211922

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 1020654..1021232 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag K1T75_RS18555 Protein ID WP_001180243.1
Coordinates 1020915..1021232 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag K1T75_RS18550 Protein ID WP_000557292.1
Coordinates 1020654..1020896 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS18500 1016048..1016494 - 447 WP_000006157.1 hypothetical protein -
K1T75_RS18510 1016744..1016869 - 126 WP_001900195.1 DUF645 family protein -
K1T75_RS18515 1017262..1017534 + 273 WP_000246253.1 DUF1778 domain-containing protein -
K1T75_RS18520 1017531..1018028 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
K1T75_RS19000 1018045..1018113 - 69 Protein_970 acetyltransferase -
K1T75_RS18525 1018178..1018639 - 462 WP_001903091.1 lipocalin family protein -
K1T75_RS18530 1018830..1019366 - 537 WP_000469482.1 GNAT family protein -
K1T75_RS18535 1019624..1019845 - 222 WP_032467793.1 DUF1289 domain-containing protein -
K1T75_RS18540 1019854..1019967 - 114 WP_001900214.1 hypothetical protein -
K1T75_RS18545 1020024..1020410 - 387 WP_001015867.1 NUDIX hydrolase -
K1T75_RS18550 1020654..1020896 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K1T75_RS18555 1020915..1021232 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1T75_RS18560 1021386..1021724 - 339 WP_000713853.1 hypothetical protein -
K1T75_RS18565 1021882..1022586 - 705 WP_000087610.1 HNH endonuclease -
K1T75_RS18570 1022748..1023956 - 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
K1T75_RS18575 1024118..1024795 - 678 WP_000254617.1 HNH endonuclease signature motif containing protein -
K1T75_RS18580 1024990..1025172 - 183 WP_000923153.1 DUF645 family protein -
K1T75_RS19005 1025344..1025406 - 63 Protein_983 acetyltransferase -
K1T75_RS18585 1025526..1025708 - 183 WP_000923340.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T211922 WP_001180243.1 NZ_CP080466:1020915-1021232 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T211922 NZ_CP106849:c1965686-1965336 [Edwardsiella ictaluri]
GTGTGGATCGTTGAAACGACAGCCGCTTTTGATGAGTGGTTTACGGCACAGAGTGAGGCTTTGCAGGACGAAATGCTGGC
CGCTTTAACCGTATTGAGCGAGTTCGGCCCTAACCTCGGACGCCCTATCGTGGATACGTTAAAGGGTGCAAAGCTGGCAA
ACCTTAAGGAGTTGCGGGTTCAGTTCGCCGGTAATCCGATTCGTGCATTTTTTGCATTCGATCCAGAACGAAAAGCAATT
GTGTTATGCGCTGGCGACAAAACAGGCATCAACGAAAAACGGTTCTATAATTCAATGATTAAGCTTGCTGAGGCTGAATT
CAGTAGTCACCTGAAAAAACGAGGTTCTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT211922 WP_000557292.1 NZ_CP080466:1020654-1020896 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT211922 NZ_CP106849:c1965334-1965035 [Edwardsiella ictaluri]
ATGGCAACGCTAGATAAGCTGTTGGCACAGCGTAGTCCTGAAAGTCGCGCGAAAATTGAAGCGCGGGCTGATGAATTGCG
TCGGGAAGTATTGCTCCATCAGCTGAGAGAAGAACTGAGTATGTCACAGAGCGAATTAGCCGCCGCGATGGGGGTAAAAC
AGCCGACAGTGGCAAGAATGGAGCAGCCAGACAACGATCCGCGTTTATCTACGCTTAAACGCTATGTGACCGCCTTGGGC
GGCCAGATAAGTATTGATGTGACGCTACCGACGGGTAAGCGGGTTGGTTTTCACCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References