66(2):166-76. [PudMed:22672387]
[410] Rachel S Koh et al (2012) Modeling suggests that gene circuit architecture controls phenotypic variability in a bacterial persistence network. BMC systems biology. 6:47. [PudMed:22607777]
[411] Natalie De Jonge et al (2012) Alternative interactions define gyrase specificity in the CcdB family. Molecular microbiology. 84(5):965-78. [PudMed:22582791]
[412] Francesca P Rothenbacher et al (2012) Clostridium difficile MazF toxin exhibits selective, not global, mRNA cleavage. Journal of bacteriology. 194(13):3464-74. [PudMed:22544268]
[413] Joanna L McKenzie et al (2012) Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry. RNA (New York, N.Y.). 18(6):1267-78. [PudMed:22539524]
[414] Hisako Masuda et al (2012) YeeU enhances the bundling of cytoskeletal polymers of MreB and FtsZ, antagonizing the CbtA (YeeV) toxicity in Escherichia coli. Molecular microbiology. 84(5):979-89. [PudMed:22515815]
[415] Ilaria Cataudella et al (2012) Conditional cooperativity in toxin-antitoxin regulation prevents random toxin activation and promotes fast translational recovery. Nucleic acids research. 40(14):6424-34. [PudMed:22495927]
[416] Bongsoo Lee et al (2012) Myxococcus xanthus developmental cell fate production: heterogeneous accumulation of developmental regulatory proteins and reexamination of the role of MazF in developmental lysis. Journal of bacteriology. 194(12):3058-68. [PudMed:22493014]
[417] Inma Moreno-Córdoba et al (2012) The toxin-antitoxin proteins relBE2Spn of Streptococcus pneumoniae: characterization and association to their DNA target. Proteins. 80(7):1834-46. [PudMed:22488579]
[418] Tim R Blower et al (2012) Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes. Nucleic acids research. 40(13):6158-73. [PudMed:22434880]
[419] Laura Sevillano et al (2012) Identification of the first functional toxin-antitoxin system in Streptomyces. PloS one. 7(3):e32977. [PudMed:22431991]
[420] Susan D Cline et al (2012) Regulation of the vapBC-1 toxin-antitoxin locus in nontypeable Haemophilus influenzae. PloS one. 7(3):e32199. [PudMed:22427824]
[421] Ariel Erental et al (2012) Two programmed cell death systems in Escherichia coli: an apoptotic-like death is inhibited by the mazEF-mediated death pathway. PLoS biology. 10(3):e1001281. [PudMed:22412352]
[422] Yuichi Otsuka et al (2012) Dmd of bacteriophage T4 functions as an antitoxin against Escherichia coli LsoA and RnlA toxins. Molecular microbiology. 83(4):669-81. [PudMed:22403819]
[423] Joanna L McKenzie et al (2012) A VapBC toxin-antitoxin module is a posttranscriptional regulator of metabolic flux in mycobacteria. Journal of bacteriology. 194(9):2189-204. [PudMed:22366418]
[424] Vincent Leung et al (2012) A stress-inducible quorum-sensing peptide mediates the formation of persister cells with noninherited multidrug tolerance. Journal of bacteriology. 194(9):2265-74. [PudMed:22366415]
[425] Assaf Shapira et al (2012) Removal of hepatitis C virus-infected cells by a zymogenized bacterial toxin. PloS one. 7(2):e32320. [PudMed:22359682]
[426] Jared D Sharp et al (2012) Growth and translation inhibition through sequence-specific RNA binding by Mycobacterium tuberculosis VapC toxin. The Journal of biological chemistry. 287(16):12835-47. [PudMed:22354968]
[427] Brook E Heaton et al (2012) Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus. The Journal of biological chemistry. 287(15):12098-110. [PudMed:22334680]
[428] Benedikt M Beckmann et al (2012) A pRNA-induced structural rearrangement triggers 6S-1 RNA release from RNA polymerase in Bacillus subtilis. The EMBO journal. 31(7):1727-38. [PudMed:22333917]
[429] Kristoffer S Winther et al (2012) Regulation of enteric vapBC transcription: induction by VapC toxin dimer-breaking. Nucleic acids research. 40(10):4347-57. [PudMed:22287572]
[430] Francesca L Short et al (2012) A promiscuous antitoxin of bacteriophage T4 ensures successful viral replication. Molecular microbiology. 83(4):665-8. [PudMed:22283468]
[431] Julija Armalyte et al (2012) Characterization of Escherichia coli dinJ-yafQ toxin-antitoxin system using insights from mutagenesis data. Journal of bacteriology. 194(6):1523-32. [PudMed:22247505]
[432] Hisako Masuda et al (2012) A novel membrane-bound toxin for cell division, CptA (YgfX), inhibits polymerization of cytoskeleton proteins, FtsZ and MreB, in Escherichia coli. FEMS microbiology letters. 328(2):174-81. [PudMed:22239607]
[433] Natalie Jahn et al (2012) BsrG/SR4 from Bacillus subtilis--the first temperature-dependent type I toxin-antitoxin system. Molecular microbiology. 83(3):579-98. [PudMed:22229825]
[434] Yosuke Tashiro et al (2012) RelE-mediated dormancy is enhanced at high cell density in Escherichia coli. Journal of bacteriology. 194(5):1169-76. [PudMed:22210768]
[435] Laura E Holberger et al (2012) A novel family of toxin/antitoxin proteins in Bacillus species. FEBS letters. 586(2):132-6. [PudMed:22200572]
[436] Rebekah Frampton et al (2012) Toxin-antitoxin systems of Mycobacterium smegmatis are essential for cell survival. The Journal of biological chemistry. 287(8):5340-56. [PudMed:22199354]
[437] Nour Sayed et al (2011) A cis-antisense RNA acts in trans in Staphylococcus aureus to control translation of a human cytolytic peptide. Nature structural & molecular biology. 19(1):105-12. [PudMed:22198463]
[438] Lukasz Dziewit et al (2011) Functional characterization of the type II PamI restriction-modification system derived from plasmid pAMI7 of Paracoccus aminophilus JCM 7686. FEMS microbiology letters. 324(1):56-63. [PudMed:22092764]
[439] Ying Hu et al (2012) Antitoxin DinJ influences the general stress response through transcript stabilizer CspE. Environmental microbiology. 14(3):669-79. [PudMed:22026739]
[440] Jeffrey B Locke et al (2012) Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05. Antimicrobial agents and chemotherapy. 56(1):332-40. [PudMed:22024827]
[441] Degang Ning et al (2011) The proteolytic activation of the relNEs (ssr1114/slr0664) toxin-antitoxin system by both proteases Lons and ClpP2s/Xs of Synechocystis sp. PCC 6803. Current microbiology. 63(5):496-502. [PudMed:21909782]
[442] Min Woo Lee et al (2012) Xylella fastidiosa plasmid-encoded PemK toxin is an endoribonuclease. Phytopathology. 102(1):32-40. [PudMed:21864087]
[443] Yukari Maezato et al (2011) VapC6, a ribonucleolytic toxin regulates thermophilicity in the crenarchaeote Sulfolobus solfataricus. RNA (New York, N.Y.). 17(7):1381-92. [PudMed:21622901]
[444] Maria Belitsky et al (2011) The Escherichia coli extracellular death factor EDF induces the endoribonucleolytic activities of the toxins MazF and ChpBK. Molecular cell. 41(6):625-35. [PudMed:21419338]
[445] Mohammad Adnan Syed et al (2011) The chromosomal mazEF locus of Streptococcus mutans encodes a functional type II toxin-antitoxin addiction system. Journal of bacteriology. 193(5):1122-30. [PudMed:21183668]
[446] Kyung-Doo Han et al (2011) Functional identification of toxin-antitoxin molecules from Helicobacter pylori 26695 and structural elucidation of the molecular interactions. The Journal of biological chemistry. 286(6):4842-53. [PudMed:21123184]
[447] Jie Yuan et al (2011) The three vibrio cholerae chromosome II-encoded ParE toxins degrade chromosome I following loss of chromosome II. Journal of bacteriology. 193(3):611-9. [PudMed:21115657]
[448] Xiulin Han et al (2011) The role of Escherichia coli YrbB in the lethal action of quinolones. The Journal of antimicrobial chemotherapy. 66(2):323-31. [PudMed:21098540]
[449] Elizabeth M Halvorsen et al (2011) Txe, an endoribonuclease of the enterococcal Axe-Txe toxin-antitoxin system, cleaves mRNA and inhibits protein synthesis. Microbiology (Reading, England). 157(Pt 2):387-397. [PudMed:21030436]
[450] Mitsunori Koga et al (2011) Escherichia coli rnlA and rnlB compose a novel toxin-antitoxin system. Genetics. 187(1):123-30. [PudMed:20980243]
[451] Jie Yuan et al (2010) Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors. The Journal of biological chemistry. 285(51):40397-408. [PudMed:20952390]
[452] Min Woo Lee et al (2010) Functional characterization of replication and stability factors of an incompatibility group P-1 plasmid from Xylella fastidiosa. Applied and environmental microbiology. 76(23):7734-40. [PudMed:20935126]
[453] Stanislava Rešetárová et al (2010) Expression and localization of SpoIISA toxin during the life cycle of Bacillus subtilis. Research in microbiology. 161(9):750-6. [PudMed:20863891]
[454] Jeong-Sun Han et al (2010) Characterization of a chromosomal toxin-antitoxin, Rv1102c-Rv1103c system in Mycobacterium tuberculosis. Biochemical and biophysical research communications. 400(3):293-8. [PudMed:20705052]
[455] Sen Ye et al (2010) [The interaction between chromosome-encoded toxin Slr0664 and antitoxin Slr1114 of cyanobacteria Synechocystis sp. PCC6803]. Wei sheng wu xue bao = Acta microbiologica Sinica. 50(6):743-8. [PudMed:20687338]
[456] Eitan Rotem et al (2010) Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence. Proceedings of the National Academy of Sciences of the United States of America. 107(28):12541-6. [PudMed:20616060]
[457] Concha Nieto et al (2010) The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates. PloS one. 5(6):e11289. [PudMed:20585658]
[458] Amanda S Fivian-Hughes et al (2010) Analyzing the regulatory role of the HigA antitoxin within Mycobacterium tuberculosis. Journal of bacteriology. 192(17):4348-56. [PudMed:20585061]
[459] Tim F Cooper et al (2010) Within-host competition selects for plasmid-encoded toxin-antitoxin systems. Proceedings. Biological sciences. 277(1697):3149-55. [PudMed:20504809]
[460] Min Yang et al (2010) Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules. PloS one. 5(5):e10672. [PudMed:20498855]
[461] Aretha Fiebig et al (2010) Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems. Molecular microbiology. 77(1):236-51. [PudMed:20487277]
[462] Céline Goulard et al (2010) The Yersinia pestis chromosome encodes active addiction toxins. Journal of bacteriology. 192(14):3669-77. [PudMed:20472800]
[463] Hannes Mutschler et al (2010) Assembly dynamics and stability of the pneumococcal epsilon zeta antitoxin toxin (PezAT) system from Streptococcus pneumoniae. The Journal of biological chemistry. 285(28):21797-806. [PudMed:20442221]
[464] Paul S Miclea et al (2010) Atypical transcriptional regulation and role of a new toxin-antitoxin-like module and its effect on the lipid composition of Bradyrhizobium japonicum. Molecular plant-microbe interactions : MPMI. 23(5):638-50. [PudMed:20367472]
[465] Régis Hallez et al (2010) New toxins homologous to ParE belonging to three-component toxin-antitoxin systems in Escherichia coli O157:H7. Molecular microbiology. 76(3):719-32. [PudMed:20345661]
[466] Villu Kasari et al (2010) The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. Journal of bacteriology. 192(11):2908-19. [PudMed:20233923]
[467] Cynthia M Sharma et al (2010) The primary transcriptome of the major human pathogen Helicobacter pylori. Nature. 464(7286):250-5. [PudMed:20164839]
[468] Elizabeth M Fozo et al (2010) Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic acids research. 38(11):3743-59. [PudMed:20156992]
[469] Younghoon Kim et al (2010) Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environmental microbiology. 12(5):1105-21. [PudMed:20105222]
[470] Mariana Gallo et al (2010) A new member of the ribbon-helix-helix transcription factor superfamily from the plant pathogen Xanthomonas axonopodis pv.citri. Journal of structural biology. 170(1):21-31. [PudMed:20060909]
[471] Niles P Donegan et al (2010) Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcus aureus. Journal of bacteriology. 192(5):1416-22. [PudMed:20038589]
[472] Shivangi Agarwal et al (2010) PemK toxin of Bacillus anthracis is a ribonuclease: an insight into its active site, structure, and function. The Journal of biological chemistry. 285(10):7254-70. [PudMed:20022964]
[473] Holly R Ramage et al (2009) Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS genetics. 5(12):e1000767. [PudMed:20011113]
