The relBE superfamily contains seven two-component subfamilies: relBE, higBA, prlF-yhaV, mqsRA, yafN-yafO, dinJ-yafQ and yefM-yoeB. These seven families are clustered together due to the sequence similarity and/or significantly similar tertiary folds of toxin proteins.

• TA families

TA family	Toxin	Antitoxin	Toxin target	Number of Exp. TA loci
relBE	relE	relB	mRNA cleavage (translation)	58
higBA	higB	higA	mRNA cleavage (translation)	22
mqsRA	mqsR	mqsA	mRNA cleavage (translation)	4
prlF-yhaV	yhaV	prlF	mRNA cleavage (translation)	1
yefM-yoeB	yoeB	yefM	mRNA cleavage (Translation)	15
DinJ-YafQ	yafQ	dinJ	mRNA cleavage (Translation)	9
yafN-yafO	yafO	yafN	mRNA cleavage (Translation)	1

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The number of experimentally validated TA loci