Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 321285..321863 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag N900_RS15450 Protein ID WP_001180243.1
Coordinates 321285..321602 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag N900_RS15455 Protein ID WP_000557292.1
Coordinates 321621..321863 (-) Length 81 a.a.

Genomic Context

N900_RS15415N900_RS15425N900_RS15430N900_RS15435N900_RS15440N900_RS15445N900_RS15460N900_RS19420N900_RS15465N900_RS15475N900_RS15480N900_RS19910N900_RS19915N900_RS15500N900_RS15450N900_RS15455N900_RS15485N900_RS15490
Location: 316809..316991 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 317345..317527 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 317722..318399 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 318561..319769 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 319931..320635 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 320793..321131 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 322107..322493 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 322550..322663 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 322672..322892 (221 bp)
Type: Others
Protein ID: Protein_279
Location: 323150..323686 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 323823..324338 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 325647..325772 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 325788..325826 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 326022..326468 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 321285..321602 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 321621..321863 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 324488..324985 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 324982..325254 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N900_RS15415316809..316991+183WP_000923340.1DUF645 family protein-
N900_RS15425317345..317527+183WP_000923153.1DUF645 family protein-
N900_RS15430317722..318399+678WP_000254617.1HNH endonuclease-
N900_RS15435318561..319769+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
N900_RS15440319931..320635+705WP_000087610.1HNH endonuclease-
N900_RS15445320793..321131+339WP_000713853.1hypothetical protein-
N900_RS15450321285..321602-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N900_RS15455321621..321863-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
N900_RS15460322107..322493+387WP_001015867.1NUDIX hydrolase-
N900_RS19420322550..322663+114WP_001900214.1hypothetical protein-
N900_RS15465322672..322892+221Protein_279DUF1289 domain-containing protein-
N900_RS15475323150..323686+537WP_000469482.1GNAT family N-acetyltransferase-
N900_RS15480323823..324338+516WP_001201509.1lipocalin family protein-
N900_RS15485324488..324985-498WP_000982260.1GNAT family N-acetyltransferase-
N900_RS15490324982..325254-273WP_000246253.1DUF1778 domain-containing protein-
N900_RS19910325647..325772+126WP_001900195.1DUF645 family protein-
N900_RS19915325788..325826+39WP_106019118.1hypothetical protein-
N900_RS15500326022..326468+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..411088106443
insideIntegron--309725..410760101035
-flankIS/Tn--326531..3277421211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T45802 WP_001180243.1 NZ_CP006948:c321602-321285 [Vibrio cholerae O1 str. KW3]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T45802 NZ_CP006948:c321602-321285 [Vibrio cholerae O1 str. KW3]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT45802 WP_000557292.1 NZ_CP006948:c321863-321621 [Vibrio cholerae O1 str. KW3]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT45802 NZ_CP006948:c321863-321621 [Vibrio cholerae O1 str. KW3]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References