[474] Mikkel Christensen-Dalsgaard et al (2010) Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Molecular microbiology. 75(2):333-48. [PudMed:19943910]
[475] Larissa A Singletary et al (2009) An SOS-regulated type 2 toxin-antitoxin system. Journal of bacteriology. 191(24):7456-65. [PudMed:19837801]
[476] Virginia S Lioy et al (2010) A toxin-antitoxin module as a target for antimicrobial development. Plasmid. 63(1):31-9. [PudMed:19800365]
[477] Martin Overgaard et al (2009) RelB and RelE of Escherichia coli form a tight complex that represses transcription via the ribbon-helix-helix motif in RelB. Journal of molecular biology. 394(2):183-96. [PudMed:19747491]
[478] Ilana Kolodkin-Gal et al (2009) A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation. PloS one. 4(8):e6785. [PudMed:19707553]
[479] Natalie De Jonge et al (2009) Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain. Molecular cell. 35(2):154-63. [PudMed:19647513]
[480] Hanna Engelberg-Kulka et al (2009) Activation of a built-in bacterial programmed cell death system as a novel mechanism of action of some antibiotics. Communicative & integrative biology. 2(3):211-2. [PudMed:19641731]
[481] Michal Respondek et al (2009) Sequence-specific 1H, 15N and 13C resonance assignments of the 23.7-kDa homodimeric toxin CcdB from Vibrio fischeri. Biomolecular NMR assignments. 3(1):145-7. [PudMed:19636967]
[482] T R Blower et al (2009) Mutagenesis and functional characterization of the RNA and protein components of the toxIN abortive infection and toxin-antitoxin locus of Erwinia. Journal of bacteriology. 191(19):6029-39. [PudMed:19633081]
[483] Satoshi Yoshizumi et al (2009) Staphylococcus aureus YoeB homologues inhibit translation initiation. Journal of bacteriology. 191(18):5868-72. [PudMed:19581360]
[484] Igor Drobnak et al (2009) Energetics of MazG unfolding in correlation with its structural features. Journal of molecular biology. 392(1):63-74. [PudMed:19523960]
[485] Gwynneth F Matcher et al (2009) The effect of the location of the proteic post-segregational stability system within the replicon of plasmid pTF-FC2 on the fine regulation of plasmid replication. Plasmid. 62(2):98-107. [PudMed:19481568]
[486] Mario Simic et al (2009) Driving forces of gyrase recognition by the addiction toxin CcdB. The Journal of biological chemistry. 284(30):20002-10. [PudMed:19465484]
[487] Jennifer Robson et al (2009) The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation. Journal of molecular biology. 390(3):353-67. [PudMed:19445953]
[488] Jennifer M Hurley et al (2009) Bacterial toxin HigB associates with ribosomes and mediates translation-dependent mRNA cleavage at A-rich sites. The Journal of biological chemistry. 284(28):18605-13. [PudMed:19423702]
[489] Kristoffer S Winther et al (2009) Ectopic production of VapCs from Enterobacteria inhibits translation and trans-activates YoeB mRNA interferase. Molecular microbiology. 72(4):918-30. [PudMed:19400780]
[490] Urszula Zielenkiewicz et al (2009) In vivo interactions between toxin-antitoxin proteins epsilon and zeta of streptococcal plasmid pSM19035 in Saccharomyces cerevisiae. Journal of bacteriology. 191(11):3677-84. [PudMed:19346303]
[491] Rachel A F Wozniak et al (2009) A toxin-antitoxin system promotes the maintenance of an integrative conjugative element. PLoS genetics. 5(3):e1000439. [PudMed:19325886]
[492] Joe J Harrison et al (2009) The chromosomal toxin gene yafQ is a determinant of multidrug tolerance for Escherichia coli growing in a biofilm. Antimicrobial agents and chemotherapy. 53(6):2253-8. [PudMed:19307375]
[493] Shahar Amitai et al (2009) Escherichia coli MazF leads to the simultaneous selective synthesis of both "death proteins" and "survival proteins". PLoS genetics. 5(3):e1000390. [PudMed:19282968]
[494] Ling Zhu et al (2009) Staphylococcus aureus MazF specifically cleaves a pentad sequence, UACAU, which is unusually abundant in the mRNA for pathogenic adhesive factor SraP. Journal of bacteriology. 191(10):3248-55. [PudMed:19251861]
[495] Ilana Kolodkin-Gal et al (2009) The stationary-phase sigma factor sigma(S) is responsible for the resistance of Escherichia coli stationary-phase cells to mazEF-mediated cell death. Journal of bacteriology. 191(9):3177-82. [PudMed:19251848]
[496] Meredith H Prysak et al (2009) Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage. Molecular microbiology. 71(5):1071-87. [PudMed:19210620]
[497] Natacha Mine et al (2009) The decay of the chromosomally encoded ccdO157 toxin-antitoxin system in the Escherichia coli species. Genetics. 181(4):1557-66. [PudMed:19189956]
[498] Niles P Donegan et al (2009) Regulation of the mazEF toxin-antitoxin module in Staphylococcus aureus and its impact on sigB expression. Journal of bacteriology. 191(8):2795-805. [PudMed:19181798]
[499] Zhibiao Fu et al (2009) Overexpression of MazFsa in Staphylococcus aureus induces bacteriostasis by selectively targeting mRNAs for cleavage. Journal of bacteriology. 191(7):2051-9. [PudMed:19168622]
[500] Mikkel Christensen-Dalsgaard et al (2008) RNA decay by messenger RNA interferases. Methods in enzymology. 447:521-35. [PudMed:19161859]
[501] Charlotte R Cooper et al (2009) Role of vapBC toxin-antitoxin loci in the thermal stress response of Sulfolobus solfataricus. Biochemical Society transactions. 37(Pt 1):123-6. [PudMed:19143615]
[502] Hiroaki Kawano et al (2009) Long-term survival of Escherichia coli lacking the HipBA toxin-antitoxin system during prolonged cultivation. Bioscience, biotechnology, and biochemistry. 73(1):117-23. [PudMed:19129642]
[503] Peter C Fineran et al (2009) The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair. Proceedings of the National Academy of Sciences of the United States of America. 106(3):894-9. [PudMed:19124776]
[504] Yonglong Zhang et al (2009) The inhibitory mechanism of protein synthesis by YoeB, an Escherichia coli toxin. The Journal of biological chemistry. 284(11):6627-38. [PudMed:19124462]
[505] Shaleen B Korch et al (2009) Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibit mycobacterial growth and are expressed in infected human macrophages. Journal of bacteriology. 191(5):1618-30. [PudMed:19114484]
[506] Sonia Shokeen et al (2009) An intramolecular upstream helix ensures the stability of a toxin-encoding RNA in Enterococcus faecalis. Journal of bacteriology. 191(5):1528-36. [PudMed:19103923]
[507] Ilana Kolodkin-Gal et al (2008) The communication factor EDF and the toxin-antitoxin module mazEF determine the mode of action of antibiotics. PLoS biology. 6(12):e319. [PudMed:19090622]
[508] M Ahmadi et al (2007) The effect of heat stress on the antibacterial resistance and plasmid profile in Escherichia coli isolates. Pakistan journal of biological sciences : PJBS. 10(23):4261-5. [PudMed:19086582]
[509] Mikkel G Jørgensen et al (2009) HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea. Journal of bacteriology. 191(4):1191-9. [PudMed:19060138]
[510] Elizabeth Diago-Navarro et al (2009) Novel Escherichia coli RF1 mutants with decreased translation termination activity and increased sensitivity to the cytotoxic effect of the bacterial toxins Kid and RelE. Molecular microbiology. 71(1):66-78. [PudMed:19019162]
[511] Amita Gupta (2009) Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis. FEMS microbiology letters. 290(1):45-53. [PudMed:19016878]
[512] Kanika Bajaj et al (2008) Structural correlates of the temperature sensitive phenotype derived from saturation mutagenesis studies of CcdB. Biochemistry. 47(49):12964-73. [PudMed:19006334]
[513] Xiaojin Liu et al (2008) Genetic characterization of two putative toxin-antitoxin systems on cryptic plasmids from Bacillus thuringiensis strain YBT-1520. Journal of microbiology and biotechnology. 18(10):1630-3. [PudMed:18955810]
[514] Eliane Trovatti et al (2008) Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases. Bioorganic & medicinal chemistry letters. 18(23):6161-4. [PudMed:18938079]
[515] Mikkel Christensen-Dalsgaard et al (2008) Translation affects YoeB and MazF messenger RNA interferase activities by different mechanisms. Nucleic acids research. 36(20):6472-81. [PudMed:18854355]
[516] Ana Herrero et al (2008) Characterization of pUO-StVR2, a virulence-resistance plasmid evolved from the pSLT virulence plasmid of Salmonella enterica serovar Typhimurium. Antimicrobial agents and chemotherapy. 52(12):4514-7. [PudMed:18852276]
[517] Lin Cheng et al (2008) A novel toxin-antitoxin operon talA/B from the Gram-positive bacterium Leifsonia xyli subsp. cynodontis. FEBS letters. 582(21-22):3211-6. [PudMed:18722371]
[518] Elizabeth M Fozo et al (2008) Repression of small toxic protein synthesis by the Sib and OhsC small RNAs. Molecular microbiology. 70(5):1076-93. [PudMed:18710431]
[519] Leo L Chan et al (2008) A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors. ACS chemical biology. 3(7):437-48. [PudMed:18582039]
[520] Ya-Li Shi et al (2008) [RelE toxin protein of Mycobacterium tuberculosis induces growth inhibition of lung cancer A-549 cell]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 39(3):368-72. [PudMed:18575317]
[521] Martin Overgaard et al (2008) Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity. Molecular microbiology. 69(4):841-57. [PudMed:18532983]
[522] H Sletvold et al (2008) Complete sequence of Enterococcus faecium pVEF3 and the detection of an omega-epsilon-zeta toxin-antitoxin module and an ABC transporter. Plasmid. 60(1):75-85. [PudMed:18511120]
[523] Guang-Yao Li et al (2008) Structural mechanism of transcriptional autorepression of the Escherichia coli RelB/RelE antitoxin/toxin module. Journal of molecular biology. 380(1):107-19. [PudMed:18501926]
[524] Manuel Saavedra De Bast et al (2008) Chromosomal toxin-antitoxin systems may act as antiaddiction modules. Journal of bacteriology. 190(13):4603-9. [PudMed:18441063]
[525] Mohan Liu et al (2008) Bacterial addiction module toxin Doc inhibits translation elongation through its association with the 30S ribosomal subunit. Proceedings of the National Academy of Sciences of the United States of America. 105(15):5885-90. [PudMed:18398006]
[526] Fang Fang et al (2008) Characterization of endogenous plasmids from Lactobacillus salivarius UCC118. Applied and environmental microbiology. 74(10):3216-28. [PudMed:18390685]
[527] Ilana Kolodkin-Gal et al (2008) The extracellular death factor: physiological and genetic factors influencing its production and response in Escherichia coli. Journal of bacteriology. 190(9):3169-75. [PudMed:18310334]
[528] Xia Li et al (2008) Cleavage of mRNAs and role of tmRNA system under amino acid starvation in Escherichia coli. Molecular microbiology. 68(2):462-73. [PudMed:18284591]
[529] Longxuan Zhao et al (2008) Biochemical characterization of a chromosomal toxin-antitoxin system in Mycobacterium tuberculosis. FEBS letters. 582(5):710-4. [PudMed:18258191]
[530] Hirofumi Nariya et al (2008) MazF, an mRNA interferase, mediates programmed cell death during multicellular Myxococcus development. Cell. 132(1):55-66. [PudMed:18191220]
[531] Patrik Florek et al (2008) Expression of functional Bacillus SpoIISAB toxin-antitoxin modules in Escherichia coli. FEMS microbiology letters. 278(2):177-84. [PudMed:18096016]
[532] Ilana Kolodkin-Gal et al (2007) A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli. Science (New York, N.Y.). 318(5850):652-5. [PudMed:17962566]
[533] Zhibiao Fu et al (2007) Characterization of MazFSa, an endoribonuclease from Staphylococcus aureus. Journal of bacteriology. 189(24):8871-9. [PudMed:17933891]
[534] Izhack Cherny et al (2007) Structural and thermodynamic characterization of the Escherichia coli RelBE toxin-antitoxin system: indication for a functional role of differential stability. Biochemistry. 46(43):12152-63. [PudMed:17924660]
[535] Oliver Schmidt et al (2007) prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli. Journal of molecular biology. 372(4):894-905. [PudMed:17706670]
[536] Nora R Wang et al (2007) A continuous fluorometric assay for the assessment of MazF ribonuclease activity. Analytical biochemistry. 371(2):173-83. [PudMed:17706586]
