Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
Location | 412514..413147 | Replicon | chromosome |
Accession | NZ_CP025937 | ||
Organism | Vibrio cholerae strain A1552 |
Toxin (Protein)
Gene name | higB | Uniprot ID | Q9KMA6 |
Locus tag | C1H56_RS16700 | Protein ID | WP_000843587.1 |
Coordinates | 412514..412846 (+) | Length | 111 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | C1H56_RS16705 | Protein ID | WP_000071008.1 |
Coordinates | 412833..413147 (+) | Length | 105 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C1H56_RS19990 | 407955..408158 | + | 204 | WP_001911745.1 | hypothetical protein | - |
C1H56_RS16630 | 408439..408612 | + | 174 | WP_001882305.1 | DUF3709 domain-containing protein | - |
C1H56_RS16635 | 408972..409241 | + | 270 | WP_001198131.1 | hypothetical protein | - |
C1H56_RS19995 | 409552..409638 | + | 87 | WP_134820423.1 | DUF645 family protein | - |
C1H56_RS20000 | 409638..409730 | + | 93 | Protein_431 | DUF645 family protein | - |
C1H56_RS16650 | 409939..410325 | + | 387 | WP_000703163.1 | VOC family protein | - |
C1H56_RS16655 | 410527..410769 | + | 243 | WP_000107461.1 | hypothetical protein | - |
C1H56_RS16660 | 410940..411317 | + | 378 | WP_000411109.1 | hypothetical protein | - |
C1H56_RS20005 | 411374..411488 | + | 115 | Protein_435 | acetyltransferase | - |
C1H56_RS16665 | 411437..411718 | + | 282 | WP_001894453.1 | DUF1289 domain-containing protein | - |
C1H56_RS16680 | 411884..411997 | + | 114 | WP_001889158.1 | hypothetical protein | - |
C1H56_RS16685 | 411946..412173 | + | 228 | WP_001894457.1 | DUF1289 domain-containing protein | - |
C1H56_RS16700 | 412514..412846 | + | 333 | WP_000843587.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
C1H56_RS16705 | 412833..413147 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | Antitoxin |
C1H56_RS16710 | 413284..413718 | + | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
C1H56_RS19860 | 413886..414041 | + | 156 | WP_000751734.1 | hypothetical protein | - |
C1H56_RS16715 | 414166..415146 | - | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
C1H56_RS16720 | 415214..415486 | + | 273 | Protein_444 | CatB-related O-acetyltransferase | - |
C1H56_RS16725 | 415657..416349 | + | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
C1H56_RS16730 | 416349..416750 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
C1H56_RS16735 | 416720..416863 | + | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
C1H56_RS16740 | 416938..417351 | + | 414 | WP_000049417.1 | VOC family protein | - |
C1H56_RS16745 | 417565..417816 | + | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
C1H56_RS16750 | 417806..418093 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 304067..433328 | 129261 | |
inside | Integron | catB9 | - | 309147..432952 | 123805 | ||
flank | IS/Tn | - | - | 414166..415146 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13005.95 Da Isoelectric Point: 9.9244
>T92511 WP_000843587.1 NZ_CP025937:412514-412846 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS
Download Length: 333 bp
>T92511 NZ_CP025937:412514-412846 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11696.20 Da Isoelectric Point: 6.7600
>AT92511 WP_000071008.1 NZ_CP025937:412833-413147 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT92511 NZ_CP025937:412833-413147 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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