87021

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 347809..348347 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag CSW01_RS15935 Protein ID WP_000802136.1
Coordinates 347809..348108 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag CSW01_RS15940 Protein ID WP_001107719.1
Coordinates 348105..348347 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSW01_RS15885 343744..343926 + 183 WP_000923182.1 DUF645 family protein -
CSW01_RS15890 344126..344599 + 474 WP_001161076.1 GrpB family protein -
CSW01_RS15895 344614..344706 + 93 WP_014378730.1 DUF3265 domain-containing protein -
CSW01_RS15900 344748..345374 + 627 WP_000365424.1 LysE family translocator -
CSW01_RS15905 345497..346195 + 699 WP_001890502.1 hypothetical protein -
CSW01_RS15910 346205..346315 + 111 WP_079857360.1 DUF3265 domain-containing protein -
CSW01_RS15925 346893..347072 + 180 WP_001883058.1 DUF645 family protein -
CSW01_RS15930 347286..347681 + 396 WP_000870857.1 DUF3465 domain-containing protein -
CSW01_RS15935 347809..348108 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSW01_RS15940 348105..348347 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CSW01_RS15945 348576..349154 + 579 WP_000110120.1 hypothetical protein -
CSW01_RS15950 349176..349268 + 93 WP_014164112.1 DUF3265 domain-containing protein -
CSW01_RS15960 349692..350375 + 684 WP_000877436.1 hypothetical protein -
CSW01_RS15965 350589..350855 + 267 WP_000937852.1 hypothetical protein -
CSW01_RS15980 351010..351609 + 600 WP_000429495.1 hypothetical protein -
CSW01_RS15985 351890..352825 + 936 WP_000051985.1 restriction endonuclease -
CSW01_RS15990 352791..352931 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304226..433944 129718
inside Integron - - 309306..433568 124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T87021 WP_000802136.1 NZ_CP024163:c348108-347809 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T87021 NZ_CP024163:c348108-347809 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT87021 WP_001107719.1 NZ_CP024163:c348347-348105 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT87021 NZ_CP024163:c348347-348105 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References