[537] Paul Carroll et al (2007) Expression of Mycobacterium tuberculosis Rv1991c using an arabinose-inducible promoter demonstrates its role as a toxin. FEMS microbiology letters. 274(1):73-82. [PudMed:17623030]
[538] Virginie Tsilibaris et al (2007) What is the benefit to Escherichia coli of having multiple toxin-antitoxin systems in its genome? Journal of bacteriology. 189(17):6101-8. [PudMed:17513477]
[539] Dayle A Daines et al (2007) VapC-1 of nontypeable Haemophilus influenzae is a ribonuclease. Journal of bacteriology. 189(14):5041-8. [PudMed:17496075]
[540] Mitsuoki Kawano et al (2007) An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxin. Molecular microbiology. 64(3):738-54. [PudMed:17462020]
[541] Shivangi Agarwal et al (2007) Identification and characterization of a novel toxin-antitoxin module from Bacillus anthracis. FEBS letters. 581(9):1727-34. [PudMed:17416361]
[542] Barbara O Gvakharia et al (2007) Global transcriptional response of Nitrosomonas europaea to chloroform and chloromethane. Applied and environmental microbiology. 73(10):3440-5. [PudMed:17369330]
[543] Maria C Monti et al (2007) Interactions of Kid-Kis toxin-antitoxin complexes with the parD operator-promoter region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of Kid-Kis oligomers. Nucleic acids research. 35(5):1737-49. [PudMed:17317682]
[544] Rūta Motiejūnaite et al (2007) Escherichia coli dinJ-yafQ genes act as a toxin-antitoxin module. FEMS microbiology letters. 268(1):112-9. [PudMed:17263853]
[545] Myriam Wilbaux et al (2007) Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7. Journal of bacteriology. 189(7):2712-9. [PudMed:17259320]
[546] Zheng-Ling Shang et al (2007) [Molecular cloning and expression of hypothetical proteins Rv1494 and Rv1495 of M.tuberculosis H37Rv strain]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 27(1):15-9. [PudMed:17259135]
[547] Monique B Kamphuis et al (2007) Interactions between the toxin Kid of the bacterial parD system and the antitoxins Kis and MazE. Proteins. 67(1):219-31. [PudMed:17206710]
[548] Elizabeth M Moritz et al (2007) Toxin-antitoxin systems are ubiquitous and plasmid-encoded in vancomycin-resistant enterococci. Proceedings of the National Academy of Sciences of the United States of America. 104(1):311-6. [PudMed:17190821]
[549] Kalyani Mondal et al (2007) Role of stimuli-sensitive polymers in protein refolding: alpha-amylase and CcdB (controller of cell division or death B) as model proteins. Langmuir : the ACS journal of surfaces and colloids. 23(1):70-5. [PudMed:17190487]
[550] Lukasz Dziewit et al (2007) The SXT conjugative element and linear prophage N15 encode toxin-antitoxin-stabilizing systems homologous to the tad-ata module of the Paracoccus aminophilus plasmid pAMI2. Journal of bacteriology. 189(5):1983-97. [PudMed:17158670]
[551] Priya Prakash Budde et al (2007) Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae. Journal of bacteriology. 189(2):491-500. [PudMed:17085558]
[552] Mikkel Christensen-Dalsgaard et al (2006) Two higBA loci in the Vibrio cholerae superintegron encode mRNA cleaving enzymes and can stabilize plasmids. Molecular microbiology. 62(2):397-411. [PudMed:17020579]
[553] Andrew B Smith et al (2006) A strand-passage conformation of DNA gyrase is required to allow the bacterial toxin, CcdB, to access its binding site. Nucleic acids research. 34(17):4667-76. [PudMed:16963775]
[554] Virginia S Lioy et al (2006) pSM19035-encoded zeta toxin induces stasis followed by death in a subpopulation of cells. Microbiology (Reading, England). 152(Pt 8):2365-2379. [PudMed:16849801]
[555] Monica Bodogai et al (2006) The ntrPR operon of Sinorhizobium meliloti is organized and functions as a toxin-antitoxin module. Molecular plant-microbe interactions : MPMI. 19(7):811-22. [PudMed:16838793]
[556] Sabrina Tachdjian et al (2006) Dynamic metabolic adjustments and genome plasticity are implicated in the heat shock response of the extremely thermoacidophilic archaeon Sulfolobus solfataricus. Journal of bacteriology. 188(12):4553-9. [PudMed:16740961]
[557] Shaleen B Korch et al (2006) Ectopic overexpression of wild-type and mutant hipA genes in Escherichia coli: effects on macromolecular synthesis and persister formation. Journal of bacteriology. 188(11):3826-36. [PudMed:16707675]
[558] C Cruzeiro-Silva et al (2006) In-Cell NMR spectroscopy: inhibition of autologous protein expression reduces Escherichia coli lysis. Cell biochemistry and biophysics. 44(3):497-502. [PudMed:16679537]
[559] Olga N Umanskaya et al (2006) Inhibition of DNA topoisomerase II may trigger illegitimate recombination in living cells: experiments with a model system. Journal of cellular biochemistry. 99(2):598-608. [PudMed:16676353]
[560] Nora Vázquez-Laslop et al (2006) Increased persistence in Escherichia coli caused by controlled expression of toxins or other unrelated proteins. Journal of bacteriology. 188(10):3494-7. [PudMed:16672603]
[561] Ilana Kolodkin-Gal et al (2006) Induction of Escherichia coli chromosomal mazEF by stressful conditions causes an irreversible loss of viability. Journal of bacteriology. 188(9):3420-3. [PudMed:16621839]
[562] Marisela Aguirre-Ramírez et al (2006) Expression of the F plasmid ccd toxin-antitoxin system in Escherichia coli cells under nutritional stress. Canadian journal of microbiology. 52(1):24-30. [PudMed:16541156]
[563] Veronica G Godoy et al (2006) Y-family DNA polymerases respond to DNA damage-independent inhibition of replication fork progression. The EMBO journal. 25(4):868-79. [PudMed:16482223]
[564] Concha Nieto et al (2006) The chromosomal relBE2 toxin-antitoxin locus of Streptococcus pneumoniae: characterization and use of a bioluminescence resonance energy transfer assay to detect toxin-antitoxin interaction. Molecular microbiology. 59(4):1280-96. [PudMed:16430700]
[565] Monique B Kamphuis et al (2006) Model for RNA binding and the catalytic site of the RNase Kid of the bacterial parD toxin-antitoxin system. Journal of molecular biology. 357(1):115-26. [PudMed:16413033]
[566] Miryam Gross et al (2006) MazG -- a regulator of programmed cell death in Escherichia coli. Molecular microbiology. 59(2):590-601. [PudMed:16390452]
[567] Kanika Bajaj et al (2005) Mutagenesis-based definitions and probes of residue burial in proteins. Proceedings of the National Academy of Sciences of the United States of America. 102(45):16221-6. [PudMed:16251276]
[568] José A C Lemos et al (2005) Characteristics of Streptococcus mutans strains lacking the MazEF and RelBE toxin-antitoxin modules. FEMS microbiology letters. 253(2):251-7. [PudMed:16243456]
[569] Jessica M Silvaggi et al (2005) Small untranslated RNA antitoxin in Bacillus subtilis. Journal of bacteriology. 187(19):6641-50. [PudMed:16166525]
[570] Urszula Zielenkiewicz et al (2005) The toxin-antitoxin system of the streptococcal plasmid pSM19035. Journal of bacteriology. 187(17):6094-105. [PudMed:16109951]
[571] Izhack Cherny et al (2005) The YoeB toxin is a folded protein that forms a physical complex with the unfolded YefM antitoxin. Implications for a structural-based differential stability of toxin-antitoxin systems. The Journal of biological chemistry. 280(34):30063-72. [PudMed:15980067]
[572] Cédric Y Szpirer et al (2005) Separate-component-stabilization system for protein and DNA production without the use of antibiotics. BioTechniques. 38(5):775-81. [PudMed:15945374]
[573] Olivier Pellegrini et al (2005) The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor. Molecular microbiology. 56(5):1139-48. [PudMed:15882409]
[574] Ana J Muñoz-Gómez et al (2005) RNase/anti-RNase activities of the bacterial parD toxin-antitoxin system. Journal of bacteriology. 187(9):3151-7. [PudMed:15838042]
[575] Xueyan Zhao et al (2005) Percolation of the phd repressor-operator interface. Journal of bacteriology. 187(6):1901-12. [PudMed:15743936]
[576] Jurij Lah et al (2005) Energetics of structural transitions of the addiction antitoxin MazE: is a programmed bacterial cell death dependent on the intrinsically flexible nature of the antitoxins? The Journal of biological chemistry. 280(17):17397-407. [PudMed:15735309]
[577] Elisabeth Sørvig et al (2005) Plasmid p256 from Lactobacillus plantarum represents a new type of replicon in lactic acid bacteria, and contains a toxin-antitoxin-like plasmid maintenance system. Microbiology (Reading, England). 151(Pt 2):421-431. [PudMed:15699191]
[578] James Estle McKinley et al (2005) Characterization of the Phd repressor-antitoxin boundary. Journal of bacteriology. 187(2):765-70. [PudMed:15629948]
[579] Jörg Vogel et al (2004) The small RNA IstR inhibits synthesis of an SOS-induced toxic peptide. Current biology : CB. 14(24):2271-6. [PudMed:15620655]
[580] Shahar Amitai et al (2004) MazF-mediated cell death in Escherichia coli: a point of no return. Journal of bacteriology. 186(24):8295-300. [PudMed:15576778]
[581] Iris Keren et al (2004) Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. Journal of bacteriology. 186(24):8172-80. [PudMed:15576765]
[582] Gilad Bachrach et al (2004) Characterization of the novel Fusobacterium nucleatum plasmid pKH9 and evidence of an addiction system. Applied and environmental microbiology. 70(12):6957-62. [PudMed:15574887]
[583] R Hazan et al (2004) Escherichia coli mazEF-mediated cell death as a defense mechanism that inhibits the spread of phage P1. Molecular genetics and genomics : MGG. 272(2):227-34. [PudMed:15316771]
[584] Susanne K Christensen et al (2004) Delayed-relaxed response explained by hyperactivation of RelE. Molecular microbiology. 53(2):587-97. [PudMed:15228536]
[585] Yi Xuan Zhang et al (2004) Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome. Cell research. 14(3):208-16. [PudMed:15225414]
[586] Ana J Muñoz-Gómez et al (2004) Insights into the specificity of RNA cleavage by the Escherichia coli MazF toxin. FEBS letters. 567(2-3):316-20. [PudMed:15178344]
[587] Ronen Hazan et al (2004) Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions. Journal of bacteriology. 186(11):3663-9. [PudMed:15150257]
[588] Jeremy Allen Smith et al (2004) Modular organization of the Phd repressor/antitoxin protein. Journal of bacteriology. 186(9):2692-8. [PudMed:15090510]
[589] Shelly M Deane et al (2004) Plasmid evolution and interaction between the plasmid addiction stability systems of two related broad-host-range IncQ-like plasmids. Journal of bacteriology. 186(7):2123-33. [PudMed:15028698]
[590] Junjie Zhang et al (2004) Interference of mRNA function by sequence-specific endoribonuclease PemK. The Journal of biological chemistry. 279(20):20678-84. [PudMed:15024022]
[591] Susanne K Christensen et al (2004) Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system. Molecular microbiology. 51(6):1705-17. [PudMed:15009896]
[592] Kanika Bajaj et al (2004) Thermodynamic characterization of monomeric and dimeric forms of CcdB (controller of cell division or death B protein). The Biochemical journal. 380(Pt 2):409-17. [PudMed:14763902]
[593] Izhack Cherny et al (2004) The YefM antitoxin defines a family of natively unfolded proteins: implications as a novel antibacterial target. The Journal of biological chemistry. 279(9):8252-61. [PudMed:14672926]
[594] Shaleen B Korch et al (2003) Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis. Molecular microbiology. 50(4):1199-213. [PudMed:14622409]
[595] Jason M Brown et al (2003) A novel family of Escherichia coli toxin-antitoxin gene pairs. Journal of bacteriology. 185(22):6600-8. [PudMed:14594833]
[596] Yonglong Zhang et al (2003) MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli. Molecular cell. 12(4):913-23. [PudMed:14580342]
[597] Susanne K Christensen et al (2003) Toxin-antitoxin loci as stress-response-elements: ChpAK/MazF and ChpBK cleave translated RNAs and are counteracted by tmRNA. Journal of molecular biology. 332(4):809-19. [PudMed:12972253]
[598] Junjie Zhang et al (2003) Characterization of the interactions within the mazEF addiction module of Escherichia coli. The Journal of biological chemistry. 278(34):32300-6. [PudMed:12810711]
