Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 321285..321863 | Replicon | chromosome |
| Accession | NZ_CP006948 | ||
| Organism | Vibrio cholerae O1 str. KW3 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | N900_RS15450 | Protein ID | WP_001180243.1 |
| Coordinates | 321285..321602 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | N900_RS15455 | Protein ID | WP_000557292.1 |
| Coordinates | 321621..321863 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N900_RS15415 | 316809..316991 | + | 183 | WP_000923340.1 | DUF645 family protein | - |
| N900_RS15425 | 317345..317527 | + | 183 | WP_000923153.1 | DUF645 family protein | - |
| N900_RS15430 | 317722..318399 | + | 678 | WP_000254617.1 | HNH endonuclease | - |
| N900_RS15435 | 318561..319769 | + | 1209 | WP_000272282.1 | deoxyguanosinetriphosphate triphosphohydrolase family protein | - |
| N900_RS15440 | 319931..320635 | + | 705 | WP_000087610.1 | HNH endonuclease | - |
| N900_RS15445 | 320793..321131 | + | 339 | WP_000713853.1 | hypothetical protein | - |
| N900_RS15450 | 321285..321602 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| N900_RS15455 | 321621..321863 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| N900_RS15460 | 322107..322493 | + | 387 | WP_001015867.1 | NUDIX hydrolase | - |
| N900_RS19420 | 322550..322663 | + | 114 | WP_001900214.1 | hypothetical protein | - |
| N900_RS15465 | 322672..322892 | + | 221 | Protein_279 | DUF1289 domain-containing protein | - |
| N900_RS15475 | 323150..323686 | + | 537 | WP_000469482.1 | GNAT family N-acetyltransferase | - |
| N900_RS15480 | 323823..324338 | + | 516 | WP_001201509.1 | lipocalin family protein | - |
| N900_RS15485 | 324488..324985 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| N900_RS15490 | 324982..325254 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| N900_RS19910 | 325647..325772 | + | 126 | WP_001900195.1 | DUF645 family protein | - |
| N900_RS19915 | 325788..325826 | + | 39 | WP_106019118.1 | hypothetical protein | - |
| N900_RS15500 | 326022..326468 | + | 447 | WP_000006157.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 304645..411088 | 106443 | |
| inside | Integron | - | - | 309725..410760 | 101035 | ||
| - | flank | IS/Tn | - | - | 326531..327742 | 1211 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T45802 WP_001180243.1 NZ_CP006948:c321602-321285 [Vibrio cholerae O1 str. KW3]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T45802 NZ_CP006948:c321602-321285 [Vibrio cholerae O1 str. KW3]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT45802 WP_000557292.1 NZ_CP006948:c321863-321621 [Vibrio cholerae O1 str. KW3]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT45802 NZ_CP006948:c321863-321621 [Vibrio cholerae O1 str. KW3]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UJR8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7DCR7 |