92511

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 412514..413147 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag C1H56_RS16700 Protein ID WP_000843587.1
Coordinates 412514..412846 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C1H56_RS16705 Protein ID WP_000071008.1
Coordinates 412833..413147 (+) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1H56_RS19990 407955..408158 + 204 WP_001911745.1 hypothetical protein -
C1H56_RS16630 408439..408612 + 174 WP_001882305.1 DUF3709 domain-containing protein -
C1H56_RS16635 408972..409241 + 270 WP_001198131.1 hypothetical protein -
C1H56_RS19995 409552..409638 + 87 WP_134820423.1 DUF645 family protein -
C1H56_RS20000 409638..409730 + 93 Protein_431 DUF645 family protein -
C1H56_RS16650 409939..410325 + 387 WP_000703163.1 VOC family protein -
C1H56_RS16655 410527..410769 + 243 WP_000107461.1 hypothetical protein -
C1H56_RS16660 410940..411317 + 378 WP_000411109.1 hypothetical protein -
C1H56_RS20005 411374..411488 + 115 Protein_435 acetyltransferase -
C1H56_RS16665 411437..411718 + 282 WP_001894453.1 DUF1289 domain-containing protein -
C1H56_RS16680 411884..411997 + 114 WP_001889158.1 hypothetical protein -
C1H56_RS16685 411946..412173 + 228 WP_001894457.1 DUF1289 domain-containing protein -
C1H56_RS16700 412514..412846 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1H56_RS16705 412833..413147 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
C1H56_RS16710 413284..413718 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
C1H56_RS19860 413886..414041 + 156 WP_000751734.1 hypothetical protein -
C1H56_RS16715 414166..415146 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
C1H56_RS16720 415214..415486 + 273 Protein_444 CatB-related O-acetyltransferase -
C1H56_RS16725 415657..416349 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
C1H56_RS16730 416349..416750 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
C1H56_RS16735 416720..416863 + 144 WP_071908341.1 DUF3265 domain-containing protein -
C1H56_RS16740 416938..417351 + 414 WP_000049417.1 VOC family protein -
C1H56_RS16745 417565..417816 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
C1H56_RS16750 417806..418093 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304067..433328 129261
inside Integron catB9 - 309147..432952 123805
flank IS/Tn - - 414166..415146 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-100)

Antitoxin

(43-92)


Sequences


Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T92511 WP_000843587.1 NZ_CP025937:412514-412846 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T92511 NZ_CP025937:412514-412846 [Vibrio cholerae]
ATGAAAAGTGTATTTGTCGAATCAACAATTTTTGAAAAGTACCGAGATGAATATCTCAGTGATGAGGAGTATAGGCTCTT
TCAAGCAGAGCTAATGCTAAACCCCAAGCTGGGTGATGTGATTCAAGGTACTGGCGGTTTGCGAAAAATTCGAGTTGCGA
GTAAAGGCAAGGGAAAGCGTGGTGGTTCACGGATTATCTATTACTTTCTCGATGAAAAGAGGCGTTTCTATTTGCTAACC
ATTTACGGCAAAAATGAAATGTCTGACTTGAATGCAAATCAAAGGAAACAACTAATGGCTTTTATGGAGGCGTGGCGCAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT92511 WP_000071008.1 NZ_CP025937:412833-413147 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT92511 NZ_CP025937:412833-413147 [Vibrio cholerae]
ATGAGCAATCGTGATTTATTTGCAGAGTTAAGCTCAGCTCTTGTTGAGGCTAAGCAGCATTCAGAAGGTAAGCTTACTCT
GAAAACACATCATGTGAATGATGTGGGTGAGTTGAACATCTCACCGGATGAAATCGTGAGTATTCGCGAGCAGTTCAATA
TGTCCCGCGGAGTCTTCGCGCGGTTACTTCATACGTCTTCGCGCACATTAGAAAACTGGGAACAAGGTCGTAGTGTGCCA
AATGGTCAAGCGGTCACTCTTTTAAAGTTAGTACAGCGTCATCCAGAAACGTTGTCACACATAGCCGAGCTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA


Antitoxin

Source ID Structure

References