[599] Boaz Sat et al (2003) The Escherichia coli mazEF suicide module mediates thymineless death. Journal of bacteriology. 185(6):1803-7. [PudMed:12618443]
[600] Ruth Grady et al (2003) Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium. Molecular microbiology. 47(5):1419-32. [PudMed:12603745]
[601] Ana G Camacho et al (2002) In vitro and in vivo stability of the epsilon2zeta2 protein complex of the broad host-range Streptococcus pyogenes pSM19035 addiction system. Biological chemistry. 383(11):1701-13. [PudMed:12530535]
[602] Kim Pedersen et al (2003) The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site. Cell. 112(1):131-40. [PudMed:12526800]
[603] Kim Pedersen et al (2002) Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins. Molecular microbiology. 45(2):501-10. [PudMed:12123459]
[604] Mitsuoki Kawano et al (2002) Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli. Molecular microbiology. 45(2):333-49. [PudMed:12123448]
[605] Noureddine Allali et al (2002) The highly conserved TldD and TldE proteins of Escherichia coli are involved in microcin B17 processing and in CcdA degradation. Journal of bacteriology. 184(12):3224-31. [PudMed:12029038]
[606] Yong Jiang et al (2002) ParE toxin encoded by the broad-host-range plasmid RK2 is an inhibitor of Escherichia coli gyrase. Molecular microbiology. 44(4):971-9. [PudMed:12010492]
[607] Belinda M Lew et al (2002) An in vivo screening system against protein splicing useful for the isolation of non-splicing mutants or inhibitors of the RecA intein of Mycobacterium tuberculosis. Gene. 282(1-2):169-77. [PudMed:11814689]
[608] Monika Oberer et al (2002) The anti-toxin ParD of plasmid RK2 consists of two structurally distinct moieties and belongs to the ribbon-helix-helix family of DNA-binding proteins. The Biochemical journal. 361(Pt 1):41-7. [PudMed:11743881]
[609] Minh-Hoa Dao-Thi et al (2002) Intricate interactions within the ccd plasmid addiction system. The Journal of biological chemistry. 277(5):3733-42. [PudMed:11741897]
[610] S K Christensen et al (2001) RelE, a global inhibitor of translation, is activated during nutritional stress. Proceedings of the National Academy of Sciences of the United States of America. 98(25):14328-33. [PudMed:11717402]
[611] T J Greenfield et al (2001) Antisense RNA regulation of the par post-segregational killing system: structural analysis and mechanism of binding of the antisense RNA, RNAII and its target, RNAI. Molecular microbiology. 42(2):527-37. [PudMed:11703673]
[612] M Picardeau et al (2001) Killing effect and antitoxic activity of the Leptospira interrogans toxin-antitoxin system in Escherichia coli. Journal of bacteriology. 183(21):6494-7. [PudMed:11591696]
[613] M Chatterji et al (2001) Effect of different classes of inhibitors on DNA gyrase from Mycobacterium smegmatis. The Journal of antimicrobial chemotherapy. 48(4):479-85. [PudMed:11581225]
[614] H Afif et al (2001) The ratio between CcdA and CcdB modulates the transcriptional repression of the ccd poison-antidote system. Molecular microbiology. 41(1):73-82. [PudMed:11454201]
[615] E Adler et al (2001) Bacillus subtilis locus encoding a killer protein and its antidote. Journal of bacteriology. 183(12):3574-81. [PudMed:11371520]
[616] J S Brown et al (2001) A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence. Molecular microbiology. 40(3):572-85. [PudMed:11359564]
[617] Q B Tian et al (2001) Specific protein-DNA and protein-protein interaction in the hig gene system, a plasmid-borne proteic killer gene system of plasmid Rts1. Plasmid. 45(2):63-74. [PudMed:11322821]
[618] C Galvani et al (2001) Purification of the RelB and RelE proteins of Escherichia coli: RelE binds to RelB and to ribosomes. Journal of bacteriology. 183(8):2700-3. [PudMed:11274135]
[619] R Hazan et al (2001) Postsegregational killing mediated by the P1 phage "addiction module" phd-doc requires the Escherichia coli programmed cell death system mazEF. Journal of bacteriology. 183(6):2046-50. [PudMed:11222604]
[620] B Sat et al (2001) Programmed cell death in Escherichia coli: some antibiotics can trigger mazEF lethality. Journal of bacteriology. 183(6):2041-5. [PudMed:11222603]
[621] I Marianovsky et al (2001) The regulation of the Escherichia coli mazEF promoter involves an unusual alternating palindrome. The Journal of biological chemistry. 276(8):5975-84. [PudMed:11071896]
[622] T F Cooper et al (2000) Postsegregational killing does not increase plasmid stability but acts to mediate the exclusion of competing plasmids. Proceedings of the National Academy of Sciences of the United States of America. 97(23):12643-8. [PudMed:11058151]
[623] M Oberer et al (1999) Thermodynamic properties and DNA binding of the ParD protein from the broad host-range plasmid RK2/RP4 killing system. Biological chemistry. 380(12):1413-20. [PudMed:10661868]
[624] K Pedersen et al (1999) Multiple hok genes on the chromosome of Escherichia coli. Molecular microbiology. 32(5):1090-102. [PudMed:10361310]
[625] E Gazit et al (1999) The Doc toxin and Phd antidote proteins of the bacteriophage P1 plasmid addiction system form a heterotrimeric complex. The Journal of biological chemistry. 274(24):16813-8. [PudMed:10358024]
[626] H Grønlund et al (1999) Toxin-antitoxin systems homologous with relBE of Escherichia coli plasmid P307 are ubiquitous in prokaryotes. Journal of molecular biology. 285(4):1401-15. [PudMed:9917385]
[627] E Gazit et al (1999) Stability and DNA binding of the phd protein of the phage P1 plasmid addiction system. The Journal of biological chemistry. 274(5):2652-7. [PudMed:9915794]
[628] H Engelberg-Kulka et al (1998) rexB of bacteriophage lambda is an anti-cell death gene. Proceedings of the National Academy of Sciences of the United States of America. 95(26):15481-6. [PudMed:9860994]
[629] F Hayes (1998) A family of stability determinants in pathogenic bacteria. Journal of bacteriology. 180(23):6415-8. [PudMed:9829958]
[630] R Magnuson et al (1998) Corepression of the P1 addiction operon by Phd and Doc. Journal of bacteriology. 180(23):6342-51. [PudMed:9829946]
[631] M Gotfredsen et al (1998) The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family. Molecular microbiology. 29(4):1065-76. [PudMed:9767574]
[632] A S Smith et al (1998) Autoregulation of the pTF-FC2 proteic poison-antidote plasmid addiction system (pas) is essential for plasmid stabilization. Journal of bacteriology. 180(20):5463-5. [PudMed:9765582]
[633] A S Smith et al (1997) The poison-antidote stability system of the broad-host-range Thiobacillus ferrooxidans plasmid pTF-FC2. Molecular microbiology. 26(5):961-70. [PudMed:9426133]
[634] C L Easter et al (1997) Contribution of different segments of the par region to stable maintenance of the broad-host-range plasmid RK2. Journal of bacteriology. 179(20):6472-9. [PudMed:9335298]
[635] Garry A Bloomfield et al (1997) Analysis of sequences flanking the vap regions of Dichelobacter nodosus: evidence for multiple integration events, a killer system, and a new genetic element. Microbiology (Reading, England). 143 ( Pt 2):553-562. [PudMed:9043132]
[636] R Magnuson et al (1996) Autoregulation of the plasmid addiction operon of bacteriophage P1. The Journal of biological chemistry. 271(31):18705-10. [PudMed:8702525]
[637] E Aizenman et al (1996) An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death. Proceedings of the National Academy of Sciences of the United States of America. 93(12):6059-63. [PudMed:8650219]
[638] Q B Tian et al (1996) A new plasmid-encoded proteic killer gene system: cloning, sequencing, and analyzing hig locus of plasmid Rts1. Biochemical and biophysical research communications. 220(2):280-4. [PudMed:8645296]
[639] E P Johnson et al (1996) Plasmid RK2 toxin protein ParE: purification and interaction with the ParD antitoxin protein. Journal of bacteriology. 178(5):1420-9. [PudMed:8631720]
[640] H Lehnherr et al (1993) Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained. Journal of molecular biology. 233(3):414-28. [PudMed:8411153]
[641] Y Masuda et al (1993) chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100. Journal of bacteriology. 175(21):6850-6. [PudMed:8226627]
[642] D S Black et al (1994) Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. Journal of bacteriology. 176(13):4081-91. [PudMed:8021189]
[643] P Bernard et al (1994) Positive-selection vectors using the F plasmid ccdB killer gene. Gene. 148(1):71-4. [PudMed:7926841]
[644] H Lehnherr et al (1995) Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 92(8):3274-7. [PudMed:7724551]
[645] B F Cheetham et al (1995) Identification of a gene encoding a bacteriophage-related integrase in a vap region of the Dichelobacter nodosus genome. Gene. 162(1):53-8. [PudMed:7557417]
[646] P Bernard (1995) New ccdB positive-selection cloning vectors with kanamycin or chloramphenicol selectable markers. Gene. 162(1):159-60. [PudMed:7557407]
[647] R B Jensen et al (1995) Comparison of ccd of F, parDE of RP4, and parD of R1 using a novel conditional replication control system of plasmid R1. Molecular microbiology. 17(2):211-20. [PudMed:7494470]
[648] H S Moyed et al (1983) hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis. Journal of bacteriology. 155(2):768-75. [PudMed:6348026]
[649] A Jaffé et al (1985) Effects of the ccd function of the F plasmid on bacterial growth. Journal of bacteriology. 163(3):841-9. [PudMed:3897195]
[650] A Bravo et al (1987) Identification of components of a new stability system of plasmid R1, ParD, that is close to the origin of replication of this plasmid. Molecular & general genetics : MGG. 210(1):101-10. [PudMed:3323833]
[651] M J Ruiz-Echevarría et al (1991) Structural and functional comparison between the stability systems ParD of plasmid R1 and Ccd of plasmid F. Molecular & general genetics : MGG. 225(3):355-62. [PudMed:2017133]
[652] A K Nielsen et al (1991) The rifampicin-inducible genes srnB from F and pnd from R483 are regulated by antisense RNAs and mediate plasmid maintenance by killing of plasmid-free segregants. Molecular microbiology. 5(8):1961-73. [PudMed:1722558]
[653] D S Black et al (1991) Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. Journal of bacteriology. 173(18):5732-9. [PudMed:1715862]
[654] K Gerdes et al (1990) Mechanism of post-segregational killing by the hok/sok system of plasmid R1: sok antisense RNA regulates formation of a hok mRNA species correlated with killing of plasmid-free cells. Molecular microbiology. 4(11):1807-18. [PudMed:1707122]
[655] G D Pullinger et al (1992) A Salmonella dublin virulence plasmid locus that affects bacterial growth under nutrient-limited conditions. Molecular microbiology. 6(12):1631-43. [PudMed:1495391]
[656] M E Katz et al (1992) Molecular characterization of a genomic region associated with virulence in Dichelobacter nodosus. Infection and immunity. 60(11):4586-92. [PudMed:1398971]
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[2] Joyeeta Chakraborty et al (2022) Comparative genomics analysis of statistically significant genomic islands of Helicobacter pylori strains for better understanding the disease prognosis. Bioscience reports. 42(3):BSR20212084. [PudMed:35258077]
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[4] Sabiha Shaik et al (2021) Genome Informatics and Machine Learning-Based Identification of Antimicrobial Resistance-Encoding Features and Virulence Attributes in Escherichia coli Genomes Representing Globally Prevalent Lineages, Including High-Risk Clonal Complexes. mBio. 13(1):e0379621. [PudMed:35164570]
[5] Ning Ling et al (2022) Rhizosphere bacteriome structure and functions. Nature communications. 13(1):836. [PudMed:35149704]
[6] Sadeghi Kalani Behrooz et al (2018) Study of MazEF, sam, and phd-doc putative toxin-antitoxin systems in Staphylococcus epidermidis. Acta microbiologica et immunologica Hungarica. 65(1):81-91. [PudMed:29471693]
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[9] Kenta Naka et al (2017) RnlB Antitoxin of the Escherichia coli RnlA-RnlB Toxin-Antitoxin Module Requires RNase HI for Inhibition of RnlA Toxin Activity. Toxins. 9(1):29. [PudMed:28085056]
