Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 1020654..1021232 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag K1T75_RS18555 Protein ID WP_001180243.1
Coordinates 1020915..1021232 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag K1T75_RS18550 Protein ID WP_000557292.1
Coordinates 1020654..1020896 (+) Length 81 a.a.

Genomic Context

K1T75_RS18515K1T75_RS18520K1T75_RS18550K1T75_RS18555K1T75_RS18500K1T75_RS18510K1T75_RS19000K1T75_RS18525K1T75_RS18530K1T75_RS18535K1T75_RS18540K1T75_RS18545K1T75_RS18560K1T75_RS18565K1T75_RS18570K1T75_RS18575K1T75_RS18580K1T75_RS19005K1T75_RS18585
Location: 1017262..1017534 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 1017531..1018028 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 1020654..1020896 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 1020915..1021232 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 1016048..1016494 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 1016744..1016869 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 1018045..1018113 (69 bp)
Type: Others
Protein ID: Protein_970
Location: 1018178..1018639 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 1018830..1019366 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 1019624..1019845 (222 bp)
Type: Others
Protein ID: WP_032467793.1
Location: 1019854..1019967 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 1020024..1020410 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 1021386..1021724 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 1021882..1022586 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 1022748..1023956 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 1024118..1024795 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 1024990..1025172 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 1025344..1025406 (63 bp)
Type: Others
Protein ID: Protein_983
Location: 1025526..1025708 (183 bp)
Type: Others
Protein ID: WP_000923340.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K1T75_RS185001016048..1016494-447WP_000006157.1hypothetical protein-
K1T75_RS185101016744..1016869-126WP_001900195.1DUF645 family protein-
K1T75_RS185151017262..1017534+273WP_000246253.1DUF1778 domain-containing protein-
K1T75_RS185201017531..1018028+498WP_000982260.1GNAT family N-acetyltransferase-
K1T75_RS190001018045..1018113-69Protein_970acetyltransferase-
K1T75_RS185251018178..1018639-462WP_001903091.1lipocalin family protein-
K1T75_RS185301018830..1019366-537WP_000469482.1GNAT family protein-
K1T75_RS185351019624..1019845-222WP_032467793.1DUF1289 domain-containing protein-
K1T75_RS185401019854..1019967-114WP_001900214.1hypothetical protein-
K1T75_RS185451020024..1020410-387WP_001015867.1NUDIX hydrolase-
K1T75_RS185501020654..1020896+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
K1T75_RS185551020915..1021232+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K1T75_RS185601021386..1021724-339WP_000713853.1hypothetical protein-
K1T75_RS185651021882..1022586-705WP_000087610.1HNH endonuclease-
K1T75_RS185701022748..1023956-1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
K1T75_RS185751024118..1024795-678WP_000254617.1HNH endonuclease signature motif containing protein-
K1T75_RS185801024990..1025172-183WP_000923153.1DUF645 family protein-
K1T75_RS190051025344..1025406-63Protein_983acetyltransferase-
K1T75_RS185851025526..1025708-183WP_000923340.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932680..1039634106954
insideIntegron--933056..103279299736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T211922 WP_001180243.1 NZ_CP080466:1020915-1021232 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T211922 NZ_CP106849:c1965686-1965336 [Edwardsiella ictaluri]
GTGTGGATCGTTGAAACGACAGCCGCTTTTGATGAGTGGTTTACGGCACAGAGTGAGGCTTTGCAGGACGAAATGCTGGC
CGCTTTAACCGTATTGAGCGAGTTCGGCCCTAACCTCGGACGCCCTATCGTGGATACGTTAAAGGGTGCAAAGCTGGCAA
ACCTTAAGGAGTTGCGGGTTCAGTTCGCCGGTAATCCGATTCGTGCATTTTTTGCATTCGATCCAGAACGAAAAGCAATT
GTGTTATGCGCTGGCGACAAAACAGGCATCAACGAAAAACGGTTCTATAATTCAATGATTAAGCTTGCTGAGGCTGAATT
CAGTAGTCACCTGAAAAAACGAGGTTCTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT211922 WP_000557292.1 NZ_CP080466:1020654-1020896 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT211922 NZ_CP106849:c1965334-1965035 [Edwardsiella ictaluri]
ATGGCAACGCTAGATAAGCTGTTGGCACAGCGTAGTCCTGAAAGTCGCGCGAAAATTGAAGCGCGGGCTGATGAATTGCG
TCGGGAAGTATTGCTCCATCAGCTGAGAGAAGAACTGAGTATGTCACAGAGCGAATTAGCCGCCGCGATGGGGGTAAAAC
AGCCGACAGTGGCAAGAATGGAGCAGCCAGACAACGATCCGCGTTTATCTACGCTTAAACGCTATGTGACCGCCTTGGGC
GGCCAGATAAGTATTGATGTGACGCTACCGACGGGTAAGCGGGTTGGTTTTCACCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References