Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 347809..348347 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag CSW01_RS15935 Protein ID WP_000802136.1
Coordinates 347809..348108 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag CSW01_RS15940 Protein ID WP_001107719.1
Coordinates 348105..348347 (-) Length 81 a.a.

Genomic Context

CSW01_RS15885CSW01_RS15890CSW01_RS15895CSW01_RS15900CSW01_RS15905CSW01_RS15910CSW01_RS15925CSW01_RS15930CSW01_RS15945CSW01_RS15950CSW01_RS15960CSW01_RS15965CSW01_RS15980CSW01_RS15985CSW01_RS15990CSW01_RS15935CSW01_RS15940
Location: 343744..343926 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 344126..344599 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 344614..344706 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 344748..345374 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 345497..346195 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 346205..346315 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 346893..347072 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 347286..347681 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 348576..349154 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 349176..349268 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 349692..350375 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 350589..350855 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 351010..351609 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 351890..352825 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 352791..352931 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 347809..348108 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 348105..348347 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSW01_RS15885343744..343926+183WP_000923182.1DUF645 family protein-
CSW01_RS15890344126..344599+474WP_001161076.1GrpB family protein-
CSW01_RS15895344614..344706+93WP_014378730.1DUF3265 domain-containing protein-
CSW01_RS15900344748..345374+627WP_000365424.1LysE family translocator-
CSW01_RS15905345497..346195+699WP_001890502.1hypothetical protein-
CSW01_RS15910346205..346315+111WP_079857360.1DUF3265 domain-containing protein-
CSW01_RS15925346893..347072+180WP_001883058.1DUF645 family protein-
CSW01_RS15930347286..347681+396WP_000870857.1DUF3465 domain-containing protein-
CSW01_RS15935347809..348108-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CSW01_RS15940348105..348347-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
CSW01_RS15945348576..349154+579WP_000110120.1hypothetical protein-
CSW01_RS15950349176..349268+93WP_014164112.1DUF3265 domain-containing protein-
CSW01_RS15960349692..350375+684WP_000877436.1hypothetical protein-
CSW01_RS15965350589..350855+267WP_000937852.1hypothetical protein-
CSW01_RS15980351010..351609+600WP_000429495.1hypothetical protein-
CSW01_RS15985351890..352825+936WP_000051985.1restriction endonuclease-
CSW01_RS15990352791..352931+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304226..433944129718
insideIntegron--309306..433568124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T87021 WP_000802136.1 NZ_CP024163:c348108-347809 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T87021 NZ_CP024163:c348108-347809 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT87021 WP_001107719.1 NZ_CP024163:c348347-348105 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT87021 NZ_CP024163:c348347-348105 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References