[10] Silvia Heiss et al (2015) Characterization of the Lactobacillus plantarum plasmid pCD033 and generation of the plasmid free strain L. plantarum 3NSH. Plasmid. 81:9-20. [PudMed:26038184]
[11] Krzysztof Fiedoruk et al (2015) Type II toxin-antitoxin systems are unevenly distributed among Escherichia coli phylogroups. Microbiology (Reading, England). 161(Pt 1):158-167. [PudMed:25378561]
[12] Magdalena Szuplewska et al (2014) Mobility and generation of mosaic non-autonomous transposons by Tn3-derived inverted-repeat miniature elements (TIMEs). PloS one. 9(8):e105010. [PudMed:25121765]
[13] Nikita Chopra et al (2013) Linkage, mobility, and selfishness in the MazF family of bacterial toxins: a snapshot of bacterial evolution. Genome biology and evolution. 5(12):2268-84. [PudMed:24265503]
[14] Vivek Anantharaman et al (2013) Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing. Biology direct. 8:15. [PudMed:23768067]
[15] O V Averina et al (2013) [Distribution of genes of toxin-antitoxin systems of mazEF and relBE families in bifidobacteria from human intestinal microbiota]. Genetika. 49(3):315-27. [PudMed:23755531]
[16] Eugeni Belda et al (2013) An updated metabolic view of the Bacillus subtilis 168 genome. Microbiology (Reading, England). 159(Pt 4):757-770. [PudMed:23429746]
[17] Cristina Socolovschi et al (2013) Connection of toxin-antitoxin modules to inoculation eschar and arthropod vertical transmission in Rickettsiales. Comparative immunology, microbiology and infectious diseases. 36(2):199-209. [PudMed:23414774]
[18] Daniel J Rankin et al (2012) The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict. Proceedings. Biological sciences. 279(1743):3706-15. [PudMed:22787022]
[19] Luiz Carlos Bertucci Barbosa et al (2010) Function inferences from a molecular structural model of bacterial ParE toxin. Bioinformation. 4(10):438-40. [PudMed:20975905]
[20] Elizabeth M Fozo et al (2010) Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic acids research. 38(11):3743-59. [PudMed:20156992]
[21] Teresa Nogueira et al (2009) Horizontal gene transfer of the secretome drives the evolution of bacterial cooperation and virulence. Current biology : CB. 19(20):1683-91. [PudMed:19800234]
[22] Patricia Romero et al (2009) Comparative genomic analysis of ten Streptococcus pneumoniae temperate bacteriophages. Journal of bacteriology. 191(15):4854-62. [PudMed:19502408]
[23] Kira S Makarova et al (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biology direct. 4:19. [PudMed:19493340]
[24] Julien Guglielmini et al (2008) Automated discovery and phylogenetic analysis of new toxin-antitoxin systems. BMC microbiology. 8:104. [PudMed:18578869]
[25] Kanika Bajaj et al (2007) Stereochemical criteria for prediction of the effects of proline mutations on protein stability. PLoS computational biology. 3(12):e241. [PudMed:18069886]
[26] Emeric W Sevin et al (2007) RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes. Genome biology. 8(8):R155. [PudMed:17678530]
[27] Kira S Makarova et al (2006) The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria. Bioinformatics (Oxford, England). 22(21):2581-4. [PudMed:16895922]
[28] Deo Prakash Pandey et al (2005) Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes. Nucleic acids research. 33(3):966-76. [PudMed:15718296]
[29] Akshay Bhinge et al (2004) Accurate detection of protein:ligand binding sites using molecular dynamics simulations. Structure (London, England : 1993). 12(11):1989-99. [PudMed:15530363]
[30] Vivek Anantharaman et al (2003) New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system. Genome biology. 4(12):R81. [PudMed:14659018]
[31] G Mittenhuber (1999) Occurrence of mazEF-like antitoxin/toxin systems in bacteria. Journal of molecular microbiology and biotechnology. 1(2):295-302. [PudMed:10943559]
[1] Bing-Shuang Xu et al (2019) Conformational changes of antitoxin HigA from Escherichia coli str. K-12 upon binding of its cognate toxin HigB reveal a new regulation mechanism in toxin-antitoxin systems. Biochemical and biophysical research communications. 514(1):37-43. [PudMed:31014676]
[2] Ashley L Molinaro et al (2019) Crystal Structure of VapBC-1 from Nontypeable Haemophilus influenzae and the Effect of PIN Domain Mutations on Survival during Infection. Journal of bacteriology. 201(12):e00026-19. [PudMed:30936373]
[3] Gang Li et al (2016) Genomic analyses of multidrug resistant Pseudomonas aeruginosa PA1 resequenced by single-molecule real-time sequencing. Bioscience reports. 36(6):e00418. [PudMed:27765811]
[4] Wing Sze Ho et al (2015) The Complete Sequence and Comparative Analysis of a Multidrug-Resistance and Virulence Multireplicon IncFII Plasmid pEC302/04 from an Extraintestinal Pathogenic Escherichia coli EC302/04 Indicate Extensive Diversity of IncFII Plasmids. Frontiers in microbiology. 6:1547. [PudMed:26793180]
[5] Miguel A Matilla et al (2014) Bacteriophage ϕMAM1, a viunalikevirus, is a broad-host-range, high-efficiency generalized transducer that infects environmental and clinical isolates of the enterobacterial genera Serratia and Kluyvera. Applied and environmental microbiology. 80(20):6446-57. [PudMed:25107968]
[6] Jennifer L Cottell et al (2014) Functional genomics to identify the factors contributing to successful persistence and global spread of an antibiotic resistance plasmid. BMC microbiology. 14:168. [PudMed:24961279]
[7] Noraida Mosqueda et al (2014) Characterization of plasmids carrying the blaOXA-24/40 carbapenemase gene and the genes encoding the AbkA/AbkB proteins of a toxin/antitoxin system. The Journal of antimicrobial chemotherapy. 69(10):2629-33. [PudMed:24879663]
[8] Lena Ciric et al (2014) Minocycline resistance in an oral Streptococcus infantis isolate is encoded by tet(S) on a novel small, low copy number plasmid. FEMS microbiology letters. 353(2):106-15. [PudMed:24605990]
[9] Kirsty Agnoli et al (2014) The third replicon of members of the Burkholderia cepacia Complex, plasmid pC3, plays a role in stress tolerance. Applied and environmental microbiology. 80(4):1340-8. [PudMed:24334662]
[10] Zongfu Wu et al (2014) Comparative genomic analysis shows that Streptococcus suis meningitis isolate SC070731 contains a unique 105K genomic island. Gene. 535(2):156-64. [PudMed:24316490]
[11] L F Mataseje et al (2014) Complete sequences of a novel blaNDM-1-harbouring plasmid from Providencia rettgeri and an FII-type plasmid from Klebsiella pneumoniae identified in Canada. The Journal of antimicrobial chemotherapy. 69(3):637-42. [PudMed:24275114]
[12] Carola Venturini et al (2013) Sequences of two related multiple antibiotic resistance virulence plasmids sharing a unique IS26-related molecular signature isolated from different Escherichia coli pathotypes from different hosts. PloS one. 8(11):e78862. [PudMed:24223859]
[13] Graham Rose et al (2013) Mapping of genotype-phenotype diversity among clinical isolates of mycobacterium tuberculosis by sequence-based transcriptional profiling. Genome biology and evolution. 5(10):1849-62. [PudMed:24115728]
[14] Carole Jaubert et al (2013) Genomics and genetics of Sulfolobus islandicus LAL14/1, a model hyperthermophilic archaeon. Open biology. 3(4):130010. [PudMed:23594878]
[15] Kingsley C Anukam et al (2013) Genome sequence of Lactobacillus pentosus KCA1: vaginal isolate from a healthy premenopausal woman. PloS one. 8(3):e59239. [PudMed:23527145]
[16] Miguel Balado et al (2013) Genetic characterization of pPHDP60, a novel conjugative plasmid from the marine fish pathogen Photobacterium damselae subsp. piscicida. Plasmid. 70(1):154-9. [PudMed:23474463]
[17] Rémy A Bonnin et al (2013) Complete sequence of broad-host-range plasmid pNOR-2000 harbouring the metallo-β-lactamase gene blaVIM-2 from Pseudomonas aeruginosa. The Journal of antimicrobial chemotherapy. 68(5):1060-5. [PudMed:23354281]
[18] Clemente Michael Vui Ling Wong et al (2013) Characterisation of a cryptic plasmid from an Antarctic bacterium Pedobacter cryoconitis strain BG5. Plasmid. 69(2):186-93. [PudMed:23266397]
[19] Daniel Wibberg et al (2013) The IncF plasmid pRSB225 isolated from a municipal wastewater treatment plant's on-site preflooder combining antibiotic resistance and putative virulence functions is highly related to virulence plasmids identified in pathogenic E. coli isolates. Plasmid. 69(2):127-37. [PudMed:23212116]
[20] Andrei N Shkoporov et al (2013) Analysis of a novel 8.9kb cryptic plasmid from Bacteroides uniformis, its long-term stability and spread within human microbiota. Plasmid. 69(2):146-59. [PudMed:23201047]
[21] Aurore Gorlas et al (2012) Draft genome sequences of Actinomyces timonensis strain 7400942T and its prophage. Journal of bacteriology. 194(23):6613-4. [PudMed:23144376]
[22] Véronique Roux et al (2012) Draft genome sequence of Actinomyces massiliensis strain 4401292T. Journal of bacteriology. 194(18):5121. [PudMed:22933754]
[23] Michael S M Brouwer et al (2012) In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes. Mobile genetic elements. 2(1):8-12. [PudMed:22754747]
[24] Fay E Dawes et al (2012) Molecular characterization of a 21.4 kilobase antibiotic resistance plasmid from an α-hemolytic Escherichia coli O108:H- human clinical isolate. PloS one. 7(4):e34718. [PudMed:22532831]
[25] Kevin S Lang et al (2012) Transcriptome mapping of pAR060302, a blaCMY-2-positive broad-host-range IncA/C plasmid. Applied and environmental microbiology. 78(9):3379-86. [PudMed:22344651]
[26] Naoto Ohtani et al (2012) The third plasmid pVV8 from Thermus thermophilus HB8: isolation, characterization, and sequence determination. Extremophiles : life under extreme conditions. 16(2):237-44. [PudMed:22212656]
[27] Amy S Gargis et al (2010) Complete nucleotide sequences of plasmids pACK1 and pACK3 from Staphylococcus simulans biovar staphylolyticus. Plasmid. 64(2):104-9. [PudMed:20493903]
[28] Brian V Jones et al (2010) Comparative metagenomic analysis of plasmid encoded functions in the human gut microbiome. BMC genomics. 11:46. [PudMed:20085629]
[29] Torill C S Rosvoll et al (2010) PCR-based plasmid typing in Enterococcus faecium strains reveals widely distributed pRE25-, pRUM-, pIP501- and pHTbeta-related replicons associated with glycopeptide resistance and stabilizing toxin-antitoxin systems. FEMS immunology and medical microbiology. 58(2):254-68. [PudMed:20015231]
[30] Daniela Lepka et al (2009) Adding to Yersinia enterocolitica gene pool diversity: two cryptic plasmids from a biotype 1A isolate. Journal of biomedicine & biotechnology. 2009:398434. [PudMed:19834620]
[31] W Florian Fricke et al (2009) Comparative genomics of the IncA/C multidrug resistance plasmid family. Journal of bacteriology. 191(15):4750-7. [PudMed:19482926]
[32] Wenyi Zhang et al (2008) Complete nucleotide sequence of plasmid plca36 isolated from Lactobacillus casei Zhang. Plasmid. 60(2):131-5. [PudMed:18634821]
[33] Bruno Périchon et al (2008) Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosides by 16S rRNA methylation and to hydrophilic fluoroquinolones by efflux. Antimicrobial agents and chemotherapy. 52(7):2581-92. [PudMed:18458128]
[34] E B O'Connor et al (2007) pEOC01: a plasmid from Pediococcus acidilactici which encodes an identical streptomycin resistance (aadE) gene to that found in Campylobacter jejuni. Plasmid. 58(2):115-26. [PudMed:17395262]
[35] Sarah Fico et al (2006) TasA-tasB, a new putative toxin-antitoxin (TA) system from Bacillus thuringiensis pGI1 plasmid is a widely distributed composite mazE-doc TA system. BMC genomics. 7:259. [PudMed:17038198]
[36] H Ogata et al (2005) Rickettsia felis, from culture to genome sequencing. Annals of the New York Academy of Sciences. 1063:26-34. [PudMed:16481487]
[37] Yan Jiang et al (2005) The complete sequence and analysis of the large virulence plasmid pSS of Shigella sonnei. Plasmid. 54(2):149-59. [PudMed:16122562]
[38] A P Pomerantsev et al (2001) Genetic organization of the Francisella plasmid pFNL10. Plasmid. 46(3):210-22. [PudMed:11735370]
[1] Amar Deep et al (2023) Structural insights into DarT toxin neutralization by cognate DarG antitoxin: ssDNA mimicry by DarG C-terminal domain keeps the DarT toxin inhibited. Structure (London, England : 1993). 31(7):780-789.e4. [PudMed:37167974]
[2] Giuliana Catara et al (2023) The DarT/DarG Toxin-Antitoxin ADP-Ribosylation System as a Novel Target for a Rational Design of Innovative Antimicrobial Strategies. Pathogens (Basel, Switzerland). 12(2):240. [PudMed:36839512]
[3] Chenchen Wang et al (2022) Structural insights into the PrpTA toxin-antitoxin system in Pseudoalteromonas rubra. Frontiers in microbiology. 13:1053255. [PudMed:36504814]
[4] Victor Yu et al (2022) MqsR is a noncanonical microbial RNase toxin that is inhibited by antitoxin MqsA via steric blockage of substrate binding. The Journal of biological chemistry. 298(11):102535. [PudMed:36162504]
[5] Do-Hee Kim et al (2022) Role of PemI in the Staphylococcus aureus PemIK toxin-antitoxin complex: PemI controls PemK by acting as a PemK loop mimic. Nucleic acids research. 50(4):2319-2333. [PudMed:35141752]
[6] Juan Zhou et al (2021) Insights into the Neutralization and DNA Binding of Toxin-Antitoxin System ParESO-CopASO by Structure-Function Studies. Microorganisms. 9(12):2506. [PudMed:34946107]
[7] Lu Xue et al (2022) The two paralogous copies of the YoeB-YefM toxin-antitoxin module in Staphylococcus aureus differ in DNA binding and recognition patterns. The Journal of biological chemistry. 298(1):101457. [PudMed:34861238]
[8] William Richardson et al (2021) Chasing the structural diversity of the transcription regulator Mycobacterium tuberculosis HigA2. IUCrJ. 8(Pt 5):823-832. [PudMed:34584743]
[9] Grzegorz J Grabe et al (2021) Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing. Nature chemical biology. 17(12):1296-1304. [PudMed:34556858]
[10] Marion Schuller et al (2021) Molecular basis for DarT ADP-ribosylation of a DNA base. Nature. 596(7873):597-602. [PudMed:34408320]
[11] Gabriela Garcia-Rodriguez et al (2021) Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA. Nucleic acids research. 49(12):7164-7178. [PudMed:34139012]
[12] Chenglong Jin et al (2021) Structural and functional analysis of the Klebsiella pneumoniae MazEF toxin-antitoxin system. IUCrJ. 8(Pt 3):362-371. [PudMed:33953923]
[13] Ran Chen et al (2021) Mechanistic Insight into the Peptide Binding Modes to Two M. tb MazF Toxins. Toxins. 13(5):319. [PudMed:33925254]
[14] Sung-Min Kang et al (2020) Structural and Functional Study of the Klebsiella pneumoniae VapBC Toxin-Antitoxin System, Including the Development of an Inhibitor That Activates VapC. Journal of medicinal chemistry. 63(22):13669-13679. [PudMed:33146528]
[15] Marie B Bertelsen et al (2021) Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System. Structure (London, England : 1993). 29(2):139-150.e3. [PudMed:33096014]
[16] Jianyun Yao et al (2020) Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system. Nucleic acids research. 48(19):11054-11067. [PudMed:33045733]
[17] Pankaj Vilas Jadhav et al (2020) 2.09 Å Resolution structure of E. coli HigBA toxin-antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitoxin. The Biochemical journal. 477(20):4001-4019. [PudMed:33000860]
[18] Lu Xue et al (2020) Distinct oligomeric structures of the YoeB-YefM complex provide insights into the conditional cooperativity of type II toxin-antitoxin system. Nucleic acids research. 48(18):10527-10541. [PudMed:32845304]
[19] Sung-Min Kang et al (2021) Structure-based design of peptides that trigger Streptococcus pneumoniae cell death. The FEBS journal. 288(5):1546-1564. [PudMed:32770723]
[20] Jin-Young Park et al (2020) Induced DNA bending by unique dimerization of HigA antitoxin. IUCrJ. 7(Pt 4):748-760. [PudMed:32695421]
[21] Ran Chen et al (2020) Conserved Conformational Changes in the Regulation of Mycobacterium tuberculosis MazEF-mt1. ACS infectious diseases. 6(7):1783-1795. [PudMed:32485099]
[22] Hyun-Jong Eun et al (2020) Crystal structure of the YoeBSa1-YefMSa1 complex from Staphylococcus aureus. Biochemical and biophysical research communications. 527(1):264-269. [PudMed:32446378]
[23] Ying Liu et al (2019) Structural Insights Into the Transcriptional Regulation of HigBA Toxin-Antitoxin System by Antitoxin HigA in Pseudomonas aeruginosa. Frontiers in microbiology. 10:3158. [PudMed:32038588]
[24] Gabriela Garcia-Rodriguez et al (2020) The Escherichia coli RnlA-RnlB toxin-antitoxin complex: production, characterization and crystallization. Acta crystallographica. Section F, Structural biology communications. 76(Pt 1):31-39. [PudMed:31929184]
[25] DongWon Park et al (2020) Crystal structure of proteolyzed VapBC and DNA-bound VapBC from Salmonella enterica Typhimurium LT2 and VapC as a putative Ca2+ -dependent ribonuclease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(2):3051-3068. [PudMed:31908032]
[26] Melek Cemre Manav et al (2019) The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNA Binding Domain. Structure (London, England : 1993). 27(11):1675-1685.e3. [PudMed:31495532]
[27] Dursun Nizam Korkut et al (2020) Structural insights into the AapA1 toxin of Helicobacter pylori. Biochimica et biophysica acta. General subjects. 1864(1):129423. [PudMed:31476357]
[28] Hongliang Qian et al (2019) Toxin-antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA-KacT complex. Nucleic acids research. 47(14):7690-7702. [PudMed:31260525]
[29] Rongjuan Zhao et al (2019) Structure and allosteric coupling of type Ⅱ antitoxin CopASO. Biochemical and biophysical research communications. 514(4):1122-1127. [PudMed:31101334]
[30] Won-Su Yoon et al (2019) Structural changes of antitoxin HigA from Shigella flexneri by binding of its cognate toxin HigB. International journal of biological macromolecules. 130:99-108. [PudMed:30797012]
[31] Marc A Schureck et al (2019) Structural basis of transcriptional regulation by the HigA antitoxin. Molecular microbiology. 111(6):1449-1462. [PudMed:30793388]
[32] Dukas Jurėnas et al (2019) Mechanism of regulation and neutralization of the AtaR-AtaT toxin-antitoxin system. Nature chemical biology. 15(3):285-294. [PudMed:30718814]
[33] Yuka Yashiro et al (2019) Crystal Structure of the Enterohemorrhagic Escherichia coli AtaT-AtaR Toxin-Antitoxin Complex. Structure (London, England : 1993). 27(3):476-484.e3. [PudMed:30612860]
[34] Amar Deep et al (2018) Structural, functional and biological insights into the role of Mycobacterium tuberculosis VapBC11 toxin-antitoxin system: targeting a tRNase to tackle mycobacterial adaptation. Nucleic acids research. 46(21):11639-11655. [PudMed:30329074]
[35] Dukas Jurėnas et al (2018) Crystallization and X-ray analysis of all of the players in the autoregulation of the ataRT toxin-antitoxin system. Acta crystallographica. Section F, Structural biology communications. 74(Pt 7):391-401. [PudMed:29969102]
[36] Do-Hee Kim et al (2018) Functional insights into the Streptococcus pneumoniae HicBA toxin-antitoxin system based on a structural study. Nucleic acids research. 46(12):6371-6386. [PudMed:29878152]
[37] Xuanyan Jia et al (2018) Structure-function analyses reveal the molecular architecture and neutralization mechanism of a bacterial HEPN-MNT toxin-antitoxin system. The Journal of biological chemistry. 293(18):6812-6823. [PudMed:29555683]
[38] Laurence Van Melderen et al (2018) Messing up translation from the start: How AtaT inhibits translation initiation in E. coli. RNA biology. 15(3):303-307. [PudMed:29099338]
[39] Amar Deep et al (2017) Crystal structure of Mycobacterium tuberculosis VapC20 toxin and its interactions with cognate antitoxin, VapB20, suggest a model for toxin-antitoxin assembly. The FEBS journal. 284(23):4066-4082. [PudMed:28986943]
[40] Do-Hwan Ahn et al (2017) Structural analyses of the MazEF4 toxin-antitoxin pair in Mycobacterium tuberculosis provide evidence for a unique extracellular death factor. The Journal of biological chemistry. 292(46):18832-18847. [PudMed:28972145]
[41] Jingsi Yang et al (2017) HicAB toxin-antitoxin complex from Escherichia coli: expression and crystallization. Acta crystallographica. Section F, Structural biology communications. 73(Pt 9):505-510. [PudMed:28876228]
[42] Sung-Min Kang et al (2017) Functional details of the Mycobacterium tuberculosis VapBC26 toxin-antitoxin system based on a structural study: insights into unique binding and antibiotic peptides. Nucleic acids research. 45(14):8564-8580. [PudMed:28575388]
[43] San Hadži et al (2017) Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a β-strand sliding mechanism. Nucleic acids research. 45(8):4972-4983. [PudMed:28334932]
[44] Hua Wan et al (2016) Structural insights into the inhibition mechanism of bacterial toxin LsoA by bacteriophage antitoxin Dmd. Molecular microbiology. 101(5):757-69. [PudMed:27169810]
[45] Yann G-J Sterckx et al (2016) A unique hetero-hexadecameric architecture displayed by the Escherichia coli O157 PaaA2-ParE2 antitoxin-toxin complex. Journal of molecular biology. 428(8):1589-603. [PudMed:26996937]
[46] Yong Wei et al (2016) Structural characterizations of phage antitoxin Dmd and its interactions with bacterial toxin RnlA. Biochemical and biophysical research communications. 472(4):592-7. [PudMed:26972252]
[47] Uddipan Das et al (2014) Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin-antitoxin assembly. Journal of structural biology. 188(3):249-58. [PudMed:25450593]
[48] Yann G J Sterckx et al (2014) Crystallization and preliminary X-ray analysis of two variants of the Escherichia coli O157 ParE2-PaaA2 toxin-antitoxin complex. Acta crystallographica. Section F, Structural biology communications. 70(Pt 9):1284-91. [PudMed:25195911]
[49] Sabrina Bibi-Triki et al (2014) Functional and structural analysis of HicA3-HicB3, a novel toxin-antitoxin system of Yersinia pestis. Journal of bacteriology. 196(21):3712-23. [PudMed:25112480]
[50] Yurong Wen et al (2014) The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic acids research. 42(15):10134-47. [PudMed:25056321]
[51] Yajing Liang et al (2014) Structural and functional characterization of Escherichia coli toxin-antitoxin complex DinJ-YafQ. The Journal of biological chemistry. 289(30):21191-202. [PudMed:24923448]
[52] Yann G J Sterckx et al (2014) Small-angle X-ray scattering- and nuclear magnetic resonance-derived conformational ensemble of the highly flexible antitoxin PaaA2. Structure (London, England : 1993). 22(6):854-65. [PudMed:24768114]
[53] Valentina Zorzini et al (2014) Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics. Nucleic acids research. 42(10):6709-25. [PudMed:24748664]
[54] Hookang Im et al (2014) Crystal structure of toxin HP0892 from Helicobacter pylori with two Zn(II) at 1.8 Å resolution. Protein science : a publication of the Protein Society. 23(6):819-32. [PudMed:24677509]
[55] Shashikala Verma et al (2015) Structural basis of Bacillus anthracis MoxXT disruption and the modulation of MoxT ribonuclease activity by rationally designed peptides. Journal of biomolecular structure & dynamics. 33(3):606-24. [PudMed:24650157]
[56] Marc A Schureck et al (2014) Structure of the Proteus vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex. The Journal of biological chemistry. 289(2):1060-70. [PudMed:24257752]
[57] Uddipan Das et al (2013) Preliminary crystallographic analysis of recombinant VapBC-15 toxin-antitoxin complex from Mycobacterium tuberculosis. Acta crystallographica. Section F, Structural biology and crystallization communications. 69(Pt 11):1242-5. [PudMed:24192359]
[58] Yong Wei et al (2013) Structure-function studies of Escherichia coli RnlA reveal a novel toxin structure involved in bacteriophage resistance. Molecular microbiology. 90(5):956-65. [PudMed:24112600]
[59] Andrej Mernik et al (2012) Differences in Unfolding Energetics of CcdB Toxins From V. fischeri and E. coli. Acta chimica Slovenica. 59(3):548-53. [PudMed:24061309]
[60] Chinar Pathak et al (2013) Crystal structure of apo and copper bound HP0894 toxin from Helicobacter pylori 26695 and insight into mRNase activity. Biochimica et biophysica acta. 1834(12):2579-90. [PudMed:24060809]
[61] Dorota Połom et al (2013) Amino acid residues crucial for specificity of toxin-antitoxin interactions in the homologous Axe-Txe and YefM-YoeB complexes. The FEBS journal. 280(22):5906-18. [PudMed:24028219]
[62] San Hadži et al (2013) Crystallization of the HigBA2 toxin-antitoxin complex from Vibrio cholerae. Acta crystallographica. Section F, Structural biology and crystallization communications. 69(Pt 9):1052-9. [PudMed:23989162]
[63] Kehan Xu et al (2013) Protein expression, crystallization and preliminary X-ray crystallographic analysis of the isolated Shigella flexneri VapC toxin. Acta crystallographica. Section F, Structural biology and crystallization communications. 69(Pt 7):762-5. [PudMed:23832203]
[64] Steven De Gieter et al (2014) ¹H, ¹³C, and ¹⁵N backbone and side-chain chemical shift assignment of the toxin Doc in the unbound state. Biomolecular NMR assignments. 8(1):145-8. [PudMed:23420131]
[65] Julie E Samson et al (2013) Structure and activity of AbiQ, a lactococcal endoribonuclease belonging to the type III toxin-antitoxin system. Molecular microbiology. 87(4):756-68. [PudMed:23279123]
[66] Andrew B Min et al (2012) The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg²⁺ ion in the active site and a putative RNA-binding site. Protein science : a publication of the Protein Society. 21(11):1754-67. [PudMed:23011806]
[67] Andreas Bøggild et al (2012) The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity. Structure (London, England : 1993). 20(10):1641-8. [PudMed:22981948]
[68] Fan Zhang et al (2012) Crystallization and preliminary crystallographic studies of the YafN-YafO complex from Escherichia coli. Acta crystallographica. Section F, Structural biology and crystallization communications. 68(Pt 8):894-7. [PudMed:22869116]
[69] Yann G J Sterckx et al (2012) The ParE2-PaaA2 toxin-antitoxin complex from Escherichia coli O157 forms a heterodocecamer in solution and in the crystal. Acta crystallographica. Section F, Structural biology and crystallization communications. 68(Pt 6):724-9. [PudMed:22684081]
[70] Ae-Ran Kwon et al (2012) Structural and biochemical characterization of HP0315 from Helicobacter pylori as a VapD protein with an endoribonuclease activity. Nucleic acids research. 40(9):4216-28. [PudMed:22241770]
[71] María J Maté et al (2012) Crystal structure of the DNA-bound VapBC2 antitoxin/toxin pair from Rickettsia felis. Nucleic acids research. 40(7):3245-58. [PudMed:22140099]
[72] Tim R Blower et al (2011) A processed noncoding RNA regulates an altruistic bacterial antiviral system. Nature structural & molecular biology. 18(2):185-90. [PudMed:21240270]
[73] Breann L Brown et al (2010) Preliminary crystallographic analysis of the Escherichia coli antitoxin MqsA (YgiT/b3021) in complex with mqsRA promoter DNA. Acta crystallographica. Section F, Structural biology and crystallization communications. 66(Pt 9):1060-3. [PudMed:20823526]
[74] Mark A Arbing et al (2010) Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems. Structure (London, England : 1993). 18(8):996-1010. [PudMed:20696400]
[75] Kevin M Dalton et al (2010) A conserved mode of protein recognition and binding in a ParD-ParE toxin-antitoxin complex. Biochemistry. 49(10):2205-15. [PudMed:20143871]
[76] Abel Garcia-Pino et al (2010) Purification and crystallization of Phd, the antitoxin of the phd/doc operon. Acta crystallographica. Section F, Structural biology and crystallization communications. 66(Pt 2):167-71. [PudMed:20124714]
[77] Breann L Brown et al (2009) Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. PLoS pathogens. 5(12):e1000706. [PudMed:20041169]
[78] Cajetan Neubauer et al (2009) The structural basis for mRNA recognition and cleavage by the ribosome-dependent endonuclease RelE. Cell. 139(6):1084-95. [PudMed:20005802]
[79] Natalie De Jonge et al (2010) Structural and thermodynamic characterization of Vibrio fischeri CcdB. The Journal of biological chemistry. 285(8):5606-13. [PudMed:19959472]
[80] Djordje Francuski et al (2009) Crystal structure of the antitoxin-toxin protein complex RelB-RelE from Methanococcus jannaschii. Journal of molecular biology. 393(4):898-908. [PudMed:19712680]
[81] Maria A Schumacher et al (2009) Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science (New York, N.Y.). 323(5912):396-401. [PudMed:19150849]
[82] Abel Garcia-Pino et al (2008) Crystallization of Doc and the Phd-Doc toxin-antitoxin complex. Acta crystallographica. Section F, Structural biology and crystallization communications. 64(Pt 11):1034-8. [PudMed:18997335]
[83] Linda Miallau et al (2009) Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. The Journal of biological chemistry. 284(1):276-283. [PudMed:18952600]
[84] Pramod Kumar et al (2008) Crystal structure of Mycobacterium tuberculosis YefM antitoxin reveals that it is not an intrinsically unstructured protein. Journal of molecular biology. 383(3):482-93. [PudMed:18793646]
[85] Abel Garcia-Pino et al (2008) Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation. The Journal of biological chemistry. 283(45):30821-7. [PudMed:18757857]
[86] Sujin Lee et al (2008) Crystal structure of Escherichia coli MazG, the regulator of nutritional stress response. The Journal of biological chemistry. 283(22):15232-40. [PudMed:18353782]
[87] Monika Oberer et al (2007) The solution structure of ParD, the antidote of the ParDE toxin antitoxin module, provides the structural basis for DNA and toxin binding. Protein science : a publication of the Protein Society. 16(8):1676-88. [PudMed:17656583]
[88] Seok Kooi Khoo et al (2007) Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae. The Journal of biological chemistry. 282(27):19606-18. [PudMed:17488720]
[89] Natalie De Jonge et al (2007) Purification and crystallization of Vibrio fischeri CcdB and its complexes with fragments of gyrase and CcdA. Acta crystallographica. Section F, Structural biology and crystallization communications. 63(Pt 4):356-60. [PudMed:17401216]
[90] Monique B Kamphuis et al (2007) Structure and function of bacterial kid-kis and related toxin-antitoxin systems. Protein and peptide letters. 14(2):113-24. [PudMed:17305597]
[91] Tobias Madl et al (2006) Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA. Journal of molecular biology. 364(2):170-85. [PudMed:17007877]
[92] Lieven Buts et al (2005) Crystallization of the C-terminal domain of the addiction antidote CcdA in complex with its toxin CcdB. Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 10):949-52. [PudMed:16511204]
[93] Katsuhiko Kamada et al (2005) Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin. Molecular cell. 19(4):497-509. [PudMed:16109374]
[94] Minh-Hoa Dao-Thi et al (2005) Molecular basis of gyrase poisoning by the addiction toxin CcdB. Journal of molecular biology. 348(5):1091-102. [PudMed:15854646]
[95] Hisanori Takagi et al (2005) Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects. Nature structural & molecular biology. 12(4):327-31. [PudMed:15768033]
[96] Minh Hoa Dao-Thi et al (2004) Crystallization of CcdB in complex with a GyrA fragment. Acta crystallographica. Section D, Biological crystallography. 60(Pt 6):1132-4. [PudMed:15159578]
[97] Katsuhiko Kamada et al (2003) Crystal structure of the MazE/MazF complex: molecular bases of antidote-toxin recognition. Molecular cell. 11(4):875-84. [PudMed:12718874]
[98] Anton Meinhart et al (2003) Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation. Proceedings of the National Academy of Sciences of the United States of America. 100(4):1661-6. [PudMed:12571357]
[99] Jurij Lah et al (2003) Recognition of the intrinsically flexible addiction antidote MazE by a dromedary single domain antibody fragment. Structure, thermodynamics of binding, stability, and influence on interactions with DNA. The Journal of biological chemistry. 278(16):14101-11. [PudMed:12533537]
[100] David Hargreaves et al (2002) Structural and functional analysis of the kid toxin protein from E. coli plasmid R1. Structure (London, England : 1993). 10(10):1425-33. [PudMed:12377128]
[101] A Meinhart et al (2001) Crystallization and preliminary X-ray diffraction studies of the epsilonzeta addiction system encoded by Streptococcus pyogenes plasmid pSM19035. Acta crystallographica. Section D, Biological crystallography. 57(Pt 5):745-7. [PudMed:11320325]
[102] R Loris et al (1999) Crystal structure of CcdB, a topoisomerase poison from E. coli. Journal of molecular biology. 285(4):1667-77. [PudMed:9917404]
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[2] Tiffany M Halvorsen et al (2022) Comparison of Kill Switch Toxins in Plant-Beneficial Pseudomonas fluorescens Reveals Drivers of Lethality, Stability, and Escape. ACS synthetic biology. 11(11):3785-3796. [PudMed:36346907]
[3] Reinaldo Rodrigues de Souza-Neto et al (2022) MqsR toxin as a biotechnological tool for plant pathogen bacterial control. Scientific reports. 12(1):2794. [PudMed:35181693]
[4] Tsutomu Shimazu et al (2014) Regression of solid tumors by induction of MazF, a bacterial mRNA endoribonuclease. Journal of molecular microbiology and biotechnology. 24(4):228-33. [PudMed:25196606]
[5] Oliver Wright et al (2015) GeneGuard: A modular plasmid system designed for biosafety. ACS synthetic biology. 4(3):307-16. [PudMed:24847673]
[6] Jacelyn M S Loh et al (2014) Comparison of firefly luciferase and NanoLuc luciferase for biophotonic labeling of group A Streptococcus. Biotechnology letters. 36(4):829-34. [PudMed:24322775]
[7] Jacelyn M S Loh et al (2013) Toxin-antitoxin-stabilized reporter plasmids for biophotonic imaging of Group A streptococcus. Applied microbiology and biotechnology. 97(22):9737-45. [PudMed:24061415]
[8] Laura Sevillano et al (2013) Stable expression plasmids for Streptomyces based on a toxin-antitoxin system. Microbial cell factories. 12:39. [PudMed:23617558]
[9] Oliver Wright et al (2013) Building-in biosafety for synthetic biology. Microbiology (Reading, England). 159(Pt 7):1221-1235. [PudMed:23519158]
[10] Luiz Carlos Bertucci Barbosa et al (2012) Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases. European journal of medicinal chemistry. 54:591-6. [PudMed:22749642]
[11] Jung-Ho Park et al (2012) Intramolecular regulation of the sequence-specific mRNA interferase activity of MazF fused to a MazE fragment with a linker cleavable by specific proteases. Applied and environmental microbiology. 78(11):3794-9. [PudMed:22447587]
[12] Iwona Brzozowska et al (2012) Functioning of the TA cassette of streptococcal plasmid pSM19035 in various Gram-positive bacteria. Plasmid. 68(1):51-60. [PudMed:22309878]
[13] Li-Ling Hu et al (2010) The use of the ccdB lethal gene for constructing a zero background vector in order to clone blunt-end PCR products. Molekuliarnaia biologiia. 44(1):174-6. [PudMed:20198872]
[14] Ghadiyaram Chakshusmathi et al (2004) Design of temperature-sensitive mutants solely from amino acid sequence. Proceedings of the National Academy of Sciences of the United States of America. 101(21):7925-30. [PudMed:15148363]
[15] Rebecca D Parr et al (2003) New donor vector for generation of histidine-tagged fusion proteins using the Gateway Cloning System. Plasmid. 49(2):179-83. [PudMed:12726771]
[1] Monica Markovski et al (2013) Preventing bacterial suicide: a novel toxin-antitoxin strategy. Molecular cell. 52(5):611-2. [PudMed:24332174]
[2] Laurence Van Melderen (2012) GhoSTly bacterial persisters. Nature chemical biology. 8(10):812-3. [PudMed:22987009]
[3] Daniel N Wilson et al (2005) RelBE or not to be. Nature structural & molecular biology. 12(4):282-4. [PudMed:15809644]
[1] Rebecca Page et al (2016) Toxin-antitoxin systems in bacterial growth arrest and persistence. Nature chemical biology. 12(4):208-14. [PudMed:26991085]
[2] Régine Brielle et al (2016) Linking bacterial type I toxins with their actions. Current opinion in microbiology. 30:114-121. [PudMed:26874964]
[3] Brooke Hamilton et al (2014) Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. PloS one. 9(11):e112921. [PudMed:25391136]
[4] Marcel Prax et al (2014) Metabolic aspects of bacterial persisters. Frontiers in cellular and infection microbiology. 4:148. [PudMed:25374846]
[5] Richard A Proctor et al (2014) Staphylococcus aureus Small Colony Variants (SCVs): a road map for the metabolic pathways involved in persistent infections. Frontiers in cellular and infection microbiology. 4:99. [PudMed:25120957]
[6] Brian P Conlon (2014) Staphylococcus aureus chronic and relapsing infections: Evidence of a role for persister cells: An investigation of persister cells, their formation and their role in S. aureus disease. BioEssays : news and reviews in molecular, cellular and developmental biology. 36(10):991-6. [PudMed:25100240]
[7] Yurong Wen et al (2014) The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic acids research. 42(15):10134-47. [PudMed:25056321]
[8] Ying Hu et al (2015) Toxin YafQ increases persister cell formation by reducing indole signalling. Environmental microbiology. 17(4):1275-85. [PudMed:25041421]
[9] Sophie Helaine et al (2014) Bacterial persisters: formation, eradication, and experimental systems. Trends in microbiology. 22(7):417-24. [PudMed:24768561]
[10] Etienne Maisonneuve et al (2014) Molecular mechanisms underlying bacterial persisters. Cell. 157(3):539-48. [PudMed:24766804]
[11] Heleen Van Acker et al (2014) Involvement of toxin-antitoxin modules in Burkholderia cenocepacia biofilm persistence. Pathogens and disease. 71(3):326-35. [PudMed:24719230]
[12] Ambre Sala et al (2014) Multiple toxin-antitoxin systems in Mycobacterium tuberculosis. Toxins. 6(3):1002-20. [PudMed:24662523]
[13] Aaron Butt et al (2014) The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation. The Biochemical journal. 459(2):333-44. [PudMed:24502667]
[14] Sophie Helaine et al (2014) Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science (New York, N.Y.). 343(6167):204-8. [PudMed:24408438]
[15] Arti Tripathi et al (2014) MazF-induced growth inhibition and persister generation in Escherichia coli. The Journal of biological chemistry. 289(7):4191-205. [PudMed:24375411]
[16] Jingchen Feng et al (2014) Growth feedback as a basis for persister bistability. Proceedings of the National Academy of Sciences of the United States of America. 111(1):544-9. [PudMed:24344277]
[17] Ilana Kaspy et al (2013) HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase. Nature communications. 4:3001. [PudMed:24343429]
[18] Elsa Germain et al (2013) Molecular mechanism of bacterial persistence by HipA. Molecular cell. 52(2):248-54. [PudMed:24095282]
[19] Lendert Gelens et al (2013) A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli. PLoS computational biology. 9(8):e1003190. [PudMed:24009490]
[20] Etienne Maisonneuve et al (2013) (p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity. Cell. 154(5):1140-1150. [PudMed:23993101]
[21] Dorothée L Schuessler et al (2013) Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA. Molecular microbiology. 90(1):195-207. [PudMed:23927792]
[22] Nicoletta Nolle et al (2013) Two paralogous yefM-yoeB loci from Staphylococcus equorum encode functional toxin-antitoxin systems. Microbiology (Reading, England). 159(Pt 8):1575-1585. [PudMed:23832005]
[23] Rick A Fasani et al (2013) Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype. Proceedings of the National Academy of Sciences of the United States of America. 110(27):E2528-37. [PudMed:23781105]
[24] Stephanie M Amato et al (2013) Metabolic control of persister formation in Escherichia coli. Molecular cell. 50(4):475-87. [PudMed:23665232]
[25] Villu Kasari et al (2013) Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli. BMC microbiology. 13:45. [PudMed:23432955]
[26] Steven De Gieter et al (2014) ¹H, ¹³C, and ¹⁵N backbone and side-chain chemical shift assignment of the toxin Doc in the unbound state. Biomolecular NMR assignments. 8(1):145-8. [PudMed:23420131]
[27] Stephanie Koyanagi et al (2013) Characterization of a Streptococcus mutans intergenic region containing a small toxic peptide and its cis-encoded antisense small RNA antitoxin. PloS one. 8(1):e54291. [PudMed:23326602]
[28] Steve P Bernier et al (2013) Starvation, together with the SOS response, mediates high biofilm-specific tolerance to the fluoroquinolone ofloxacin. PLoS genetics. 9(1):e1003144. [PudMed:23300476]
[29] Brian W Kwan et al (2013) Arrested protein synthesis increases persister-like cell formation. Antimicrobial agents and chemotherapy. 57(3):1468-73. [PudMed:23295927]
[30] Christopher F Schuster et al (2013) Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate. FEMS microbiology letters. 340(2):73-85. [PudMed:23289536]
[31] Andrew Slattery et al (2013) Isolation of highly persistent mutants of Salmonella enterica serovar typhimurium reveals a new toxin-antitoxin module. Journal of bacteriology. 195(4):647-57. [PudMed:23204462]
[32] Breann L Brown et al (2013) The Escherichia coli toxin MqsR destabilizes the transcriptional repression complex formed between the antitoxin MqsA and the mqsRA operon promoter. The Journal of biological chemistry. 288(2):1286-94. [PudMed:23172222]
[33] E Gerhart H Wagner et al (2012) The toxin-antitoxin system tisB-istR1: Expression, regulation, and biological role in persister phenotypes. RNA biology. 9(12):1513-9. [PudMed:23093802]
[34] Kim Lewis (2012) Persister cells: molecular mechanisms related to antibiotic tolerance. Handbook of experimental pharmacology. (211):121-33. [PudMed:23090599]
[35] Iris Keren et al (2012) Persister eradication: lessons from the world of natural products. Methods in enzymology. 517:387-406. [PudMed:23084949]
[36] J Paul Norton et al (2012) Toxin-antitoxin systems are important for niche-specific colonization and stress resistance of uropathogenic Escherichia coli. PLoS pathogens. 8(10):e1002954. [PudMed:23055930]
[37] Kenn Gerdes et al (2012) Bacterial persistence and toxin-antitoxin loci. Annual review of microbiology. 66:103-23. [PudMed:22994490]
[38] Laurence Van Melderen (2012) GhoSTly bacterial persisters. Nature chemical biology. 8(10):812-3. [PudMed:22987009]
[39] Xiaoxue Wang et al (2012) A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nature chemical biology. 8(10):855-61. [PudMed:22941047]
[40] Arti Tripathi et al (2012) Additional role for the ccd operon of F-plasmid as a transmissible persistence factor. Proceedings of the National Academy of Sciences of the United States of America. 109(31):12497-502. [PudMed:22802647]
[41] Lígia S Muranaka et al (2012) Global expression profile of biofilm resistance to antimicrobial compounds in the plant-pathogenic bacterium Xylella fastidiosa reveals evidence of persister cells. Journal of bacteriology. 194(17):4561-9. [PudMed:22730126]
[42] Sonja Hansen et al (2012) Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis. PloS one. 7(6):e39185. [PudMed:22720069]
[43] Rachel S Koh et al (2012) Modeling suggests that gene circuit architecture controls phenotypic variability in a bacterial persistence network. BMC systems biology. 6:47. [PudMed:22607777]
[44] Bongsoo Lee et al (2012) Myxococcus xanthus developmental cell fate production: heterogeneous accumulation of developmental regulatory proteins and reexamination of the role of MazF in developmental lysis. Journal of bacteriology. 194(12):3058-68. [PudMed:22493014]
[45] Ying Zhang et al (2012) Targeting persisters for tuberculosis control. Antimicrobial agents and chemotherapy. 56(5):2223-30. [PudMed:22391538]
[46] Vincent Leung et al (2012) A stress-inducible quorum-sensing peptide mediates the formation of persister cells with noninherited multidrug tolerance. Journal of bacteriology. 194(9):2265-74. [PudMed:22366415]
[47] Yosuke Tashiro et al (2012) RelE-mediated dormancy is enhanced at high cell density in Escherichia coli. Journal of bacteriology. 194(5):1169-76. [PudMed:22210768]
[48] Jeong-Sun Han et al (2010) Characterization of a chromosomal toxin-antitoxin, Rv1102c-Rv1103c system in Mycobacterium tuberculosis. Biochemical and biophysical research communications. 400(3):293-8. [PudMed:20705052]
[49] Kim Lewis (2010) Persister cells. Annual review of microbiology. 64:357-72. [PudMed:20528688]
[50] Younghoon Kim et al (2010) Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environmental microbiology. 12(5):1105-21. [PudMed:20105222]
[51] Breann L Brown et al (2009) Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. PLoS pathogens. 5(12):e1000706. [PudMed:20041169]
[52] W Florian Fricke et al (2009) Comparative genomics of the IncA/C multidrug resistance plasmid family. Journal of bacteriology. 191(15):4750-7. [PudMed:19482926]
[53] R Jayaraman (2008) Bacterial persistence: some new insights into an old phenomenon. Journal of biosciences. 33(5):795-805. [PudMed:19179767]
[54] Maria A Schumacher et al (2009) Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science (New York, N.Y.). 323(5912):396-401. [PudMed:19150849]
[55] Shaleen B Korch et al (2006) Ectopic overexpression of wild-type and mutant hipA genes in Escherichia coli: effects on macromolecular synthesis and persister formation. Journal of bacteriology. 188(11):3826-36. [PudMed:16707675]
[56] Nora Vázquez-Laslop et al (2006) Increased persistence in Escherichia coli caused by controlled expression of toxins or other unrelated proteins. Journal of bacteriology. 188(10):3494-7. [PudMed:16672603]
[57] Iris Keren et al (2004) Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. Journal of bacteriology. 186(24):8172-80. [PudMed:15576765]
[58] Shaleen B Korch et al (2003) Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis. Molecular microbiology. 50(4):1199-213. [PudMed:14622409]
[59] H S Moyed et al (1983) hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis. Journal of bacteriology. 155(2):768-75. [PudMed:6348026]
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[2] Dukas Jurėnas et al (2021) Bistable Expression of a Toxin-Antitoxin System Located in a Cryptic Prophage of Escherichia coli O157:H7. mBio. 12(6):e0294721. [PudMed:34844426]
[3] Aya Takashima et al (2022) A toxin-antitoxin system confers stability to the IncP-7 plasmid pCAR1. Gene. 812:146068. [PudMed:34838639]
[4] Songwei Ni et al (2021) Conjugative plasmid-encoded toxin-antitoxin system PrpT/PrpA directly controls plasmid copy number. Proceedings of the National Academy of Sciences of the United States of America. 118(4):e2011577118. [PudMed:33483419]
[5] Yingjie Song et al (2021) Pseudomonas aeruginosa antitoxin HigA functions as a diverse regulatory factor by recognizing specific pseudopalindromic DNA motifs. Environmental microbiology. 23(3):1541-1558. [PudMed:33346387]
[6] Yangmei Li et al (2020) Prophage encoding toxin/antitoxin system PfiT/PfiA inhibits Pf4 production in Pseudomonas aeruginosa. Microbial biotechnology. 13(4):1132-1144. [PudMed:32246813]
[7] Paula Bustamante et al (2019) The roles of HicBA and a novel toxin-antitoxin-like system, TsxAB, in the stability of IncX4 resistance plasmids in Escherichia coli. The Journal of antimicrobial chemotherapy. 74(3):553-556. [PudMed:30535076]
[8] Jianyun Yao et al (2018) Type II toxin/antitoxin system ParESO /CopASO stabilizes prophage CP4So in Shewanella oneidensis. Environmental microbiology. 20(3):1224-1239. [PudMed:29411516]
[9] Alexander Harms et al (2017) A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella. PLoS genetics. 13(10):e1007077. [PudMed:29073136]
[10] K C Hernández-Ramírez et al (2017) Plasmid pUM505 encodes a Toxin-Antitoxin system conferring plasmid stability and increased Pseudomonas aeruginosa virulence. Microbial pathogenesis. 112:259-268. [PudMed:28970172]
[11] Giulia Pilla et al (2017) Genetic plasticity of the Shigella virulence plasmid is mediated by intra- and inter-molecular events between insertion sequences. PLoS genetics. 13(9):e1007014. [PudMed:28945748]
[12] Andrea M Hujer et al (2017) Nosocomial Outbreak of Extensively Drug-Resistant Acinetobacter baumannii Isolates Containing blaOXA-237 Carried on a Plasmid. Antimicrobial agents and chemotherapy. 61(11):e00797-17. [PudMed:28893775]
[13] Krzysztof Romaniuk et al (2017) Molecular characterization of the pA3J1 plasmid from the psychrotolerant Antarctic bacterium Pseudomonas sp. ANT_J3. Plasmid. 92:49-56. [PudMed:28802584]
[14] Zhongling Wen et al (2017) Interaction of Type IV Toxin/Antitoxin Systems in Cryptic Prophages of Escherichia coli K-12. Toxins. 9(3):77. [PudMed:28257056]